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PRKAG1 [cytosol]
Stable Identifier
R-HSA-380946
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
AMPK gamma1, 5'-AMP-activated protein kinase subunit gamma-1, AAKG1_HUMAN
Locations in the PathwayBrowser
Expand all
Autophagy (Homo sapiens)
Macroautophagy (Homo sapiens)
AMPK (complex) phosphorylates ULK1 (complex) (Homo sapiens)
p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK gamma [cytosol] (Homo sapiens)
PRKAG1 [cytosol] (Homo sapiens)
p-AMPK heterotrimer:AMP:ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Homo sapiens)
p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK gamma [cytosol] (Homo sapiens)
PRKAG1 [cytosol] (Homo sapiens)
p-AMPK heterotrimer:AMP:p-S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Homo sapiens)
p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK gamma [cytosol] (Homo sapiens)
PRKAG1 [cytosol] (Homo sapiens)
Selective autophagy (Homo sapiens)
Lipophagy (Homo sapiens)
PRKAA2 phosphorylates PLINs (Homo sapiens)
AMPK-alpha2:AMPK-beta:AMPK-gamma:AMP [cytosol] (Homo sapiens)
AMPK gamma:AMP [cytosol] (Homo sapiens)
AMPK gamma [cytosol] (Homo sapiens)
PRKAG1 [cytosol] (Homo sapiens)
Thr-180 of ULK1 is phosphorylated (Homo sapiens)
p-AMPK heterotrimer:AMP:p-S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Homo sapiens)
p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK gamma [cytosol] (Homo sapiens)
PRKAG1 [cytosol] (Homo sapiens)
p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Homo sapiens)
p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK gamma [cytosol] (Homo sapiens)
PRKAG1 [cytosol] (Homo sapiens)
ULK complex translocates to the ER (Homo sapiens)
p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [endoplasmic reticulum membrane] (Homo sapiens)
p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK gamma [cytosol] (Homo sapiens)
PRKAG1 [cytosol] (Homo sapiens)
p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:p-ATG13:p-RB1CC1:ATG101 [cytosol] (Homo sapiens)
p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK gamma [cytosol] (Homo sapiens)
PRKAG1 [cytosol] (Homo sapiens)
ULK1 phosphorylates AMBRA1:BECN1 complex (Homo sapiens)
p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [endoplasmic reticulum membrane] (Homo sapiens)
p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK gamma [cytosol] (Homo sapiens)
PRKAG1 [cytosol] (Homo sapiens)
ULK1 phosphorylates ATG13 and RB1CC1 (Homo sapiens)
p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Homo sapiens)
p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK gamma [cytosol] (Homo sapiens)
PRKAG1 [cytosol] (Homo sapiens)
p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:p-ATG13:p-RB1CC1:ATG101 [cytosol] (Homo sapiens)
p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK gamma [cytosol] (Homo sapiens)
PRKAG1 [cytosol] (Homo sapiens)
ULK1 phosphorylates Beclin-1 (Homo sapiens)
p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [endoplasmic reticulum membrane] (Homo sapiens)
p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK gamma [cytosol] (Homo sapiens)
PRKAG1 [cytosol] (Homo sapiens)
p-AMPK:AMP binds the ULK complex (Homo sapiens)
p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK gamma [cytosol] (Homo sapiens)
PRKAG1 [cytosol] (Homo sapiens)
p-AMPK heterotrimer:AMP:ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Homo sapiens)
p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK gamma [cytosol] (Homo sapiens)
PRKAG1 [cytosol] (Homo sapiens)
