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Schema
>
BlackBoxEvent
>
Entries
NOTCH1 PEST domain mutants stimulate HEY transcription
Show undefined attributes
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authored
[InstanceEdit:2958607] Orlic-Milacic, M, 2013-01-04
category
omitted
compartment
[Compartment:7660] nucleoplasm
created
[InstanceEdit:2220965] Orlic-Milacic, M, 2012-05-03
dbId
2220981
disease
[Disease:1485587] T-cell acute lymphoblastic leukemia
[Disease:1500689] cancer
displayName
NOTCH1 PEST domain mutants stimulate HEY transcription
edited
[InstanceEdit:2980626] Jassal, B, 2013-01-09
entityFunctionalStatus
[EntityFunctionalStatus:4396403] gain_of_function of NOTCH1 PEST Domain Mutants Coactivator Complex:HEY Genes [nucleoplasm]
eventOf
[Pathway:R-HSA-2894862] Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants - Homo sapiens
[Pathway:R-HSA-2644606] Constitutive Signaling by NOTCH1 PEST Domain Mutants - Homo sapiens
input
[DefinedSet:R-HSA-4396360] HEY Genes [nucleoplasm]
isChimeric
false
isInDisease
true
isInferred
false
literatureReference
[LiteratureReference:1911389] The Notch target genes Hey1 and Hey2 are required for embryonic vascular development
[LiteratureReference:1890288] Analysis of HeyL expression in wild-type and Notch pathway mutant mouse embryos
[LiteratureReference:2065301] Comparative analysis of the human and mouse Hey1 promoter: Hey genes are new Notch target genes
[LiteratureReference:1911382] Structural and mechanistic insights into cooperative assembly of dimeric Notch transcription complexes
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name
NOTCH1 PEST domain mutants stimulate HEY transcription
normalReaction
[BlackBoxEvent:R-HSA-1980065] NOTCH1 stimulates HEY transcription
output
[DefinedSet:R-HSA-1911450] HEY [nucleoplasm]
precedingEvent
[Reaction:R-HSA-4396402] NOTCH1 PEST domain mutants bind promoters of HEY genes - Homo sapiens
regulatedBy
[PositiveRegulation:R-HSA-2220973] Positive regulation by 'NOTCH1 PEST Domain Mutants Coactivator Complex:HEY Genes [nucleoplasm]'
releaseDate
2012-03-12
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:3110296] Haw, R, 2013-02-10
schemaClass
BlackBoxEvent
species
[Species:48887] Homo sapiens
stId
R-HSA-2220981
summation
[Summation:2851299] NICD1 PEST domain mutants are expected to stimulate transcri...
Referrals
(hasEvent)
[Pathway:R-HSA-2894862] Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
[Pathway:R-HSA-2644606] Constitutive Signaling by NOTCH1 PEST Domain Mutants
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