Reactome | PolyUb-IFIH1 [cytosol]

PolyUb-IFIH1 [cytosol]

Stable Identifier

R-HSA-6782812

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

IFIH1, MDA5, Interferon-induced helicase C domain-containing protein 1

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Deubiquitination (Homo sapiens)
    - Ub-specific processing proteases (Homo sapiens)
      - USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1 (Homo sapiens)
        
        USP17:PolyUb-RCE1, PolyUb-CDC25A, PolyUb-DDX58, PolyUb-IFIH1 [cytosol] (Homo sapiens)
        
        PolyUb-RCE1, PolyUb-CDC25A, PolyUb-DDX58, PolyUb-IFIH1 [cytosol] (Homo sapiens)
        
        PolyUb-IFIH1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9BYX4 IFIH1

Gene Names

IFIH1, MDA5, RH116

Chain

chain:1-1025

Reference Genes

BioGPS Gene:64135 IFIH1

COSMIC (genes):IFIH1 IFIH1

CTD Gene:64135 IFIH1

dbSNP Gene:64135 IFIH1

ENSEMBL:ENSG00000115267 IFIH1

HGNC:18873 IFIH1

KEGG:hsa:64135 IFIH1

Monarch:64135 IFIH1

NCBI Gene:64135 IFIH1

OMIM:606951 IFIH1

UCSC:Q9BYX4 IFIH1

Reference Transcript

RefSeq:NM_022168.3 IFIH1

Other Identifiers

11724346_a_at

11761686_at

1555464_PM_at

1555464_at

16904365

216020_PM_at

216020_at

219209_PM_at

219209_at

2584206

2584208

2584209

2584210

2584211

2584212

2584213

2584215

2584216

2584218

2584219

2584220

2584221

2584222

2584223

2584224

2584225

2584226

2584227

2584228

2584229

2584230

2584231

2584234

2584235

2584236

2584238

2584239

2584240

2584241

2584242

33612_at

51920_at

64135

8056285

GE590898

GE62756

GO:0002376

GO:0002753

GO:0003677

GO:0003723

GO:0003724

GO:0003725

GO:0003727

GO:0003824

GO:0004386

GO:0005515

GO:0005524

GO:0005634

GO:0005737

GO:0005739

GO:0005829

GO:0008270

GO:0009597

GO:0009615

GO:0016787

GO:0016887

GO:0016925

GO:0032727

GO:0032728

GO:0032755

GO:0032760

GO:0034344

GO:0038187

GO:0039530

GO:0042802

GO:0043021

GO:0043226

GO:0045071

GO:0045087

GO:0046872

GO:0051259

GO:0051607

GO:0060089

GO:0060337

GO:0060760

GO:0065003

GO:0071360

GO:0098542

GO:0098586

GO:0140098

GO:0140374

GO:0140640

GO:0140657

HMNXSV003051681

Hs2Affx.1.318.S1_3p_at

ILMN_1781373

PH_hs_0024506

TC02002481.hg

g11545921_3p_at

Participates

as a member of

PolyUb-RCE1, PolyUb-CDC25A, PolyUb-DDX58, PolyUb-IFIH1 [cytosol] (Homo sapiens)

Other forms of this molecule

IFIH1 [cytosol]

K48polyUb-IFIH1 [cytosol]

Inferred To

helF [cytosol] (Dictyostelium discoideum)

Ifih1 [cytosol] (Rattus norvegicus)

Homologues of PolyUb-IFIH1 [cytosol] (Caenorhabditis elegans)

Homologues of PolyUb-IFIH1 [cytosol] (Saccharomyces cerevisiae)

ifih1 [cytosol] (Danio rerio)

drh-1 [cytosol] (Caenorhabditis elegans)

PolyUb-IFIH1 [cytosol] (Bos taurus)

PolyUb-IFIH1 [cytosol] (Caenorhabditis elegans)

PolyUb-IFIH1 [cytosol] (Canis familiaris)

PolyUb-IFIH1 [cytosol] (Mus musculus)

PolyUb-IFIH1 [cytosol] (Saccharomyces cerevisiae)

PolyUb-IFIH1 [cytosol] (Sus scrofa)

Modified Residues

Name

ubiquitinylated lysine (PolyUb [cytosol]) at unknown position

Modification

PolyUb [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

NP_071451.2

Guide to Pharmacology - Targets

2921

OpenTargets

ENSG00000115267

ENSEMBL

ENST00000649979, ENSP00000497271, ENSP00000408450, ENST00000421365

IntEnz

3.6.4.13

HPA

ENSG00000115267-IFIH1

PRO

Q9BYX4

Pharos - Targets

Q9BYX4

Orphanet

IFIH1

PDB

7DNI, 4GL2, 7JL2, 7JL0, 2RQB, 3B6E, 3GA3, 7DNJ

HMDB Protein

HMDBP11796

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q7Z434 MAVS	2	MAVS [mitochondrial outer membrane] (R-HSA-913730) K48polyUb-MAVS [mitochondrial outer membrane] (R-HSA-983463)	0.775	7
UniProt:P05161 ISG15	4	ISG15 [cytosol] (R-HSA-936552) K168-PCNA-G157-ISG15 [nucleoplasm] (R-HSA-5653744) K164-PCNA-G157-ISG15 [nucleoplasm] (R-HSA-5653745) ISG15 [nucleoplasm] (R-HSA-5653665)	0.623	7
UniProt:P0DTC5 M	10	M [plasma membrane] (R-COV-9755780) N-glycan M [virion membrane] (R-COV-9694385) M [virion membrane] (R-COV-9694320) M [endocytic vesicle membrane] (R-COV-9694563) N-glycan M [endocytic vesicle membrane] (R-COV-9694738) M [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9694439) N-glycan M [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9694446) M [endoplasmic reticulum membrane] (R-COV-9767620) nascent M [endoplasmic reticulum lumen] (R-COV-9694279) N-glycan M [endoplasmic reticulum membrane] (R-COV-9694684)	0.621	3
UniProt:Q3LXA3 TKFC	1	TKFC [cytosol] (R-HSA-918185)	0.616	5
UniProt:Q14145 KEAP1	3	KEAP1 [cytosol] (R-HSA-976038) ub-KEAP1 [cytosol] (R-HSA-9766647) Ub-KEAP1 [cytosol] (R-HSA-6782766)	0.556	3
UniProt:O14730 RIOK3	1	RIOK3 [cytosol] (R-HSA-6791522)	0.543	6
UniProt:Q14164 IKBKE	5	IKBKE [cytosol] (R-HSA-450225) p-S172-IKBKE [cytosol] (R-HSA-450278) K63polyUb-K30,K401-IKBKE [cytosol] (R-HSA-9730436) p-S172-IKBKE [nucleoplasm] (R-HSA-4755521) monoSUMO1-K231-p-S172-IKBKE [nucleoplasm] (R-HSA-4755535)	0.499	2
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) p-11S,2T-N [cytosol] (R-COV-9729264) p-8S,2T-N [cytosol] (R-COV-9729277) p-8S-N [cytosol] (R-COV-9729335) p-S188,206-N [cytosol] (R-COV-9729324) N [cytosol] (R-COV-9694300) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [plasma membrane] (R-COV-9694356) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325)	0.463	2
UniProt:P0DTD2 9b	3	p-S53-9b [cytosol] (R-COV-9758478) 9b [cytosol] (R-COV-9694649) 9b [mitochondrial outer membrane] (R-COV-9709803)	0.463	2

Cite Us!