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About
What is Reactome ?
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Digital Preservation
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TERF1 [nucleoplasm]
Stable Identifier
R-HSA-164618
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
TRF1
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Chromosome Maintenance (Homo sapiens)
Telomere Maintenance (Homo sapiens)
Extension of Telomeres (Homo sapiens)
Telomere C-strand (Lagging Strand) Synthesis (Homo sapiens)
Disassociation of Processive Complex and Completed Telomere End (Homo sapiens)
Extended And Processed Telomere End [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF1 homodimer [nucleoplasm] (Homo sapiens)
TERF1 [nucleoplasm] (Homo sapiens)
Processive complex loaded on telomere:ligated C-strand Okazaki fragments [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF1 homodimer [nucleoplasm] (Homo sapiens)
TERF1 [nucleoplasm] (Homo sapiens)
Polymerase switching on the C-strand of the telomere (Homo sapiens)
Formation of Processive Complex on the C-strand of the telomere (Homo sapiens)
Processive complex loaded on telomere [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:G-strand extended telomere:PCNA [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF1 homodimer [nucleoplasm] (Homo sapiens)
TERF1 [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:G-strand extended telomere:PCNA [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF1 homodimer [nucleoplasm] (Homo sapiens)
TERF1 [nucleoplasm] (Homo sapiens)
Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere (Homo sapiens)
RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF1 homodimer [nucleoplasm] (Homo sapiens)
TERF1 [nucleoplasm] (Homo sapiens)
RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end duplex:PCNA homotrimer [nucleoplasm] (Homo sapiens)
RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF1 homodimer [nucleoplasm] (Homo sapiens)
TERF1 [nucleoplasm] (Homo sapiens)
RFC binding displaces Pol Alpha on the C-strand of the telomere (Homo sapiens)
RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF1 homodimer [nucleoplasm] (Homo sapiens)
TERF1 [nucleoplasm] (Homo sapiens)
RNA primer:DNA primer:G-strand extended telomere:POLA:primase [nucleoplasm] (Homo sapiens)
RNA primer:G-strand extended telomere end:POLA:primase [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF1 homodimer [nucleoplasm] (Homo sapiens)
TERF1 [nucleoplasm] (Homo sapiens)
RFC dissociates after sliding clamp formation on the C-strand of the telomere (Homo sapiens)
RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end duplex:PCNA homotrimer [nucleoplasm] (Homo sapiens)
RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF1 homodimer [nucleoplasm] (Homo sapiens)
TERF1 [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:G-strand extended telomere:PCNA [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF1 homodimer [nucleoplasm] (Homo sapiens)
TERF1 [nucleoplasm] (Homo sapiens)
Processive synthesis on the C-strand of the telomere (Homo sapiens)
Formation of C-strand Okazaki fragments (Homo sapiens)
Processive complex loaded on telomere [nucleoplasm] (Homo sapiens)
RNA primer-DNA primer:G-strand extended telomere:PCNA [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF1 homodimer [nucleoplasm] (Homo sapiens)
TERF1 [nucleoplasm] (Homo sapiens)
Processive complex loaded on telomere:Okazaki fragment complex [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF1 homodimer [nucleoplasm] (Homo sapiens)
TERF1 [nucleoplasm] (Homo sapiens)
Formation of the Flap Intermediate on the C-strand (Homo sapiens)
Processive complex loaded on telomere:Okazaki fragment complex [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF1 homodimer [nucleoplasm] (Homo sapiens)
