Reactome | FBXW7 WD mutants [nucleoplasm]

Schema > DefinedSet > Entries

compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-HSA-2220975] FBXW7 WD mutants:SKP1:CUL1:RBX1 [nucleoplasm] - Homo sapiens
created	[InstanceEdit:1602327] Orlic-Milacic, M, 2011-09-14
crossReference	[DatabaseIdentifier:12020841] Mondo:0004963
dbId	1602340
disease	[Disease:1485587] T-cell acute lymphoblastic leukemia [Disease:1500689] cancer
displayName	FBXW7 WD mutants [nucleoplasm]
hasMember	[CandidateSet:R-HSA-1602341] FBXW7 R465/347C mutant [nucleoplasm] - Homo sapiens [CandidateSet:R-HSA-1602334] FBXW7 R465/347H mutant [nucleoplasm] - Homo sapiens [CandidateSet:R-HSA-1602324] FBXW7 R479/361Q mutant [nucleoplasm] - Homo sapiens [CandidateSet:R-HSA-1602342] FBXW7 R505/387C mutant [nucleoplasm] - Homo sapiens [CandidateSet:R-HSA-1602442] FBXW7 R505/387L mutant [nucleoplasm] - Homo sapiens
inDisease	true
literatureReference	[LiteratureReference:1602315] FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors
maxDepth	3
modified	[InstanceEdit:2220992] Orlic-Milacic, M, 2012-05-03
name	FBXW7 WD mutants
schemaClass	DefinedSet
species	[Species:48887] Homo sapiens
stId	R-HSA-1602340

(hasComponent)