Reactome | Keap1 [cytosol]

Keap1 [cytosol]

Stable Identifier

R-DME-9766647

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

cytosol

Synonyms

ub-KEAP1, Q7KSF5

Locations in the PathwayBrowser

Expand all

Cellular responses to stimuli (Drosophila melanogaster)

- Cellular responses to stress (Drosophila melanogaster)
  - Cellular response to chemical stress (Drosophila melanogaster)
    - KEAP1-NFE2L2 pathway (Drosophila melanogaster)
      - CUL3:RBX1 ubiquitinates KEAP1 (Drosophila melanogaster)
        
        SESN1,SESN2:ub-K420 p-S349 SQSTM1 oligomer:ub-KEAP1:CUL3:RBX1 [cytosol] (Drosophila melanogaster)
        
        ub-KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Drosophila melanogaster)
        
        Keap1 [cytosol] (Drosophila melanogaster)
      - RBX1:CUL3 dissociates from forming autophagosome (Drosophila melanogaster)
        
        MAP1LC3B:SESN1,2:ub K420 p-S349 SQSTM1 oligomer:ub-KEAP1 [cytosol] (Drosophila melanogaster)
        
        Keap1 [cytosol] (Drosophila melanogaster)
        
        MAP1LC3B:SESN1,SESN2:ub-K420 p-S349 SQSTM1 oligomer:ub-KEAP1:CUL3:RBX1 [cytosol] (Drosophila melanogaster)
        
        SESN1,SESN2:ub-K420 p-S349 SQSTM1 oligomer:ub-KEAP1:CUL3:RBX1 [cytosol] (Drosophila melanogaster)
        
        ub-KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Drosophila melanogaster)
        
        Keap1 [cytosol] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:Q7KSF5

Gene Names

Keap1

Reference Genes

BioGPS Gene:42062 Keap1

ENSEMBL:FBgn0038475

FlyBase:FBgn0038475

Monarch:42062 Keap1

NCBI Gene:42062 Keap1

UCSC:Q7KSF5 Keap1

Reference Transcript

RefSeq:NM_169744.3 Keap1

Other Identifiers

152189_at

1633773_s_at

42062

GO:0003779

GO:0005515

GO:0005634

GO:0005703

GO:0005737

GO:0006979

GO:0008092

GO:0030163

GO:0031463

GO:0043161

GO:0060090

GO:0061709

GO:1990756

Participates

as a component of

Other forms of this molecule

Keap1 [cytosol]

Inferred From

ub-KEAP1 [cytosol] (Homo sapiens)

Modified Residues

Name

ubiquitinylated lysine (K48polyUb [cytosol]) at unknown position

Modification

K48polyUb [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

NP_732202.2

FlyBase

FBgn0038475

Cite Us!