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SMARCD1 [nucleoplasm]
Stable Identifier
R-HSA-389255
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
BAF60a
Locations in the PathwayBrowser
Expand all
Chromatin organization (Homo sapiens)
Chromatin modifying enzymes (Homo sapiens)
RMTs methylate histone arginines (Homo sapiens)
CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-9 of histone H3 (H3R8) (Homo sapiens)
SWI/SNF chromatin remodelling complex:PRMT5:pT5-WDR77 [nucleoplasm] (Homo sapiens)
SWI/SNF chromatin remodelling complex [nucleoplasm] (Homo sapiens)
SWI/SNF additional components [nucleoplasm] (Homo sapiens)
SMARCD1 [nucleoplasm] (Homo sapiens)
COPRS:CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-4 of histone H4 (H4R3) (Homo sapiens)
SWI/SNF chromatin remodelling complex:PRMT5:pT5-WDR77 [nucleoplasm] (Homo sapiens)
SWI/SNF chromatin remodelling complex [nucleoplasm] (Homo sapiens)
SWI/SNF additional components [nucleoplasm] (Homo sapiens)
SMARCD1 [nucleoplasm] (Homo sapiens)
SWI/SNF chromatin remodelling complex enhances MEP50:PRMT5 methyltransferase activity (Homo sapiens)
SWI/SNF chromatin remodelling complex [nucleoplasm] (Homo sapiens)
SWI/SNF additional components [nucleoplasm] (Homo sapiens)
SMARCD1 [nucleoplasm] (Homo sapiens)
SWI/SNF chromatin remodelling complex:PRMT5:pT5-WDR77 [nucleoplasm] (Homo sapiens)
SWI/SNF chromatin remodelling complex [nucleoplasm] (Homo sapiens)
SWI/SNF additional components [nucleoplasm] (Homo sapiens)
SMARCD1 [nucleoplasm] (Homo sapiens)
Developmental Biology (Homo sapiens)
MITF-M-regulated melanocyte development (Homo sapiens)
MITF-M-dependent gene expression (Homo sapiens)
Regulation of MITF-M-dependent genes involved in pigmentation (Homo sapiens)
MITF-M and the SWI/SNF complex bind the TYR promoter (Homo sapiens)
BAF complex [nucleoplasm] (Homo sapiens)
SMARCD1,2,3 [nucleoplasm] (Homo sapiens)
SMARCD1 [nucleoplasm] (Homo sapiens)
M-MITF dimer:BAF complex:TYR gene [nucleoplasm] (Homo sapiens)
BAF complex [nucleoplasm] (Homo sapiens)
SMARCD1,2,3 [nucleoplasm] (Homo sapiens)
SMARCD1 [nucleoplasm] (Homo sapiens)
MITF-M dimer and the SWI/SNF complex bind the TYRP1 promoter (Homo sapiens)
BAF complex [nucleoplasm] (Homo sapiens)
SMARCD1,2,3 [nucleoplasm] (Homo sapiens)
SMARCD1 [nucleoplasm] (Homo sapiens)
MITF-M dimer:BAF complex:TYRP1 gene [nucleoplasm] (Homo sapiens)
BAF complex [nucleoplasm] (Homo sapiens)
SMARCD1,2,3 [nucleoplasm] (Homo sapiens)
SMARCD1 [nucleoplasm] (Homo sapiens)
MITF-M-dependent TYR gene expression (Homo sapiens)
M-MITF dimer:BAF complex:TYR gene [nucleoplasm] (Homo sapiens)
BAF complex [nucleoplasm] (Homo sapiens)
