Reactome | OCRL [plasma membrane]

OCRL [plasma membrane]

Stable Identifier

R-HSA-3769049

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Inositol polyphosphate 5-phosphatase OCRL-1, OCRL_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q01968 OCRL

Gene Names

OCRL, INPP5F, OCRL1

Chain

chain:1-901

Reference Genes

BioGPS Gene:4952 OCRL

COSMIC (genes):INPP5F INPP5F

COSMIC (genes):OCRL OCRL

CTD Gene:4952 OCRL

dbSNP Gene:4952 OCRL

ENSEMBL:ENSG00000122126 OCRL

HGNC:8108 OCRL

KEGG:hsa:4952 OCRL

Monarch:4952 OCRL

NCBI Gene:4952 OCRL

OMIM:300535 OCRL

UCSC:Q01968 OCRL

Reference Transcript

Participates

as a candidate of

Inositol polyphosphate 5-phosphatase [plasma membrane] (Homo sapiens)

Other forms of this molecule

OCRL [Golgi membrane]

OCRL [cytoplasmic vesicle membrane]

OCRL [cytosol]

Inferred To

ocrl [plasma membrane] (Xenopus tropicalis)

Dd5P4 [plasma membrane] (Dictyostelium discoideum)

OCRL [plasma membrane] (Bos taurus)

OCRL [plasma membrane] (Canis familiaris)

OCRL [plasma membrane] (Gallus gallus)

OCRL [plasma membrane] (Plasmodium falciparum)

OCRL [plasma membrane] (Schizosaccharomyces pombe)

OCRL [plasma membrane] (Sus scrofa)

ocrl-1 [plasma membrane] (Caenorhabditis elegans)

Ocrl [plasma membrane] (Drosophila melanogaster)

Ocrl [plasma membrane] (Mus musculus)

Ocrl [plasma membrane] (Rattus norvegicus)

Cross References

RefSeq

NP_000267.2, NP_001578.2

Guide to Pharmacology - Targets

1460

ENSEMBL

ENST00000371113, ENSP00000360154, ENST00000357121, ENSP00000349635, ENSG00000122126

OpenTargets

ENSG00000122126

PRO

Q01968

GlyGen

Q01968

PDB

2QV2, 4CMN, 3QBT, 3QIS, 2KIE

IntEnz

3.1.3.86

GeneCards

OCRL

HPA

ENSG00000122126-OCRL

Pharos - Targets

Q01968

Orphanet

OCRL

HMDB Protein

HMDBP01569

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P20340 RAB6A	8	RAB6A [Golgi membrane] (R-HSA-1604442) RAB6A [secretory granule membrane] (R-HSA-6804970) RAB6A [plasma membrane] (R-HSA-6804981) RAB6A [cytosol] (R-HSA-6810979) GGC-RAB6A [cytosol] (R-HSA-8874052) GGC-RAB6A [trans-Golgi network membrane] (R-HSA-8876079) RAB6A [trans-Golgi network membrane] (R-HSA-6810981) RAB6A [endoplasmic reticulum membrane] (R-HSA-8849253)	0.875	14
UniProt:P20339 RAB5A	7	RAB5A [cytosol] (R-HSA-2201187) GGC-RAB5A [macropinosome membrane] (R-HSA-9837697) RAB5A [endosome membrane] (R-HSA-452257) RAB5A [early endosome membrane] (R-HSA-2130175) GGC-RAB5A [cytosol] (R-HSA-8870432) GGC-RAB5A [early endosome membrane] (R-HSA-8875323) GGC-RAB5A [clathrin-coated endocytic vesicle membrane] (R-HSA-8871125)	0.799	11
UniProt:P63000 RAC1	6	RAC1 [plasma membrane] (R-HSA-351141) RAC1 [cytosol] (R-HSA-442615) RAC1 [endoplasmic reticulum membrane] (R-HSA-5672076) GGC-PalmC-RAC1 [plasma membrane] (R-HSA-2316446) RAC1 [secretory granule membrane] (R-HSA-6804770) RAC1 [ficolin-1-rich granule membrane] (R-HSA-6804802)	0.556	3
UniProt:Q9UKG1 APPL1	1	APPL1 [endosome membrane] (R-HSA-373630)	0.534	2
UniProt:Q9NYZ3 GTSE1	4	GTSE1 [cytosol] (R-HSA-8852264) p-S435-GTSE1 [cytosol] (R-HSA-8852316) p-S435-GTSE1 [nucleoplasm] (R-HSA-8852332) p-T513,T526-GTSE1 [cytosol] (R-HSA-8852308)	0.527	2
UniProt:Q96CW1 AP2M1	6	AP2M1 [plasma membrane] (R-HSA-167585) AP2M1 [lysosomal membrane] (R-HSA-196144) AP2M1 [cytosol] (R-HSA-182227) AP2M1 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130423) AP2M1 [endolysosome membrane] (R-HSA-6784828) p-T156 AP2M1 [cytosol] (R-HSA-8856805)	0.508	3

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