Reactome | NOTCH1 HD domain mutants bind DLL1

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NOTCH1 HD domain mutants bind DLL1 Show undefined attributes

authored	[InstanceEdit:2958607] Orlic-Milacic, M, 2013-01-04
category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:2691222] Orlic-Milacic, M, 2012-12-03
dbId	2691219
disease	[Disease:1485587] T-cell acute lymphoblastic leukemia [Disease:1500689] cancer
displayName	NOTCH1 HD domain mutants bind DLL1
edited	[InstanceEdit:2980626] Jassal, B, 2013-01-09
entityFunctionalStatus	[EntityFunctionalStatus:2711103] gain_of_function of NOTCH1 HD domain mutants [plasma membrane]
entityOnOtherCell	[EntityWithAccessionedSequence:R-HSA-157089] DLL1 [plasma membrane] - Homo sapiens
eventOf	[Pathway:R-HSA-2691232] Constitutive Signaling by NOTCH1 HD Domain Mutants - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-157089] DLL1 [plasma membrane] [CandidateSet:R-HSA-2220961] NOTCH1 HD domain mutants [plasma membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:2691227] Leukemia-associated mutations within the NOTCH1 heterodimerization domain fall into at least two distinct mechanistic classes
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	NOTCH1 HD domain mutants bind DLL1
normalReaction	[Reaction:R-HSA-1980039] NOTCH1 binds DLL1
output	[Complex:R-HSA-2691216] DLL1:NOTCH1 HD domain mutants [plasma membrane]
releaseDate	2012-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:3110296] Haw, R, 2013-02-10
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2691219
summation	[Summation:2691213] DLL1 binds to NOTCH1 HD (heterodimerization) domain mutants,...

Referrals

(hasEvent)

[Pathway:R-HSA-2691232] Constitutive Signaling by NOTCH1 HD Domain Mutants

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