Reactome | Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580

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Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Show undefined attributes

authored	[InstanceEdit:2958607] Orlic-Milacic, M, 2013-01-04
created	[InstanceEdit:2660827] Orlic-Milacic, M, 2012-11-23
crossReference	[DatabaseIdentifier:12020841] Mondo:0004963
dbId	2660826
disease	[Disease:1485587] T-cell acute lymphoblastic leukemia [Disease:1500689] cancer
displayName	Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
edited	[InstanceEdit:2980626] Jassal, B, 2013-01-09
eventOf	[Pathway:R-HSA-2660825] Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[FailedReaction:R-HSA-2660819] NOTCH1 t(7;9)(NOTCH1:M1580_K2555) does not bind DLL1 - Homo sapiens [FailedReaction:R-HSA-2660815] NOTCH1 t(7;9)(NOTCH1:M1580_K2555) does not bind DLL4 - Homo sapiens [FailedReaction:R-HSA-2660822] NOTCH1 t(7;9)(NOTCH1:M1580_K2555) does not bind JAG1 - Homo sapiens [FailedReaction:R-HSA-2660816] NOTCH1 t(7;9)(NOTCH1:M1580_K2555) does not bind JAG2 - Homo sapiens [Reaction:R-HSA-2666278] NOTCH1 t(7;9)(NOTCH1:M1580_K2555) is cleaved to produce NEXT1 - Homo sapiens
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:2025693] TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms [LiteratureReference:2672396] Notch activity influences the alphabeta versus gammadelta T cell lineage decision [LiteratureReference:2672421] Deficient T cell fate specification in mice with an induced inactivation of Notch1 [LiteratureReference:2672402] Mastermind critically regulates Notch-mediated lymphoid cell fate decisions [LiteratureReference:2672399] Requirement for Notch1 signals at sequential early stages of intrathymic T cell development [LiteratureReference:2672416] Notch signaling controls the generation and differentiation of early T lineage progenitors
maxDepth	2
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
releaseDate	2012-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:3110296] Haw, R, 2013-02-10
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-2660826
summation	[Summation:2672410] NOTCH1 t(7;9)(NOTCH1:M1580_K2555) mutant is expressed in a s...

Referrals

(hasEvent)

[Pathway:R-HSA-2660825] Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant

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