Reactome | NICD1 PEST domain mutants displace co-repressor complex from RBPJ (CSL)

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NICD1 PEST domain mutants displace co-repressor complex from RBPJ (CSL) Show undefined attributes

authored	[InstanceEdit:2958607] Orlic-Milacic, M, 2013-01-04
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:2220965] Orlic-Milacic, M, 2012-05-03
crossReference	[DatabaseIdentifier:12020841] Mondo:0004963
dbId	2220982
disease	[Disease:1485587] T-cell acute lymphoblastic leukemia [Disease:1500689] cancer
displayName	NICD1 PEST domain mutants displace co-repressor complex from RBPJ (CSL)
edited	[InstanceEdit:2980626] Jassal, B, 2013-01-09
entityFunctionalStatus	[EntityFunctionalStatus:2775826] gain_of_function of NICD1 PEST Domain Mutants [nucleoplasm]
eventOf	[Pathway:R-HSA-2894862] Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants - Homo sapiens
followingEvent	[Reaction:R-HSA-2220964] NICD1 PEST domain mutants in complex with RBPJ (CSL) bind MAML - Homo sapiens
input	[DefinedSet:R-HSA-2769016] NICD1 PEST Domain Mutants [nucleoplasm] [Complex:R-HSA-350052] RBPJ:NCOR corepressor complex [nucleoplasm]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:2063949] A histone deacetylase corepressor complex regulates the Notch signal transduction pathway [LiteratureReference:351549] SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function [LiteratureReference:2063951] TBL1 and TBLR1 phosphorylation on regulated gene promoters overcomes dual CtBP and NCoR/SMRT transcriptional repression checkpoints [LiteratureReference:383069] A corepressor/coactivator exchange complex required for transcriptional activation by nuclear receptors and other regulated transcription factors [LiteratureReference:2156433] Disruption of the mouse RBP-J kappa gene results in early embryonic death
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	NICD1 PEST domain mutants displace co-repressor complex from RBPJ (CSL)
normalReaction	[Reaction:R-HSA-1912388] NICD1 displaces co-repressor complex from RBPJ (CSL)
output	[Complex:R-HSA-1911465] NCOR:HDAC:TBL1 [nucleoplasm] [Complex:R-HSA-2220969] NICD1 PEST domain mutants:RBPJ:SNW1 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-2769015] NICD1 PEST domain mutants translocate from cytosol to nucleus - Homo sapiens
releaseDate	2012-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:3110296] Haw, R, 2013-02-10
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2220982
summation	[Summation:2851303] In the nucleus, NICD1 PEST domain mutants are expected to di...
updateTrackers	[UpdateTracker:9784419] Update Tracker - [Reaction:2220982] NICD1 PEST domain mutants displace co-repressor complex from RBPJ (CSL) - v54:[addLiteratureReference, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9784419] Update Tracker - [Reaction:2220982] NICD1 PEST domain mutants displace co-repressor complex from RBPJ (CSL) - v54:[addLiteratureReference, modifyText]
(hasEvent)	[Pathway:R-HSA-2894862] Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants [Pathway:R-HSA-2644606] Constitutive Signaling by NOTCH1 PEST Domain Mutants
(precedingEvent)	[Reaction:R-HSA-2220964] NICD1 PEST domain mutants in complex with RBPJ (CSL) bind MAML

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