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GlyK130-ATG5 [cytosol]
Stable Identifier
R-HSA-5683582
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Autophagy protein 5, ATG5_HUMAN
Locations in the PathwayBrowser
Expand all
Autophagy (Homo sapiens)
Macroautophagy (Homo sapiens)
ATG10 dissociates from ATG12:ATG5 (Homo sapiens)
ATG10:GlyK130-ATG5:ATG12 [cytosol] (Homo sapiens)
GlyK130-ATG5:ATG12 [cytosol] (Homo sapiens)
GlyK130-ATG5 [cytosol] (Homo sapiens)
GlyK130-ATG5:ATG12 [cytosol] (Homo sapiens)
GlyK130-ATG5 [cytosol] (Homo sapiens)
ATG10 transfers ATG12 from ATG10 to ATG5 (Homo sapiens)
ATG10:GlyK130-ATG5:ATG12 [cytosol] (Homo sapiens)
GlyK130-ATG5:ATG12 [cytosol] (Homo sapiens)
GlyK130-ATG5 [cytosol] (Homo sapiens)
ATG16L1 complex transfers LC3 from ATG3 to PE (Homo sapiens)
ATG16L1 complex:WIPI2:PI(3,5)P2 [phagophore assembly site membrane] (Homo sapiens)
ATG16L1 complex [cytosol] (Homo sapiens)
GlyK130-ATG5:ATG12 [cytosol] (Homo sapiens)
GlyK130-ATG5 [cytosol] (Homo sapiens)
ATG5:ATG12 binds ATG16L1 (Homo sapiens)
ATG16L1 complex [cytosol] (Homo sapiens)
GlyK130-ATG5:ATG12 [cytosol] (Homo sapiens)
GlyK130-ATG5 [cytosol] (Homo sapiens)
GlyK130-ATG5:ATG12 [cytosol] (Homo sapiens)
GlyK130-ATG5 [cytosol] (Homo sapiens)
WIPI2 binds ATG12:ATG5:ATG16L (Homo sapiens)
ATG16L1 complex [cytosol] (Homo sapiens)
GlyK130-ATG5:ATG12 [cytosol] (Homo sapiens)
GlyK130-ATG5 [cytosol] (Homo sapiens)
ATG16L1 complex:WIPI2:PI(3,5)P2 [phagophore assembly site membrane] (Homo sapiens)
ATG16L1 complex [cytosol] (Homo sapiens)
GlyK130-ATG5:ATG12 [cytosol] (Homo sapiens)
GlyK130-ATG5 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9H1Y0 ATG5
Gene Names
ATG5, APG5L, ASP
Chain
chain:1-275
Reference Genes
BioGPS Gene:9474 ATG5
COSMIC (genes):ATG5 ATG5
CTD Gene:9474 ATG5
dbSNP Gene:9474 ATG5
ENSEMBL:ENSG00000057663.16 ATG5
HGNC:589 ATG5
KEGG Gene (Homo sapiens):9474 ATG5
Monarch:9474 ATG5
NCBI Gene:9474 ATG5
OMIM:604261 ATG5
UCSC:Q9H1Y0 ATG5
Reference Transcript
RefSeq:NM_001286106.1 ATG5
RefSeq:NM_001286108.1 ATG5
RefSeq:NM_004849.3 ATG5
RefSeq:NM_001286107.1 ATG5
RefSeq:NM_001286111.1 ATG5
Other Identifiers
11718147_a_at
11745992_a_at
11757828_s_at
17022190
202511_PM_s_at
202511_s_at
202512_PM_s_at
202512_s_at
210639_PM_s_at
210639_s_at
2967554
2967555
2967556
2967557
2967558
2967559
2967570
2967571
2967581
2967586
2967591
2967594
2967596
2967597
2967600
2967601
2967602
2967603
39013_at
8128592
9474
A_23_P111381
A_24_P175059
GE60290
GO:0000045
GO:0000422
GO:0001974
GO:0002376
GO:0002718
GO:0003013
GO:0005515
GO:0005737
GO:0005773
GO:0005776
GO:0005829
GO:0005856
GO:0005929
GO:0005930
GO:0006497
GO:0006501
GO:0006914
GO:0006915
GO:0006995
GO:0007005
GO:0009267
GO:0009410
GO:0009620
GO:0010040
GO:0010659
GO:0010667
GO:0012501
GO:0016020
GO:0016192
GO:0016236
GO:0016567
GO:0019883
GO:0030154
GO:0030163
GO:0030424
GO:0030670
GO:0031397
GO:0031410
GO:0032480
GO:0032991
GO:0034045
GO:0034274
GO:0035973
GO:0036211
GO:0039689
GO:0042311
GO:0043066
GO:0043226
GO:0043687
GO:0044233
GO:0044782
GO:0044804
GO:0045060
GO:0045824
GO:0048840
GO:0048856
GO:0050687
GO:0050765
GO:0051279
GO:0051649
GO:0055015
GO:0055065
GO:0055085
GO:0060047
GO:0060548
GO:0061684
GO:0061739
GO:0070254
GO:0070257
GO:0071500
GO:0098542
GO:1901096
GO:1902017
GO:1902617
GO:1904973
GO:1990234
GO:2000377
GO:2000378
GO:2000619
HMNXSV003009650
HMNXSV003048204
Hs.11171.0.S1_3p_a_at
ILMN_1718265
PH_hs_0001090
TC06001982.hg
g12006863_3p_a_at
g4757797_3p_a_at
Participates
as a component of
GlyK130-ATG5:ATG12 [cytosol] (Homo sapiens)
Other forms of this molecule
ATG5 [phagocytic vesicle membrane]
ATG5 [cytosol]
Inferred To
Ghost homologue of GlyK130-ATG5 [cytosol]
(Xenopus tropicalis)
ATG5 [cytosol]
(Bos taurus)
ATG5 [cytosol]
(Saccharomyces cerevisiae)
Atg5 [cytosol]
(Drosophila melanogaster)
Atg5 [cytosol]
(Mus musculus)
Atg5 [cytosol]
(Rattus norvegicus)
apg5l [cytosol]
(Danio rerio)
atg-5 [cytosol]
(Caenorhabditis elegans)
atg5 [cytosol]
(Dictyostelium discoideum)
atg5 [cytosol]
(Schizosaccharomyces pombe)
GlyK130-ATG5 [cytosol]
(Canis familiaris)
GlyK130-ATG5 [cytosol]
(Gallus gallus)
GlyK130-ATG5 [cytosol]
(Sus scrofa)
Modified Residues
Name
N6-glycyl-L-lysine at 130
Coordinate
130
PsiMod Name
N6-glycyl-L-lysine
PsiMod Definition
A protein modification that effectively crosslinks an L-lysine residue and a glycine residue by an isopeptide bond to form N6-glycyl-L-lysine.