SMARCD1,2,3 [nucleoplasm] (Homo sapiens)
SMARCD1 [nucleoplasm] (Homo sapiens)
MITF-M-dependent TYRP1 gene expression (Homo sapiens)
MITF-M dimer:BAF complex:TYRP1 gene [nucleoplasm] (Homo sapiens)
BAF complex [nucleoplasm] (Homo sapiens)
SMARCD1,2,3 [nucleoplasm] (Homo sapiens)
SMARCD1 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
Epigenetic regulation of gene expression (Homo sapiens)
Regulation of endogenous retroelements (Homo sapiens)
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) (Homo sapiens)
DNMT3A:DNMT3L in nascent RNA transcript:MeR-PIWIL4:2'-O-methyl-piRNA:SPOCD1:DNMT3A:DNMT3L methylates cytosine in DNA (Homo sapiens)
nascent LINE-1 RNA transcript:MeR-PIWIL4:2'-O-methyl-piRNA:SPOCD1:DNMT3A:DNMT3L [nucleoplasm] (Homo sapiens)
BAF complex [nucleoplasm] (Homo sapiens)
SMARCD1,2,3 [nucleoplasm] (Homo sapiens)
SMARCD1 [nucleoplasm] (Homo sapiens)
PIWIL4:piRNA binds nascent LINE1 pre-RNA and recruits SPOCD1, C19ORF84, DNMT3A, DNMT3L, the NURD complex, and the BAF complex (Homo sapiens)
BAF complex [nucleoplasm] (Homo sapiens)
SMARCD1,2,3 [nucleoplasm] (Homo sapiens)
SMARCD1 [nucleoplasm] (Homo sapiens)
nascent LINE-1 RNA transcript:MeR-PIWIL4:2'-O-methyl-piRNA:SPOCD1:DNMT3A:DNMT3L [nucleoplasm] (Homo sapiens)
BAF complex [nucleoplasm] (Homo sapiens)
SMARCD1,2,3 [nucleoplasm] (Homo sapiens)
SMARCD1 [nucleoplasm] (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX1 (Homo sapiens)
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known (Homo sapiens)
RUNX1 binds the SWI/SNF complex (Homo sapiens)
RUNX1:CBFB:SWI/SNF [nucleoplasm] (Homo sapiens)
SWI/SNF chromatin remodelling complex [nucleoplasm] (Homo sapiens)
SWI/SNF additional components [nucleoplasm] (Homo sapiens)
SMARCD1 [nucleoplasm] (Homo sapiens)
SWI/SNF chromatin remodelling complex [nucleoplasm] (Homo sapiens)
SWI/SNF additional components [nucleoplasm] (Homo sapiens)
SMARCD1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q96GM5 SMARCD1
Gene Names
SMARCD1, BAF60A
Chain
chain:1-515
Reference Genes
BioGPS Gene:6602 SMARCD1
COSMIC (genes):SMARCD1 SMARCD1
CTD Gene:6602 SMARCD1
dbSNP Gene:6602 SMARCD1
ENSEMBL:ENSG00000066117 SMARCD1
HGNC:11106 SMARCD1
KEGG:hsa:6602 SMARCD1
Monarch:6602 SMARCD1
NCBI Gene:6602 SMARCD1
OMIM:601735 SMARCD1
UCSC:Q96GM5 SMARCD1
Reference Transcript
RefSeq:NM_003076.4 SMARCD1
RefSeq:NM_139071.2 SMARCD1
Other Identifiers
11741620_a_at
11751008_a_at
11755827_a_at
11761111_at
16751020
203183_PM_s_at
203183_s_at
209518_PM_at
209518_at
3414391
3414392
3414393
3414394
3414395
3414396
3414397
3414398
3414399
3414400
3414401
3414402
3414403
3414404
3414405
3414406
3414407
3414408
3414409
3414411
3414412
3414413
3414414
