Reactome | PRKAG1 [cytosol]

PRKAG1

Stable Identifier

R-HSA-380946

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

AMPK gamma1, 5'-AMP-activated protein kinase subunit gamma-1, AAKG1_HUMAN

Locations in the PathwayBrowser

Expand all

Cellular responses to external stimuli (Homo sapiens)

- Macroautophagy (Homo sapiens)
  - AMPK (complex) phosphorylates ULK1 (complex) (Homo sapiens)
    - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
      - p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK gamma [cytosol] (Homo sapiens)
        
        PRKAG1 [cytosol] (Homo sapiens)
    - p-AMPK heterotrimer:AMP:ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Homo sapiens)
      - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK gamma [cytosol] (Homo sapiens)
        
        PRKAG1 [cytosol] (Homo sapiens)
    - p-AMPK heterotrimer:AMP:p-S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Homo sapiens)
      - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK gamma [cytosol] (Homo sapiens)
        
        PRKAG1 [cytosol] (Homo sapiens)
  - Thr-180 of ULK1 is phosphorylated (Homo sapiens)
    - p-AMPK heterotrimer:AMP:p-S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Homo sapiens)
      - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK gamma [cytosol] (Homo sapiens)
        
        PRKAG1 [cytosol] (Homo sapiens)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Homo sapiens)
      - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK gamma [cytosol] (Homo sapiens)
        
        PRKAG1 [cytosol] (Homo sapiens)
  - ULK complex translocates to the ER (Homo sapiens)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [endoplasmic reticulum membrane] (Homo sapiens)
      - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK gamma [cytosol] (Homo sapiens)
        
        PRKAG1 [cytosol] (Homo sapiens)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:p-ATG13:p-RB1CC1:ATG101 [cytosol] (Homo sapiens)
      - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK gamma [cytosol] (Homo sapiens)
        
        PRKAG1 [cytosol] (Homo sapiens)
  - ULK1 phosphorylates AMBRA1:Beclin-1 complex (Homo sapiens)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [endoplasmic reticulum membrane] (Homo sapiens)
      - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK gamma [cytosol] (Homo sapiens)
        
        PRKAG1 [cytosol] (Homo sapiens)
  - ULK1 phosphorylates ATG13 and RB1CC1 (Homo sapiens)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Homo sapiens)
      - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK gamma [cytosol] (Homo sapiens)
        
        PRKAG1 [cytosol] (Homo sapiens)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:p-ATG13:p-RB1CC1:ATG101 [cytosol] (Homo sapiens)
      - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK gamma [cytosol] (Homo sapiens)
        
        PRKAG1 [cytosol] (Homo sapiens)
  - ULK1 phosphorylates Beclin-1 (Homo sapiens)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [endoplasmic reticulum membrane] (Homo sapiens)
      - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK gamma [cytosol] (Homo sapiens)
        
        PRKAG1 [cytosol] (Homo sapiens)
  - p-AMPK:AMP binds the ULK complex (Homo sapiens)
    - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
      - p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK gamma [cytosol] (Homo sapiens)
        
        PRKAG1 [cytosol] (Homo sapiens)
    - p-AMPK heterotrimer:AMP:ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Homo sapiens)
      - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK gamma [cytosol] (Homo sapiens)
        
        PRKAG1 [cytosol] (Homo sapiens)
  - p-AMPK:AMP phosphorylates Raptor in the mTORC1 complex (Homo sapiens)
    - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
      - p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK gamma [cytosol] (Homo sapiens)
        
        PRKAG1 [cytosol] (Homo sapiens)

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Metabolic Genes (Homo sapiens)
        
        SESN1,2,3 bind AMPK (Homo sapiens)
        
        SESN1,2,3:p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK gamma [cytosol] (Homo sapiens)
        
        PRKAG1 [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK gamma [cytosol] (Homo sapiens)
        
        PRKAG1 [cytosol] (Homo sapiens)
        
        p-AMPK phosphorylates TSC1:TSC2 (Homo sapiens)
        
        p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK gamma [cytosol] (Homo sapiens)
        
        PRKAG1 [cytosol] (Homo sapiens)

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - Translocation of GLUT4 to the plasma membrane (Homo sapiens)
    - AMPK-alpha2 phosphorylates TBC1D1 (Homo sapiens)
      - AMPK-alpha2:AMPK-beta:AMPK-gamma:AMP [cytosol] (Homo sapiens)
        
        AMPK gamma:AMP [cytosol] (Homo sapiens)
        
        AMPK gamma [cytosol] (Homo sapiens)
        
