Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
Activated MAD2L1 [cytosol]
Stable Identifier
R-HSA-141447
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Icon
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle Checkpoints (Homo sapiens)
Mitotic Spindle Checkpoint (Homo sapiens)
Amplification of signal from the kinetochores (Homo sapiens)
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (Homo sapiens)
MAD2 converted to an inhibitory state via interaction with Mad1 (Homo sapiens)
Kinetochore:Mad1:MAD2* Complex [cytosol] (Homo sapiens)
Activated MAD2L1 [cytosol] (Homo sapiens)
Release of activated MAD2 from kinetochores (Homo sapiens)
Activated MAD2L1 [cytosol] (Homo sapiens)
Kinetochore:Mad1:MAD2* Complex [cytosol] (Homo sapiens)
Activated MAD2L1 [cytosol] (Homo sapiens)
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components (Homo sapiens)
Inactivation of APC/C via CDC20 sequestration (Homo sapiens)
Activated MAD2L1 [cytosol] (Homo sapiens)
MAD2*CDC20 complex [cytosol] (Homo sapiens)
Activated MAD2L1 [cytosol] (Homo sapiens)
Inactivation of APC/C via direct inhibition of the APC/C complex (Homo sapiens)
Binding of the MCC complex to the APC/C complex (Homo sapiens)
MCC:APC/C complex [cytosol] (Homo sapiens)
hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Homo sapiens)
Activated MAD2L1 [cytosol] (Homo sapiens)
hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Homo sapiens)
Activated MAD2L1 [cytosol] (Homo sapiens)
Formation of the MCC complex (Homo sapiens)
Activated MAD2L1 [cytosol] (Homo sapiens)
hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Homo sapiens)
Activated MAD2L1 [cytosol] (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Regulation of mitotic cell cycle (Homo sapiens)
APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (Homo sapiens)
APC/C:Cdc20 mediated degradation of mitotic proteins (Homo sapiens)
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint (Homo sapiens)
APC-Cdc20 mediated degradation of Nek2A (Homo sapiens)
Association of Nek2A with MCC:APC/C (Homo sapiens)
MCC:APC/C complex [cytosol] (Homo sapiens)
hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Homo sapiens)
Activated MAD2L1 [cytosol] (Homo sapiens)
Nek2A:MCC:APC/C complex [cytosol] (Homo sapiens)
MCC:APC/C complex [cytosol] (Homo sapiens)
hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Homo sapiens)
Activated MAD2L1 [cytosol] (Homo sapiens)
Degradation of multiubiquitinated Nek2A (Homo sapiens)
MCC:APC/C complex [cytosol] (Homo sapiens)
hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Homo sapiens)
Activated MAD2L1 [cytosol] (Homo sapiens)
Multiubiquitinated Nek2A [cytosol] (Homo sapiens)
Nek2A:MCC:APC/C complex [cytosol] (Homo sapiens)
MCC:APC/C complex [cytosol] (Homo sapiens)
hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Homo sapiens)
Activated MAD2L1 [cytosol] (Homo sapiens)
Multiubiquitination of Nek2A (Homo sapiens)
Multiubiquitinated Nek2A [cytosol] (Homo sapiens)
Nek2A:MCC:APC/C complex [cytosol] (Homo sapiens)
MCC:APC/C complex [cytosol] (Homo sapiens)
hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Homo sapiens)
Activated MAD2L1 [cytosol] (Homo sapiens)
Nek2A:MCC:APC/C complex [cytosol] (Homo sapiens)
MCC:APC/C complex [cytosol] (Homo sapiens)
hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Homo sapiens)
Activated MAD2L1 [cytosol] (Homo sapiens)
Cdc20:Phospho-APC/C mediated degradation of Cyclin A (Homo sapiens)
Association of Cyclin A with the APC/C (Homo sapiens)
Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Homo sapiens)
MCC:APC/C complex [cytosol] (Homo sapiens)
hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Homo sapiens)
Activated MAD2L1 [cytosol] (Homo sapiens)
MCC:APC/C complex [cytosol] (Homo sapiens)
hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Homo sapiens)
Activated MAD2L1 [cytosol] (Homo sapiens)
Degradation multiubiquitinated Cyclin A (Homo sapiens)
MCC:APC/C complex [cytosol] (Homo sapiens)
hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Homo sapiens)
Activated MAD2L1 [cytosol] (Homo sapiens)
multiubiquitinated Cyclin A associated with MCC:APC/C complex [cytosol] (Homo sapiens)
Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Homo sapiens)
MCC:APC/C complex [cytosol] (Homo sapiens)
hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Homo sapiens)
Activated MAD2L1 [cytosol] (Homo sapiens)
Ubiquitination of Cyclin A by APC/C:Cdc20 complex (Homo sapiens)
Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Homo sapiens)
MCC:APC/C complex [cytosol] (Homo sapiens)
hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Homo sapiens)
Activated MAD2L1 [cytosol] (Homo sapiens)
MCC:APC/C complex [cytosol] (Homo sapiens)
hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Homo sapiens)
Activated MAD2L1 [cytosol] (Homo sapiens)
multiubiquitinated Cyclin A associated with MCC:APC/C complex [cytosol] (Homo sapiens)
Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Homo sapiens)
MCC:APC/C complex [cytosol] (Homo sapiens)
hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Homo sapiens)
Activated MAD2L1 [cytosol] (Homo sapiens)
Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 (Homo sapiens)
MCC:APC/C complex [cytosol] (Homo sapiens)
hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Homo sapiens)
Activated MAD2L1 [cytosol] (Homo sapiens)
hBUBR1:hBUB3:MAD2* complex [cytosol] (Homo sapiens)
Activated MAD2L1 [cytosol] (Homo sapiens)
Regulation of APC/C activators between G1/S and early anaphase (Homo sapiens)
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components (Homo sapiens)
Inactivation of APC/C via CDC20 sequestration (Homo sapiens)
Activated MAD2L1 [cytosol] (Homo sapiens)
MAD2*CDC20 complex [cytosol] (Homo sapiens)
Activated MAD2L1 [cytosol] (Homo sapiens)
Inactivation of APC/C via direct inhibition of the APC/C complex (Homo sapiens)
Binding of the MCC complex to the APC/C complex (Homo sapiens)
MCC:APC/C complex [cytosol] (Homo sapiens)
hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Homo sapiens)
Activated MAD2L1 [cytosol] (Homo sapiens)
hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Homo sapiens)
Activated MAD2L1 [cytosol] (Homo sapiens)
Formation of the MCC complex (Homo sapiens)
Activated MAD2L1 [cytosol] (Homo sapiens)
hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Homo sapiens)
Activated MAD2L1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13257 MAD2L1
Gene Names
MAD2L1, MAD2
Chain
initiator methionine:1, chain:2-205
Reference Genes
BioGPS Gene:4085 MAD2L1
COSMIC (genes):MAD2L1 MAD2L1
CTD Gene:4085 MAD2L1
dbSNP Gene:4085 MAD2L1
ENSEMBL:ENSG00000164109.14 MAD2L1
HGNC:6763 MAD2L1
KEGG Gene (Homo sapiens):4085 MAD2L1
Monarch:4085 MAD2L1
NCBI Gene:4085 MAD2L1
OMIM:601467 MAD2L1
UCSC:Q13257 MAD2L1
Reference Transcript
RefSeq:NM_002358.3 MAD2L1
Other Identifiers
11720185_a_at
11720186_s_at
11748136_a_at
1554768_PM_a_at
1554768_a_at
16979389
1721_g_at
203362_PM_s_at
203362_s_at
236312_PM_at
236312_at
2783726
2783727
2783728
2783729
2783730
2783731
2783732
2783733
2783734
2783735
2783736
2783737
2783739
2783742
2783743
2783744
3538716
3538718
3538720
3538721
3538722
37282_at
4085
46436_at
55824_at
8102560
A_23_P92441
GE59318
GO:0000070
GO:0000132
GO:0000278
GO:0000775
GO:0000776
GO:0000922
GO:0005515
GO:0005634
GO:0005635
GO:0005654
GO:0005694
GO:0005737
GO:0005829
GO:0005856
GO:0007010
GO:0007049
GO:0007059
GO:0007094
GO:0007163
GO:0008022
GO:0012501
GO:0023052
GO:0030163
GO:0033597
GO:0036211
GO:0042177
GO:0042802
GO:0042803
GO:0043066
GO:0043226
GO:0044615
GO:0045930
GO:0048471
