Reactome | FBXW7 R465/347H mutant [nucleoplasm]

Schema > CandidateSet > Entries

compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:1602327] Orlic-Milacic, M, 2011-09-14
crossReference	[DatabaseIdentifier:12020841] Mondo:0004963 [DatabaseIdentifier:2220826] COSMIC:COSV55891746
dbId	1602334
disease	[Disease:1485587] T-cell acute lymphoblastic leukemia [Disease:1500689] cancer
displayName	FBXW7 R465/347H mutant [nucleoplasm]
hasCandidate	[EntityWithAccessionedSequence:R-HSA-1602325] FBXW7gamma R347H [nucleoplasm] - Homo sapiens
hasMember	[EntityWithAccessionedSequence:R-HSA-1602330] FBXW7alpha R465H [nucleoplasm] - Homo sapiens
inDisease	true
literatureReference	[LiteratureReference:1602315] FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors
maxDepth	2
memberOf	[DefinedSet:R-HSA-1602340] FBXW7 WD mutants [nucleoplasm] - Homo sapiens
modified	[InstanceEdit:2220827] Orlic-Milacic, M, 2012-05-01
name	FBXW7 R465/347H mutant FBXW7 Arg465/347H mutant
schemaClass	CandidateSet
species	[Species:48887] Homo sapiens
stId	R-HSA-1602334

(hasMember)

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