Reactome | FBXW7gamma R387C [nucleoplasm]

Schema > EntityWithAccessionedSequence > Entries

candidateOf	[CandidateSet:R-HSA-1602342] FBXW7 R505/387C mutant [nucleoplasm] - Homo sapiens
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:1602327] Orlic-Milacic, M, 2011-09-14
crossReference	[DatabaseIdentifier:12020841] Mondo:0004963 [DatabaseIdentifier:2220835] COSMIC:COSV55891274 [DatabaseIdentifier:2220834] COSMIC:COSM33844
dbId	1602335
disease	[Disease:1485587] T-cell acute lymphoblastic leukemia [Disease:1500689] cancer
displayName	FBXW7gamma R387C [nucleoplasm]
endCoordinate	589
hasModifiedResidue	[ReplacedResidue:1602337] L-arginine 387 replaced with L-cysteine
inDisease	true
literatureReference	[LiteratureReference:1602315] FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors
maxDepth	1
modified	[InstanceEdit:3662293] Orlic-Milacic, M, 2013-06-06
name	FBXW7gamma R387C FBXW7gamma Arg387Cys FBXW7-4 R387C FBXW7 isoform 4 R387C
referenceEntity	[ReferenceIsoform:uniprot:Q969H0-4] UniProt:Q969H0-4 FBXW7
referenceType	ReferenceIsoform
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-1602335
startCoordinate	1
updateTrackers	[UpdateTracker:9885507] Update Tracker - [EntityWithAccessionedSequence:1602335] FBXW7gamma R387C [nucleoplasm] - v45:[addName] [UpdateTracker:9887485] Update Tracker - [EntityWithAccessionedSequence:1602335] FBXW7gamma R387C [nucleoplasm] - v46:[modifyName]

(updatedInstance)	[UpdateTracker:9885507] Update Tracker - [EntityWithAccessionedSequence:1602335] FBXW7gamma R387C [nucleoplasm] - v45:[addName] [UpdateTracker:9887485] Update Tracker - [EntityWithAccessionedSequence:1602335] FBXW7gamma R387C [nucleoplasm] - v46:[modifyName]
(hasCandidate)	[CandidateSet:R-HSA-1602342] FBXW7 R505/387C mutant [nucleoplasm]

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