Reactome | NOTCH1 t(7;9)(NOTCH1:M1580_K2555) [plasma membrane]

Schema > Complex > Entries

compartment	[Compartment:876] plasma membrane
consumedByEvent	[Reaction:R-HSA-2666278] NOTCH1 t(7;9)(NOTCH1:M1580_K2555) is cleaved to produce NEXT1 - Homo sapiens [FailedReaction:R-HSA-2660822] NOTCH1 t(7;9)(NOTCH1:M1580_K2555) does not bind JAG1 - Homo sapiens [FailedReaction:R-HSA-2660819] NOTCH1 t(7;9)(NOTCH1:M1580_K2555) does not bind DLL1 - Homo sapiens [FailedReaction:R-HSA-2660816] NOTCH1 t(7;9)(NOTCH1:M1580_K2555) does not bind JAG2 - Homo sapiens [FailedReaction:R-HSA-2660815] NOTCH1 t(7;9)(NOTCH1:M1580_K2555) does not bind DLL4 - Homo sapiens
created	[InstanceEdit:2672450] Orlic-Milacic, M, 2012-11-27
crossReference	[DatabaseIdentifier:12020841] Mondo:0004963
dbId	2672451
disease	[Disease:1485587] T-cell acute lymphoblastic leukemia [Disease:1500689] cancer
displayName	NOTCH1 t(7;9)(NOTCH1:M1580_K2555) [plasma membrane]
hasComponent	[EntityWithAccessionedSequence:R-HSA-2220929] NOTCH1 P2_M1580del extracellular fragment [extracellular region] [EntityWithAccessionedSequence:R-HSA-157239] NOTCH1(1665-2555) [plasma membrane]
inDisease	true
includedLocation	[Compartment:984] extracellular region
isChimeric	false
literatureReference	[LiteratureReference:2025693] TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms
maxDepth	2
name	NOTCH1 t(7;9)(NOTCH1:M1580_K2555)
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-2672451

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