GO:0051301
GO:0051444
GO:0051660
GO:0072686
GO:0090267
GO:0140014
GO:1904667
GO:1990728
HMNXSV003035103
Hs.44380.0.A1_3p_at
Hs2.79078.2.S1_3p_s_at
ILMN_1777564
ILMN_2112460
TC04001507.hg
U65410_at
g6466452_3p_s_at
Participates
as a component of
MAD2*CDC20 complex [cytosol] (Homo sapiens)
hBUBR1:hBUB3:MAD2* complex [cytosol] (Homo sapiens)
hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Homo sapiens)
Kinetochore:Mad1:MAD2* Complex [cytosol] (Homo sapiens)
as an input of
Inactivation of APC/C via CDC20 sequestration (Homo sapiens)
Formation of the MCC complex (Homo sapiens)
as an output of
Release of activated MAD2 from kinetochores (Homo sapiens)
Other forms of this molecule
MAD2L1 [cytosol]
Inferred To
Mad2l1 [cytosol]
(Mus musculus)
Mad2l1 [cytosol]
(Rattus norvegicus)
Ghost homologue of Activated MAD2L1 [cytosol]
(Xenopus tropicalis)
mad2l1-1 [cytosol]
(Dictyostelium discoideum)
MAD2L1 [cytosol]
(Bos taurus)
MAD2L1 [cytosol]
(Canis familiaris)
MAD2L1 [cytosol]
(Danio rerio)
MAD2L1 [cytosol]
(Gallus gallus)
MAD2L1 [cytosol]
(Sus scrofa)
mdf-2 [cytosol]
(Caenorhabditis elegans)
MAD2 [cytosol]
(Saccharomyces cerevisiae)
mad2 [cytosol]
(Drosophila melanogaster)
mad2 [cytosol]
(Schizosaccharomyces pombe)
Cross References
RefSeq
NP_002349.1
OpenTargets
ENSG00000164109
HPA
ENSG00000164109-MAD2L1
GeneCards
Q13257
Ensembl
ENST00000296509
,
ENST00000333047
,
ENSG00000164109
,
ENSP00000296509
,
ENSP00000332295
PRO
Q13257
Pharos - Targets
Q13257
PDB
3GMH
,
1DUJ
,
1S2H
,
2VFX
,
2QYF
,
5KHU
,
6F0X
,
2V64
,
1GO4
,
5LCW
,
1KLQ
,
6TLJ
Interactors (22)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q12834 CDC20
3
CDC20 [cytosol]
(R-HSA-141412)
CDC20 [nucleoplasm]
(R-HSA-174112)
PolyUb-CDC20 [nucleoplasm]
(R-HSA-6783069)
0.98
34
UniProt:Q9Y6D9 MAD1L1
1
MAD1L1 [cytosol]
(R-HSA-141433)
0.979
39
UniProt:Q15013 MD2BP
0.958
18
UniProt:Q13257 MAD2L1
2
MAD2L1 [cytosol]
(R-HSA-141400)
Activated MAD2L1 [cytosol]
(R-HSA-141447)
0.889
9
UniProt:O60566 BUB1B
1
BUB1B [cytosol]
(R-HSA-141436)
0.883
14
UniProt:P30260 CDC27
2
CDC27 [cytosol]
(R-HSA-174073)
CDC27 [nucleoplasm]
(R-HSA-174175)
0.871
8
UniProt:Q14145 KEAP1
3
Ub-KEAP1 [cytosol]
(R-HSA-6782766)
ub-KEAP1 [cytosol]
(R-HSA-9766647)
KEAP1 [cytosol]
(R-HSA-976038)
0.834
8
UniProt:Q9Y3Q8 T22D4
0.743
5
IntAct:EBI-1563533 MAD2 PEPTIDE
0.667
3
UniProt:Q562F6 SGO2
1
SGOL2 [cytosol]
(R-HSA-376242)
0.649
10
UniProt:P06213 INSR
6
p-6Y-INSR(763-1382) [endosome membrane]
(R-HSA-141719)
INSR(763-1382) [endosome membrane]
(R-HSA-141722)
INSR(28-758) [endosome membrane]
(R-HSA-141718)
INSR(763-1382) [plasma membrane]
(R-HSA-74669)
p-6Y-INSR(763-1382) [plasma membrane]
(R-HSA-74670)
INSR(28-758) [plasma membrane]
(R-HSA-74668)
0.608
3
UniProt:P78536 ADAM17
6
ADAM17 [endoplasmic reticulum lumen]
(R-HSA-9662763)
ADAM17(215-827) [Golgi membrane]
(R-HSA-9662839)
ADAM17(1-214) [Golgi membrane]
(R-HSA-9662784)
ADAM17 [Golgi membrane]
(R-HSA-9662835)
ADAM17(215-827) [plasma membrane]
(R-HSA-9663048)
ADAM17 [plasma membrane]
(R-HSA-179878)
0.581
3
UniProt:Q8BGZ4
2
Cdc23 [nucleoplasm]
(R-MMU-174228)
Cdc23 [cytosol]
(R-MMU-174137)
0.564
2
UniProt:Q9DCX1 MD2BP
0.564
2
UniProt:Q8R349
2
Cdc16 [nucleoplasm]
(R-MMU-174049)
Cdc16 [cytosol]
(R-MMU-174156)
0.564
2
UniProt:Q9JJ66
3
Cdc20 [nucleoplasm]
(R-MMU-6783069)
Cdc20 [nucleoplasm]
(R-MMU-174112)
Cdc20 [cytosol]
(R-MMU-141412)
0.564
2
UniProt:O00560 SDCBP
3
SDCBP [cytosol]
(R-HSA-373639)
SDCBP [extracellular region]
(R-HSA-6806206)
SDCBP [azurophil granule lumen]
(R-HSA-6799372)
0.556
3
UniProt:Q7L775 EPMIP
0.556
3
IntAct:EBI-25890541 CCSB
0.556
3
UniProt:P06213-2 INSR
0.556
3
UniProt:O75140-2 DEPDC5
0.556
3
UniProt:Q9UJX5 ANAPC4
2
ANAPC4 [cytosol]
(R-HSA-174168)
ANAPC4 [nucleoplasm]
(R-HSA-174115)
0.527
5
© 2023
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text