TERF1 [nucleoplasm] (Homo sapiens)
Processive complex loaded on telomere:Okazaki fragment:Flap [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF1 homodimer [nucleoplasm] (Homo sapiens)
TERF1 [nucleoplasm] (Homo sapiens)
Joining of adjacent Okazaki fragments of the C-strand (Homo sapiens)
Processive complex loaded on telomere:ligated C-strand Okazaki fragments [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF1 homodimer [nucleoplasm] (Homo sapiens)
TERF1 [nucleoplasm] (Homo sapiens)
Processive complex loaded on telomere:nicked DNA from adjacent Okazaki fragments [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF1 homodimer [nucleoplasm] (Homo sapiens)
TERF1 [nucleoplasm] (Homo sapiens)
Removal of the Flap Intermediate from the C-strand (Homo sapiens)
RPA binds to the Flap on the C-strand (Homo sapiens)
Processive complex loaded on telomere:Okazaki fragment:Flap [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF1 homodimer [nucleoplasm] (Homo sapiens)
TERF1 [nucleoplasm] (Homo sapiens)
Processive complex loaded on telomere:Okazaki fragment:Flap:RPA heterotrimer [nucleoplasm] (Homo sapiens)
Processive complex loaded on telomere:Okazaki fragment:Flap [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF1 homodimer [nucleoplasm] (Homo sapiens)
TERF1 [nucleoplasm] (Homo sapiens)
Recruitment of DNA2 endonuclease to the C strand (Homo sapiens)
Processive complex loaded on telomere:Okazaki fragment:Flap:RPA heterotrimer [nucleoplasm] (Homo sapiens)
Processive complex loaded on telomere:Okazaki fragment:Flap [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF1 homodimer [nucleoplasm] (Homo sapiens)
TERF1 [nucleoplasm] (Homo sapiens)
Processive complex loaded on telomere:Okazaki fragment:Flap:RPA heterotrimer:DNA2 [nucleoplasm] (Homo sapiens)
Processive complex loaded on telomere:Okazaki fragment:Flap:RPA heterotrimer [nucleoplasm] (Homo sapiens)
Processive complex loaded on telomere:Okazaki fragment:Flap [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF1 homodimer [nucleoplasm] (Homo sapiens)
TERF1 [nucleoplasm] (Homo sapiens)
Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand (Homo sapiens)
Processive complex loaded on telomere:Okazaki fragment:Flap:RPA heterotrimer:DNA2 [nucleoplasm] (Homo sapiens)
Processive complex loaded on telomere:Okazaki fragment:Flap:RPA heterotrimer [nucleoplasm] (Homo sapiens)
Processive complex loaded on telomere:Okazaki fragment:Flap [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF1 homodimer [nucleoplasm] (Homo sapiens)
TERF1 [nucleoplasm] (Homo sapiens)
Processive complex loaded on telomere:Okazaki fragments:Remaining Flap [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF1 homodimer [nucleoplasm] (Homo sapiens)
TERF1 [nucleoplasm] (Homo sapiens)
Removal of remaining Flap from the C-strand (Homo sapiens)
Processive complex loaded on telomere:Okazaki fragments:Remaining Flap [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF1 homodimer [nucleoplasm] (Homo sapiens)
TERF1 [nucleoplasm] (Homo sapiens)
Processive complex loaded on telomere:nicked DNA from adjacent Okazaki fragments [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF1 homodimer [nucleoplasm] (Homo sapiens)
TERF1 [nucleoplasm] (Homo sapiens)
Telomere C-strand synthesis initiation (Homo sapiens)
DNA polymerase:primase binds G-strand of the telomere (Homo sapiens)
POLA:primase:G-strand extended telomere end [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF1 homodimer [nucleoplasm] (Homo sapiens)
TERF1 [nucleoplasm] (Homo sapiens)
Telomeric G-strand chromosome end with two additional single strand repeats [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF1 homodimer [nucleoplasm] (Homo sapiens)
