Reactome | Activated MAD2L1 [cytosol]

Activated MAD2L1 [cytosol]

Stable Identifier

R-HSA-141447

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Icon

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q13257 MAD2L1

Gene Names

MAD2L1, MAD2

Chain

initiator methionine:, chain:2-205

Reference Genes

BioGPS Gene:4085 MAD2L1

COSMIC (genes):MAD2L1 MAD2L1

CTD Gene:4085 MAD2L1

dbSNP Gene:4085 MAD2L1

ENSEMBL:ENSG00000164109 MAD2L1

HGNC:6763 MAD2L1

KEGG:hsa:4085 MAD2L1

Monarch:4085 MAD2L1

NCBI Gene:4085 MAD2L1

OMIM:601467 MAD2L1

UCSC:Q13257 MAD2L1

Reference Transcript

RefSeq:NM_002358.4 MAD2L1

Participates

as a component of

as an input of

as an output of

Release of activated MAD2 from kinetochores (Homo sapiens)

Other forms of this molecule

MAD2L1 [cytosol]

Inferred To

Mad2l1 [cytosol] (Mus musculus)

Mad2l1 [cytosol] (Rattus norvegicus)

MAD2L1 [cytosol] (Bos taurus)

MAD2L1 [cytosol] (Canis familiaris)

MAD2L1 [cytosol] (Gallus gallus)

MAD2L1 [cytosol] (Sus scrofa)

mdf-2 [cytosol] (Caenorhabditis elegans)

MAD2 [cytosol] (Saccharomyces cerevisiae)

mad2 [cytosol] (Drosophila melanogaster)

mad2 [cytosol] (Schizosaccharomyces pombe)

mad2l1 [cytosol] (Danio rerio)

mad2l1 [cytosol] (Xenopus tropicalis)

mad2l1-1; mad2l1-2 [cytosol] (Dictyostelium discoideum)

