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Mondo:0004963 Show undefined attributes

databaseName	Mondo
dbId	12020841
displayName	Mondo:0004963
identifier	0004963
referenceDatabase	[ReferenceDatabase:12020742] Mondo
schemaClass	DatabaseIdentifier
url	https://monarchinitiative.org/MONDO:0004963

Referrals

(crossReference)

[Complex:R-HSA-2691216] DLL1:NOTCH1 HD domain mutants [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-2159809] p-NICD1 P2514Rfs*4 [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-2902193] NICD1 P2474Afs*4 [cytosol]
[DefinedSet:R-HSA-1602340] FBXW7 WD mutants [nucleoplasm]
[Complex:R-HSA-2900745] DLL4:NOTCH1 HD+PEST Domain Mutants [plasma membrane]
[CandidateSet:R-HSA-1602342] FBXW7 R505/387C mutant [nucleoplasm]
[DefinedSet:R-HSA-2220958] p-NICD1 PEST domain mutants [nucleoplasm]
[Complex:R-HSA-2902218] JAG1:NOTCH1 HD+PEST Domain Mutant Fragments [plasma membrane]
[CandidateSet:R-HSA-2220939] NOTCH1 PEST domain mutants [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-2220929] NOTCH1 P2_M1580del extracellular fragment [extracellular region]
[EntityWithAccessionedSequence:R-HSA-1485582] NOTCH1 L1574P Extracellular Fragment [extracellular region]
[EntityWithAccessionedSequence:R-HSA-1602335] FBXW7gamma R387C [nucleoplasm]
[Complex:R-HSA-2902217] DLL4:NOTCH1 HD+PEST Domain Mutant Fragments [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-1602328] FBXW7alpha R465C [nucleoplasm]
[Complex:R-HSA-2900746] DLL1:NOTCH1 HD+PEST Domain Mutants [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-2768989] NEXT1 P2514Rfs*4 [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-2902196] NEXT1 Q2440* [plasma membrane]
[DefinedSet:R-HSA-2902219] NOTCH1 HD+PEST Domain Mutant Fragments [extracellular region]
[EntityWithAccessionedSequence:R-HSA-2902205] p-NICD1 Q2395* [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-2902195] NICD1 Q2395* [cytosol]
[Complex:R-HSA-2902189] NOTCH1 Q2440* [plasma membrane]
[DefinedSet:R-HSA-2902212] NOTCH1 HD+PEST Domain Mutants/Ub-DLL/JAG:NOTCH1 HD+PEST Domain Mutants [plasma membrane]
[Complex:R-HSA-2894879] NOTCH1 L1600P;Q2440* [plasma membrane]
[DefinedSet:R-HSA-2900761] DLL/JAG:NOTCH1 HD+PEST Domain Mutants [plasma membrane]
[DefinedSet:R-HSA-2902211] NOTCH1 HD+PEST Domain Mutant Fragments/Ub-DLL/JAG:NOTCH1 HD+PEST Domain Mutant Fragments [plasma membrane]
[Complex:R-HSA-2900763] Ub-DLL/JAG:NOTCH1 HD+PEST Domain Mutants [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-2902208] NICD1 P2474Afs*4 [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-1602336] FBXW7alpha R505C [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-2768996] NICD1 P2514Rfs*4 [cytosol]
[EntityWithAccessionedSequence:R-HSA-2681764] NOTCH1 L1600P Extracellular Fragment [extracellular region]
[Complex:R-HSA-2894878] NOTCH1 L1600P;Q2395* [plasma membrane]
[Complex:R-HSA-2900751] JAG1:NOTCH1 HD+PEST Domain Mutants [plasma membrane]
[Complex:R-HSA-2902216] Ub-DLL/JAG:NOTCH1 HD+PEST Domain Mutant Fragments [plasma membrane]
[Complex:R-HSA-2902214] JAG2:NOTCH1 HD+PEST Domain Mutant Fragments [plasma membrane]
[DefinedSet:R-HSA-2289143] NEXT1 PEST domain mutants [plasma membrane]
