Reactome | NOTCH1 PEST domain mutants bind DLL1

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NOTCH1 PEST domain mutants bind DLL1 Show undefined attributes

authored	[InstanceEdit:2958607] Orlic-Milacic, M, 2013-01-04
category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:2769005] Orlic-Milacic, M, 2012-12-10
crossReference	[DatabaseIdentifier:12020841] Mondo:0004963
dbId	2769008
disease	[Disease:1485587] T-cell acute lymphoblastic leukemia [Disease:1500689] cancer
displayName	NOTCH1 PEST domain mutants bind DLL1
edited	[InstanceEdit:2980626] Jassal, B, 2013-01-09
entityFunctionalStatus	[EntityFunctionalStatus:2775821] gain_of_function of NOTCH1 PEST domain mutants [plasma membrane]
entityOnOtherCell	[EntityWithAccessionedSequence:R-HSA-157089] DLL1 [plasma membrane] - Homo sapiens
eventOf	[Pathway:R-HSA-2644606] Constitutive Signaling by NOTCH1 PEST Domain Mutants - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-157089] DLL1 [plasma membrane] [CandidateSet:R-HSA-2220939] NOTCH1 PEST domain mutants [plasma membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:2046385] Localization of the delta-like-1-binding site in human Notch-1 and its modulation by calcium affinity [LiteratureReference:186662] Delta-1 activation of notch-1 signaling results in HES-1 transactivation [LiteratureReference:2050520] Fringe glycosyltransferases differentially modulate Notch1 proteolysis induced by Delta1 and Jagged1
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	NOTCH1 PEST domain mutants bind DLL1
normalReaction	[Reaction:R-HSA-1980039] NOTCH1 binds DLL1
output	[Complex:R-HSA-2768988] DLL1:NOTCH1 PEST Domain Mutants [plasma membrane]
releaseDate	2012-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:3110296] Haw, R, 2013-02-10
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2769008
summation	[Summation:2768990] NOTCH1 PEST domain mutants are expected to bind to DLL1 liga...
updateTrackers	[UpdateTracker:9784252] Update Tracker - [Reaction:2769008] NOTCH1 PEST domain mutants bind DLL1 - v54:[addLiteratureReference, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9784252] Update Tracker - [Reaction:2769008] NOTCH1 PEST domain mutants bind DLL1 - v54:[addLiteratureReference, modifyText]
(hasEvent)	[Pathway:R-HSA-2644606] Constitutive Signaling by NOTCH1 PEST Domain Mutants

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