Reactome | Activated MAD2L1 [cytosol]

Activated MAD2L1

Stable Identifier

R-HSA-141447

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q13257 MAD2L1

Gene Names

MAD2L1, MAD2

Chain

initiator methionine:1, chain:2-205

Reference Genes

BioGPS Gene:4085 MAD2L1

COSMIC (genes):MAD2L1 MAD2L1

CTD Gene:4085 MAD2L1

dbSNP Gene:4085 MAD2L1

ENSEMBL:ENSG00000164109 MAD2L1

HGNC:6763 MAD2L1

KEGG Gene (Homo sapiens):hsa:4085 MAD2L1

Monarch:4085 MAD2L1

NCBI Gene:4085 MAD2L1

OMIM:601467 MAD2L1

UCSC:Q13257 MAD2L1

Reference Transcript

RefSeq:NM_002358.3 MAD2L1

Other Identifiers

0003850519

11720185_a_at

11720186_s_at

11748136_a_at

1554768_a_at

16979389

1721_g_at

1DUJ

1KLQ

1S2H

203362_s_at

236312_at

2783728

2783729

2783730

2783731

2783732

2783733

2783734

2783735

2783736

2783737

2783739

2783742

2783743

2783744

2783745

2QYF

2V64

2VFX

3348

3538716

3538718

3538720

3538721

3538722

37282_at

3GMH

4085

46436_at

55824_at

5KHU

5LCW

8102560

A_23_P92441

AAC50781

AAC52060

AAH00356

AAH05945

AAH70283

AAK38174

AAN74648

AAY40945

BAB63410

BAD97153

BAG36562

BAG60497

CAA03943

CCDS3715

EAX05271

EAX05273

ENSG00000164109

ENSP00000296509

ENSP00000332295

ENST00000296509

ENST00000333047

EntrezGene:4085

g6466452_3p_s_at

GE59318

GO:0000070

GO:0000775

GO:0000776

GO:0000777

GO:0000922

GO:0005515

GO:0005634

GO:0005643

GO:0005654

GO:0005694

GO:0005737

GO:0005829

GO:0005856

GO:0007049

GO:0007062

GO:0007093

GO:0007094

GO:0031145

GO:0042177

GO:0042787

GO:0042802

GO:0042803

GO:0043066

GO:0043161

GO:0045930

GO:0048471

GO:0051301

GO:0051436

GO:0051437

GO:0072686

GO:0090267

GO:1904667

HGNC:6763

HPA003348

Hs.44380.0.A1_3p_at

Hs2.79078.2.S1_3p_s_at

ILMN_1777564

ILMN_2112460

MAD2L1

MAD2L1-201

MAD2L1-202

MIM:601467

NM_002358

NP_002349

PF02301

TC04001507.hg

U65410_at

uc003idl.3

uc003idm.3

UPI0000000A29

UPI000007408B

Participant Of

input

hasComponent

output

Release of activated MAD2 from kinetochores

Other forms of this molecule

MAD2L1 [cytosol]

Inferred To

Activated MAD2L1 [cytosol] (Arabidopsis thaliana)

Activated MAD2L1 [cytosol] (Caenorhabditis elegans)

Activated MAD2L1 [cytosol] (Dictyostelium discoideum)

Activated MAD2L1 [cytosol] (Drosophila melanogaster)

Activated MAD2L1 [cytosol] (Oryza sativa)

Activated MAD2L1 [cytosol] (Saccharomyces cerevisiae)

Activated MAD2L1 [cytosol] (Schizosaccharomyces pombe)

MAD2L1 [cytosol] (Bos taurus)

MAD2L1 [cytosol] (Canis familiaris)

MAD2L1 [cytosol] (Danio rerio)

MAD2L1 [cytosol] (Gallus gallus)

MAD2L1 [cytosol] (Mus musculus)

MAD2L1 [cytosol] (Rattus norvegicus)

MAD2L1 [cytosol] (Sus scrofa)

MAD2L1 [cytosol] (Taeniopygia guttata)

MAD2L1 [cytosol] (Xenopus tropicalis)

Homologues of Activated MAD2L1 [cytosol] (Caenorhabditis elegans)

Homologues of Activated MAD2L1 [cytosol] (Oryza sativa)

Homologues of MAD2L1 [cytosol] (Bos taurus)

Homologues of MAD2L1 [cytosol] (Canis familiaris)

Cross References

RefSeq

NP_002349.1

GeneCards

Q13257

DOCK Blaster

2QYF, 1GO4, 2V64, 3GMH, 2VFX

PRO

Q13257

PDB

1GO4, 2V64, 2QYF, 5LCW, 1DUJ, 5KHU, 1S2H, 3GMH, 2VFX, 1KLQ

Interactors (18)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q12834 CDC20	3	CDC20 [nucleoplasm] (R-HSA-174112) CDC20 [cytosol] (R-HSA-141412) PolyUb-CDC20 [nucleoplasm] (R-HSA-6783069)	0.979	33
UniProt:Q9Y6D9 MAD1L1	1	MAD1L1 [cytosol] (R-HSA-141433)	0.968	23
UniProt:Q15013 MD2BP			0.926	13
UniProt:Q13257 MAD2L1	2	Activated MAD2L1 [cytosol] (R-HSA-141447) MAD2L1 [cytosol] (R-HSA-141400)	0.889	9
UniProt:O60566 BUB1B	1	BUB1B [cytosol] (R-HSA-141436)	0.883	14
UniProt:P30260 CDC27	2	CDC27 [nucleoplasm] (R-HSA-174175) CDC27 [cytosol] (R-HSA-174073)	0.871	8
UniProt:Q14145 KEAP1	2	KEAP1 [cytosol] (R-HSA-976038) Ub-KEAP1 [cytosol] (R-HSA-6782766)	0.77	6
IntAct:EBI-1563533 MAD2 PEPTIDE			0.667	3
UniProt:Q9Y3Q8 T22D4			0.666	4
UniProt:Q562F6 SGO2	1	SGOL2 [cytosol] (R-HSA-376242)	0.649	10
UniProt:P78536 ADAM17	1	ADAM17 [plasma membrane] (R-HSA-179878)	0.581	3
UniProt:Q8BGZ4 CDC23			0.564	2
UniProt:Q9JJ66	3	CDC20 [nucleoplasm] (R-MMU-174112) PolyUb-CDC20 [nucleoplasm] (R-MMU-6783069) CDC20 [cytosol] (R-MMU-141412)	0.564	2
UniProt:Q8R349	2	CDC16 [cytosol] (R-MMU-174156) CDC16 [nucleoplasm] (R-MMU-174049)	0.564	2
UniProt:Q9DCX1 MD2BP			0.564	2
UniProt:O00560 SDCBP	3	SDCBP [extracellular region] (R-HSA-6806206) SDCBP [cytosol] (R-HSA-373639) SDCBP [azurophil granule lumen] (R-HSA-6799372)	0.556	3
UniProt:Q9UJX5 ANAPC4	2	ANAPC4 [cytosol] (R-HSA-174168) ANAPC4 [nucleoplasm] (R-HSA-174115)	0.527	5
UniProt:P06213 INSR	6	INSR(763-1382) [endosome membrane] (R-HSA-141722) p-6Y-INSR(763-1382) [endosome membrane] (R-HSA-141719) INSR(28-758) [endosome membrane] (R-HSA-141718) INSR(763-1382) [plasma membrane] (R-HSA-74669) p-6Y-INSR(763-1382) [plasma membrane] (R-HSA-74670) INSR(28-758) [plasma membrane] (R-HSA-74668)	0.463	2