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OCRL [plasma membrane]
Stable Identifier
R-HSA-3769049
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Inositol polyphosphate 5-phosphatase OCRL-1, OCRL_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Inositol phosphate metabolism (Homo sapiens)
Synthesis of IP3 and IP4 in the cytosol (Homo sapiens)
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane (Homo sapiens)
Inositol polyphosphate 5-phosphatase [plasma membrane] (Homo sapiens)
OCRL [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q01968 OCRL
Gene Names
OCRL, OCRL1
Chain
chain:1-901
Reference Genes
BioGPS Gene:4952 OCRL
COSMIC (genes):OCRL OCRL
CTD Gene:4952 OCRL
dbSNP Gene:4952 OCRL
ENSEMBL:ENSG00000122126 OCRL
ENSEMBL:ENSG00000122126.18 OCRL
HGNC:8108 OCRL
KEGG Gene (Homo sapiens):4952 OCRL
Monarch:4952 OCRL
NCBI Gene:4952 OCRL
OMIM:300535 OCRL
UCSC:Q01968 OCRL
Reference Transcript
RefSeq:NM_001587.3 OCRL
RefSeq:NM_000276.3 OCRL
Other Identifiers
11717180_at
11717181_a_at
11755916_a_at
17106822
203446_PM_s_at
208316_PM_s_at
208316_s_at
34169_s_at
3990377
3990378
3990381
3990382
3990383
3990385
3990386
3990387
3990388
3990389
3990390
3990391
3990392
3990394
3990395
3990396
3990397
3990398
3990399
3990408
3990410
3990412
3990414
3990415
3990416
3990417
3990418
3990419
3990420
41227_at
4952
8169811
A_14_P121440
A_23_P170246
GO:0001701
GO:0001750
GO:0003824
GO:0004439
GO:0004445
GO:0005096
GO:0005515
GO:0005634
GO:0005737
GO:0005764
GO:0005768
GO:0005769
GO:0005773
GO:0005794
GO:0005795
GO:0005798
GO:0005802
GO:0005829
GO:0005886
GO:0005905
GO:0005929
GO:0006629
GO:0006661
GO:0007165
GO:0010008
GO:0016020
GO:0016787
GO:0016791
GO:0023052
GO:0030030
GO:0030136
GO:0030670
GO:0031267
GO:0031410
GO:0031901
GO:0034485
GO:0034596
GO:0036092
GO:0042995
GO:0043087
GO:0043226
GO:0043647
GO:0043813
GO:0044782
GO:0046488
GO:0046856
GO:0048856
GO:0052658
GO:0052659
GO:0052745
GO:0060271
GO:0061024
GO:0098772
HMNXSV003019089
HMNXSV003041935
ILMN_1760855
ILMN_2382121
PH_hs_0022390
TC0X000616.hg
U57627_at
g13249984_3p_a_at
g13325071_3p_a_at
Participates
as a candidate of
Inositol polyphosphate 5-phosphatase [plasma membrane] (Homo sapiens)
Other forms of this molecule
OCRL [Golgi membrane]
OCRL [cytoplasmic vesicle membrane]
OCRL [cytosol]
Inferred To
Dd5P4 [plasma membrane]
(Dictyostelium discoideum)
OCRL [plasma membrane]
(Bos taurus)
OCRL [plasma membrane]
(Canis familiaris)
OCRL [plasma membrane]
(Gallus gallus)
OCRL [plasma membrane]
(Plasmodium falciparum)
OCRL [plasma membrane]
(Schizosaccharomyces pombe)
OCRL [plasma membrane]
(Sus scrofa)
wu:fi09g03 [plasma membrane]
(Danio rerio)
ocrl-1 [plasma membrane]
(Caenorhabditis elegans)
Ocrl [plasma membrane]
(Drosophila melanogaster)
Ocrl [plasma membrane]
(Mus musculus)
Ocrl [plasma membrane]
(Rattus norvegicus)
INP54 [plasma membrane]
(Saccharomyces cerevisiae)
emilin2 [plasma membrane]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001578.2
,
NP_000267.2
Guide to Pharmacology - Targets
1460
OpenTargets
ENSG00000122126
IntEnz
3.1.3.86
HPA
ENSG00000122126-OCRL
GeneCards
Q01968
Ensembl
ENSP00000349635
,
ENST00000371113
,
ENSP00000360154
,
ENST00000357121
,
ENSG00000122126
PRO
Q01968
Pharos - Targets
Q01968
Orphanet
16585
HMDB Protein
HMDBP01569
PDB
3QBT
,
2KIE
,
4CMN
,
2QV2
,
3QIS
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P20340 RAB6A
8
RAB6A [endoplasmic reticulum membrane]
(R-HSA-8849253)
RAB6A [trans-Golgi network membrane]
(R-HSA-6810981)
GGC-RAB6A [trans-Golgi network membrane]
(R-HSA-8876079)
RAB6A [Golgi membrane]
(R-HSA-1604442)
RAB6A [secretory granule membrane]
(R-HSA-6804970)
RAB6A [plasma membrane]
(R-HSA-6804981)
RAB6A [cytosol]
(R-HSA-6810979)
GGC-RAB6A [cytosol]
(R-HSA-8874052)
0.835
13
UniProt:P20339 RAB5A
6
GGC-RAB5A [clathrin-coated endocytic vesicle membrane]
(R-HSA-8871125)
GGC-RAB5A [early endosome membrane]
(R-HSA-8875323)
RAB5A [cytosol]
(R-HSA-2201187)
RAB5A [endosome membrane]
(R-HSA-452257)
RAB5A [early endosome membrane]
(R-HSA-2130175)
GGC-RAB5A [cytosol]
(R-HSA-8870432)
0.799
11
UniProt:P63000 RAC1
6
RAC1 [ficolin-1-rich granule membrane]
(R-HSA-6804802)
RAC1 [secretory granule membrane]
(R-HSA-6804770)
RAC1 [endoplasmic reticulum membrane]
(R-HSA-5672076)
GGC-PalmC-RAC1 [plasma membrane]
(R-HSA-2316446)
RAC1 [cytosol]
(R-HSA-442615)
RAC1 [plasma membrane]
(R-HSA-351141)
0.556
3
UniProt:Q9UKG1 APPL1
1
APPL1 [endosome membrane]
(R-HSA-373630)
0.534
2
UniProt:Q9NYZ3 GTSE1
4
p-T513,T526-GTSE1 [cytosol]
(R-HSA-8852308)
p-S435-GTSE1 [nucleoplasm]
(R-HSA-8852332)
p-S435-GTSE1 [cytosol]
(R-HSA-8852316)
GTSE1 [cytosol]
(R-HSA-8852264)
0.527
2
UniProt:Q96CW1 AP2M1
6
AP2M1 [plasma membrane]
(R-HSA-167585)
AP2M1 [lysosomal membrane]
(R-HSA-196144)
AP2M1 [cytosol]
(R-HSA-182227)
AP2M1 [clathrin-coated endocytic vesicle membrane]
(R-HSA-2130423)
AP2M1 [endolysosome membrane]
(R-HSA-6784828)
p-T156 AP2M1 [cytosol]
(R-HSA-8856805)
0.508
3
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