Cross References

RefSeq

NP_002349.1

OpenTargets

ENSG00000164109

ENSEMBL

ENST00000333047, ENST00000296509, ENSG00000164109, ENSP00000332295, ENSP00000296509

GeneCards

MAD2L1

HPA

ENSG00000164109-MAD2L1

PRO

Q13257

Pharos - Targets

Q13257

PDB

1GO4, 5KHU, 2V64, 2VFX, 6TLJ, 3GMH, 6F0X, 1DUJ, 1S2H, 2QYF, 5LCW, 1KLQ

Interactors (54)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q12834 CDC20	3	CDC20 [cytosol] (R-HSA-141412) CDC20 [nucleoplasm] (R-HSA-174112) PolyUb-CDC20 [nucleoplasm] (R-HSA-6783069)	0.982	39
UniProt:Q9Y6D9 MAD1L1	1	MAD1L1 [cytosol] (R-HSA-141433)	0.982	51
UniProt:Q15013 MD2BP			0.963	21
UniProt:P30260 CDC27	2	CDC27 [cytosol] (R-HSA-174073) CDC27 [nucleoplasm] (R-HSA-174175)	0.922	11
UniProt:O60566 BUB1B	1	BUB1B [cytosol] (R-HSA-141436)	0.914	15
UniProt:Q13257 MAD2L1	2	MAD2L1 [cytosol] (R-HSA-141400) Activated MAD2L1 [cytosol] (R-HSA-141447)	0.889	9
UniProt:Q14145 KEAP1	3	KEAP1 [cytosol] (R-HSA-976038) ub-KEAP1 [cytosol] (R-HSA-9766647) Ub-KEAP1 [cytosol] (R-HSA-6782766)	0.831	8
UniProt:Q9Y3Q8 T22D4			0.801	8
UniProt:Q7L775 EPMIP			0.742	5
UniProt:Q562F6 SGO2	1	SGOL2 [cytosol] (R-HSA-376242)	0.731	11
UniProt:Q9UJX5 ANAPC4	2	ANAPC4 [cytosol] (R-HSA-174168) ANAPC4 [nucleoplasm] (R-HSA-174115)	0.725	7
UniProt:P06213 INSR	6	INSR(28-758) [plasma membrane] (R-HSA-74668) p-6Y-INSR(763-1382) [plasma membrane] (R-HSA-74670) INSR(763-1382) [plasma membrane] (R-HSA-74669) INSR(28-758) [endosome membrane] (R-HSA-141718) INSR(763-1382) [endosome membrane] (R-HSA-141722) p-6Y-INSR(763-1382) [endosome membrane] (R-HSA-141719)	0.701	4
IntAct:EBI-1563533 MAD2 PEPTIDE			0.667	3
UniProt:O95235 KIF20A	3	KIF20A [cytosol] (R-HSA-1015868) p-S528-KIF20A [nucleoplasm] (R-HSA-156685) KIF20A [nucleoplasm] (R-HSA-156721)	0.643	3
UniProt:Q9UJX2 CDC23	2	CDC23 [cytosol] (R-HSA-174137) CDC23 [nucleoplasm] (R-HSA-174228)	0.643	3
UniProt:Q9Y2K7 KDM2A	1	KDM2A [nucleoplasm] (R-HSA-3214392)	0.643	4
UniProt:P78536 ADAM17	6	ADAM17 [plasma membrane] (R-HSA-179878) ADAM17(215-827) [plasma membrane] (R-HSA-9663048) ADAM17 [Golgi membrane] (R-HSA-9662835) ADAM17(1-214) [Golgi membrane] (R-HSA-9662784) ADAM17(215-827) [Golgi membrane] (R-HSA-9662839) ADAM17 [endoplasmic reticulum lumen] (R-HSA-9662763)	0.581	3
UniProt:Q9JJ66	3	Cdc20 [nucleoplasm] (R-MMU-6783069) Cdc20 [nucleoplasm] (R-MMU-174112) Cdc20 [cytosol] (R-MMU-141412)	0.564	2
UniProt:Q9DCX1 MD2BP			0.564	2
UniProt:Q8BGZ4	2	Cdc23 [nucleoplasm] (R-MMU-174228) Cdc23 [cytosol] (R-MMU-174137)	0.564	2
UniProt:Q8R349	2	Cdc16 [nucleoplasm] (R-MMU-174049) Cdc16 [cytosol] (R-MMU-174156)	0.564	2
UniProt:O00560 SDCBP	3	SDCBP [cytosol] (R-HSA-373639) SDCBP [azurophil granule lumen] (R-HSA-6799372) SDCBP [extracellular region] (R-HSA-6806206)	0.556	3
IntAct:EBI-25890541 CCSB			0.556	3
UniProt:O75140-2 DEPDC5			0.556	3
UniProt:P06213-2 INSR			0.556	3
UniProt:Q9H2P0 ADNP			0.527	2