p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Homo sapiens)
p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK gamma [cytosol] (Homo sapiens)
PRKAG1 [cytosol] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
TP53 Regulates Metabolic Genes (Homo sapiens)
SESN1,2,3 bind AMPK (Homo sapiens)
SESN1,2,3:p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK gamma [cytosol] (Homo sapiens)
PRKAG1 [cytosol] (Homo sapiens)
p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK gamma [cytosol] (Homo sapiens)
PRKAG1 [cytosol] (Homo sapiens)
p-AMPK phosphorylates TSC1:TSC2 (Homo sapiens)
p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK gamma [cytosol] (Homo sapiens)
PRKAG1 [cytosol] (Homo sapiens)
Neuronal System (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
Activation of NMDA receptors and postsynaptic events (Homo sapiens)
Post NMDA receptor activation events (Homo sapiens)
Activation of AMPK downstream of NMDARs (Homo sapiens)
AMPK negatively regulates binding of MAPT to microtubules (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK gamma [cytosol] (Homo sapiens)
PRKAG1 [cytosol] (Homo sapiens)
AMPK phosphorylates MAPT (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK gamma [cytosol] (Homo sapiens)
PRKAG1 [cytosol] (Homo sapiens)
CAMKK2 phosphorylates AMPK (Homo sapiens)
AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK gamma [cytosol] (Homo sapiens)
PRKAG1 [cytosol] (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK gamma [cytosol] (Homo sapiens)
PRKAG1 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
MTOR signalling (Homo sapiens)
Energy dependent regulation of mTOR by LKB1-AMPK (Homo sapiens)
AMPK is dephosphorylated (Homo sapiens)
AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK gamma [cytosol] (Homo sapiens)
PRKAG1 [cytosol] (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK gamma [cytosol] (Homo sapiens)
PRKAG1 [cytosol] (Homo sapiens)
AMPK phosphorylates Raptor in the mTORC1 complex (Homo sapiens)
p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK gamma [cytosol] (Homo sapiens)
PRKAG1 [cytosol] (Homo sapiens)
Activation of cytosolic AMPK by phosphorylation (Homo sapiens)
AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK gamma [cytosol] (Homo sapiens)
PRKAG1 [cytosol] (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK gamma [cytosol] (Homo sapiens)
PRKAG1 [cytosol] (Homo sapiens)
Phosphorylated AMPK binds AMP (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK gamma [cytosol] (Homo sapiens)
PRKAG1 [cytosol] (Homo sapiens)
p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK gamma [cytosol] (Homo sapiens)
PRKAG1 [cytosol] (Homo sapiens)
p-AMPK phosphorylates TSC1:TSC2 (Homo sapiens)
p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
p-AMPK heterotrimer [cytosol] (Homo sapiens)
AMPK gamma [cytosol] (Homo sapiens)
PRKAG1 [cytosol] (Homo sapiens)
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
Translocation of SLC2A4 (GLUT4) to the plasma membrane (Homo sapiens)
AMPK-alpha2 phosphorylates TBC1D1 (Homo sapiens)
AMPK-alpha2:AMPK-beta:AMPK-gamma:AMP [cytosol] (Homo sapiens)
AMPK gamma:AMP [cytosol] (Homo sapiens)
AMPK gamma [cytosol] (Homo sapiens)
PRKAG1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P54619 PRKAG1
Gene Names
PRKAG1
Chain
chain:1-331
Reference Genes
BioGPS Gene:5571 PRKAG1
COSMIC (genes):PRKAG1 PRKAG1
CTD Gene:5571 PRKAG1
dbSNP Gene:5571 PRKAG1
ENSEMBL:ENSG00000181929 PRKAG1
HGNC:9385 PRKAG1
KEGG Gene (Homo sapiens):5571 PRKAG1
Monarch:5571 PRKAG1
NCBI Gene:5571 PRKAG1
