Reactome | FBXW7 R505/387C mutant [nucleoplasm]

Schema > CandidateSet > Entries

compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:1602327] Orlic-Milacic, M, 2011-09-14
crossReference	[DatabaseIdentifier:12020841] Mondo:0004963
dbId	1602342
disease	[Disease:1485587] T-cell acute lymphoblastic leukemia [Disease:1500689] cancer
displayName	FBXW7 R505/387C mutant [nucleoplasm]
hasCandidate	[EntityWithAccessionedSequence:R-HSA-1602335] FBXW7gamma R387C [nucleoplasm] - Homo sapiens
hasMember	[EntityWithAccessionedSequence:R-HSA-1602336] FBXW7alpha R505C [nucleoplasm] - Homo sapiens
inDisease	true
literatureReference	[LiteratureReference:1602315] FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors
maxDepth	2
memberOf	[DefinedSet:R-HSA-1602340] FBXW7 WD mutants [nucleoplasm] - Homo sapiens
modified	[InstanceEdit:9750523] Orlic-Milacic, Marija, 2021-08-13
name	FBXW7 R505/387C mutant FBXW7 Arg505/387Cys mutant
schemaClass	CandidateSet
species	[Species:48887] Homo sapiens
stId	R-HSA-1602342

(hasMember)

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