UniProt:O76064 RNF8	1	RNF8 [nucleoplasm] (R-HSA-5682539)	0.527	2
UniProt:Q3V6T2 CCDC88A	1	CCDC88A [cytosol] (R-HSA-9715191)	0.527	2
UniProt:Q8TEQ6 GEMIN5	2	GEMIN5 [cytosol] (R-HSA-191833) GEMIN5 [nucleoplasm] (R-HSA-191765)	0.527	3
UniProt:P49643 PRIM2	1	PRIM2 [nucleoplasm] (R-HSA-68495)	0.527	2
UniProt:Q9H1A4 ANAPC1	2	ANAPC1 [cytosol] (R-HSA-174189) ANAPC1 [nucleoplasm] (R-HSA-174217)	0.527	2
UniProt:Q8N6N3 CA052			0.527	3
UniProt:P41212 ETV6	14	ETV6(1-384)-p-6Y-FLT3(573-993) fusion [cytosol] (R-HSA-9703308) ETV6(1-154)insGSFILG-p-6Y-FLT3(573-993) fusion [cytosol] (R-HSA-9703302) ETV6(1-336)insGCS-p-6Y-FLT3(573-993) fusion [cytosol] (R-HSA-9703305) ETV6(1-301)-p-6Y-FLT3(574-993) fusion [cytosol] (R-HSA-9703318) ETV6(1-384)-p-3Y-FLT3(659-1620) fusion [cytosol] (R-HSA-9703313) ETV6(1-154)insGSFILG-FLT3(573-993) fusion [cytosol] (R-HSA-9703312) ETV6(1-336)insGCS-FLT3(573-993) fusion [cytosol] (R-HSA-9703320) ETV6(1-384)-FLT3(573-993) fusion [cytosol] (R-HSA-9703307) ETV6(1-301)-FLT3(574-993) fusion [cytosol] (R-HSA-9703315) ETV6(1-384)-FLT3(569-993) fusion [cytosol] (R-HSA-9697944) ETV6(1-384)-PDGFRA(552-1089) fusion [plasma membrane] (R-HSA-9673898) ETV6(1-154)-PDGFRB(527-1106) fusion [plasma membrane] (R-HSA-9673893) p-11Y-ETV6(1-384)-PDGFRA(552-1089) fusion [plasma membrane] (R-HSA-9673905) p-12Y-ETV6(1-154)-PDGFRB(527-1106) fusion [plasma membrane] (R-HSA-9673912)	0.527	2
UniProt:Q9UBZ4 APEX2			0.527	2
UniProt:Q13042 CDC16	2	CDC16 [cytosol] (R-HSA-174156) CDC16 [nucleoplasm] (R-HSA-174049)	0.527	3
UniProt:Q9UPN9 TRIM33	1	TRIM33 [nucleoplasm] (R-HSA-870522)	0.527	2
UniProt:O75380 NDUFS6	1	NDUFS6 [mitochondrial inner membrane] (R-HSA-163922)	0.527	2
UniProt:Q14839 CHD4	1	CHD4 [nucleoplasm] (R-HSA-3702078)	0.527	2
UniProt:Q13309 SKP2	3	SKP2 [nucleoplasm] (R-HSA-975554) PolyUb-SKP2 [nucleoplasm] (R-HSA-9687073) SKP2 [cytosol] (R-HSA-975495)	0.527	2
UniProt:O43511 SLC26A4	6	SLC26A4 T416P [plasma membrane] (R-HSA-5627850) SLC26A4 H723R [plasma membrane] (R-HSA-5627865) SLC26A4 L236P [plasma membrane] (R-HSA-5627857) SLC26A4 F667C [plasma membrane] (R-HSA-5627873) SLC26A4 E384G [plasma membrane] (R-HSA-5627860) SLC26A4 [plasma membrane] (R-HSA-425403)	0.527	2
UniProt:P09884 POLA1	1	POLA1 [nucleoplasm] (R-HSA-68487)	0.527	3
UniProt:Q9H8H0 NOL11	1	NOL11 [nucleoplasm] (R-HSA-6790684)	0.527	3
UniProt:Q9Y232 CDYL			0.527	3
UniProt:Q15545 TAF7	1	TAF7 [nucleoplasm] (R-HSA-212347)	0.527	2
UniProt:Q6ZRI6 CO039			0.527	3
UniProt:Q8WWK9 CKAP2			0.527	2
UniProt:O95873 CF047			0.527	2
UniProt:Q5JTV8 TOR1AIP1	1	TOR1AIP1 [cytosol] (R-HSA-9715083)	0.527	2
UniProt:Q14181 POLA2	1	POLA2 [nucleoplasm] (R-HSA-68493)	0.527	2
UniProt:Q96RK0 CIC			0.527	2
UniProt:Q9UHF7 TRPS1			0.527	2
UniProt:O43314 PPIP5K2	1	PPIP5K2 [cytosol] (R-HSA-1604631)	0.527	2
UniProt:Q9ULJ3 ZBT21			0.527	2
UniProt:Q6ZRS2 SRCAP			0.527	2

Cite Us!