Reactome | p-NICD1 PEST domain mutants [nucleoplasm]

Schema > DefinedSet > Entries

compartment	[Compartment:7660] nucleoplasm
consumedByEvent	[FailedReaction:R-HSA-2220967] p-NICD1 PEST domain mutants do not bind FBXW7 - Homo sapiens
created	[InstanceEdit:2220965] Orlic-Milacic, M, 2012-05-03
crossReference	[DatabaseIdentifier:12020841] Mondo:0004963
dbId	2220958
disease	[Disease:1485587] T-cell acute lymphoblastic leukemia [Disease:1500689] cancer
displayName	p-NICD1 PEST domain mutants [nucleoplasm]
hasMember	[EntityWithAccessionedSequence:R-HSA-2159809] p-NICD1 P2514Rfs4 [nucleoplasm] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2902205] p-NICD1 Q2395 [nucleoplasm] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2902207] p-NICD1 Q2440* [nucleoplasm] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2902204] p-NICD1 P2474Afs*4 [nucleoplasm] - Homo sapiens
inDisease	true
maxDepth	2
modified	[InstanceEdit:3159221] Orlic-Milacic, M, 2013-02-19
name	p-NICD1 PEST domain mutants
producedByEvent	[Reaction:R-HSA-2220971] CDK8 phosphorylates NICD1 PEST domain mutants - Homo sapiens
schemaClass	DefinedSet
species	[Species:48887] Homo sapiens
stId	R-HSA-2220958

(output)	[Reaction:R-HSA-2220971] CDK8 phosphorylates NICD1 PEST domain mutants
(input)	[FailedReaction:R-HSA-2220967] p-NICD1 PEST domain mutants do not bind FBXW7
(diseaseEntity)	[EntityFunctionalStatus:2638178] loss_of_function of p-NICD1 PEST domain mutants [nucleoplasm]

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