Reactome | PRKAG1 [cytosol]

PRKAG1 [cytosol]

Stable Identifier

R-HSA-380946

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

AMPK gamma1, 5'-AMP-activated protein kinase subunit gamma-1, AAKG1_HUMAN

Locations in the PathwayBrowser

Expand all

Autophagy (Homo sapiens)

- Macroautophagy (Homo sapiens)
  - AMPK (complex) phosphorylates ULK1 (complex) (Homo sapiens)
    - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
      - p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK gamma [cytosol] (Homo sapiens)
        
        PRKAG1 [cytosol] (Homo sapiens)
    - p-AMPK heterotrimer:AMP:ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Homo sapiens)
      - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK gamma [cytosol] (Homo sapiens)
        
        PRKAG1 [cytosol] (Homo sapiens)
    - p-AMPK heterotrimer:AMP:p-S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Homo sapiens)
      - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK gamma [cytosol] (Homo sapiens)
        
        PRKAG1 [cytosol] (Homo sapiens)
  - Selective autophagy (Homo sapiens)
    - Lipophagy (Homo sapiens)
      - PRKAA2 phosphorylates PLINs (Homo sapiens)
        
        AMPK-alpha2:AMPK-beta:AMPK-gamma:AMP [cytosol] (Homo sapiens)
        
        AMPK gamma:AMP [cytosol] (Homo sapiens)
        
        AMPK gamma [cytosol] (Homo sapiens)
        
        PRKAG1 [cytosol] (Homo sapiens)
  - Thr-180 of ULK1 is phosphorylated (Homo sapiens)
    - p-AMPK heterotrimer:AMP:p-S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Homo sapiens)
      - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK gamma [cytosol] (Homo sapiens)
        
        PRKAG1 [cytosol] (Homo sapiens)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Homo sapiens)
      - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK gamma [cytosol] (Homo sapiens)
        
        PRKAG1 [cytosol] (Homo sapiens)
  - ULK complex translocates to the ER (Homo sapiens)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [endoplasmic reticulum membrane] (Homo sapiens)
      - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK gamma [cytosol] (Homo sapiens)
        
        PRKAG1 [cytosol] (Homo sapiens)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:p-ATG13:p-RB1CC1:ATG101 [cytosol] (Homo sapiens)
      - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK gamma [cytosol] (Homo sapiens)
        
        PRKAG1 [cytosol] (Homo sapiens)
  - ULK1 phosphorylates AMBRA1:BECN1 complex (Homo sapiens)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [endoplasmic reticulum membrane] (Homo sapiens)
      - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK gamma [cytosol] (Homo sapiens)
        
        PRKAG1 [cytosol] (Homo sapiens)
  - ULK1 phosphorylates ATG13 and RB1CC1 (Homo sapiens)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Homo sapiens)
      - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK gamma [cytosol] (Homo sapiens)
        
        PRKAG1 [cytosol] (Homo sapiens)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:p-ATG13:p-RB1CC1:ATG101 [cytosol] (Homo sapiens)
      - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK gamma [cytosol] (Homo sapiens)
        
        PRKAG1 [cytosol] (Homo sapiens)
  - ULK1 phosphorylates Beclin-1 (Homo sapiens)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [endoplasmic reticulum membrane] (Homo sapiens)
      - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK gamma [cytosol] (Homo sapiens)
        
        PRKAG1 [cytosol] (Homo sapiens)
  - p-AMPK:AMP binds the ULK complex (Homo sapiens)
    - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
      - p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK gamma [cytosol] (Homo sapiens)
        
        PRKAG1 [cytosol] (Homo sapiens)
    - p-AMPK heterotrimer:AMP:ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Homo sapiens)
      - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK gamma [cytosol] (Homo sapiens)
        
        PRKAG1 [cytosol] (Homo sapiens)
  - p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Homo sapiens)
    - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
      - p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK gamma [cytosol] (Homo sapiens)
        
        PRKAG1 [cytosol] (Homo sapiens)

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Metabolic Genes (Homo sapiens)
        
        SESN1,2,3 bind AMPK (Homo sapiens)
        
        SESN1,2,3:p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK gamma [cytosol] (Homo sapiens)
        
        PRKAG1 [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK gamma [cytosol] (Homo sapiens)
        
        PRKAG1 [cytosol] (Homo sapiens)
        
        p-AMPK phosphorylates TSC1:TSC2 (Homo sapiens)
        
        p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        AMPK gamma [cytosol] (Homo sapiens)
        
        PRKAG1 [cytosol] (Homo sapiens)

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - Translocation of SLC2A4 (GLUT4) to the plasma membrane (Homo sapiens)
    - AMPK-alpha2 phosphorylates TBC1D1 (Homo sapiens)
      - AMPK-alpha2:AMPK-beta:AMPK-gamma:AMP [cytosol] (Homo sapiens)
        
        AMPK gamma:AMP [cytosol] (Homo sapiens)
        
        AMPK gamma [cytosol] (Homo sapiens)
        
