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Schema
>
BlackBoxEvent
>
Entries
NOTCH1 PEST domain mutants stimulate HES1 transcription
Show undefined attributes
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authored
[InstanceEdit:2958607] Orlic-Milacic, M, 2013-01-04
category
omitted
compartment
[Compartment:7660] nucleoplasm
created
[InstanceEdit:2220965] Orlic-Milacic, M, 2012-05-03
crossReference
[DatabaseIdentifier:12020841] Mondo:0004963
dbId
2220979
disease
[Disease:1485587] T-cell acute lymphoblastic leukemia
[Disease:1500689] cancer
displayName
NOTCH1 PEST domain mutants stimulate HES1 transcription
edited
[InstanceEdit:2980626] Jassal, B, 2013-01-09
entityFunctionalStatus
[EntityFunctionalStatus:4396400] gain_of_function of NOTCH1 PEST Domain Mutants Coactivator Complex:HES1 Gene [nucleoplasm]
eventOf
[Pathway:R-HSA-2894862] Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants - Homo sapiens
input
[EntityWithAccessionedSequence:R-HSA-2197548] HES1 gene [nucleoplasm]
isInDisease
true
isInferred
false
literatureReference
[LiteratureReference:1602204] Signalling downstream of activated mammalian Notch
maxDepth
1
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name
NOTCH1 PEST domain mutants stimulate HES1 transcription
normalReaction
[BlackBoxEvent:R-HSA-1980047] NOTCH1 stimulates HES1 transcription
output
[EntityWithAccessionedSequence:R-HSA-210825] HES1 [nucleoplasm]
precedingEvent
[Reaction:R-HSA-4396392] NOTCH1 PEST domain mutants bind HES1 promoter - Homo sapiens
regulatedBy
[PositiveGeneExpressionRegulation:R-HSA-2220991] Positive gene expression regulation by 'NOTCH1 PEST Domain Mutants Coactivator Complex:HES1 Gene [nucleoplasm]'
releaseDate
2012-03-12
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:3110296] Haw, R, 2013-02-10
schemaClass
BlackBoxEvent
species
[Species:48887] Homo sapiens
stId
R-HSA-2220979
summation
[Summation:2851297] NICD1 PEST domain mutants are expected to stimulate HES1 tra...
updateTrackers
[UpdateTracker:9784317] Update Tracker - [BlackBoxEvent:2220979] NOTCH1 PEST domain mutants stimulate HES1 transcription - v54:[addLiteratureReference]
[UpdateTracker:9787091] Update Tracker - [BlackBoxEvent:2220979] NOTCH1 PEST domain mutants stimulate HES1 transcription - v46:[addInput, add_removeRegulator]
Referrals
(updatedInstance)
[UpdateTracker:9784317] Update Tracker - [BlackBoxEvent:2220979] NOTCH1 PEST domain mutants stimulate HES1 transcription - v54:[addLiteratureReference]
[UpdateTracker:9787091] Update Tracker - [BlackBoxEvent:2220979] NOTCH1 PEST domain mutants stimulate HES1 transcription - v46:[addInput, add_removeRegulator]
(hasEvent)
[Pathway:R-HSA-2894862] Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
[Pathway:R-HSA-2644606] Constitutive Signaling by NOTCH1 PEST Domain Mutants
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