Reactome | NICD1 PEST Domain Mutants [nucleoplasm]

Schema > DefinedSet > Entries

compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-HSA-2220969] NICD1 PEST domain mutants:RBPJ:SNW1 [nucleoplasm] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-2220982] NICD1 PEST domain mutants displace co-repressor complex from RBPJ (CSL) - Homo sapiens
created	[InstanceEdit:2769014] Orlic-Milacic, M, 2012-12-10
crossReference	[DatabaseIdentifier:12020841] Mondo:0004963
dbId	2769016
disease	[Disease:1485587] T-cell acute lymphoblastic leukemia [Disease:1500689] cancer
displayName	NICD1 PEST Domain Mutants [nucleoplasm]
hasMember	[EntityWithAccessionedSequence:R-HSA-2769013] NICD1 P2514Rfs4 [nucleoplasm] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2902200] NICD1 Q2440 [nucleoplasm] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2902201] NICD1 Q2395* [nucleoplasm] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2902208] NICD1 P2474Afs*4 [nucleoplasm] - Homo sapiens
inDisease	true
maxDepth	2
modified	[InstanceEdit:3159221] Orlic-Milacic, M, 2013-02-19
name	NICD1 PEST Domain Mutants
producedByEvent	[Reaction:R-HSA-2769015] NICD1 PEST domain mutants translocate from cytosol to nucleus - Homo sapiens
schemaClass	DefinedSet
species	[Species:48887] Homo sapiens
stId	R-HSA-2769016

(output)	[Reaction:R-HSA-2769015] NICD1 PEST domain mutants translocate from cytosol to nucleus
(input)	[Reaction:R-HSA-2220982] NICD1 PEST domain mutants displace co-repressor complex from RBPJ (CSL)
(diseaseEntity)	[EntityFunctionalStatus:2775826] gain_of_function of NICD1 PEST Domain Mutants [nucleoplasm]
(hasComponent)	[Complex:R-HSA-2220969] NICD1 PEST domain mutants:RBPJ:SNW1 [nucleoplasm]