[Complex:R-HSA-4396396] NOTCH1 PEST Domain Mutants Coactivator Complex:HES1 Gene [nucleoplasm]
[Complex:R-HSA-2769002] JAG1:NOTCH1 PEST Domain Mutants [plasma membrane]
[DefinedSet:R-HSA-2902222] DLL/JAG:NOTCH1 HD+PEST Domain Mutant Fragments [plasma membrane]
[Complex:R-HSA-2769006] Ub-DLL/JAG:NOTCH1 PEST Domain Mutants [plasma membrane]
[CandidateSet:R-HSA-1602334] FBXW7 R465/347H mutant [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-2902204] p-NICD1 P2474Afs*4 [nucleoplasm]
[Complex:R-HSA-2768978] NOTCH1 P2514Rfs*4 [plasma membrane]
[Complex:R-HSA-2681765] NOTCH1 L1600P [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-1602331] FBXW7gamma R347C [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-2902207] p-NICD1 Q2440* [nucleoplasm]
[CandidateSet:R-HSA-1602442] FBXW7 R505/387L mutant [nucleoplasm]
[Complex:R-HSA-2768998] JAG2:NOTCH1 PEST Domain Mutants [plasma membrane]
[CandidateSet:R-HSA-1602341] FBXW7 R465/347C mutant [nucleoplasm]
[Complex:R-HSA-4396397] NOTCH1 PEST Domain Mutants Coactivator Complex:HES5 Gene [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-1602332] FBXW7gamma R361Q [nucleoplasm]
[Complex:R-HSA-2902215] DLL1:NOTCH1 HD+PEST Domain Mutant Fragments [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-1602440] FBXW7gamma R387L [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-1485596] NOTCH1 Q2395* Transmembrane Fragment [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-1602439] FBXW7alpha R505L [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-2902191] NICD1 Q2440* [cytosol]
[EntityWithAccessionedSequence:R-HSA-1485602] NOTCH1 Q2440* Transmembrane Fragment [plasma membrane]
[Complex:R-HSA-2768992] DLL4:NOTCH1 PEST Domain Mutants [plasma membrane]
[CandidateSet:R-HSA-2894870] NOTCH1 HD+PEST Domain Mutants [plasma membrane]
[CandidateSet:R-HSA-1602324] FBXW7 R479/361Q mutant [nucleoplasm]
[DefinedSet:R-HSA-2769016] NICD1 PEST Domain Mutants [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-2691203] NOTCH1 L1574Q Extracellular Fragment [extracellular region]
[Complex:R-HSA-2681760] NOTCH1 L1574P [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-2902192] NEXT1 Q2395* [plasma membrane]
[Complex:R-HSA-4396404] NOTCH1 PEST Domain Mutants Coactivator Complex:MYC Gene [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-2902201] NICD1 Q2395* [nucleoplasm]
[Complex:R-HSA-2220969] NICD1 PEST domain mutants:RBPJ:SNW1 [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-2902194] NEXT1 P2474Afs*4 [plasma membrane]
[Complex:R-HSA-2900758] JAG2:NOTCH1 HD+PEST Domain Mutants [plasma membrane]
[DefinedSet:R-HSA-2768995] DLL/JAG:NOTCH1 PEST Domain Mutants [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-1602325] FBXW7gamma R347H [nucleoplasm]
[Complex:R-HSA-2220975] FBXW7 WD mutants:SKP1:CUL1:RBX1 [nucleoplasm]
[Complex:R-HSA-2672449] NOTCH1 t(7;9)(NOTCH1:M1580_K2555) fragment [extracellular region]
[Complex:R-HSA-2768988] DLL1:NOTCH1 PEST Domain Mutants [plasma membrane]
[DefinedSet:R-HSA-2220987] NICD1 PEST Domain Mutants [cytosol]
[Complex:R-HSA-2672451] NOTCH1 t(7;9)(NOTCH1:M1580_K2555) [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-2769013] NICD1 P2514Rfs*4 [nucleoplasm]
