Reactome | NEXT1 PEST domain mutants are cleaved to produce NICD1 PEST domain mutants

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NEXT1 PEST domain mutants are cleaved to produce NICD1 PEST domain mutants Show undefined attributes

authored	[InstanceEdit:2958607] Orlic-Milacic, M, 2013-01-04
catalystActivity	[CatalystActivity:157355] aspartic-type endopeptidase activity of gamma-secretase complex [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:2220965] Orlic-Milacic, M, 2012-05-03
crossReference	[DatabaseIdentifier:12020841] Mondo:0004963
dbId	2220988
disease	[Disease:1485587] T-cell acute lymphoblastic leukemia [Disease:1500689] cancer
displayName	NEXT1 PEST domain mutants are cleaved to produce NICD1 PEST domain mutants
edited	[InstanceEdit:2980626] Jassal, B, 2013-01-09
entityFunctionalStatus	[EntityFunctionalStatus:2775816] gain_of_function of NEXT1 PEST domain mutants [plasma membrane]
eventOf	[Pathway:R-HSA-2894862] Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants - Homo sapiens
followingEvent	[Reaction:R-HSA-2769015] NICD1 PEST domain mutants translocate from cytosol to nucleus - Homo sapiens
input	[DefinedSet:R-HSA-2289143] NEXT1 PEST domain mutants [plasma membrane]
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:157796] Gamma-secretase-mediated proteolysis in cell-surface-receptor signalling [LiteratureReference:163904] A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain [LiteratureReference:163911] Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain [LiteratureReference:163903] Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1 [LiteratureReference:2157466] The prolyl-isomerase Pin1 is a Notch1 target that enhances Notch1 activation in cancer
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	NEXT1 PEST domain mutants are cleaved to produce NICD1 PEST domain mutants
normalReaction	[Reaction:R-HSA-157353] NEXT1 is cleaved to produce NICD1
output	[DefinedSet:R-HSA-2220987] NICD1 PEST Domain Mutants [cytosol] [EntityWithAccessionedSequence:R-HSA-157656] NOTCH1(1721-1753) [plasma membrane]
precedingEvent	[Reaction:R-HSA-2220976] NOTCH1 HD+PEST domain mutants are cleaved by ADAM10/17 irrespective of ligand binding - Homo sapiens
releaseDate	2012-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:3110296] Haw, R, 2013-02-10
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2220988
summation	[Summation:2851306] NEXT1 PEST domain mutant fragments are expected to be cleave...
updateTrackers	[UpdateTracker:9784196] Update Tracker - [Reaction:2220988] NEXT1 PEST domain mutants are cleaved to produce NICD1 PEST domain mutants - v54:[addLiteratureReference, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9784196] Update Tracker - [Reaction:2220988] NEXT1 PEST domain mutants are cleaved to produce NICD1 PEST domain mutants - v54:[addLiteratureReference, modifyText]
(hasEvent)	[Pathway:R-HSA-2894862] Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants [Pathway:R-HSA-2644606] Constitutive Signaling by NOTCH1 PEST Domain Mutants
(precedingEvent)	[Reaction:R-HSA-2769015] NICD1 PEST domain mutants translocate from cytosol to nucleus

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