Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
DDIT4 [cytosol]
Stable Identifier
R-HSA-5632374
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
DNA damage-inducible transcript 4 protein, REDD1, HIF-1 responsive protein RTP801, RTP801
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
TP53 Regulates Metabolic Genes (Homo sapiens)
DDIT4 binds 14-3-3 dimer (Homo sapiens)
DDIT4 [cytosol] (Homo sapiens)
DDIT4:14-3-3 dimer [cytosol] (Homo sapiens)
DDIT4 [cytosol] (Homo sapiens)
TP63/TP53 stimulates transcription of DDIT4 gene (Homo sapiens)
DDIT4 [cytosol] (Homo sapiens)
p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4 (Homo sapiens)
DDIT4 [cytosol] (Homo sapiens)
DDIT4:14-3-3 dimer [cytosol] (Homo sapiens)
DDIT4 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9NX09 DDIT4
Gene Names
DDIT4, REDD1, RTP801
Chain
chain:1-232
Reference Genes
BioGPS Gene:54541 DDIT4
COSMIC (genes):DDIT4 DDIT4
CTD Gene:54541 DDIT4
dbSNP Gene:54541 DDIT4
ENSEMBL:ENSG00000168209 DDIT4
ENSEMBL_homo_sapiens_GENE:ENSG00000168209.6 DDIT4
HGNC:24944 DDIT4
KEGG Gene (Homo sapiens):54541 DDIT4
Monarch:54541 DDIT4
NCBI Gene:54541 DDIT4
OMIM:607729 DDIT4
UCSC:Q9NX09 DDIT4
Reference Transcript
RefSeq:NM_019058.3 DDIT4
Other Identifiers
11743972_a_at
16705961
202887_PM_s_at
202887_s_at
3251401
3251403
3251404
3251406
3251407
3251408
3251409
3251410
39827_at
43853_at
54541
64010_s_at
7928308
A_14_P122194
A_23_P104318
GE80055
GO:0001666
GO:0001764
GO:0005515
GO:0005737
GO:0005739
GO:0005829
GO:0005975
GO:0006091
GO:0006915
GO:0007420
GO:0009968
GO:0012501
GO:0023052
GO:0030154
GO:0030182
GO:0032007
GO:0032984
GO:0035556
GO:0042771
GO:0043226
GO:0045820
GO:0048011
GO:0048856
GO:0048870
GO:0051607
GO:0055086
GO:0071549
GO:0071889
GO:0072593
GO:0098542
GO:1901135
HMNXSV003011933
ILMN_1661599
PH_hs_0006110
TC10000449.hg
g9506686_3p_s_at
Participates
as an output of
TP63/TP53 stimulates transcription of DDIT4 gene (Homo sapiens)
as a component of
DDIT4:14-3-3 dimer [cytosol] (Homo sapiens)
as an input of
DDIT4 binds 14-3-3 dimer (Homo sapiens)
Inferred To
Homologues of DDIT4 [cytosol]
(Drosophila melanogaster)
ddit4 [cytosol]
(Danio rerio)
ddit4 [cytosol]
(Xenopus tropicalis)
scyl [cytosol]
(Drosophila melanogaster)
Ddit4 [cytosol]
(Mus musculus)
Ddit4 [cytosol]
(Rattus norvegicus)
DDIT4 [cytosol]
(Bos taurus)
DDIT4 [cytosol]
(Canis familiaris)
DDIT4 [cytosol]
(Gallus gallus)
DDIT4 [cytosol]
(Sus scrofa)
chrb [cytosol]
(Drosophila melanogaster)
Cross References
RefSeq
NP_061931.1
OpenTargets
ENSG00000168209
GeneCards
Q9NX09
HPA
ENSG00000168209-DDIT4
Ensembl
ENSP00000307305
,
ENST00000491934
,
ENST00000307365
,
ENSG00000168209
,
ENSP00000506356
PRO
Q9NX09
Pharos - Targets
Q9NX09
PDB
3LQ9
,
7MOP
Interactors (14)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P57682 KLF3
0.556
3
UniProt:Q96MN9-2 Q96MN92
0.556
3
UniProt:P58304 VSX2
0.556
3
IntAct:EBI-25850457 CCSB
0.556
3
UniProt:P08195-4 SLC3A2
0.556
3
UniProt:P61086 UBE2K
2
UBE2K [cytosol]
(R-HSA-934631)
Ub-C92-UBE2K [cytosol]
(R-HSA-8864200)
0.556
3
UniProt:P40337-2 VHL
0.556
3
UniProt:Q9Y483-4 MTF2
0.556
3
UniProt:Q3SYB3 FX4L6
0.556
3
UniProt:Q6P1K2 PMF1
1
PMF1 [cytosol]
(R-HSA-375320)
0.556
3
UniProt:P16284 PECAM1
5
PECAM1 [platelet alpha granule membrane]
(R-HSA-61489)
PECAM1 [plasma membrane]
(R-HSA-114686)
PECAM1 [secretory granule membrane]
(R-HSA-6804778)
p-Y663,Y686-PECAM1(27-?) [plasma membrane]
(R-HSA-210007)
p-Y713-PECAM1 [plasma membrane]
(R-HSA-9860772)
0.556
3
UniProt:Q14145 KEAP1
3
Ub-KEAP1 [cytosol]
(R-HSA-6782766)
ub-KEAP1 [cytosol]
(R-HSA-9766647)
KEAP1 [cytosol]
(R-HSA-976038)
0.556
3
UniProt:Q16531 DDB1
1
DDB1 [nucleoplasm]
(R-HSA-53489)
0.462
2
UniProt:Q9Y297 BTRC
2
BTRC [cytosol]
(R-HSA-174237)
BTRC [nucleoplasm]
(R-HSA-3361753)
0.462
2
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text