Reactome | CDK8 phosphorylates NICD1 PEST domain mutants

Schema > Reaction > Entries

CDK8 phosphorylates NICD1 PEST domain mutants Show undefined attributes

authored	[InstanceEdit:2958607] Orlic-Milacic, M, 2013-01-04
catalystActivity	[CatalystActivity:2220956] cyclin-dependent protein serine/threonine kinase activity of NOTCH1 PEST Domain Mutants Coactivator Complex:CDK8:CCNC [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:2220965] Orlic-Milacic, M, 2012-05-03
dbId	2220971
disease	[Disease:1485587] T-cell acute lymphoblastic leukemia [Disease:1500689] cancer
displayName	CDK8 phosphorylates NICD1 PEST domain mutants
edited	[InstanceEdit:2980626] Jassal, B, 2013-01-09
entityFunctionalStatus	[EntityFunctionalStatus:2775819] gain_of_function of NOTCH1 PEST Domain Mutants Coactivator Complex:CDK8:CCNC [nucleoplasm]
eventOf	[Pathway:R-HSA-2894862] Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants - Homo sapiens [Pathway:R-HSA-2644606] Constitutive Signaling by NOTCH1 PEST Domain Mutants - Homo sapiens
followingEvent	[FailedReaction:R-HSA-2220967] p-NICD1 PEST domain mutants do not bind FBXW7 - Homo sapiens
input	[SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [Complex:R-HSA-2220980] NOTCH1 PEST Domain Mutants Coactivator Complex:CDK8:CCNC [nucleoplasm]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:351516] Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	CDK8 phosphorylates NICD1 PEST domain mutants
normalReaction	[Reaction:R-HSA-1912391] NICD1 is phosphorylated by CDK8
output	[SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [Complex:R-HSA-1604465] CDK8:CCNC [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-193545] CREBBP [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-381325] EP300 [nucleoplasm] [CandidateSet:R-HSA-212357] MAML [nucleoplasm] [DefinedSet:R-HSA-2220958] p-NICD1 PEST domain mutants [nucleoplasm] [CandidateSet:R-HSA-350078] PCAF [nucleoplasm] [Complex:R-HSA-1911412] RBPJ:SNW1 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-2220957] NOTCH1 PEST domain mutants coactivator complex binds CDK8:CCNC - Homo sapiens
releaseDate	2012-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:3110296] Haw, R, 2013-02-10
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2220971
summation	[Summation:2851296] While CDK8 can probably phosphorylate the TAD domain of NICD...

Referrals

(hasEvent)	[Pathway:R-HSA-2894862] Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants [Pathway:R-HSA-2644606] Constitutive Signaling by NOTCH1 PEST Domain Mutants
(precedingEvent)	[FailedReaction:R-HSA-2220967] p-NICD1 PEST domain mutants do not bind FBXW7