Reactome | Ub-DLL/JAG:NOTCH1 PEST Domain Mutants [plasma membrane]

Schema > Complex > Entries

compartment	[Compartment:876] plasma membrane
consumedByEvent	[Reaction:R-HSA-2220944] ADAM10/17 cleaves ligand-bound NOTCH1 PEST domain mutants to produce NEXT1 PEST domain mutants - Homo sapiens
created	[InstanceEdit:2769005] Orlic-Milacic, M, 2012-12-10
crossReference	[DatabaseIdentifier:12020841] Mondo:0004963
dbId	2769006
disease	[Disease:1485587] T-cell acute lymphoblastic leukemia [Disease:1500689] cancer
displayName	Ub-DLL/JAG:NOTCH1 PEST Domain Mutants [plasma membrane]
entityOnOtherCell	[EntityWithAccessionedSequence:R-HSA-157089] DLL1 [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-158437] DLL4 [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-157098] JAG1 [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-157120] JAG2 [plasma membrane] - Homo sapiens [DefinedSet:R-HSA-113595] Ub [cytosol] - Homo sapiens
hasComponent	[DefinedSet:R-HSA-2768995] DLL/JAG:NOTCH1 PEST Domain Mutants [plasma membrane] [DefinedSet:R-HSA-113595] Ub [cytosol]
inDisease	true
includedLocation	[Compartment:70101] cytosol
isChimeric	false
maxDepth	6
name	Ub-DLL/JAG:NOTCH1 PEST Domain Mutants
producedByEvent	[Reaction:R-HSA-2769007] Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 PEST domain mutants - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-2769006

(input)	[Reaction:R-HSA-2220944] ADAM10/17 cleaves ligand-bound NOTCH1 PEST domain mutants to produce NEXT1 PEST domain mutants
(diseaseEntity)	[EntityFunctionalStatus:2775820] gain_of_function of Ub-DLL/JAG:NOTCH1 PEST Domain Mutants [plasma membrane]
(output)	[Reaction:R-HSA-2769007] Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 PEST domain mutants

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