Reactome | GlyK130-ATG5 [cytosol]

GlyK130-ATG5 [cytosol]

Stable Identifier

R-HSA-5683582

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Autophagy protein 5, ATG5_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q9H1Y0 ATG5

Gene Names

ATG5, APG5L, ASP

Chain

chain:1-275

Reference Genes

BioGPS Gene:9474 A9UGY9

COSMIC (genes):ATG5 ATG5

CTD Gene:9474 A9UGY9

dbSNP Gene:9474 A9UGY9

ENSEMBL:ENSG00000057663 ATG5

HGNC:589 ATG5

KEGG:hsa:9474 A9UGY9

Monarch:9474 A9UGY9

NCBI Gene:9474 A9UGY9

OMIM:604261 ATG5

UCSC:Q9H1Y0 ATG5

Reference Transcript

Other Identifiers

11718147_a_at

11745992_a_at

11757828_s_at

17022190

202511_PM_s_at

202511_s_at

202512_PM_s_at

202512_s_at

210639_PM_s_at

210639_s_at

2967510

2967512

2967513

2967514

2967554

2967555

2967556

2967557

2967558

2967559

2967567

2967568

2967569

2967570

2967571

2967572

2967576

2967581

2967586

2967591

2967594

2967596

2967597

2967600

2967601

2967602

2967603

39013_at

8128592

9474

A_23_P111381

A_24_P175059

GE60290

GO:0000045

GO:0000422

GO:0000423

GO:0001974

GO:0002376

GO:0002718

GO:0003013

GO:0003824

GO:0005515

GO:0005737

GO:0005773

GO:0005776

GO:0005829

GO:0005930

GO:0006325

GO:0006914

GO:0006915

GO:0006995

GO:0007005

GO:0007018

GO:0009267

GO:0009410

GO:0009620

GO:0010040

GO:0010659

GO:0010667

GO:0012501

GO:0016020

GO:0016236

GO:0016567

GO:0016740

GO:0019776

GO:0019883

GO:0030163

GO:0030424

GO:0030670

GO:0031397

GO:0032480

GO:0032991

GO:0034045

GO:0034274

GO:0034727

GO:0035973

GO:0039689

GO:0042311

GO:0043066

GO:0043226

GO:0043687

GO:0044233

GO:0044804

GO:0045060

GO:0045087

GO:0045202

GO:0045824

GO:0048840

GO:0048856

GO:0050687

GO:0050765

GO:0051279

GO:0051607

GO:0051649

GO:0055015

GO:0060047

GO:0061684

GO:0061908

GO:0062029

GO:0070254

GO:0070257

GO:0071500

GO:0098542

GO:0098685

GO:0098930

GO:0098978

GO:0099072

GO:0099170

GO:0140096

GO:1901096

GO:1902017

GO:1902617

GO:1904093

GO:1904973

GO:1990234

GO:2000377

GO:2000378

HMNXSV003009650

HMNXSV003048204

Hs.11171.0.S1_3p_a_at

ILMN_1718265

PH_hs_0001090

TC06001982.hg

g12006863_3p_a_at

g4757797_3p_a_at

Participates

as a component of

GlyK130-ATG5:ATG12 [cytosol] (Homo sapiens)

Other forms of this molecule

ATG5 [phagocytic vesicle membrane]

ATG5 [cytosol]

Inferred To

ATG5 [cytosol] (Bos taurus)

ATG5 [cytosol] (Canis familiaris)

ATG5 [cytosol] (Saccharomyces cerevisiae)

Atg5 [cytosol] (Drosophila melanogaster)

Atg5 [cytosol] (Mus musculus)

Atg5 [cytosol] (Rattus norvegicus)

atg-5 [cytosol] (Caenorhabditis elegans)

atg5 [cytosol] (Danio rerio)

atg5 [cytosol] (Dictyostelium discoideum)

atg5 [cytosol] (Schizosaccharomyces pombe)

atg5 [cytosol] (Xenopus tropicalis)

GlyK130-ATG5 [cytosol] (Gallus gallus)

GlyK130-ATG5 [cytosol] (Plasmodium falciparum)

GlyK130-ATG5 [cytosol] (Sus scrofa)

Modified Residues

Name

N6-glycyl-L-lysine at 130

Coordinate

130

PsiMod Name

N6-glycyl-L-lysine

PsiMod Definition

A protein modification that effectively crosslinks an L-lysine residue and a glycine residue by an isopeptide bond to form N6-glycyl-L-lysine.

