Reactome | p-NICD1 P2514Rfs*4 [nucleoplasm]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:2159812] Orlic-Milacic, M, 2012-03-02
crossReference	[DatabaseIdentifier:12020841] Mondo:0004963 [DatabaseIdentifier:2220871] COSMIC:COSV53024776 [DatabaseIdentifier:2220869] COSMIC:COSM33946
dbId	2159809
disease	[Disease:1485587] T-cell acute lymphoblastic leukemia
displayName	p-NICD1 P2514Rfs*4 [nucleoplasm]
endCoordinate	2516
hasModifiedResidue	[FragmentReplacedModification:9827803] Replacement of residues 2514 to 2516 by RVP [ModifiedResidue:1604443] O-phospho-L-serine at unknown position
inDisease	true
literatureReference	[LiteratureReference:1485609] Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia
maxDepth	1
memberOf	[DefinedSet:R-HSA-2220958] p-NICD1 PEST domain mutants [nucleoplasm] - Homo sapiens
modified	[InstanceEdit:9827806] Orlic-Milacic, Marija, 2023-02-06
name	p-NICD1 P2514Rfs4 p-NICD1 Pro2514Argfs3 p-NICD1mutPEST P2514Rfs4 p-NICD1 PEST domain mutant P2514Rfs4
referenceEntity	[ReferenceGeneProduct:uniprot:P46531] UniProt:P46531 NOTCH1
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-2159809
startCoordinate	1755
updateTrackers	[UpdateTracker:9904517] Update Tracker - [EntityWithAccessionedSequence:2159809] p-NICD1 P2514Rfs*4 [nucleoplasm] - v84:[add_removeHasModifiedResidue]

(updatedInstance)	[UpdateTracker:9904517] Update Tracker - [EntityWithAccessionedSequence:2159809] p-NICD1 P2514Rfs*4 [nucleoplasm] - v84:[add_removeHasModifiedResidue]
(hasMember)	[DefinedSet:R-HSA-2220958] p-NICD1 PEST domain mutants [nucleoplasm]

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