OMIM:602742 PRKAG1
UCSC:P54619 PRKAG1
Reference Transcript
RefSeq:NM_001206709.1 PRKAG1
RefSeq:XM_006719499.2 PRKAG1
RefSeq:NM_001206710.1 PRKAG1
RefSeq:NM_002733.4 PRKAG1
RefSeq:XM_011538562.2 PRKAG1
Other Identifiers
0002100056
11730242_a_at
11741462_a_at
16764131
201805_PM_at
201805_at
34346_at
3453557
3453558
3453559
3453561
3453562
3453563
3453564
3453565
3453566
3453567
3453568
3453570
3453573
3453583
3453588
3453589
3453590
3453591
5571
7962935
A_23_P36513
A_33_P3340254
GE59156
GO:0000003
GO:0000166
GO:0003674
GO:0004672
GO:0004691
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005975
GO:0006091
GO:0006110
GO:0006464
GO:0006468
GO:0006629
GO:0006631
GO:0006633
GO:0006810
GO:0006913
GO:0006950
GO:0007165
GO:0007283
GO:0008150
GO:0008603
GO:0009056
GO:0009058
GO:0010628
GO:0016020
GO:0016208
GO:0016301
GO:0016310
GO:0019887
GO:0019899
GO:0019901
GO:0030234
GO:0031588
GO:0031669
GO:0032559
GO:0032991
GO:0034641
GO:0042149
GO:0043167
GO:0043226
GO:0043531
GO:0044281
GO:0045860
GO:0050790
GO:0051170
GO:0071900
HMNXSV003016868
HMNXSV003050202
ILMN_1751984
ILMN_1774687
ILMN_2412101
PH_hs_0000393
TC12003276.hg
U42412_at
g4506060_3p_at
Participates
as a member of
AMPK gamma [cytosol] (Homo sapiens)
Other forms of this molecule
PRKAG1 [nucleoplasm]
Inferred To
Homologues of PRKAG1 [cytosol]
(Caenorhabditis elegans)
Homologues of PRKAG1 [cytosol]
(Sus scrofa)
aakg-1 [cytosol]
(Caenorhabditis elegans)
cbs2 [cytosol]
(Schizosaccharomyces pombe)
PRKAG1 [cytosol]
(Bos taurus)
PRKAG1 [cytosol]
(Canis familiaris)
PRKAG1 [cytosol]
(Gallus gallus)
PRKAG1 [cytosol]
(Sus scrofa)
SNF4 [cytosol]
(Saccharomyces cerevisiae)
SNF4Agamma [cytosol]
(Drosophila melanogaster)
prkag [cytosol]
(Dictyostelium discoideum)
aakg-5 [cytosol]
(Caenorhabditis elegans)
prkag1 [cytosol]
(Danio rerio)
aakg-4 [cytosol]
(Caenorhabditis elegans)
aakg-3 [cytosol]
(Caenorhabditis elegans)
Prkag1 [cytosol]
(Mus musculus)
Prkag1 [cytosol]
(Rattus norvegicus)
aakg-2 [cytosol]
(Caenorhabditis elegans)
Cross References
RefSeq
XP_006719562.1
,
NP_002724.1
,
NP_001193638.1
,
NP_001193639.1
,
XP_011536864.1
Guide to Pharmacology - Targets
1545
OpenTargets
ENSG00000181929
HPA
ENSG00000181929-PRKAG1
GeneCards
P54619
ZINC target
P54619
Ensembl
ENSP00000448972
,
ENSP00000323867
,
ENST00000316299
,
ENST00000548065
,
ENSG00000181929
,
ENST00000552212
,
ENSP00000447433
PRO
P54619
Pharos - Targets
P54619
Orphanet
28979
PDB
6C9G
,
4ZHX
,
5ISO
,
6B1U
,
7JHH
,
4CFE
,
6C9J
,
7JHG
,
4RER
,
6C9H
,
2UV4
,
4REW
,
2UV5
,
4CFF
,
7JIJ
,
6B2E
,
5EZV
,
2UV6
,
6C9F
,
2UV7
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P54646 PRKAA2
4
PRKAA2 [cytosol]
(R-HSA-200405)
p-T172-PRKAA2 [cytosol]
(R-HSA-200417)
p-T172-PRKAA2 [nucleoplasm]
(R-HSA-164171)
PRKAA2 [nucleoplasm]
(R-HSA-163682)
0.905
13
UniProt:O75385 ULK1
7
ULK1 [recycling endosome]
(R-HSA-8854761)
p-S758-ULK1 [cytosol]
(R-HSA-5672131)
ULK1 [cytosol]
(R-HSA-1632847)
ULK1 [mitochondrial outer membrane]
(R-HSA-8948145)
p-T180,S317,S467,S556,S638,T575-ULK1 [endoplasmic reticulum membrane]
(R-HSA-8948047)
p-T180,S317,S467,S556,S638,T575-ULK1 [cytosol]
(R-HSA-5675858)
p-S317,467,556,638,T575-ULK1 [cytosol]
(R-HSA-5673747)
0.669
3
UniProt:P55212 CASP6
5
CASP6 (1-293) [cytosol]
(R-HSA-6798132)
CASP6(194-293) [nucleoplasm]
(R-HSA-352246)
CASP6(24-179) [nucleoplasm]
(R-HSA-352247)
CASP6(24-179) [cytosol]
(R-HSA-350313)
CASP6(194-293) [cytosol]
(R-HSA-266128)
0.556
3
UniProt:P26367 PAX6
1
PAX6 [nucleoplasm]
(R-HSA-3009044)
0.556
3
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