Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
HIST1H2BC [extracellular region]
Stable Identifier
R-HSA-977564
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Histone H2B.a/g/h/k/l
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Amyloid fiber formation (Homo sapiens)
Serum amyloid P binds DNA and chromatin (Homo sapiens)
Double-stranded DNA and chromatin [extracellular region] (Homo sapiens)
Chromatin [extracellular region] (Homo sapiens)
Nucleosome (Deacetylated) [extracellular region] (Homo sapiens)
Histone H2B [extracellular region] (Homo sapiens)
HIST1H2BC [extracellular region] (Homo sapiens)
Serum amyloid P-component pentamer:Double-stranded DNA [extracellular region] (Homo sapiens)
Double-stranded DNA and chromatin [extracellular region] (Homo sapiens)
Chromatin [extracellular region] (Homo sapiens)
Nucleosome (Deacetylated) [extracellular region] (Homo sapiens)
Histone H2B [extracellular region] (Homo sapiens)
HIST1H2BC [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P62807 H2BC4
Gene Names
H2BC4, H2BFL, HIST1H2BC, H2BC6, H2BFH, HIST1H2BE, H2BC7, H2BFG, HIST1H2BF, H2BC8, H2BFA, HIST1H2BG, H2BC10, H2BFK, HIST1H2BI
Chain
initiator methionine:, chain:2-126
Reference Genes
BioGPS Gene:3017 H2BC4
BioGPS Gene:8339 H2BC4
BioGPS Gene:8343 H2BC4
BioGPS Gene:8344 H2BC4
BioGPS Gene:8346 H2BC4
BioGPS Gene:8347 H2BC4
COSMIC (genes):HIST1H2BC H2BC4
COSMIC (genes):HIST1H2BE H2BC4
COSMIC (genes):HIST1H2BF H2BC4
COSMIC (genes):HIST1H2BG H2BC4
COSMIC (genes):HIST1H2BI H2BC4
CTD Gene:3017 H2BC4
CTD Gene:8339 H2BC4
CTD Gene:8343 H2BC4
CTD Gene:8344 H2BC4
CTD Gene:8346 H2BC4
CTD Gene:8347 H2BC4
dbSNP Gene:3017 H2BC4
dbSNP Gene:8339 H2BC4
dbSNP Gene:8343 H2BC4
dbSNP Gene:8344 H2BC4
dbSNP Gene:8346 H2BC4
dbSNP Gene:8347 H2BC4
ENSEMBL:ENSG00000180596 HIST1H2BC
ENSEMBL:ENSG00000273802 HIST1H2BC
ENSEMBL:ENSG00000274290 HIST1H2BC
ENSEMBL:ENSG00000277224 HIST1H2BC
ENSEMBL:ENSG00000278588 HIST1H2BC
HGNC:4746 H2BC4
HGNC:4752 H2BC4
HGNC:4753 H2BC4
HGNC:4756 H2BC4
HGNC:4757 H2BC4
KEGG:hsa:3017 H2BC4
KEGG:hsa:8339 H2BC4
KEGG:hsa:8343 H2BC4
KEGG:hsa:8344 H2BC4
KEGG:hsa:8346 H2BC4
KEGG:hsa:8347 H2BC4
Monarch:3017 H2BC4
Monarch:8339 H2BC4
Monarch:8343 H2BC4
Monarch:8344 H2BC4
Monarch:8346 H2BC4
Monarch:8347 H2BC4
NCBI Gene:3017 H2BC4
NCBI Gene:8339 H2BC4
NCBI Gene:8343 H2BC4
NCBI Gene:8344 H2BC4
NCBI Gene:8346 H2BC4
NCBI Gene:8347 H2BC4
OMIM:602798 H2BC4
OMIM:602804 H2BC4
OMIM:602805 H2BC4
OMIM:602807 H2BC4
OMIM:602847 H2BC4
UCSC:P62807 H2BC4
Reference Transcript
RefSeq:NM_003522.3 H2BC4
RefSeq:NM_003526.2 H2BC4
RefSeq:NM_003525.2 H2BC4
RefSeq:NM_021063.3 H2BC4
RefSeq:NM_003523.2 H2BC4
RefSeq:NM_003518.3 H2BC4
Other Identifiers
11715115_s_at
11715118_s_at
11715120_s_at
11724021_at
11734796_s_at
11734797_x_at
11741704_x_at
11759157_at
11759167_at
11759168_x_at
11759272_at
11759273_x_at
11759760_s_at
17005578
17005603
17016379
17016390
208490_PM_x_at
208490_x_at
208523_3p_x_at
208523_PM_x_at
208523_x_at
208527_3p_x_at
208527_PM_x_at
208527_x_at
209911_PM_x_at
209911_x_at
214455_PM_at
214455_at
215779_PM_s_at
215779_s_at
2899193
2899195
2899196
2899197
2899199
2899200
2899201
2899207
2899208
2899262
2899263
2899264
2946243
2946281
2946282
