Reactome | FBXW7 WD mutants:SKP1:CUL1:RBX1 [nucleoplasm]

Schema > Complex > Entries

compartment	[Compartment:7660] nucleoplasm
consumedByEvent	[FailedReaction:R-HSA-2220978] FBXW7 WD mutants do not bind NICD1 - Homo sapiens
created	[InstanceEdit:2220965] Orlic-Milacic, M, 2012-05-03
crossReference	[DatabaseIdentifier:12020841] Mondo:0004963
dbId	2220975
disease	[Disease:1485587] T-cell acute lymphoblastic leukemia [Disease:1500689] cancer
displayName	FBXW7 WD mutants:SKP1:CUL1:RBX1 [nucleoplasm]
hasComponent	[EntityWithAccessionedSequence:R-HSA-187551] CUL1 [nucleoplasm] [DefinedSet:R-HSA-1602340] FBXW7 WD mutants [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-1234142] RBX1 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-187538] SKP1 [nucleoplasm]
inDisease	true
isChimeric	false
maxDepth	4
name	FBXW7 WD mutants:SKP1:CUL1:RBX1
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-2220975

(input)	[FailedReaction:R-HSA-2220978] FBXW7 WD mutants do not bind NICD1
(diseaseEntity)	[EntityFunctionalStatus:2642421] loss_of_function of FBXW7 WD mutants:SKP1:CUL1:RBX1 [nucleoplasm]

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