Reactome | ADAM10/17 cleaves ligand-bound NOTCH1 PEST domain mutants to produce NEXT1 PEST domain mutants

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ADAM10/17 cleaves ligand-bound NOTCH1 PEST domain mutants to produce NEXT1 PEST domain mutants Show undefined attributes

authored	[InstanceEdit:2958607] Orlic-Milacic, M, 2013-01-04
catalystActivity	[CatalystActivity:1852619] metallopeptidase activity of ADAM10/17:Zn2+ [plasma membrane]
category	transition
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:2220945] Orlic-Milacic, M, 2012-05-02
dbId	2220944
disease	[Disease:1500689] cancer [Disease:1485587] T-cell acute lymphoblastic leukemia
displayName	ADAM10/17 cleaves ligand-bound NOTCH1 PEST domain mutants to produce NEXT1 PEST domain mutants
edited	[InstanceEdit:2980626] Jassal, B, 2013-01-09
entityFunctionalStatus	[EntityFunctionalStatus:2775820] gain_of_function of Ub-DLL/JAG:NOTCH1 PEST Domain Mutants [plasma membrane]
entityOnOtherCell	[Complex:R-HSA-1911540] Ub-DLL/JAG:NOTCH1 fragment [plasma membrane] - Homo sapiens [DefinedSet:R-HSA-113595] Ub [cytosol] - Homo sapiens [DefinedSet:R-HSA-157643] DLL/JAG [plasma membrane] - Homo sapiens
eventOf	[Pathway:R-HSA-2644606] Constitutive Signaling by NOTCH1 PEST Domain Mutants - Homo sapiens
input	[Complex:R-HSA-2769006] Ub-DLL/JAG:NOTCH1 PEST Domain Mutants [plasma membrane]
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:2059852] Metalloprotease ADAM10 is required for Notch1 site 2 cleavage [LiteratureReference:157210] A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE [LiteratureReference:2059841] The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts [LiteratureReference:2059844] Kuzbanian controls proteolytic processing of Notch and mediates lateral inhibition during Drosophila and vertebrate neurogenesis [LiteratureReference:2153446] Structural basis for autoinhibition of Notch
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	ADAM10/17 cleaves ligand-bound NOTCH1 PEST domain mutants to produce NEXT1 PEST domain mutants
normalReaction	[Reaction:R-HSA-157632] Complex of NOTCH1 with its ligand is cleaved to produce NEXT1
output	[DefinedSet:R-HSA-2289143] NEXT1 PEST domain mutants [plasma membrane] [Complex:R-HSA-1911540] Ub-DLL/JAG:NOTCH1 fragment [plasma membrane]
releaseDate	2012-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:3110296] Haw, R, 2013-02-10
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2220944
summation	[Summation:2851305] After NOTCH1 PEST domain mutants bind a DLL (DLL1 or DLL4) o...

Referrals

(hasEvent)

[Pathway:R-HSA-2644606] Constitutive Signaling by NOTCH1 PEST Domain Mutants

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