[Complex:R-HSA-2894875] NOTCH1 L1574P;P2474Afs*4 [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-2902200] NICD1 Q2440* [nucleoplasm]
[Complex:R-HSA-2894869] NOTCH1 L1600P;P2514Rfs*4 [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-2894873] NOTCH1 P2474Afs*4 Transmembrane Fragment [plasma membrane]
[Complex:R-HSA-4396391] NOTCH1 PEST Domain Mutants Coactivator Complex:HEY Genes [nucleoplasm]
[Complex:R-HSA-2220989] NOTCH1 PEST Domain Mutants Coactivator Complex [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-1602330] FBXW7alpha R465H [nucleoplasm]
[Complex:R-HSA-2902198] NOTCH1 P2474Afs*4 [plasma membrane]
[Complex:R-HSA-2730737] NOTCH1 L1600P fragment [extracellular region]
[EntityWithAccessionedSequence:R-HSA-2768982] NOTCH1 P2514Rfs*4 Transmembrane Fragment [plasma membrane]
[Complex:R-HSA-2730751] NOTCH1 L1574P fragment [extracellular region]
[Complex:R-HSA-2902190] NOTCH1 Q2395* [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-1602329] FBXW7alpha R479Q [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-2684852] NOTCH1 V1576E Extracellular Fragment [extracellular region]
[EntityWithAccessionedSequence:R-HSA-1485592] NOTCH1 R1598P Extracellular Fragment [extracellular region]
[Complex:R-HSA-2730743] NOTCH1 L1574Q fragment [extracellular region]
[Complex:R-HSA-2684867] NOTCH1 I1616T [plasma membrane]
[DefinedSet:R-HSA-2717729] NOTCH1 HD domain mutants/Ub-DLL/JAG:NOTCH1 HD domain mutants [plasma membrane]
[Complex:R-HSA-2731154] JAG1:NOTCH1 HD domain mutant fragments [extracellular region]
[Complex:R-HSA-2691221] DLL4:NOTCH1 HD domain mutants [plasma membrane]
[Complex:R-HSA-2730754] NOTCH1 I1718T fragment [extracellular region]
[Complex:R-HSA-2691215] JAG1:NOTCH1 HD domain mutants [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-1485584] NOTCH1 L1593P Extracellular Fragment [extracellular region]
[Complex:R-HSA-2684856] NOTCH1 F1592S [plasma membrane]
[Complex:R-HSA-2684861] NOTCH1 I1616N [plasma membrane]
[Complex:R-HSA-2730738] NOTCH1 L1593P fragment [extracellular region]
[Complex:R-HSA-2691204] NOTCH1 L1574Q [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-2684853] NOTCH1 L1596H Extracellular Fragment [extracellular region]
[DefinedSet:R-HSA-2737725] DLL/JAG:NOTCH1 HD domain mutants [plasma membrane]
[Complex:R-HSA-2902223] Ub-DLL/JAG:NOTCH1 HD Domain Mutant Fragments [extracellular region]
[Complex:R-HSA-2731152] DLL1:NOTCH1 HD domain mutant fragments [extracellular region]
[CandidateSet:R-HSA-2730739] NOTCH1 HD domain mutant fragments [extracellular region]
[Complex:R-HSA-2730746] NOTCH1 I1616T fragment [extracellular region]
[Complex:R-HSA-2730748] NOTCH1 L1596H fragment [extracellular region]
[Complex:R-HSA-2730736] NOTCH1 A1701P fragment [extracellular region]
[EntityWithAccessionedSequence:R-HSA-2684847] NOTCH1 F1592S Extracellular Fragment [extracellular region]
[EntityWithAccessionedSequence:R-HSA-2684862] NOTCH1 I1616N Extracellular Fragment [extracellular region]
[Complex:R-HSA-2684844] NOTCH1 V1576E [plasma membrane]
[Complex:R-HSA-2730747] NOTCH1 V1676D fragment [extracellular region]
