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KLHL2 [cytosol]
Stable Identifier
R-HSA-8863217
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Kelch-like protein 2, KLHL2_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing: Ubiquitination & Proteasome degradation (Homo sapiens)
Interaction of E3 with substrate and E2-Ub complex (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL2 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL2 [cytosol] (Homo sapiens)
Polyubiquitination of substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL2 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL2 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL2 [cytosol] (Homo sapiens)
Release of E3 from polyubiquitinated substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL2 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL2 [cytosol] (Homo sapiens)
Transfer of Ub from E2 to substrate and release of E2 (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL2 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL2 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL2 [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Neddylation (Homo sapiens)
AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Homo sapiens)
NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL2 [cytosol] (Homo sapiens)
NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
NEDD8-CUL3:RBX1:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL2 [cytosol] (Homo sapiens)
CAND1 binds cytosolic CRL E3 ubiquitin ligases (Homo sapiens)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Homo sapiens)
CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL2 [cytosol] (Homo sapiens)
CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL2 [cytosol] (Homo sapiens)
COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Homo sapiens)
CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL2 [cytosol] (Homo sapiens)
CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL2 [cytosol] (Homo sapiens)
COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL2 [cytosol] (Homo sapiens)
NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
NEDD8-CUL3:RBX1:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL2 [cytosol] (Homo sapiens)
NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex (Homo sapiens)
CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL2 [cytosol] (Homo sapiens)
NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
RBX1:CUL3:BTB [cytosol] (Homo sapiens)
BTB proteins [cytosol] (Homo sapiens)
KLHL2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O95198 KLHL2
Gene Names
KLHL2
Chain
chain:1-593
Reference Genes
BioGPS Gene:11275 KLHL2
COSMIC (genes):KLHL2 KLHL2
CTD Gene:11275 KLHL2
dbSNP Gene:11275 KLHL2
ENSEMBL:ENSG00000109466 KLHL2
ENSEMBL_homo_sapiens_GENE:ENSG00000109466.14 KLHL2
HGNC:6353 KLHL2
KEGG Gene (Homo sapiens):11275 KLHL2
Monarch:11275 KLHL2
NCBI Gene:11275 KLHL2
OMIM:605774 KLHL2
UCSC:O95198 KLHL2
Reference Transcript
RefSeq:NM_007246.3 KLHL2
RefSeq:NM_001331023.1 KLHL2
RefSeq:NM_001161521.1 KLHL2
RefSeq:XM_017007676.1 KLHL2
RefSeq:NM_001331024.1 KLHL2
RefSeq:NM_001161522.1 KLHL2
Other Identifiers
11275
11724676_a_at
11748596_a_at
16972129
219157_PM_at
219157_at
2741300
2741301
2741303
2741307
2741321
2750539
2750540
2750541
2750542
2750544
2750547
2750548
2750550
2750555
2750561
2750565
2750566
2750567
2750570
2750573
2750576
2750577
2750578
2750580
2750583
2750585
2750586
2750587
2750588
76319_at
8098177
A_23_P72503
GE61646
GO:0001726
GO:0003779
GO:0005515
GO:0005737
GO:0005829
GO:0005856
GO:0008092
GO:0015629
GO:0016567
GO:0030027
GO:0031463
GO:0036211
GO:0042802
GO:0042995
GO:0043226
GO:0060090
GO:1990756
HMNXSV003014648
HMNXSV003017873
ILMN_1701837
PH_hs_0006888
TC04000826.hg
TC04002168.hg
g6005702_3p_at
Participates
as a member of
BTB proteins [cytosol] (Homo sapiens)
Inferred To
kel-1 [cytosol]
(Caenorhabditis elegans)
KLHL2 [cytosol]
(Bos taurus)
KLHL2 [cytosol]
(Canis familiaris)
KLHL2 [cytosol]
(Dictyostelium discoideum)
KLHL2 [cytosol]
(Gallus gallus)
KLHL2 [cytosol]
(Sus scrofa)
Klhl2 [cytosol]
(Mus musculus)
Klhl2 [cytosol]
(Rattus norvegicus)
kel [cytosol]
(Drosophila melanogaster)
klhl2 [cytosol]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001317952.1
,
NP_001154993.1
,
NP_009177.3
,
NP_001317953.1
,
NP_001154994.1
,
XP_016863165.1
OpenTargets
ENSG00000109466
GeneCards
O95198
HPA
ENSG00000109466-KLHL2
Ensembl
ENSG00000109466
,
ENSP00000437526
,
ENSP00000424198
,
ENST00000226725
,
ENSP00000226725
,
ENST00000514860
,
ENST00000538127
PRO
O95198
Pharos - Targets
O95198
PDB
4CHB
,
2XN4
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q14145 KEAP1
3
Ub-KEAP1 [cytosol]
(R-HSA-6782766)
ub-KEAP1 [cytosol]
(R-HSA-9766647)
KEAP1 [cytosol]
(R-HSA-976038)
0.77
7
UniProt:P55081 MFAP1
1
MFAP1 [nucleoplasm]
(R-HSA-2396419)
0.556
3
UniProt:O00560 SDCBP
3
SDCBP [extracellular region]
(R-HSA-6806206)
SDCBP [azurophil granule lumen]
(R-HSA-6799372)
SDCBP [cytosol]
(R-HSA-373639)
0.556
3
UniProt:Q13895 BYSL
2
BYSL [nucleoplasm]
(R-HSA-6791526)
BYSL [cytosol]
(R-HSA-6791518)
0.556
3
UniProt:Q08273
3
RBX1 [nucleoplasm]
(R-SCE-1234142)
RNF7 (RBX2) [cytosol]
(R-SCE-8863132)
RBX1 [cytosol]
(R-SCE-180582)
0.556
3
UniProt:Q9HCG8 CWC22
1
CWC22 [nucleoplasm]
(R-HSA-8865956)
0.556
3
UniProt:Q9UF56 FBXL17
1
FBXL17 [nucleoplasm]
(R-HSA-9708570)
0.527
7
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