Cross References
RefSeq
NP_001273037.1
,
NP_001273040.1
,
NP_001273036.1
,
NP_004840.1
,
NP_001273035.1
OpenTargets
ENSG00000057663
GeneCards
Q9H1Y0
HPA
ENSG00000057663-ATG5
Ensembl
ENSP00000358072
,
ENSP00000343313
,
ENST00000635758
,
ENST00000369076
,
ENST00000343245
,
ENSP00000490493
,
ENSG00000057663
PRO
Q9H1Y0
Pharos - Targets
Q9H1Y0
PDB
4TQ0
,
5NPV
,
4GDK
,
4NAW
,
4TQ1
,
5NPW
,
5D7G
,
7W36
,
4GDL
Interactors (24)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q676U5 ATG16L1
1
ATG16L1 [cytosol]
(R-HSA-5671734)
0.743
7
UniProt:Q7Z6L1 TCPR1
0.703
9
UniProt:P09936 UCHL1
1
UCHL1 [cytosol]
(R-HSA-5660679)
0.675
4
UniProt:Q8WW24 TEKT4
0.666
6
UniProt:Q8WUD4 CCDC12
1
CCDC12 [nucleoplasm]
(R-HSA-9769561)
0.666
4
UniProt:Q7Z434-1 MAVS
0.632
4
UniProt:Q8IZQ1 WDFY3
0.631
7
UniProt:Q8TDY2 RB1CC1
3
RB1CC1 [cytosol]
(R-HSA-5333627)
p-RB1CC1 [cytosol]
(R-HSA-5675845)
RB1CC1 [endoplasmic reticulum membrane]
(R-HSA-8948046)
0.623
3
UniProt:O95786-1 DDX58
0.591
4
UniProt:O94817 ATG12
2
ATG12 [phagocytic vesicle membrane]
(R-HSA-5205625)
ATG12 [cytosol]
(R-HSA-936011)
0.564
4
UniProt:Q86T90 K1328
0.556
3
UniProt:Q9Y6D9 MAD1L1
1
MAD1L1 [cytosol]
(R-HSA-141433)
0.556
3
UniProt:Q8TD31-3 CCHCR1
0.556
3
UniProt:Q9Y6H3 ATP23
0.556
3
UniProt:Q0VD86 INCA1
0.556
3
UniProt:Q96ED9-2 HOOK2
0.556
3
UniProt:Q14145 KEAP1
3
Ub-KEAP1 [cytosol]
(R-HSA-6782766)
ub-KEAP1 [cytosol]
(R-HSA-9766647)
KEAP1 [cytosol]
(R-HSA-976038)
0.556
3
UniProt:Q4V328 GRAP1
0.556
3
UniProt:Q9H0Y0 ATG10
2
GlyK166-ATG10 [cytosol]
(R-HSA-5683572)
ATG10 [cytosol]
(R-HSA-5671733)
0.556
5
UniProt:Q8IXW7 Q8IXW7
0.556
3
UniProt:A5LHX3 PSMB11
1
PSMB11 [cytosol]
(R-HSA-947607)
0.556
3
UniProt:O95166 GABARAP
3
GABARAP [autophagosome membrane]
(R-HSA-5683634)
GABARAP(1-117) [cytosol]
(R-HSA-5682696)
GABARAP [cytosol]
(R-HSA-975521)
0.544
2
UniProt:Q9GZQ8 MAP1LC3B
3
MAP1LC3B [autophagosome membrane]
(R-HSA-5683641)
MAP1LC3B(2-121) [cytosol]
(R-HSA-5682674)
MAP1LC3B [cytosol]
(R-HSA-5205651)
0.525
2
UniProt:Q8C0J2-3 ATG16L1
0.499
2
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