Reactome | SESN2 [cytosol]

SESN2 [cytosol]

Stable Identifier

R-HSA-5629143

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Sestrin-2, Hi95

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External Reference Information

External Reference

UniProt:P58004 SESN2

Gene Names

SESN2, Hi95, SEST2

Chain

chain:1-480

Reference Genes

BioGPS Gene:83667 SESN2

COSMIC (genes):SESN2 SESN2

CTD Gene:83667 SESN2

dbSNP Gene:83667 SESN2

ENSEMBL:ENSG00000130766 SESN2

HGNC:20746 SESN2

KEGG:hsa:83667 SESN2

Monarch:83667 SESN2

NCBI Gene:83667 SESN2

OMIM:607767 SESN2

UCSC:P58004 SESN2

Reference Transcript

RefSeq:NM_031459.4 SESN2

Other Identifiers

11718324_s_at

11718325_at

16661544

223195_PM_s_at

223195_s_at

223196_PM_s_at

223196_s_at

2327393

2327394

2327395

2327396

2327397

2327402

2327403

2327404

2327406

2327407

2327408

2327409

2327410

2327412

2327414

2327415

48062_at

55022_at

7899436

83667

A_23_P35082

GE63362

GO:0001932

GO:0003824

GO:0004601

GO:0005092

GO:0005515

GO:0005634

GO:0005737

GO:0005739

GO:0005765

GO:0005829

GO:0006111

GO:0006629

GO:0006635

GO:0007005

GO:0009749

GO:0016209

GO:0016239

GO:0016491

GO:0016684

GO:0030308

GO:0030330

GO:0031588

GO:0031932

GO:0032042

GO:0032542

GO:0032868

GO:0034198

GO:0034599

GO:0042149

GO:0042593

GO:0042731

GO:0043226

GO:0044877

GO:0046323

GO:0051897

GO:0055085

GO:0070328

GO:0070728

GO:0071230

GO:0071233

GO:0072593

GO:0098754

GO:0098772

GO:0098869

GO:0140311

GO:0140313

GO:1900182

GO:1901031

GO:1902010

GO:1903432

GO:1904262

GO:1904263

GO:1904504

GO:1990253

GO:1990316

HMNXSV003003062

Hs.8026.0.S1_3p_a_at

ILMN_1751598

PH_hs_0000852

TC01000377.hg

g13276608_3p_a_at

Participates

as a member of

Inferred To

Sesn2 [cytosol] (Rattus norvegicus)

SESN2 [cytosol] (Bos taurus)

SESN2 [cytosol] (Canis familiaris)

SESN2 [cytosol] (Dictyostelium discoideum)

SESN2 [cytosol] (Gallus gallus)

SESN2 [cytosol] (Mus musculus)

SESN2 [cytosol] (Sus scrofa)

sesn2 [cytosol] (Danio rerio)

sesn-1 [cytosol] (Caenorhabditis elegans)

Sesn [cytosol] (Drosophila melanogaster)

Cross References

ENSEMBL

ENSP00000496365, ENSP00000253063, ENST00000645231, ENST00000253063

OpenTargets

ENSG00000130766

HPA

ENSG00000130766-SESN2

PRO

P58004

Pharos - Targets

P58004

GlyGen

P58004

PDB

5CUF, 5DJ4, 6N0M, 5T0N

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13501 SQSTM1	7	SQSTM1 [cytosol] (R-HSA-193937) SQSTM1 [nucleoplasm] (R-HSA-210961) ub K420 p-S349 SQSTM1 [cytosol] (R-HSA-9766536) p-S349 SQSTM1 [cytosol] (R-HSA-9766524) K7 ub-SQSTM1 [cytosol] (R-HSA-9759088) SQSTM1(2-251)-ALK(1058-1620) fusion [cytosol] (R-HSA-9711954) SQSTM1(2-251)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9711967)	0.728	9
UniProt:P61964 WDR5	1	WDR5 [nucleoplasm] (R-HSA-1629838)	0.643	3
UniProt:P62877 RBX1	2	RBX1 [cytosol] (R-HSA-180582) RBX1 [nucleoplasm] (R-HSA-1234142)	0.641	3
UniProt:O70405	7	ULK1 [recycling endosome] (R-MMU-8854761) phospho-p-S758-ULK1 [cytosol] (R-MMU-5672131) phospho-p-S317,467,556,638,T575-ULK1 [cytosol] (R-MMU-5673747) phospho-p-T180,S317,S467,S556,S638,T575-ULK1 [cytosol] (R-MMU-5675858) phospho-p-T180,S317,S467,S556,S638,T575-ULK1 [endoplasmic reticulum membrane] (R-MMU-8948047) ULK1 [mitochondrial outer membrane] (R-MMU-8948145) ULK1 [cytosol] (R-MMU-1632847)	0.576	5
UniProt:P55735 SEC13	4	SEC13 [lysosomal membrane] (R-HSA-9638246) SEC13 [endoplasmic reticulum membrane] (R-HSA-203994) SEC13 [ER to Golgi transport vesicle membrane] (R-HSA-204012) SEC13 [cytosol] (R-HSA-203981)	0.527	4
UniProt:Q14145 KEAP1	3	KEAP1 [cytosol] (R-HSA-976038) ub-KEAP1 [cytosol] (R-HSA-9766647) Ub-KEAP1 [cytosol] (R-HSA-6782766)	0.499	3

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