Reactome | ICAM1 [plasma membrane]

ICAM1 [plasma membrane]

Stable Identifier

R-HSA-197683

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Intercellular adhesion molecule-1 precursor, ICA1_HUMAN, CD54

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P05362 ICAM1

Gene Names

ICAM1

Chain

signal peptide:1-27, chain:28-532

Reference Genes

BioGPS Gene:3383 ICAM1

COSMIC (genes):ICAM1 ICAM1

CTD Gene:3383 ICAM1

dbSNP Gene:3383 ICAM1

ENSEMBL:ENSG00000090339 ICAM1

HGNC:5344 ICAM1

KEGG:hsa:3383 ICAM1

Monarch:3383 ICAM1

NCBI Gene:3383 ICAM1

OMIM:147840 ICAM1

UCSC:P05362 ICAM1

Reference Transcript

RefSeq:NM_000201.2 ICAM1

Other Identifiers

11732999_a_at

11733000_at

11747499_a_at

16858137

16858148

202637_PM_s_at

202637_s_at

202638_PM_s_at

202638_s_at

215485_PM_s_at

215485_s_at

32640_at

3383

3820444

3820445

3820446

3820447

3820449

3820450

3820451

3820452

3820453

3820454

3820455

3820459

3820460

3820461

3820462

3820463

3820464

3820465

8025601

8025612

A_14_P107071

A_14_P134785

A_14_P200519

A_23_P130537

GE62810

GE82686

GO:0001618

GO:0001772

GO:0001910

GO:0002291

GO:0002376

GO:0002457

GO:0002693

GO:0004888

GO:0005178

GO:0005515

GO:0005615

GO:0005886

GO:0005925

GO:0007155

GO:0007157

GO:0007159

GO:0009897

GO:0009986

GO:0016020

GO:0022614

GO:0030312

GO:0031012

GO:0033627

GO:0038023

GO:0043226

GO:0044406

GO:0045121

GO:0046718

GO:0046813

GO:0048856

GO:0048870

GO:0050900

GO:0060089

GO:0061028

GO:0062023

GO:0070062

GO:0070374

GO:0071333

GO:0072683

GO:0098609

GO:1900027

GO:1902042

GO:1904646

GO:1990830

GO:2000352

HMNXSV003023566

HMNXSV003043999

Hs.168383.0.A1_3p_a_at

Hs.168383.1.A1_3p_a_at

ILMN_1734660

ILMN_1812226

M24283_at

M55024_s_at

PH_hs_0024395

TC19000174.hg

TC19001977.hg

TC19001978.hg

g4557877_3p_a_at

Participates

as a member of

Inferred To

si:ch73-208g10.1 [plasma membrane] (Danio rerio)

ICAM1 [plasma membrane] (Bos taurus)

ICAM1 [plasma membrane] (Canis familiaris)

ICAM1 [plasma membrane] (Sus scrofa)

Icam1 [plasma membrane] (Mus musculus)

Icam1 [plasma membrane] (Rattus norvegicus)

Cross References

RefSeq

NP_000192.2

ZINC - World Drugs

ICAM1_HUMAN

OpenTargets

ENSG00000090339

ENSEMBL

ENST00000264832, ENSP00000264832

ZINC - FDA approved

ICAM1_HUMAN

ZINC - Substances

ICAM1_HUMAN

ZINC target

P05362

PRO

P05362

GlyGen

P05362

PDB

1D3E, 1IC1, 1IAM, 1MQ8, 1D3I, 1D3L, 1Z7Z, 2OZ4, 7BG7, 6EIT, 3TCX, 6S8U, 1P53, 5MZA

ZINC - Investigational

ICAM1_HUMAN

HPA

ENSG00000090339-ICAM1

Pharos - Targets

P05362

ZINC - Predictions - Purchasable

ICAM1_HUMAN

HMDB Protein

HMDBP02089

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P18440 NAT1	2	NAT1 [cytosol] (R-HSA-174956) AcC-NAT1 [cytosol] (R-HSA-174972)	0.589	2
UniProt:Q14145 KEAP1	3	KEAP1 [cytosol] (R-HSA-976038) ub-KEAP1 [cytosol] (R-HSA-9766647) Ub-KEAP1 [cytosol] (R-HSA-6782766)	0.556	3
UniProt:Q13177 PAK2	11	p-S141,T402-PAK2 [cytosol] (R-HSA-399824) PAK2 [cytosol] (R-HSA-211604) p-5S-PAK2 [cytosol] (R-HSA-211609) PAK2(213-524) [cytosol] (R-HSA-211653) p-5S-PAK2(2-212) [cytosol] (R-HSA-211588) p-T402-PAK2(213-524) [cytosol] (R-HSA-211654) p-T402-PAK2(213-524) [nucleoplasm] (R-HSA-211709) K48polyUb-p-T402-PAK-2p43 [cytosol] (R-HSA-3095873) p-Y130,S141,T402-PAK2 [cytosol] (R-HSA-5218705) PAK2(1-524) [plasma membrane] (R-HSA-164946) p-S141,T402-PAK2 [plasma membrane] (R-HSA-5096524)	0.527	2
UniProt:P15514 AREG	5	AREG(101-187) [clathrin-coated endocytic vesicle membrane] (R-HSA-9628809) AREG precursor [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5689774) AREG precursor [ER to Golgi transport vesicle membrane] (R-HSA-5689771) AREG precursor [endoplasmic reticulum membrane] (R-HSA-5689438) AREG(101-187) [extracellular region] (R-HSA-9624190)	0.527	2
UniProt:O60543 CIDEA	1	CIDEA [cytosol] (R-HSA-8856626)	0.527	2
UniProt:Q12946 FOXF1	1	FOXF1 [nucleoplasm] (R-HSA-9759879)	0.527	2
UniProt:Q9HAV5 EDA2R	1	EDA2R [plasma membrane] (R-HSA-5669018)	0.527	2