Reactome | NOTCH1 HD domain mutants/Ub-DLL/JAG:NOTCH1 HD domain mutants [plasma membrane]

Schema > DefinedSet > Entries

compartment	[Compartment:876] plasma membrane
consumedByEvent	[Reaction:R-HSA-2730752] NOTCH1 HD domain mutants are cleaved to produce NEXT1 irrespective of ligand binding - Homo sapiens
created	[InstanceEdit:2717730] Orlic-Milacic, M, 2012-12-03
crossReference	[DatabaseIdentifier:12020841] Mondo:0004963
dbId	2717729
disease	[Disease:1485587] T-cell acute lymphoblastic leukemia [Disease:1500689] cancer
displayName	NOTCH1 HD domain mutants/Ub-DLL/JAG:NOTCH1 HD domain mutants [plasma membrane]
hasMember	[CandidateSet:R-HSA-2220961] NOTCH1 HD domain mutants [plasma membrane] - Homo sapiens [Complex:R-HSA-2737729] Ub-DLL/JAG:NOTCH1 HD domain mutants [plasma membrane] - Homo sapiens
inDisease	true
maxDepth	7
modified	[InstanceEdit:2902224] Orlic-Milacic, M, 2013-01-03
name	NOTCH1 HD domain mutants/Ub-DLL/JAG:NOTCH1 HD domain mutants
schemaClass	DefinedSet
species	[Species:48887] Homo sapiens
stId	R-HSA-2717729

(input)	[Reaction:R-HSA-2730752] NOTCH1 HD domain mutants are cleaved to produce NEXT1 irrespective of ligand binding
(diseaseEntity)	[EntityFunctionalStatus:9630141] gain_of_function of NOTCH1 HD domain mutants/Ub-DLL/JAG:NOTCH1 HD domain mutants [plasma membrane]

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