Reactome | NOTCH1 HD domain mutants [plasma membrane]

Schema > CandidateSet > Entries

NOTCH1 HD domain mutants [plasma membrane] Show undefined attributes

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-HSA-2691215] JAG1:NOTCH1 HD domain mutants [plasma membrane] - Homo sapiens [Complex:R-HSA-2691216] DLL1:NOTCH1 HD domain mutants [plasma membrane] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-2691219] NOTCH1 HD domain mutants bind DLL1 - Homo sapiens [Reaction:R-HSA-2691214] NOTCH1 HD domain mutants bind JAG2 - Homo sapiens [Reaction:R-HSA-2691226] NOTCH1 HD domain mutants bind JAG1 - Homo sapiens [Reaction:R-HSA-2691211] NOTCH1 HD domain mutants bind DLL4 - Homo sapiens
created	[InstanceEdit:2220965] Orlic-Milacic, M, 2012-05-03
dbId	2220961
disease	[Disease:1485587] T-cell acute lymphoblastic leukemia [Disease:1500689] cancer
displayName	NOTCH1 HD domain mutants [plasma membrane]
hasCandidate	[Complex:R-HSA-2681760] NOTCH1 L1574P [plasma membrane] - Homo sapiens [Complex:R-HSA-2681765] NOTCH1 L1600P [plasma membrane] - Homo sapiens [Complex:R-HSA-2691204] NOTCH1 L1574Q [plasma membrane] - Homo sapiens
hasMember	[Complex:R-HSA-2684844] NOTCH1 V1576E [plasma membrane] - Homo sapiens [Complex:R-HSA-2684856] NOTCH1 F1592S [plasma membrane] - Homo sapiens [Complex:R-HSA-2681757] NOTCH1 L1593P [plasma membrane] - Homo sapiens [Complex:R-HSA-2684851] NOTCH1 L1596H [plasma membrane] - Homo sapiens [Complex:R-HSA-2681756] NOTCH1 R1598P [plasma membrane] - Homo sapiens [Complex:R-HSA-2684861] NOTCH1 I1616N [plasma membrane] - Homo sapiens [Complex:R-HSA-2684867] NOTCH1 I1616T [plasma membrane] - Homo sapiens [Complex:R-HSA-2684873] NOTCH1 V1676D [plasma membrane] - Homo sapiens [Complex:R-HSA-2681761] NOTCH1 L1678P [plasma membrane] - Homo sapiens [Complex:R-HSA-2684871] NOTCH1 I1680N [plasma membrane] - Homo sapiens [Complex:R-HSA-2681758] NOTCH1 A1701P [plasma membrane] - Homo sapiens [Complex:R-HSA-2684883] NOTCH1 I1718T [plasma membrane] - Homo sapiens
inDisease	true
memberOf	[DefinedSet:R-HSA-2717729] NOTCH1 HD domain mutants/Ub-DLL/JAG:NOTCH1 HD domain mutants [plasma membrane] - Homo sapiens
modified	[InstanceEdit:2691228] Orlic-Milacic, M, 2012-12-03
name	NOTCH1 HD domain mutants NOTCH1 heterodimerization domain mutants
schemaClass	CandidateSet
species	[Species:48887] Homo sapiens
stId	R-HSA-2220961

Referrals

(input)	[Reaction:R-HSA-2691219] NOTCH1 HD domain mutants bind DLL1 [Reaction:R-HSA-2691214] NOTCH1 HD domain mutants bind JAG2 [Reaction:R-HSA-2691226] NOTCH1 HD domain mutants bind JAG1 [Reaction:R-HSA-2691211] NOTCH1 HD domain mutants bind DLL4
(hasMember)	[DefinedSet:R-HSA-2717729] NOTCH1 HD domain mutants/Ub-DLL/JAG:NOTCH1 HD domain mutants [plasma membrane]
(hasComponent)	[Complex:R-HSA-2691216] DLL1:NOTCH1 HD domain mutants [plasma membrane] [Complex:R-HSA-2691218] JAG2:NOTCH1 HD domain mutants [plasma membrane] [Complex:R-HSA-2691215] JAG1:NOTCH1 HD domain mutants [plasma membrane] [Complex:R-HSA-2691221] DLL4:NOTCH1 HD domain mutants [plasma membrane]
(diseaseEntity)	[EntityFunctionalStatus:9631997] gain_of_function of NOTCH1 HD domain mutants [plasma membrane] [EntityFunctionalStatus:2711103] gain_of_function of NOTCH1 HD domain mutants [plasma membrane]

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