[Complex:R-HSA-2730750] NOTCH1 F1592S fragment [extracellular region]
[Complex:R-HSA-2684873] NOTCH1 V1676D [plasma membrane]
[Complex:R-HSA-2691218] JAG2:NOTCH1 HD domain mutants [plasma membrane]
[Complex:R-HSA-2681761] NOTCH1 L1678P [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-2730755] NOTCH1 V1676D S2 cleavage fragment [extracellular region]
[Complex:R-HSA-2681757] NOTCH1 L1593P [plasma membrane]
[Complex:R-HSA-2731150] DLL4:NOTCH1 HD domain mutant fragments [extracellular region]
[Complex:R-HSA-2730756] NOTCH1 R1598P fragment [extracellular region]
[Complex:R-HSA-2731151] JAG2:NOTCH1 HD domain mutant fragments [extracellular region]
[Complex:R-HSA-2730740] NOTCH1 V1576E fragment [extracellular region]
[Complex:R-HSA-2681756] NOTCH1 R1598P [plasma membrane]
[Complex:R-HSA-2730741] NOTCH1 I1680N fragment [extracellular region]
[CandidateSet:R-HSA-2220961] NOTCH1 HD domain mutants [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-2730744] NOTCH1 I1680N S2 cleavage fragment [extracellular region]
[DefinedSet:R-HSA-2902220] DLL/JAG:NOTCH1 HD Domain Mutant Fragments [extracellular region]
[DefinedSet:R-HSA-2731153] NOTCH1 HD domain mutant fragments/Ub-DLL/JAG:NOTCH1 HD domain mutant fragments [extracellular region]
[Complex:R-HSA-2730759] NOTCH1 I1616N fragment [extracellular region]
[Complex:R-HSA-2684871] NOTCH1 I1680N [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-2730745] NOTCH1 L1678P S2 cleavage fragment [extracellular region]
[EntityWithAccessionedSequence:R-HSA-2730742] NOTCH1 A1701P S2 cleavage fragment [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-2684866] NOTCH1 I1616T Extracellular Fragment [extracellular region]
[EntityWithAccessionedSequence:R-HSA-2730757] NOTCH1 I1718T S2 cleavage fragment [extracellular region]
[Complex:R-HSA-2730758] NOTCH1 L1678P fragment [extracellular region]
[EntityWithAccessionedSequence:R-HSA-1485585] NOTCH1 A1701P Transmembrane Fragment [plasma membrane]
[Complex:R-HSA-2684851] NOTCH1 L1596H [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-2684881] NOTCH1 I1718T Transmembrane Fragment [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-1485591] NOTCH1 L1678P Transmembrane Fragment [plasma membrane]
[Complex:R-HSA-2681758] NOTCH1 A1701P [plasma membrane]
[Complex:R-HSA-2684883] NOTCH1 I1718T [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-2684874] NOTCH1 V1676D Transmembrane Fragment [plasma membrane]
[Reaction:R-HSA-2737728] Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 HD domain mutants
[BlackBoxEvent:R-HSA-2220981] NOTCH1 PEST domain mutants stimulate HEY transcription
[Reaction:R-HSA-4396392] NOTCH1 PEST domain mutants bind HES1 promoter
[Reaction:R-HSA-2900747] NOTCH1 HD+PEST domain mutants bind DLL4
[BlackBoxEvent:R-HSA-2220966] NOTCH1 PEST domain mutants stimulate HES5 transcription
[FailedReaction:R-HSA-2660816] NOTCH1 t(7;9)(NOTCH1:M1580_K2555) does not bind JAG2
[Reaction:R-HSA-2691226] NOTCH1 HD domain mutants bind JAG1
[Pathway:R-HSA-2660826] Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
[Reaction:R-HSA-2666278] NOTCH1 t(7;9)(NOTCH1:M1580_K2555) is cleaved to produce NEXT1