        PRKAG1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P54619 PRKAG1

Gene Names

PRKAG1

Chain

chain:1-331

Reference Genes

BioGPS Gene:5571 PRKAG1

COSMIC (genes):PRKAG1 PRKAG1

CTD Gene:5571 PRKAG1

dbSNP Gene:5571 PRKAG1

ENSEMBL:ENSG00000181929 PRKAG1

HGNC:9385 PRKAG1

KEGG Gene (Homo sapiens):hsa:5571 PRKAG1

Monarch:5571 PRKAG1

NCBI Gene:5571 PRKAG1

OMIM:602742 PRKAG1

UCSC:P54619 PRKAG1

Reference Transcript

Other Identifiers

0002100056

11730242_a_at

11741462_a_at

16764131

201805_at

227527_at

2UV4

2UV5

2UV6

2UV7

34346_at

3453557

3453558

3453559

3453561

3453562

3453563

3453564

3453565

3453566

3453567

3453568

3453570

3453573

3453583

3453588

3453589

3453590

3453591

3453593

4CFE

4CFF

4RER

4REW

4ZHX

5571

5EZV

5ISO

77805

7962935

A0A024R125

A_23_P36513

A_33_P3340254

CCDS55824

CCDS55825

CCDS8777

ENSG00000181929

ENSP00000323867

ENSP00000447433

ENSP00000448972

ENST00000316299

ENST00000548065

ENST00000552212

EntrezGene:5571

g4506060_3p_at

GO:0000166

GO:0004672

GO:0004679

GO:0004691

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005829

GO:0006110

GO:0006468

GO:0006629

GO:0006631

GO:0006633

GO:0007050

GO:0007165

GO:0007283

GO:0008603

GO:0010628

GO:0016020

GO:0016208

GO:0016236

GO:0016241

GO:0016301

GO:0016310

GO:0019901

GO:0031588

GO:0043531

GO:0045860

GO:0051170

GO:0070062

GO:1901796

GO:1902593

HGNC:9385

HPA077805

Hs.3640.0.S1_3p_at

Hs.733223

ILMN_1751984

ILMN_1774687

ILMN_2412101

MIM:602742

NM_001206709

NM_001206710

NM_002733

NP_001193638

NP_001193639

NP_002724

PF00571

PH_hs_0000393

PRKAG1

PRKAG1-201

PRKAG1-206

PRKAG1-217

SM00116

TC12003276.hg

U42412_at

uc001rsy.4

uc001rsz.4

uc010smd.3

UPI000007202F

UPI00001250B2

UPI00005307F8

XM_006719499

XM_011538562

XM_017019622

XP_006719562

XP_011536864

XP_016875111

Participant Of

hasMember

AMPK gamma [cytosol]

Other forms of this molecule

PRKAG1 [nucleoplasm]

Inferred To

Homologues of PRKAG1 [cytosol] (Caenorhabditis elegans)

Homologues of PRKAG1 [cytosol] (Drosophila melanogaster)

Homologues of PRKAG1 [cytosol] (Gallus gallus)

Homologues of PRKAG1 [cytosol] (Oryza sativa)

Homologues of PRKAG1 [cytosol] (Sus scrofa)

Homologues of PRKAG1 [cytosol] (Xenopus tropicalis)

PRKAG1 [cytosol] (Arabidopsis thaliana)

PRKAG1 [cytosol] (Bos taurus)

PRKAG1 [cytosol] (Caenorhabditis elegans)

PRKAG1 [cytosol] (Canis familiaris)

PRKAG1 [cytosol] (Danio rerio)

PRKAG1 [cytosol] (Dictyostelium discoideum)

PRKAG1 [cytosol] (Drosophila melanogaster)

PRKAG1 [cytosol] (Gallus gallus)

PRKAG1 [cytosol] (Mus musculus)

PRKAG1 [cytosol] (Oryza sativa)

PRKAG1 [cytosol] (Saccharomyces cerevisiae)

PRKAG1 [cytosol] (Schizosaccharomyces pombe)

PRKAG1 [cytosol] (Sus scrofa)

PRKAG1 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_001193639.1, NP_001193638.1, XP_011536864.1, XP_006719562.1, NP_002724.1

GeneCards

P54619

DOCK Blaster

4REW, 5ISO, 4ZHX, 4CFF, 4CFE, 2UV7, 2UV6, 2UV5, 5EZV, 2UV4, 4RER

ZINC target

P54619

PRO

P54619

PDB

4ZHX, 2UV6, 2UV5, 4REW, 2UV4, 4RER, 5ISO, 4CFF, 5EZV, 4CFE, 2UV7

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O75385 ULK1	7	p-S758-ULK1 [cytosol] (R-HSA-5672131) p-T180,S317,S467,S556,S638,T575-ULK1 [endoplasmic reticulum membrane] (R-HSA-8948047) ULK1 [cytosol] (R-HSA-1632847) p-T180,S317,S467,S556,S638,T575-ULK1 [cytosol] (R-HSA-5675858) p-S317,467,556,638,T575-ULK1 [cytosol] (R-HSA-5673747) ULK1 [mitochondrial outer membrane] (R-HSA-8948145) ULK1 [recycling endosome] (R-HSA-8854761)	0.564	2
UniProt:P06782	7	TRIB3 [cytosol] (R-SCE-162411) TRIB3 [plasma membrane] (R-SCE-199447) phospho-p-T174-PRKAA1 [cytosol] (R-SCE-380964) phospho-p-T172-PRKAA2 [cytosol] (R-SCE-200417) PRKAA1 [cytosol] (R-SCE-380935) PRKAA2 [cytosol] (R-SCE-200405) PRKAA2 [nucleoplasm] (R-SCE-163682)	0.556	3
UniProt:P26367 PAX6	1	PAX6 [nucleoplasm] (R-HSA-3009044)	0.488	2