Reactome | NEU2 [cytosol]

NEU2 [cytosol]

Stable Identifier

R-HSA-1605759

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Sialidase-2, NEUR2_HUMAN

Locations in the PathwayBrowser

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Homo sapiens)
      - Synthesis of substrates in N-glycan biosythesis (Homo sapiens)
        
        Sialic acid metabolism (Homo sapiens)
        
        NEU2 hydrolyzes Neu5Ac from glycoconjugates (Homo sapiens)
        
        NEU2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9Y3R4 NEU2

Gene Names

NEU2

Chain

chain:1-380

Reference Genes

BioGPS Gene:4759 NEU2

COSMIC (genes):NEU2 NEU2

CTD Gene:4759 NEU2

dbSNP Gene:4759 NEU2

ENSEMBL:ENSG00000115488 NEU2

ENSEMBL_homo_sapiens_GENE:ENSG00000115488 NEU2

HGNC:7759 NEU2

KEGG Gene (Homo sapiens):4759 NEU2

Monarch:4759 NEU2

NCBI Gene:4759 NEU2

OMIM:605528 NEU2

UCSC:Q9Y3R4 NEU2

Reference Transcript

RefSeq:NM_005383.2 NEU2

Other Identifiers

0002640601

00511+3.2.1.18

00600+3.2.1.18

11735974_at

16892443

1SNT

1SO7

1VCU

221368_at

22336

2532683

2532684

2532685

2532686

2F0Z

2F10

2F11

2F12

2F13

2F24

2F25

2F26

2F27

2F28

2F29

4759

4NC5

4NCS

8049243

A_23_P90980

AAH69151

AAI07054

AAY24360

AC106876

BC069151

BC107053

CAB022336

CAB41449

CCDS2501

CH471063

EAW71028

ENSG00000115488

ENSP00000233840

ENST00000233840

EntrezGene:4759

g4885514_3p_at

GE565077

GO:0003674

GO:0004308

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005737

GO:0005829

GO:0005975

GO:0006629

GO:0006687

GO:0006689

GO:0008150

GO:0008152

GO:0009056

GO:0009313

GO:0016042

GO:0016787

GO:0016798

GO:0032991

GO:0034641

GO:0043226

GO:0043231

GO:0051692

GO:0052794

GO:0052795

GO:0052796

GO:1902494

HGNC:7759

ILMN_1752557

IPR011040

IPR026856

IPR026945

IPR036278

MIM:605528

NEU2

NEU2-201

NM_005383

NP_005374

PF13088

PH_hs_0013168

TC02001413.hg

uc010zmn.2

UPI000013C98F

Y16535

Inferred To

NEU2 [cytosol] (Bos taurus)

NEU2 [cytosol] (Canis familiaris)

NEU2 [cytosol] (Gallus gallus)

NEU2 [cytosol] (Mus musculus)

NEU2 [cytosol] (Rattus norvegicus)

NEU2 [cytosol] (Sus scrofa)

NEU2 [cytosol] (Taeniopygia guttata)

Cross References

RefSeq

NP_005374.2

OpenTargets

ENSG00000115488

ZINC - Substances

NEUR2_HUMAN

GeneCards

Q9Y3R4

DOCK Blaster

2F0Z, 4NC5, 2F27, 1SO7, 1SNT, 2F28, 4NCS, 2F29, 1VCU, 2F26, 2F24, 2F25, 2F11, 2F12, 2F10, 2F13

ZINC target

Q9Y3R4

PRO

Q9Y3R4

BRENDA (Homo sapiens)

3.2.1.18

ZINC - Predictions - Purchasable

NEUR2_HUMAN

HMDB Protein

HMDBP00317

PDB

2F10, 1SNT, 4NC5, 2F24, 2F12, 2F0Z, 2F26, 2F28, 4NCS, 2F11, 1SO7, 2F13, 2F25, 1VCU, 2F27, 2F29

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q7Z3S9 NT2NA			0.718	6
UniProt:A8MQ03 CRTP1			0.488	2