TERF1 [nucleoplasm] (Homo sapiens)
The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere (Homo sapiens)
RNA primer:DNA primer:G-strand extended telomere:POLA:primase [nucleoplasm] (Homo sapiens)
RNA primer:G-strand extended telomere end:POLA:primase [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF1 homodimer [nucleoplasm] (Homo sapiens)
TERF1 [nucleoplasm] (Homo sapiens)
RNA primer:G-strand extended telomere end:POLA:primase [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF1 homodimer [nucleoplasm] (Homo sapiens)
TERF1 [nucleoplasm] (Homo sapiens)
The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere (Homo sapiens)
POLA:primase:G-strand extended telomere end [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF1 homodimer [nucleoplasm] (Homo sapiens)
TERF1 [nucleoplasm] (Homo sapiens)
RNA primer:G-strand extended telomere end:POLA:primase [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF1 homodimer [nucleoplasm] (Homo sapiens)
TERF1 [nucleoplasm] (Homo sapiens)
Telomere Extension By Telomerase (Homo sapiens)
Alignment Of The RNA Template On The Telomeric Chromosome End (Homo sapiens)
Telomerase RNP Bound and base-paired to the Telomeric Chromosome End [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF1 homodimer [nucleoplasm] (Homo sapiens)
TERF1 [nucleoplasm] (Homo sapiens)
Telomerase RNP:G-strand telomeric chromosome end [nucleoplasm] (Homo sapiens)
Telomeric G-strand chromosome end:Shelterin [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF1 homodimer [nucleoplasm] (Homo sapiens)
TERF1 [nucleoplasm] (Homo sapiens)
CDK2:CCNA phosphorylates TERF2 (Homo sapiens)
Telomeric G-strand chromosome end:Shelterin (p-S365-TERF2) [nucleoplasm] (Homo sapiens)
Shelterin complex (p-S365-TERF2) [nucleoplasm] (Homo sapiens)
TERF1 homodimer [nucleoplasm] (Homo sapiens)
TERF1 [nucleoplasm] (Homo sapiens)
Telomeric G-strand chromosome end:Shelterin [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF1 homodimer [nucleoplasm] (Homo sapiens)
TERF1 [nucleoplasm] (Homo sapiens)
Disassociation of Telomerase RNP and the Chromosome End (Homo sapiens)
Telomerase Holoenzyme:Telomeric RNP End with Two Additional Single Stranded Telomere Repeats [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF1 homodimer [nucleoplasm] (Homo sapiens)
TERF1 [nucleoplasm] (Homo sapiens)
Telomeric G-strand chromosome end with two additional single strand repeats [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF1 homodimer [nucleoplasm] (Homo sapiens)
TERF1 [nucleoplasm] (Homo sapiens)
Elongation Of The Telomeric Chromosome End (Homo sapiens)
Telomerase RNP Bound and base-paired to the Telomeric Chromosome End [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF1 homodimer [nucleoplasm] (Homo sapiens)
TERF1 [nucleoplasm] (Homo sapiens)
Telomerase RNP:Telomeric Chromosome End with an Additional single Stranded Telomere repeat [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF1 homodimer [nucleoplasm] (Homo sapiens)
TERF1 [nucleoplasm] (Homo sapiens)
Elongation of Extended Telomeric Chromosome End (Homo sapiens)
Telomerase Holoenzyme Base-paired to the Telomeric Chromosome End with an Additional single Stranded Telomere repeat [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF1 homodimer [nucleoplasm] (Homo sapiens)
TERF1 [nucleoplasm] (Homo sapiens)
Telomerase Holoenzyme:Telomeric RNP End with Two Additional Single Stranded Telomere Repeats [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF1 homodimer [nucleoplasm] (Homo sapiens)
TERF1 [nucleoplasm] (Homo sapiens)
PP6-PPP6R3 dephosphorylates TERF2 (Homo sapiens)
Telomeric G-strand chromosome end:Shelterin (p-S365-TERF2) [nucleoplasm] (Homo sapiens)
Shelterin complex (p-S365-TERF2) [nucleoplasm] (Homo sapiens)
