Reactome | Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 HD+PEST domain mutants

Schema > Reaction > Entries

Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 HD+PEST domain mutants Show undefined attributes

authored	[InstanceEdit:2958607] Orlic-Milacic, M, 2013-01-04
catalystActivity	[CatalystActivity:1980072] ubiquitin-protein transferase activity of MIB/NEURL [cytosol]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:2900764] Orlic-Milacic, M, 2013-01-03
crossReference	[DatabaseIdentifier:12020841] Mondo:0004963
dbId	2900765
disease	[Disease:1485587] T-cell acute lymphoblastic leukemia [Disease:1500689] cancer
displayName	Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 HD+PEST domain mutants
edited	[InstanceEdit:2980626] Jassal, B, 2013-01-09
entityFunctionalStatus	[EntityFunctionalStatus:9630147] gain_of_function of DLL/JAG:NOTCH1 HD+PEST Domain Mutants [plasma membrane]
entityOnOtherCell	[CandidateSet:R-HSA-1911464] MIB/NEURL [cytosol] - Homo sapiens [DefinedSet:R-HSA-157643] DLL/JAG [plasma membrane] - Homo sapiens [DefinedSet:R-HSA-113595] Ub [cytosol] - Homo sapiens
eventOf	[Pathway:R-HSA-2894862] Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants - Homo sapiens
followingEvent	[Reaction:R-HSA-2220976] NOTCH1 HD+PEST domain mutants are cleaved by ADAM10/17 irrespective of ligand binding - Homo sapiens
input	[DefinedSet:R-HSA-2900761] DLL/JAG:NOTCH1 HD+PEST Domain Mutants [plasma membrane] [DefinedSet:R-HSA-113595] Ub [cytosol]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:1602210] An obligatory role of mind bomb-1 in notch signaling of mammalian development [LiteratureReference:1602191] Mind bomb-2 is an E3 ligase for Notch ligand [LiteratureReference:1602202] Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta [LiteratureReference:208262] The ubiquitin ligase Drosophila Mind bomb promotes Notch signaling by regulating the localization and activity of Serrate and Delta [LiteratureReference:208089] Two distinct E3 ubiquitin ligases have complementary functions in the regulation of delta and serrate signaling in Drosophila [LiteratureReference:208396] The interplay between DSL proteins and ubiquitin ligases in Notch signaling [LiteratureReference:208133] Drosophila neuralized is a ubiquitin ligase that promotes the internalization and degradation of delta [LiteratureReference:2084254] Neuralized-like 1 (Neurl1) targeted to the plasma membrane by N-myristoylation regulates the Notch ligand Jagged1 [LiteratureReference:2084252] Neuralized-2 regulates a Notch ligand in cooperation with Mind bomb-1
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 HD+PEST domain mutants
normalReaction	[Reaction:R-HSA-1980074] Ubiquitination of DLL/JAG ligands upon binding to NOTCH1
output	[Complex:R-HSA-2900763] Ub-DLL/JAG:NOTCH1 HD+PEST Domain Mutants [plasma membrane]
releaseDate	2012-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:3110296] Haw, R, 2013-02-10
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2900765
summation	[Summation:2900762] Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 HD+...
updateTrackers	[UpdateTracker:9784436] Update Tracker - [Reaction:2900765] Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 HD+PEST domain mutants - v54:[addLiteratureReference, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9784436] Update Tracker - [Reaction:2900765] Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 HD+PEST domain mutants - v54:[addLiteratureReference, modifyText]
(hasEvent)	[Pathway:R-HSA-2894862] Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
(precedingEvent)	[Reaction:R-HSA-2220976] NOTCH1 HD+PEST domain mutants are cleaved by ADAM10/17 irrespective of ligand binding