Reactome | FBXW7alpha R479Q [nucleoplasm]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:1602327] Orlic-Milacic, M, 2011-09-14
crossReference	[DatabaseIdentifier:12020841] Mondo:0004963 [DatabaseIdentifier:2220829] COSMIC:COSV55890822 [DatabaseIdentifier:2220831] COSMIC:COSM33845
dbId	1602329
disease	[Disease:1485587] T-cell acute lymphoblastic leukemia [Disease:1500689] cancer
displayName	FBXW7alpha R479Q [nucleoplasm]
endCoordinate	707
hasModifiedResidue	[ReplacedResidue:1602339] L-arginine 479 replaced with L-glutamine
inDisease	true
literatureReference	[LiteratureReference:1602315] FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors
maxDepth	1
memberOf	[CandidateSet:R-HSA-1602324] FBXW7 R479/361Q mutant [nucleoplasm] - Homo sapiens
modified	[InstanceEdit:3662293] Orlic-Milacic, M, 2013-06-06
name	FBXW7alpha R479Q FBXW7-1 R479Q FBXW7alpha Arg479Gln
referenceEntity	[ReferenceIsoform:uniprot:Q969H0-1] UniProt:Q969H0-1 FBXW7
referenceType	ReferenceIsoform
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-1602329
startCoordinate	1
updateTrackers	[UpdateTracker:9887472] Update Tracker - [EntityWithAccessionedSequence:1602329] FBXW7alpha R479Q [nucleoplasm] - v46:[modifyName] [UpdateTracker:9881615] Update Tracker - [EntityWithAccessionedSequence:1602329] FBXW7alpha R479Q [nucleoplasm] - v45:[addName]

(updatedInstance)	[UpdateTracker:9887472] Update Tracker - [EntityWithAccessionedSequence:1602329] FBXW7alpha R479Q [nucleoplasm] - v46:[modifyName] [UpdateTracker:9881615] Update Tracker - [EntityWithAccessionedSequence:1602329] FBXW7alpha R479Q [nucleoplasm] - v45:[addName]
(hasMember)	[CandidateSet:R-HSA-1602324] FBXW7 R479/361Q mutant [nucleoplasm]

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