Reactome | NEU2 [cytosol]

NEU2 [cytosol]

Stable Identifier

R-HSA-1605759

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Sialidase-2, NEUR2_HUMAN

Locations in the PathwayBrowser

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Homo sapiens)
      - Synthesis of substrates in N-glycan biosythesis (Homo sapiens)
        
        Sialic acid metabolism (Homo sapiens)
        
        NEU2 hydrolyzes Neu5Ac from glycoconjugates (Homo sapiens)
        
        NEU2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9Y3R4 NEU2

Gene Names

NEU2

Chain

chain:1-380

Reference Genes

BioGPS Gene:4759 NEU2

COSMIC (genes):NEU2 NEU2

CTD Gene:4759 NEU2

dbSNP Gene:4759 NEU2

ENSEMBL:ENSG00000115488 NEU2

HGNC:7759 NEU2

KEGG Gene (Homo sapiens):4759 NEU2

Monarch:4759 NEU2

NCBI Gene:4759 NEU2

OMIM:605528 NEU2

UCSC:Q9Y3R4 NEU2

Reference Transcript

RefSeq:NM_005383.2 NEU2

Other Identifiers

0002640601

11735974_at

16892443

221368_at

2532682

2532683

2532684

2532685

2532686

4759

8049243

A_23_P90980

GE565077

GO:0003674

GO:0004308

GO:0005515

GO:0005575

GO:0005622

GO:0005737

GO:0005829

GO:0005975

GO:0006516

GO:0006629

GO:0006687

GO:0006689

GO:0008150

GO:0008152

GO:0009056

GO:0009313

GO:0016020

GO:0016042

GO:0016787

GO:0016798

GO:0032991

GO:0034641

GO:0043226

GO:0043231

GO:0051692

GO:0052794

GO:0052795

GO:0052796

GO:1902494

HMNXSV003043638

ILMN_1752557

PH_hs_0013168

TC02001413.hg

g4885514_3p_at

Inferred To

neu4 [cytosol] (Danio rerio)

Neu2 [cytosol] (Mus musculus)

Neu2 [cytosol] (Rattus norvegicus)

NEU2 [cytosol] (Bos taurus)

NEU2 [cytosol] (Canis familiaris)

NEU2 [cytosol] (Gallus gallus)

NEU2 [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_005374.2

OpenTargets

ENSG00000115488

HPA

ENSG00000115488-NEU2

ZINC - Substances

NEUR2_HUMAN

GeneCards

Q9Y3R4

ZINC target

Q9Y3R4

Ensembl

ENSP00000233840, ENST00000233840, ENSG00000115488

PRO

Q9Y3R4

ZINC - Predictions - Purchasable

NEUR2_HUMAN

HMDB Protein

HMDBP00317

PDB

2F13, 1VCU, 2F27, 2F26, 2F12, 1SO7, 1SNT, 2F11, 2F29, 2F25, 2F24, 2F28, 2F0Z, 2F10, 4NC5, 4NCS

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q7Z3S9 NT2NA			0.718	6
UniProt:A8MQ03 CRTP1			0.556	3

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