2946347
2946348
31522_f_at
31523_f_at
31524_f_at
32980_f_at
36347_f_at
38576_at
44344_at
69527_at
8117389
8117395
8117429
8124406
8124423
8339
8343
8344
8346
8347
ADDON002432.hg
ADDON002497.hg
ADDON002742.hg
ADDON002744.hg
ADDON002904.hg
A_14_P101509
A_14_P114239
A_14_P115478
A_23_P111041
A_23_P167997
A_23_P30776
A_23_P42178
A_33_P3229122
A_33_P3302632
GE514715
GE534699
GE538621
GE62836
GE81295
GE85033
GE894502
GO:0000786
GO:0002227
GO:0002376
GO:0003677
GO:0005198
GO:0005515
GO:0005615
GO:0005634
GO:0005654
GO:0005694
GO:0005829
GO:0006325
GO:0006334
GO:0019731
GO:0030527
GO:0042742
GO:0042802
GO:0043226
GO:0043229
GO:0046982
GO:0050830
GO:0061844
GO:0065003
GO:0070062
GO:0098542
HMNXSV003000583
HMNXSV003009547
HMNXSV003031628
HMNXSV003035129
HMNXSV003044042
HMNXSV003044807
Hs.239884.0.S1_3p_at
Hs.239884.0.S1_3p_x_at
Hs.247817.2.S1_3p_a_at
ILMN_1651496
ILMN_1680937
ILMN_1687947
ILMN_1716195
ILMN_1775925
ILMN_1779373
M60750_f_at
PH_hs_0010698
PH_hs_0034684
TC06000170.hg
TC06000171.hg
TC06000178.hg
TC06001347.hg
TC06001350.hg
TC06003538.hg
Z80780_f_at
Z80783_at
g12803984_3p_at
g12803984_3p_x_at
g4504264_3p_x_at
g4504266_3p_x_at
g4504270_3p_at
g4504270_3p_x_at
Participates
as a candidate of
Histone H2B [extracellular region] (Homo sapiens)
Other forms of this molecule
HIST1H2BC [nucleoplasm]
Ub-121-HIST1H2BC [nucleoplasm]
AcK21-HIST1H2BC [nucleoplasm]
AcK13-HIST1H2BC [nucleoplasm]
AcK6-HIST1H2BC [nucleoplasm]
AcK16-HIST1H2BC [nucleoplasm]
AcK-HIST1H2BC [nucleoplasm]
Ub-HIST1H2BC [nucleoplasm]
Cross References
RefSeq
NP_003513.1
,
NP_003514.2
,
NP_003516.1
,
NP_066407.1
,
NP_003517.2
,
NP_003509.1
OpenTargets
ENSG00000273802
,
ENSG00000180596
,
ENSG00000274290
,
ENSG00000277224
,
ENSG00000278588
ENSEMBL
ENSP00000321744
,
ENST00000707188
,
ENSP00000366962
,
ENSP00000483237
,
ENST00000541790
,
ENST00000377733
,
ENSP00000348924
,
ENSP00000489317
,
ENST00000314332
,
ENST00000634910
,
ENSP00000445633
,
ENSP00000380180
,
ENSP00000516775
,
ENST00000396984
,
ENST00000356530
,
ENST00000614097
HPA
ENSG00000180596-H2BC4
,
ENSG00000278588-H2BC10
,
ENSG00000274290-H2BC6
,
ENSG00000273802-H2BC8
,
ENSG00000277224-H2BC7
PRO
P62807
Pharos - Targets
P62807
GlyGen
P62807
PDB
8X15
,
7JO9
,
8OO7
,
8OFF
,
7Y8R
,
6R0C
,
8X1C
,
6SE6
,
6RNY
,
8OOA
,
7U50
,
5GT0
,
7U52
,
7R5R
,
7TRF
,
7YYH
,
6UPL
,
7U51
,
6X59
,
6SEF
,
8AV6
,
6SEE
,
7TAN
,
6C0W
,
7U46
,
8OOS
,
8X19
,
8TXX
,
8U13
,
7U53
,
5KGF
,
6ACO
,
6XJD
,
7PII
,
8OX0
,
8OOP
,
8OX1
,
6SE0
,
7UV9
,
7U4D
,
6FML
,
7A08
,
6X5A
,
6UPK
,
8TXW
,
8TXV
,
6SEG
,
7JOA
,
8JBX
,
7YWX
,
7U47
,
8ATF
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q96CW1 AP2M1
6
AP2M1 [plasma membrane]
(R-HSA-167585)
AP2M1 [lysosomal membrane]
(R-HSA-196144)
AP2M1 [cytosol]
(R-HSA-182227)
AP2M1 [clathrin-coated endocytic vesicle membrane]
(R-HSA-2130423)
AP2M1 [endolysosome membrane]
(R-HSA-6784828)
p-T156 AP2M1 [cytosol]
(R-HSA-8856805)
0.556
5
UniProt:Q12888 TP53BP1
3
TP53BP1 [nucleoplasm]
(R-HSA-61175)
p-S25,S1778-TP53BP1 [nucleoplasm]
(R-HSA-5683418)
monoSUMO1-K-TP53BP1 [nucleoplasm]
(R-HSA-2997591)
0.544
6
UniProt:P51858 HDGF
1
HDGF [nucleoplasm]
(R-HSA-535593)
0.483
2
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text