Reactome | NOTCH1 PEST Domain Mutants Coactivator Complex:HES1 Gene [nucleoplasm]

Schema > Complex > Entries

compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:4396405] Orlic-Milacic, M, 2013-08-23
crossReference	[DatabaseIdentifier:12020841] Mondo:0004963
dbId	4396396
disease	[Disease:1485587] T-cell acute lymphoblastic leukemia [Disease:1500689] cancer
displayName	NOTCH1 PEST Domain Mutants Coactivator Complex:HES1 Gene [nucleoplasm]
hasComponent	[EntityWithAccessionedSequence:R-HSA-2197548] HES1 gene [nucleoplasm] [Complex:R-HSA-2220989] NOTCH1 PEST Domain Mutants Coactivator Complex [nucleoplasm]
inDisease	true
isChimeric	false
maxDepth	5
name	NOTCH1 PEST Domain Mutants Coactivator Complex:HES1 Gene
positivelyRegulates	[PositiveGeneExpressionRegulation:R-HSA-2220991] Positive gene expression regulation by 'NOTCH1 PEST Domain Mutants Coactivator Complex:HES1 Gene [nucleoplasm]'
producedByEvent	[Reaction:R-HSA-4396392] NOTCH1 PEST domain mutants bind HES1 promoter - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-4396396

(regulator)	[PositiveGeneExpressionRegulation:R-HSA-2220991] Positive gene expression regulation by 'NOTCH1 PEST Domain Mutants Coactivator Complex:HES1 Gene [nucleoplasm]'
(diseaseEntity)	[EntityFunctionalStatus:4396400] gain_of_function of NOTCH1 PEST Domain Mutants Coactivator Complex:HES1 Gene [nucleoplasm]
(output)	[Reaction:R-HSA-4396392] NOTCH1 PEST domain mutants bind HES1 promoter

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