Reactome | NICD1 PEST domain mutants:RBPJ:SNW1 [nucleoplasm]

Schema > Complex > Entries

compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-HSA-2220989] NOTCH1 PEST Domain Mutants Coactivator Complex [nucleoplasm] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-2220964] NICD1 PEST domain mutants in complex with RBPJ (CSL) bind MAML - Homo sapiens
created	[InstanceEdit:2220965] Orlic-Milacic, M, 2012-05-03
crossReference	[DatabaseIdentifier:12020841] Mondo:0004963
dbId	2220969
disease	[Disease:1485587] T-cell acute lymphoblastic leukemia [Disease:1500689] cancer
displayName	NICD1 PEST domain mutants:RBPJ:SNW1 [nucleoplasm]
hasComponent	[DefinedSet:R-HSA-2769016] NICD1 PEST Domain Mutants [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-3008668] RBPJ [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-351663] SNW1 [nucleoplasm]
inDisease	true
isChimeric	false
maxDepth	3
modified	[InstanceEdit:3008669] Jassal, B, 2013-02-01
name	NICD1 PEST domain mutants:RBPJ:SNW1
producedByEvent	[Reaction:R-HSA-2220982] NICD1 PEST domain mutants displace co-repressor complex from RBPJ (CSL) - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-2220969

(output)	[Reaction:R-HSA-2220982] NICD1 PEST domain mutants displace co-repressor complex from RBPJ (CSL)
(hasComponent)	[Complex:R-HSA-2220989] NOTCH1 PEST Domain Mutants Coactivator Complex [nucleoplasm]
(input)	[Reaction:R-HSA-2220964] NICD1 PEST domain mutants in complex with RBPJ (CSL) bind MAML
(diseaseEntity)	[EntityFunctionalStatus:2775822] gain_of_function of NICD1 PEST domain mutants:RBPJ:SNW1 [nucleoplasm]

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