Cross References

RefSeq

NP_001273036.1, NP_001273035.1, NP_001273037.1, NP_004840.1, NP_001273040.1

OpenTargets

ENSG00000057663

ENSEMBL

ENSP00000343313, ENST00000635758, ENSG00000057663, ENSP00000358072, ENSP00000490493, ENST00000369076, ENST00000343245

HPA

ENSG00000057663-ATG5

GeneCards

ATG5

PRO

Q9H1Y0

Pharos - Targets

Q9H1Y0

GlyGen

Q9H1Y0

PDB

5NPV, 5D7G, 4GDL, 5NPW, 4TQ0, 4GDK, 4TQ1, 7W36, 4NAW

Interactors (27)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q676U5 ATG16L1	1	ATG16L1 [cytosol] (R-HSA-5671734)	0.8	11
UniProt:Q7Z6L1 TCPR1			0.77	12
UniProt:O94817 ATG12	2	ATG12 [phagocytic vesicle membrane] (R-HSA-5205625) ATG12 [cytosol] (R-HSA-936011)	0.744	8
UniProt:Q8WUD4 CCDC12	1	CCDC12 [nucleoplasm] (R-HSA-9769561)	0.742	7
UniProt:P09936 UCHL1	1	UCHL1 [cytosol] (R-HSA-5660679)	0.675	4
UniProt:Q8WW24 TEKT4			0.666	6
UniProt:Q9NT62 ATG3	8	CysO264-ATG3-GABARAPL3 [cytosol] (R-HSA-5683569) CysO264-ATG3-MAP1LC3B [cytosol] (R-HSA-9819365) CysO264-ATG3-GABARAPL1 [cytosol] (R-HSA-9819381) CysO264-ATG3-MAP1LC3C [cytosol] (R-HSA-9819377) CysO264-ATG3-GABARAPL2 [cytosol] (R-HSA-9819376) CysO264-ATG3-GABARAP [cytosol] (R-HSA-9819379) CysO264-ATG3-MAP1LC3A [cytosol] (R-HSA-9819371) ATG3 [cytosol] (R-HSA-5671860)	0.643	5
UniProt:Q7Z434-1 MAVS			0.632	4
UniProt:Q8IZQ1 WDFY3			0.631	7
UniProt:Q8TDY2 RB1CC1	3	RB1CC1 [endoplasmic reticulum membrane] (R-HSA-8948046) p-RB1CC1 [cytosol] (R-HSA-5675845) RB1CC1 [cytosol] (R-HSA-5333627)	0.623	3
UniProt:O95786-1 RIGI			0.591	4
UniProt:Q9Y6D9 MAD1L1	1	MAD1L1 [cytosol] (R-HSA-141433)	0.556	3
UniProt:A5LHX3 PSMB11	3	PSMB11(1-49) [cytosol] (R-HSA-9908124) PSMB11 [cytosol] (R-HSA-947607) pro-PSMB11 [cytosol] (R-HSA-9908126)	0.556	3
UniProt:Q8IXW7 Q8IXW7			0.556	3
UniProt:Q9H0Y0 ATG10	2	GlyK166-ATG10 [cytosol] (R-HSA-5683572) ATG10 [cytosol] (R-HSA-5671733)	0.556	5
UniProt:Q4V328 GRAP1			0.556	3
UniProt:Q96ED9-2 HOOK2			0.556	3
UniProt:Q0VD86 INCA1			0.556	3
UniProt:Q9Y6H3 ATP23			0.556	3
UniProt:Q14145 KEAP1	3	KEAP1 [cytosol] (R-HSA-976038) ub-KEAP1 [cytosol] (R-HSA-9766647) Ub-KEAP1 [cytosol] (R-HSA-6782766)	0.556	3
UniProt:Q8TD31-3 CCHCR1			0.556	3
UniProt:Q86T90 K1328			0.556	3
UniProt:O95166 GABARAP	3	GABARAP [cytosol] (R-HSA-975521) GABARAP(1-117) [cytosol] (R-HSA-5682696) GABARAP [autophagosome membrane] (R-HSA-5683634)	0.544	2
UniProt:O75143 ATG13	3	p-ATG13 [endoplasmic reticulum membrane] (R-HSA-8948049) p-ATG13 [cytosol] (R-HSA-5675831) ATG13 [cytosol] (R-HSA-5333624)	0.527	2
UniProt:Q8NAA4 ATG16L2	1	ATG16L2 [cytosol] (R-HSA-9936619)	0.527	5
UniProt:Q9GZQ8 MAP1LC3B	3	MAP1LC3B [cytosol] (R-HSA-5205651) MAP1LC3B(2-121) [cytosol] (R-HSA-5682674) MAP1LC3B [autophagosome membrane] (R-HSA-5683641)	0.525	2
UniProt:Q8C0J2-3 ATG16L1			0.499	2