TERF1 homodimer [nucleoplasm] (Homo sapiens)
TERF1 [nucleoplasm] (Homo sapiens)
Telomeric G-strand chromosome end:Shelterin [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF1 homodimer [nucleoplasm] (Homo sapiens)
TERF1 [nucleoplasm] (Homo sapiens)
Recruitment of Telomerase RNP to the Telomeric Chromosome End (Homo sapiens)
Telomerase RNP:G-strand telomeric chromosome end [nucleoplasm] (Homo sapiens)
Telomeric G-strand chromosome end:Shelterin [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF1 homodimer [nucleoplasm] (Homo sapiens)
TERF1 [nucleoplasm] (Homo sapiens)
Telomeric G-strand chromosome end:Shelterin [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF1 homodimer [nucleoplasm] (Homo sapiens)
TERF1 [nucleoplasm] (Homo sapiens)
Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End (Homo sapiens)
Telomerase Holoenzyme Base-paired to the Telomeric Chromosome End with an Additional single Stranded Telomere repeat [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF1 homodimer [nucleoplasm] (Homo sapiens)
TERF1 [nucleoplasm] (Homo sapiens)
Telomerase RNP:Telomeric Chromosome End with an Additional single Stranded Telomere repeat [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF1 homodimer [nucleoplasm] (Homo sapiens)
TERF1 [nucleoplasm] (Homo sapiens)
Inhibition of DNA recombination at telomere (Homo sapiens)
ATRX:DAXX binds to subtelomeric chromosomal regions (Homo sapiens)
Extended And Processed Telomere End and Associated DNA Binding and Packaging Protein Complex Folded Into Higher Order Structure [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF1 homodimer [nucleoplasm] (Homo sapiens)
TERF1 [nucleoplasm] (Homo sapiens)
Telomere:Shelterin:Nucleosome:ATRX:DAXX [nucleoplasm] (Homo sapiens)
Extended And Processed Telomere End and Associated DNA Binding and Packaging Protein Complex Folded Into Higher Order Structure [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF1 homodimer [nucleoplasm] (Homo sapiens)
TERF1 [nucleoplasm] (Homo sapiens)
Histone H3.3 deposition at telomere (Homo sapiens)
Telomere:Shelterin:Nucleosome (H3F3A):ATRX:DAXX [nucleoplasm] (Homo sapiens)
Telomere:Shelterin:Nucleosome (H3F3A) [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF1 homodimer [nucleoplasm] (Homo sapiens)
TERF1 [nucleoplasm] (Homo sapiens)
Telomere:Shelterin:Nucleosome:ATRX:DAXX [nucleoplasm] (Homo sapiens)
Extended And Processed Telomere End and Associated DNA Binding and Packaging Protein Complex Folded Into Higher Order Structure [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF1 homodimer [nucleoplasm] (Homo sapiens)
TERF1 [nucleoplasm] (Homo sapiens)
TERRA transcription (Homo sapiens)
Telomere:Shelterin:Nucleosome (H3F3A):ATRX:DAXX [nucleoplasm] (Homo sapiens)
Telomere:Shelterin:Nucleosome (H3F3A) [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF1 homodimer [nucleoplasm] (Homo sapiens)
TERF1 [nucleoplasm] (Homo sapiens)
Packaging Of Telomere Ends (Homo sapiens)
Incorporation Of Extended And Processed Telomere End Into Associated Protein Structure (Homo sapiens)
Extended And Processed Telomere End [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF1 homodimer [nucleoplasm] (Homo sapiens)
TERF1 [nucleoplasm] (Homo sapiens)
Extended And Processed Telomere End and Associated DNA Binding and Packaging Protein Complex [nucleoplasm] (Homo sapiens)
Extended And Processed Telomere End [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF1 homodimer [nucleoplasm] (Homo sapiens)
TERF1 [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF1 homodimer [nucleoplasm] (Homo sapiens)
TERF1 [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF1 homodimer [nucleoplasm] (Homo sapiens)
TERF1 [nucleoplasm] (Homo sapiens)