3414415
3414416
3414417
3414418
37753_at
454_at
6602
7955331
A_23_P204745
A_24_P232696
GE59341
GO:0000776
GO:0000785
GO:0003682
GO:0003712
GO:0003713
GO:0005102
GO:0005515
GO:0005634
GO:0005654
GO:0006325
GO:0006337
GO:0006338
GO:0006355
GO:0006357
GO:0007399
GO:0008284
GO:0016363
GO:0016514
GO:0016586
GO:0030071
GO:0035060
GO:0043226
GO:0043231
GO:0045582
GO:0045596
GO:0045597
GO:0045663
GO:0045815
GO:0045893
GO:0048856
GO:0060090
GO:0070316
GO:0071398
GO:0071564
GO:0071565
GO:0140110
GO:0140288
GO:1902459
GO:2000045
GO:2000781
GO:2000819
HMNXSV003050983
Hs.79335.1.S2_3p_at
ILMN_1727173
ILMN_1728845
PH_hs_0004588
TC12000387.hg
U66617_at
g4507082_3p_a_at
Participates
as a member of
SMARCD1,2,3 [nucleoplasm] (Homo sapiens)
as a candidate of
SWI/SNF additional components [nucleoplasm] (Homo sapiens)
Inferred To
SNF12 [nucleoplasm]
(Saccharomyces cerevisiae)
SMARCD1 [nucleoplasm]
(Bos taurus)
SMARCD1 [nucleoplasm]
(Canis familiaris)
SMARCD1 [nucleoplasm]
(Gallus gallus)
SMARCD1 [nucleoplasm]
(Sus scrofa)
snf12-1 [nucleoplasm]
(Dictyostelium discoideum)
ham-3 [nucleoplasm]
(Caenorhabditis elegans)
smarcd1 [nucleoplasm]
(Xenopus tropicalis)
ssr3 [nucleoplasm]
(Schizosaccharomyces pombe)
Bap60 [nucleoplasm]
(Drosophila melanogaster)
Smarcd1 [nucleoplasm]
(Mus musculus)
Smarcd1 [nucleoplasm]
(Rattus norvegicus)
Cross References
OpenTargets
ENSG00000066117
ENSEMBL
ENST00000394963
,
ENSP00000370924
,
ENSP00000378414
,
ENST00000381513
HPA
ENSG00000066117-SMARCD1
PRO
Q96GM5
Pharos - Targets
Q96GM5
Orphanet
SMARCD1
GlyGen
Q96GM5
PDB
6LTH
,
7Y8R
,
6LTJ
,
7VDV
Interactors (21)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P51532 SMARCA4
1
SMARCA4 [nucleoplasm]
(R-HSA-201686)
0.871
14
UniProt:Q9NPJ6 MED4
1
MED4 [nucleoplasm]
(R-HSA-350263)
0.718
6
UniProt:O00308 WWP2
1
WWP2 [cytosol]
(R-HSA-6807279)
0.666
5
UniProt:Q01201 RELB
2
RELB [nucleoplasm]
(R-HSA-5607656)
RELB [cytosol]
(R-HSA-5607652)
0.564
2
UniProt:Q15742 NAB2
1
NAB2 [nucleoplasm]
(R-HSA-9612177)
0.556
3
UniProt:P19404 NDUFV2
1
NDUFV2 [mitochondrial inner membrane]
(R-HSA-163939)
0.556
3
UniProt:Q96CV9 OPTN
6
p-S177,S473,S513-OPTN [cytosol]
(R-HSA-9687840)
OPTN [cytosol]
(R-HSA-9687907)
p-S177-OPTN [cytosol]
(R-HSA-2562525)
p-S177-OPTN [nucleoplasm]
(R-HSA-2562595)
OPTN [Golgi membrane]
(R-HSA-2161111)
OPTN [recycling endosome membrane]
(R-HSA-8854141)
0.556
3
UniProt:P14136 GFAP
3
p-GFAP [lysosomal membrane]
(R-HSA-9626054)
GFAP [lysosomal membrane]
(R-HSA-9625195)
GFAP [cytosol]
(R-HSA-1253311)
0.556
3
UniProt:Q9BRX5 GINS3
1
GINS3 [nucleoplasm]
(R-HSA-5688046)
0.556
3
UniProt:P31249 HOXD3
1
HOXD3 [nucleoplasm]
(R-HSA-5617674)
0.556
3
