Reactome | GLP1R [plasma membrane]

GLP1R [plasma membrane]

Stable Identifier

R-HSA-381684

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

GLP-1R, GLP-1 Receptor

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (s) signalling events (Homo sapiens)
      - Liganded Gs-activating GPCR acts as a GEF for Gs (Homo sapiens)
        
        GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        GLP-1:GLP-1R [plasma membrane] (Homo sapiens)
        
        GLP1R [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        GLP-1:GLP-1R [plasma membrane] (Homo sapiens)
        
        GLP1R [plasma membrane] (Homo sapiens)
      - Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        GLP-1:GLP-1R [plasma membrane] (Homo sapiens)
        
        GLP1R [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        GLP-1:GLP-1R [plasma membrane] (Homo sapiens)
        
        GLP1R [plasma membrane] (Homo sapiens)
      - The Ligand:GPCR:Gs complex dissociates (Homo sapiens)
        
        GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        GLP-1:GLP-1R [plasma membrane] (Homo sapiens)
        
        GLP1R [plasma membrane] (Homo sapiens)
        
        GPCRs that activate Gs [plasma membrane] (Homo sapiens)
        
        GLP1R [plasma membrane] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class B/2 (Secretin family receptors) (Homo sapiens)
      - Glucagon-type ligand receptors (Homo sapiens)
        
        GLP1R binds GLP1 (Homo sapiens)
        
        GLP1:GLP1R:Heterotrimeric G(s):GDP [plasma membrane] (Homo sapiens)
        
        GLP-1:GLP-1R [plasma membrane] (Homo sapiens)
        
        GLP1R [plasma membrane] (Homo sapiens)
        
        GLP1R:Heterotrimeric G(s):GDP [plasma membrane] (Homo sapiens)
        
        GLP1R [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P43220 GLP1R

Gene Names

GLP1R

Chain

signal peptide:1-23, chain:24-463

Reference Genes

BioGPS Gene:2740 GLP1R

COSMIC (genes):GLP1R GLP1R

CTD Gene:2740 GLP1R

dbSNP Gene:2740 GLP1R

ENSEMBL:ENSG00000112164 GLP1R

HGNC:4324 GLP1R

KEGG:hsa:2740 GLP1R

Monarch:2740 GLP1R

NCBI Gene:2740 GLP1R

OMIM:138032 GLP1R

UCSC:P43220 GLP1R

Reference Transcript

RefSeq:NM_002062.4 GLP1R

Other Identifiers

11738401_a_at

11750707_a_at

17008325

208390_PM_s_at

208390_s_at

208391_PM_s_at

208391_s_at

208400_PM_at

208400_at

208401_PM_s_at

208401_s_at

211232_PM_x_at

211232_x_at

2740

2906106

2906107

2906114

2906115

2906116

2906124

2906126

2906128

2906129

2906134

2906135

2906136

2906137

2906138

2906143

2906144

2906145

2906146

2906147

2906148

2906149

2906150

2906151

36404_at

36405_s_at

8119338

A_23_P392402

GE56132

GE740048

GE80815

GO:0004888

GO:0004930

GO:0004967

GO:0005515

GO:0005886

GO:0006886

GO:0007166

GO:0007186

GO:0007189

GO:0007190

GO:0007204

GO:0007611

GO:0008016

GO:0008528

GO:0016020

GO:0017046

GO:0019933

GO:0031204

GO:0038023

GO:0044508

GO:0045776

GO:0045777

GO:0046879

GO:0050877

GO:0055085

GO:0060089

GO:0071377

GO:1990911

HMNXSV003054346

ILMN_1787257

PH_hs_0018856

PH_hs_0019050

TC06000557.hg

U01157_at

g405081_3p_a_at

g4504016_3p_a_at

g684918_3p_s_at

Participates

as a component of

as a member of

GPCRs that activate Gs [plasma membrane] (Homo sapiens)

Inferred To

Glp1r [plasma membrane] (Mus musculus)

Glp1r [plasma membrane] (Rattus norvegicus)

gcgra [plasma membrane] (Danio rerio)

GLP-1R [plasma membrane] (Gallus gallus)

GLP1R [plasma membrane] (Bos taurus)

GLP1R [plasma membrane] (Canis familiaris)

GLP1R [plasma membrane] (Sus scrofa)

Cross References

RefSeq

NP_002053.3

Guide to Pharmacology - Targets

249

OpenTargets

ENSG00000112164

ENSEMBL

ENSP00000362353, ENST00000373256

ZINC - Substances

GLP1R_HUMAN

ZINC target

P43220

PRO

P43220

GlyGen

P43220

PDB

5OTX, 7LCK, 6VCB, 7X8S, 7C2E, 7RG9, 8JIS, 7S3I, 7DUR, 5OTT, 5OTU, 6GB1, 6X18, 8WG7, 7VBH, 7VBI, 7LLL, 7KI1, 7LCJ, 6ORV, 4ZGM, 3C59, 7RGP, 5VEX, 7RTB, 7X8R, 5OTW, 5OTV, 5NX2, 7S1M, 7KI0, 7LCI, 7EVM, 7E14, 6X1A, 8JIR, 7DUQ, 6X19, 5VEW, 6XOX, 3C5T, 6B3J, 3IOL, 7FIM, 7LLY, 8JIP, 5E94, 7S15

HPA

ENSG00000112164-GLP1R

Pharos - Targets

P43220

ZINC - Predictions - Purchasable

GLP1R_HUMAN

HMDB Protein

HMDBP14647

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P0DPK4 NOTCH2NLC	1	NOTCH2NLC [extracellular region] (R-HSA-9908932)	0.556	3
UniProt:Q7Z3S9 NOTCH2NLA	3	NOTCH2NLA [extracellular region] (R-HSA-9908935) NOTCH2NLA(1-?) [extracellular region] (R-HSA-9911493) NOTCH2NLA(?-236) [extracellular region] (R-HSA-9911490)	0.556	3