[Reaction:R-HSA-4396393] NOTCH1 PEST domain mutants bind MYC promoter
[Reaction:R-HSA-2691219] NOTCH1 HD domain mutants bind DLL1
[FailedReaction:R-HSA-2220967] p-NICD1 PEST domain mutants do not bind FBXW7
[FailedReaction:R-HSA-2660819] NOTCH1 t(7;9)(NOTCH1:M1580_K2555) does not bind DLL1
[Reaction:R-HSA-2220971] CDK8 phosphorylates NICD1 PEST domain mutants
[Reaction:R-HSA-2900765] Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 HD+PEST domain mutants
[FailedReaction:R-HSA-2660822] NOTCH1 t(7;9)(NOTCH1:M1580_K2555) does not bind JAG1
[FailedReaction:R-HSA-2220978] FBXW7 WD mutants do not bind NICD1
[Reaction:R-HSA-2691211] NOTCH1 HD domain mutants bind DLL4
[Reaction:R-HSA-2220957] NOTCH1 PEST domain mutants coactivator complex binds CDK8:CCNC
[Reaction:R-HSA-2900756] NOTCH1 HD+PEST domain mutants bind JAG2
[Pathway:R-HSA-2691230] Signaling by NOTCH1 HD Domain Mutants in Cancer
[Reaction:R-HSA-2900748] NOTCH1 HD+PEST domain mutants bind DLL1
[Reaction:R-HSA-2220944] ADAM10/17 cleaves ligand-bound NOTCH1 PEST domain mutants to produce NEXT1 PEST domain mutants
[Reaction:R-HSA-4396402] NOTCH1 PEST domain mutants bind promoters of HEY genes
[Reaction:R-HSA-2768999] NOTCH1 PEST domain mutants bind JAG1
[Reaction:R-HSA-2220982] NICD1 PEST domain mutants displace co-repressor complex from RBPJ (CSL)
[Reaction:R-HSA-2900743] NOTCH1 HD+PEST domain mutants bind JAG1
[Reaction:R-HSA-2768993] NOTCH1 PEST domain mutants bind JAG2
[Pathway:R-HSA-2644606] Constitutive Signaling by NOTCH1 PEST Domain Mutants
[Reaction:R-HSA-2220976] NOTCH1 HD+PEST domain mutants are cleaved by ADAM10/17 irrespective of ligand binding
[Pathway:R-HSA-2660825] Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
[Reaction:R-HSA-2730752] NOTCH1 HD domain mutants are cleaved to produce NEXT1 irrespective of ligand binding
[Reaction:R-HSA-4396401] NOTCH1 PEST domain mutants bind HES5 promoter
[Reaction:R-HSA-2220988] NEXT1 PEST domain mutants are cleaved to produce NICD1 PEST domain mutants
[Reaction:R-HSA-2769007] Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 PEST domain mutants
[Reaction:R-HSA-2691214] NOTCH1 HD domain mutants bind JAG2
[BlackBoxEvent:R-HSA-2220985] NOTCH1 PEST domain mutants stimulate MYC transcription
[BlackBoxEvent:R-HSA-2220979] NOTCH1 PEST domain mutants stimulate HES1 transcription
[FailedReaction:R-HSA-2660815] NOTCH1 t(7;9)(NOTCH1:M1580_K2555) does not bind DLL4
[Pathway:R-HSA-2894862] Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
[Reaction:R-HSA-2769008] NOTCH1 PEST domain mutants bind DLL1
[Pathway:R-HSA-2691232] Constitutive Signaling by NOTCH1 HD Domain Mutants
[Reaction:R-HSA-2769015] NICD1 PEST domain mutants translocate from cytosol to nucleus
[Reaction:R-HSA-2220964] NICD1 PEST domain mutants in complex with RBPJ (CSL) bind MAML
[Reaction:R-HSA-2769000] NOTCH1 PEST domain mutants bind DLL4
[Pathway:R-HSA-2894858] Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
[EntityWithAccessionedSequence:R-HSA-2684869] NOTCH1 I1680N Transmembrane Fragment [plasma membrane]
[Complex:R-HSA-2737729] Ub-DLL/JAG:NOTCH1 HD domain mutants [plasma membrane]

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