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
12
UniProt:Q00994 BEX3
1
NGFRAP1 [cytosol]
(R-HSA-194333)
0.556
3
UniProt:Q9NRD5 PICK1
2
PICK1 [plasma membrane]
(R-HSA-416989)
PICK1 [endocytic vesicle membrane]
(R-HSA-417017)
0.556
3
UniProt:P14373 TRIM27
2
TRIM27 [cytosol]
(R-HSA-8851002)
TRIM27 [nucleoplasm]
(R-HSA-2997690)
0.556
3
UniProt:O43464 HTRA2
1
HTRA2 [mitochondrial intermembrane space]
(R-HSA-56655)
0.556
3
UniProt:Q8N2W9 PIAS4
2
PIAS4 [nucleoplasm]
(R-HSA-2993789)
monoSUMO1-K35-PIAS4 [nucleoplasm]
(R-HSA-3968415)
0.556
3
UniProt:Q6ZMU5 TRIM72
1
TRIM72 [cytoplasmic vesicle membrane]
(R-HSA-5263653)
0.556
3
UniProt:Q14145 KEAP1
3
KEAP1 [cytosol]
(R-HSA-976038)
ub-KEAP1 [cytosol]
(R-HSA-9766647)
Ub-KEAP1 [cytosol]
(R-HSA-6782766)
0.556
3
UniProt:P08123 COL1A2
20
GlcGalHyl-COL1A2(25-1366) [endoplasmic reticulum lumen]
(R-HSA-2023602)
3x4Hyp-3Hyp-GalHyl-COL1A2(25-1366) [endoplasmic reticulum lumen]
(R-HSA-2023558)
GalHyl-COL1A2(25-1366) [endoplasmic reticulum lumen]
(R-HSA-2023547)
3x4Hyp-GlcGalHyl-COL1A2(25-1366) [endoplasmic reticulum lumen]
(R-HSA-2023674)
3x4Hyp-GalHyl-COL1A2(25-1366) [endoplasmic reticulum lumen]
(R-HSA-2023580)
3x4Hyp-3Hyp-GlcGalHyl-COL1A2(25-1366) [endoplasmic reticulum lumen]
(R-HSA-2023663)
3x4Hyp-COL1A2(25-1366) [endoplasmic reticulum lumen]
(R-HSA-2022070)
3x4Hyp-3Hyp-COL1A2(25-1366) [endoplasmic reticulum lumen]
(R-HSA-2022501)
3x4Hyp-5Hyl-COL1A2(25-1366) [endoplasmic reticulum lumen]
(R-HSA-2022977)
3x4Hyp-3Hyp-5Hyl-COL1A2(25-1366) [endoplasmic reticulum lumen]
(R-HSA-2022966)
5Hyl-COL1A2(25-1366) [endoplasmic reticulum lumen]
(R-HSA-2022455)
Lysyl-pyrrolyl 5-hydroxylysyl collagen alpha-2(I) chain [extracellular region]
(R-HSA-2396490)
Lysyl-pyrrolyl 3,4-Hyp 5-Hyl collagen alpha-2(I) chain [extracellular region]
(R-HSA-2396080)
Lysyl-pyrrolyl 4-Hyp 5-Hyl collagen alpha-2(I) chain [extracellular region]
(R-HSA-2396375)
Lysyl-pyridinolyl 3,4-Hyp 5-Hyl collagen alpha-2(I) chain [extracellular region]
(R-HSA-2396493)
Lysyl-pyridinolyl 4-Hyp 5-Hyl collagen alpha-2(I) chain [extracellular region]
(R-HSA-2396241)
Lysyl-pyridinolyl 5-hydroxylysyl collagen alpha-2(I) chain [extracellular region]
(R-HSA-2396064)
Dehydrolysinonorlysyl 4-Hyp 5-Hyl collagen alpha-2(I) chain [extracellular region]
(R-HSA-2396361)
Dehydrolysinonorlysyl 4-hydroxyprolyl collagen alpha-2(I) chain [extracellular region]
(R-HSA-2396431)
Dehydrolysinonorlysyl 4-Hyp Glu-Gal-Hyl collagen alpha-2(I) chain [extracellular region]
(R-HSA-2396174)
0.556
3
UniProt:Q9H3P2 NELFA
1
NELFA [nucleoplasm]
(R-HSA-112426)
0.556
3
UniProt:Q9NPI1 BRD7
1
BRD7 [nucleoplasm]
(R-HSA-3222092)
0.527
4
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