        PRKAG1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P54619 PRKAG1

Gene Names

PRKAG1

Chain

chain:1-331

Reference Genes

BioGPS Gene:5571 PRKAG1

COSMIC (genes):PRKAG1 PRKAG1

CTD Gene:5571 PRKAG1

dbSNP Gene:5571 PRKAG1

ENSEMBL:ENSG00000181929 PRKAG1

HGNC:9385 PRKAG1

KEGG Gene (Homo sapiens):5571 PRKAG1

Monarch:5571 PRKAG1

NCBI Gene:5571 PRKAG1

OMIM:602742 PRKAG1

UCSC:P54619 PRKAG1

Reference Transcript

Other Identifiers

0002100056

11730242_a_at

11741462_a_at

16764131

201805_PM_at

201805_at

34346_at

3453557

3453558

3453559

3453561

3453562

3453563

3453564

3453565

3453566

3453567

3453568

3453570

3453573

3453583

3453588

3453589

3453590

3453591

5571

7962935

A_23_P36513

A_33_P3340254

GE59156

GO:0000003

GO:0000166

GO:0003674

GO:0004672

GO:0004691

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005975

GO:0006091

GO:0006110

GO:0006464

GO:0006468

GO:0006629

GO:0006631

GO:0006633

GO:0006810

GO:0006913

GO:0006950

GO:0007165

GO:0007283

GO:0008150

GO:0008603

GO:0009056

GO:0009058

GO:0010628

GO:0016020

GO:0016208

GO:0016301

GO:0016310

GO:0019887

GO:0019899

GO:0019901

GO:0030234

GO:0031588

GO:0031669

GO:0032559

GO:0032991

GO:0034641

GO:0042149

GO:0043167

GO:0043226

GO:0043531

GO:0044281

GO:0045860

GO:0050790

GO:0051170

GO:0071900

HMNXSV003016868

HMNXSV003050202

ILMN_1751984

ILMN_1774687

ILMN_2412101

PH_hs_0000393

TC12003276.hg

U42412_at

g4506060_3p_at

Participates

as a member of

AMPK gamma [cytosol] (Homo sapiens)

Other forms of this molecule

PRKAG1 [nucleoplasm]

Inferred To

Homologues of PRKAG1 [cytosol] (Caenorhabditis elegans)

Homologues of PRKAG1 [cytosol] (Sus scrofa)

aakg-1 [cytosol] (Caenorhabditis elegans)

cbs2 [cytosol] (Schizosaccharomyces pombe)

PRKAG1 [cytosol] (Bos taurus)

PRKAG1 [cytosol] (Canis familiaris)

PRKAG1 [cytosol] (Gallus gallus)

PRKAG1 [cytosol] (Sus scrofa)

SNF4 [cytosol] (Saccharomyces cerevisiae)

SNF4Agamma [cytosol] (Drosophila melanogaster)

prkag [cytosol] (Dictyostelium discoideum)

aakg-5 [cytosol] (Caenorhabditis elegans)

prkag1 [cytosol] (Danio rerio)

aakg-4 [cytosol] (Caenorhabditis elegans)

aakg-3 [cytosol] (Caenorhabditis elegans)

Prkag1 [cytosol] (Mus musculus)

Prkag1 [cytosol] (Rattus norvegicus)

aakg-2 [cytosol] (Caenorhabditis elegans)

Cross References

RefSeq

XP_006719562.1, NP_002724.1, NP_001193638.1, NP_001193639.1, XP_011536864.1

Guide to Pharmacology - Targets

1545

OpenTargets

ENSG00000181929

HPA

ENSG00000181929-PRKAG1

GeneCards

P54619

ZINC target

P54619

Ensembl

ENSP00000448972, ENSP00000323867, ENST00000316299, ENST00000548065, ENSG00000181929, ENST00000552212, ENSP00000447433

PRO

P54619

Pharos - Targets

P54619

Orphanet

28979

PDB

6C9G, 4ZHX, 5ISO, 6B1U, 7JHH, 4CFE, 6C9J, 7JHG, 4RER, 6C9H, 2UV4, 4REW, 2UV5, 4CFF, 7JIJ, 6B2E, 5EZV, 2UV6, 6C9F, 2UV7

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P54646 PRKAA2	4	PRKAA2 [cytosol] (R-HSA-200405) p-T172-PRKAA2 [cytosol] (R-HSA-200417) p-T172-PRKAA2 [nucleoplasm] (R-HSA-164171) PRKAA2 [nucleoplasm] (R-HSA-163682)	0.905	13
UniProt:O75385 ULK1	7	ULK1 [recycling endosome] (R-HSA-8854761) p-S758-ULK1 [cytosol] (R-HSA-5672131) ULK1 [cytosol] (R-HSA-1632847) ULK1 [mitochondrial outer membrane] (R-HSA-8948145) p-T180,S317,S467,S556,S638,T575-ULK1 [endoplasmic reticulum membrane] (R-HSA-8948047) p-T180,S317,S467,S556,S638,T575-ULK1 [cytosol] (R-HSA-5675858) p-S317,467,556,638,T575-ULK1 [cytosol] (R-HSA-5673747)	0.669	3
UniProt:P55212 CASP6	5	CASP6 (1-293) [cytosol] (R-HSA-6798132) CASP6(194-293) [nucleoplasm] (R-HSA-352246) CASP6(24-179) [nucleoplasm] (R-HSA-352247) CASP6(24-179) [cytosol] (R-HSA-350313) CASP6(194-293) [cytosol] (R-HSA-266128)	0.556	3
UniProt:P26367 PAX6	1	PAX6 [nucleoplasm] (R-HSA-3009044)	0.556	3

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