Incorporation Of Extended And Processed Telomere End Into Higher Order T-Loop And Associated Protein Structure (Homo sapiens)
Extended And Processed Telomere End and Associated DNA Binding and Packaging Protein Complex Folded Into Higher Order Structure [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF1 homodimer [nucleoplasm] (Homo sapiens)
TERF1 [nucleoplasm] (Homo sapiens)
Extended And Processed Telomere End and Associated DNA Binding and Packaging Protein Complex [nucleoplasm] (Homo sapiens)
Extended And Processed Telomere End [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF1 homodimer [nucleoplasm] (Homo sapiens)
TERF1 [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF1 homodimer [nucleoplasm] (Homo sapiens)
TERF1 [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF1 homodimer [nucleoplasm] (Homo sapiens)
TERF1 [nucleoplasm] (Homo sapiens)
Meiosis (Homo sapiens)
Meiotic synapsis (Homo sapiens)
Telomeres cluster at the nuclear membrane (Homo sapiens)
Extended And Processed Telomere End and Associated DNA Binding and Packaging Protein Complex Folded Into Higher Order Structure [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF1 homodimer [nucleoplasm] (Homo sapiens)
TERF1 [nucleoplasm] (Homo sapiens)
Telomere Attachment Plate [nuclear envelope] (Homo sapiens)
Extended And Processed Telomere End and Associated DNA Binding and Packaging Protein Complex Folded Into Higher Order Structure [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF1 homodimer [nucleoplasm] (Homo sapiens)
TERF1 [nucleoplasm] (Homo sapiens)
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular Senescence (Homo sapiens)
DNA Damage/Telomere Stress Induced Senescence (Homo sapiens)
Telomere shortening during replicative exhaustion (Homo sapiens)
Extended And Processed Telomere End and Associated DNA Binding and Packaging Protein Complex Folded Into Higher Order Structure [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF1 homodimer [nucleoplasm] (Homo sapiens)
TERF1 [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF1 homodimer [nucleoplasm] (Homo sapiens)
TERF1 [nucleoplasm] (Homo sapiens)
DNA Repair (Homo sapiens)
Base Excision Repair (Homo sapiens)
Base-Excision Repair, AP Site Formation (Homo sapiens)
Depurination (Homo sapiens)
Cleavage of the damaged purine (Homo sapiens)
NEIL3 cleaves 5-guanidinohydantoin (Gh) from damaged telomeric DNA (Homo sapiens)
NEIL3:AP-Telomeric DNA:Shelterin [nucleoplasm] (Homo sapiens)
AP-Telomeric DNA:Shelterin [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF1 homodimer [nucleoplasm] (Homo sapiens)
TERF1 [nucleoplasm] (Homo sapiens)
NEIL3:Gh-Telomeric DNA:Shelterin [nucleoplasm] (Homo sapiens)
Gh-Telomeric DNA:Shelterin [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF1 homodimer [nucleoplasm] (Homo sapiens)
TERF1 [nucleoplasm] (Homo sapiens)
NEIL3 cleaves spiroiminodihydantoin from damaged telomeric DNA (Homo sapiens)
NEIL3:AP-Telomeric DNA:Shelterin [nucleoplasm] (Homo sapiens)
AP-Telomeric DNA:Shelterin [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF1 homodimer [nucleoplasm] (Homo sapiens)
TERF1 [nucleoplasm] (Homo sapiens)
NEIL3:Sp-Telomeric DNA:Shelterin [nucleoplasm] (Homo sapiens)
Sp-Telomeric DNA:Shelterin [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF1 homodimer [nucleoplasm] (Homo sapiens)
TERF1 [nucleoplasm] (Homo sapiens)
Recognition and association of DNA glycosylase with site containing an affected purine (Homo sapiens)
NEIL3 recognizes and binds to 5-guanidinohydantoin (Gh) in telomeric DNA (Homo sapiens)
Gh-Telomeric DNA:Shelterin [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF1 homodimer [nucleoplasm] (Homo sapiens)
TERF1 [nucleoplasm] (Homo sapiens)
NEIL3:Gh-Telomeric DNA:Shelterin [nucleoplasm] (Homo sapiens)
Gh-Telomeric DNA:Shelterin [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF1 homodimer [nucleoplasm] (Homo sapiens)
TERF1 [nucleoplasm] (Homo sapiens)
NEIL3 recognizes and binds to spiroiminodihydantoin in telomeric DNA (Homo sapiens)
NEIL3:Sp-Telomeric DNA:Shelterin [nucleoplasm] (Homo sapiens)
Sp-Telomeric DNA:Shelterin [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF1 homodimer [nucleoplasm] (Homo sapiens)
TERF1 [nucleoplasm] (Homo sapiens)
Sp-Telomeric DNA:Shelterin [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF1 homodimer [nucleoplasm] (Homo sapiens)
TERF1 [nucleoplasm] (Homo sapiens)
Depyrimidination (Homo sapiens)
Cleavage of the damaged pyrimidine (Homo sapiens)
NEIL3 cleaves thymine glycol from telomeric DNA (Homo sapiens)
NEIL3:AP-Telomeric DNA:Shelterin [nucleoplasm] (Homo sapiens)
AP-Telomeric DNA:Shelterin [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF1 homodimer [nucleoplasm] (Homo sapiens)
TERF1 [nucleoplasm] (Homo sapiens)
NEIL3:Tg-Telomeric DNA:Shelterin [nucleoplasm] (Homo sapiens)
Tg-Telomeric DNA:Shelterin [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF1 homodimer [nucleoplasm] (Homo sapiens)
TERF1 [nucleoplasm] (Homo sapiens)
Recognition and association of DNA glycosylase with site containing an affected pyrimidine (Homo sapiens)
NEIL3 recognizes and binds to thymine glycol in telomeric DNA (Homo sapiens)
NEIL3:Tg-Telomeric DNA:Shelterin [nucleoplasm] (Homo sapiens)
Tg-Telomeric DNA:Shelterin [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF1 homodimer [nucleoplasm] (Homo sapiens)
TERF1 [nucleoplasm] (Homo sapiens)
Tg-Telomeric DNA:Shelterin [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF1 homodimer [nucleoplasm] (Homo sapiens)
TERF1 [nucleoplasm] (Homo sapiens)
Reproduction (Homo sapiens)
Meiosis (Homo sapiens)
Meiotic synapsis (Homo sapiens)
Telomeres cluster at the nuclear membrane (Homo sapiens)
Extended And Processed Telomere End and Associated DNA Binding and Packaging Protein Complex Folded Into Higher Order Structure [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF1 homodimer [nucleoplasm] (Homo sapiens)
TERF1 [nucleoplasm] (Homo sapiens)
Telomere Attachment Plate [nuclear envelope] (Homo sapiens)
Extended And Processed Telomere End and Associated DNA Binding and Packaging Protein Complex Folded Into Higher Order Structure [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
TERF1 homodimer [nucleoplasm] (Homo sapiens)
TERF1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P54274 TERF1
Gene Names
TERF1, PIN2, TRBF1, TRF, TRF1
Chain
initiator methionine:, chain:2-439
Reference Genes
BioGPS Gene:7013 TERF1
COSMIC (genes):TERF1 TERF1
CTD Gene:7013 TERF1
dbSNP Gene:7013 TERF1
ENSEMBL:ENSG00000147601 TERF1
ENSEMBL_homo_sapiens_GENE:ENSG00000147601.15 TERF1
HGNC:11728 TERF1
KEGG Gene (Homo sapiens):7013 TERF1
Monarch:7013 TERF1
NCBI Gene:7013 TERF1
OMIM:600951 TERF1
UCSC:P54274 TERF1
Reference Transcript
RefSeq:NM_003218.3 TERF1
RefSeq:NM_017489.2 TERF1
Other Identifiers
11732463_x_at
11739301_x_at
11745759_x_at
1329_s_at
1342_g_at
1361_at
17069989
203448_PM_s_at
203448_s_at
203449_PM_s_at
203449_s_at
2591973
2786101
2786102
2786103
2966957
3103194
3103195
3103196
3103199
3103200
3103202
3103203
3103206
3103207
3103209
3103212
3103213
3103216
3103217
3103218
3103219
3103220
3103222
32255_i_at
32256_r_at
32257_f_at
3479715
3479716
3479718
3800248
3914654
3914655
4013002
4013007
4013995
4013997
4013998
4013999
4014001
4014002
4014003
4014006
4014008
51815_at
7013
8102789
8146914
A_23_P216149
A_24_P192434
A_32_P220696
GE63000
GO:0000723
GO:0000781
GO:0000783
GO:0001650
GO:0003677
GO:0003691
GO:0003720
GO:0003824
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005730
GO:0005737
GO:0005819
GO:0005856
GO:0006260
GO:0007004
GO:0007049
GO:0007059
GO:0008017
GO:0008092
GO:0008156
GO:0008301
GO:0016233
GO:0016604
GO:0016740
GO:0022414
GO:0032200
GO:0032206
GO:0032211
GO:0032214
GO:0042162
GO:0042802
GO:0042803
GO:0043226
GO:0045141
GO:0051301
GO:0051974
GO:0060090
GO:0061820
GO:0065003
GO:0070187
GO:0071532
GO:0090656
GO:0098505
GO:0140013
GO:0140097
GO:1904357
GO:1904792
GO:1904850
GO:1904911
GO:1904914
GO:1905778
GO:1905839
HMNXSV003030658
Hs.194562.0.A1_3p_a_at
ILMN_1694847
TC08000479.hg
U40705_at
U74382_s_at
X93511_s_at
g9257245_3p_a_at
Participates
as a component of
TERF1 homodimer [nucleoplasm] (Homo sapiens)
Inferred To
Terf1 [nucleoplasm]
(Mus musculus)
TERF1 [nucleoplasm]
(Bos taurus)
TERF1 [nucleoplasm]
(Canis familiaris)
TERF1 [nucleoplasm]
(Gallus gallus)
TERF1 [nucleoplasm]
(Rattus norvegicus)
TERF1 [nucleoplasm]
(Sus scrofa)
terf1 [nucleoplasm]
(Xenopus tropicalis)
teb1 [nucleoplasm]
(Schizosaccharomyces pombe)
Cross References
RefSeq
NP_059523.2
,
NP_003209.2
OpenTargets
ENSG00000147601
GeneCards
P54274
HPA
ENSG00000147601-TERF1
Ensembl
ENSP00000276603
,
ENSP00000276602
,
ENST00000276603
,
ENST00000276602
,
ENSG00000147601
PRO
P54274
Pharos - Targets
P54274
PDB
8F0U
,
8F26
,
1H6O
,
8F1T
,
8F0A
,
1ITY
,
1IV6
,
3BQO
,
8OX1
,
5HKP
,
8F1U
,
1W0T
,
5WIR
,
8F21
,
5XUP
,
1BA5
,
3L82
Interactors (21)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13315 ATM
5
Ac-K3016-ATM [nucleoplasm]
(R-HSA-5682043)
ATM [nucleoplasm]
(R-HSA-69484)
p-S1981,Ac-K3016-ATM [nucleoplasm]
(R-HSA-5693527)
ATM [peroxisomal matrix]
(R-HSA-9665169)
ATM [cytosol]
(R-HSA-9665171)
0.609
3
UniProt:P54132 BLM
2
4SUMO2,3-BLM [nucleoplasm]
(R-HSA-4568883)
BLM [nucleoplasm]
(R-HSA-174881)
0.558
3
UniProt:Q9NUX5 POT1
1
POT1 [nucleoplasm]
(R-HSA-174890)
0.527
2
UniProt:O43598 DNPH1
1
DNPH1 [cytosol]
(R-HSA-8953358)
0.508
2
UniProt:O76024 WFS1
3
WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956747)
p-WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956998)
WFS1 [endoplasmic reticulum membrane]
(R-HSA-535474)
0.508
2
UniProt:Q9NXH9 TRMT1
1
TRMT1 [nucleoplasm]
(R-HSA-6782450)
0.508
2
UniProt:Q06830 PRDX1
3
p-T90-PRDX1 [cytosol]
(R-HSA-8868564)
PRDX1 [cytosol]
(R-HSA-3341270)
HOOS-C52-PRDX1 [cytosol]
(R-HSA-5629198)
0.508
2
UniProt:P25685 DNAJB1
3
p-S149,S151,S171 DNAJB1 [cytosol]
(R-HSA-5690241)
DNAJB1 [cytosol]
(R-HSA-3299666)
DNAJB1 [nucleoplasm]
(R-HSA-5082366)
0.508
2
UniProt:Q14894 CRYM
1
CRYM [peroxisomal matrix]
(R-HSA-5693333)
0.508
2
UniProt:O95197 RTN3
1
RTN3 [plasma membrane]
(R-HSA-8849907)
0.508
2
UniProt:P26038 MSN
4
MSN [cytosol]
(R-HSA-437350)
MSN(2-448)-ALK(1064-1620) fusion [cytosol]
(R-HSA-9711966)
MSN(2-448)-p-7Y-ALK(1064-1620) fusion [cytosol]
(R-HSA-9711971)
p-T558-MSN [cytosol]
(R-HSA-9663005)
0.508
2
UniProt:P19623 SRM
1
SRM [cytosol]
(R-HSA-351212)
0.508
2
UniProt:Q9H4G0 EPB41L1
2
EPB41L1 [cytosol]
(R-HSA-392241)
EPB41L1 [plasma membrane]
(R-HSA-416333)
0.508
2
UniProt:Q9BUQ8 DDX23
1
DDX23 [nucleoplasm]
(R-HSA-71879)
0.508
2
UniProt:Q9NWX6 THG1L
1
THG1L [cytosol]
(R-HSA-6782438)
0.508
2
UniProt:P07332 FES
1
FES [cytosol]
(R-HSA-396937)
0.508
2
UniProt:P07196 NEFL
1
NEFL [cytosol]
(R-HSA-432284)
0.508
2
UniProt:P43405 SYK
6
p-Y-SYK [cytosol]
(R-HSA-9705732)
p-Y-SYK [plasma membrane]
(R-HSA-429432)
SYK [plasma membrane]
(R-HSA-139844)
p-6Y-SYK [cytosol]
(R-HSA-1861712)
p-Y348-SYK [cytosol]
(R-HSA-437953)
SYK [cytosol]
(R-HSA-58268)
0.508
2
UniProt:Q9UGY1 NOL12
1
NOL12 [nucleoplasm]
(R-HSA-6791195)
0.508
2
UniProt:Q14145 KEAP1
3
Ub-KEAP1 [cytosol]
(R-HSA-6782766)
ub-KEAP1 [cytosol]
(R-HSA-9766647)
KEAP1 [cytosol]
(R-HSA-976038)
0.508
2
UniProt:O00267 SUPT5H
1
p-SUPT5H [nucleoplasm]
(R-HSA-3009372)
0.508
2
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