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Activated MAD2L1 [cytosol]
Stable Identifier
R-HSA-141447
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Icon
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle Checkpoints (Homo sapiens)
Mitotic Spindle Checkpoint (Homo sapiens)
Amplification of signal from the kinetochores (Homo sapiens)
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (Homo sapiens)
MAD2 converted to an inhibitory state via interaction with Mad1 (Homo sapiens)
Kinetochore:Mad1:MAD2* Complex [cytosol] (Homo sapiens)
Activated MAD2L1 [cytosol] (Homo sapiens)
Release of activated MAD2 from kinetochores (Homo sapiens)
Activated MAD2L1 [cytosol] (Homo sapiens)
Kinetochore:Mad1:MAD2* Complex [cytosol] (Homo sapiens)
Activated MAD2L1 [cytosol] (Homo sapiens)
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components (Homo sapiens)
Inactivation of APC/C via CDC20 sequestration (Homo sapiens)
Activated MAD2L1 [cytosol] (Homo sapiens)
MAD2*CDC20 complex [cytosol] (Homo sapiens)
Activated MAD2L1 [cytosol] (Homo sapiens)
Inactivation of APC/C via direct inhibition of the APC/C complex (Homo sapiens)
Binding of the MCC complex to the APC/C complex (Homo sapiens)
MCC:APC/C complex [cytosol] (Homo sapiens)
hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Homo sapiens)
Activated MAD2L1 [cytosol] (Homo sapiens)
hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Homo sapiens)
Activated MAD2L1 [cytosol] (Homo sapiens)
Formation of the MCC complex (Homo sapiens)
Activated MAD2L1 [cytosol] (Homo sapiens)
hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Homo sapiens)
Activated MAD2L1 [cytosol] (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Regulation of mitotic cell cycle (Homo sapiens)
APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (Homo sapiens)
APC/C:Cdc20 mediated degradation of mitotic proteins (Homo sapiens)
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint (Homo sapiens)
APC-Cdc20 mediated degradation of Nek2A (Homo sapiens)
Association of Nek2A with MCC:APC/C (Homo sapiens)
MCC:APC/C complex [cytosol] (Homo sapiens)
hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Homo sapiens)
Activated MAD2L1 [cytosol] (Homo sapiens)
Nek2A:MCC:APC/C complex [cytosol] (Homo sapiens)
MCC:APC/C complex [cytosol] (Homo sapiens)
hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Homo sapiens)
Activated MAD2L1 [cytosol] (Homo sapiens)
Degradation of multiubiquitinated Nek2A (Homo sapiens)
MCC:APC/C complex [cytosol] (Homo sapiens)
hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Homo sapiens)
Activated MAD2L1 [cytosol] (Homo sapiens)
Multiubiquitinated Nek2A [cytosol] (Homo sapiens)
Nek2A:MCC:APC/C complex [cytosol] (Homo sapiens)
MCC:APC/C complex [cytosol] (Homo sapiens)
hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Homo sapiens)
Activated MAD2L1 [cytosol] (Homo sapiens)
Multiubiquitination of Nek2A (Homo sapiens)
Multiubiquitinated Nek2A [cytosol] (Homo sapiens)
Nek2A:MCC:APC/C complex [cytosol] (Homo sapiens)
MCC:APC/C complex [cytosol] (Homo sapiens)
hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Homo sapiens)
Activated MAD2L1 [cytosol] (Homo sapiens)
Nek2A:MCC:APC/C complex [cytosol] (Homo sapiens)
MCC:APC/C complex [cytosol] (Homo sapiens)
hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Homo sapiens)
Activated MAD2L1 [cytosol] (Homo sapiens)
Cdc20:Phospho-APC/C mediated degradation of Cyclin A (Homo sapiens)
Association of Cyclin A with the APC/C (Homo sapiens)
Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Homo sapiens)
MCC:APC/C complex [cytosol] (Homo sapiens)
hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Homo sapiens)
Activated MAD2L1 [cytosol] (Homo sapiens)
MCC:APC/C complex [cytosol] (Homo sapiens)
hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Homo sapiens)
Activated MAD2L1 [cytosol] (Homo sapiens)
Degradation multiubiquitinated Cyclin A (Homo sapiens)
MCC:APC/C complex [cytosol] (Homo sapiens)
hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Homo sapiens)
Activated MAD2L1 [cytosol] (Homo sapiens)
multiubiquitinated Cyclin A associated with MCC:APC/C complex [cytosol] (Homo sapiens)
Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Homo sapiens)
MCC:APC/C complex [cytosol] (Homo sapiens)
hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Homo sapiens)
Activated MAD2L1 [cytosol] (Homo sapiens)
Ubiquitination of Cyclin A by APC/C:Cdc20 complex (Homo sapiens)
Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Homo sapiens)
MCC:APC/C complex [cytosol] (Homo sapiens)
hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Homo sapiens)
Activated MAD2L1 [cytosol] (Homo sapiens)
MCC:APC/C complex [cytosol] (Homo sapiens)
hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Homo sapiens)
Activated MAD2L1 [cytosol] (Homo sapiens)
multiubiquitinated Cyclin A associated with MCC:APC/C complex [cytosol] (Homo sapiens)
Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Homo sapiens)
MCC:APC/C complex [cytosol] (Homo sapiens)
hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Homo sapiens)
Activated MAD2L1 [cytosol] (Homo sapiens)
Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 (Homo sapiens)
MCC:APC/C complex [cytosol] (Homo sapiens)
hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Homo sapiens)
Activated MAD2L1 [cytosol] (Homo sapiens)
hBUBR1:hBUB3:MAD2* complex [cytosol] (Homo sapiens)
Activated MAD2L1 [cytosol] (Homo sapiens)
Regulation of APC/C activators between G1/S and early anaphase (Homo sapiens)
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components (Homo sapiens)
Inactivation of APC/C via CDC20 sequestration (Homo sapiens)
Activated MAD2L1 [cytosol] (Homo sapiens)
MAD2*CDC20 complex [cytosol] (Homo sapiens)
Activated MAD2L1 [cytosol] (Homo sapiens)
Inactivation of APC/C via direct inhibition of the APC/C complex (Homo sapiens)
Binding of the MCC complex to the APC/C complex (Homo sapiens)
MCC:APC/C complex [cytosol] (Homo sapiens)
hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Homo sapiens)
Activated MAD2L1 [cytosol] (Homo sapiens)
hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Homo sapiens)
Activated MAD2L1 [cytosol] (Homo sapiens)
Formation of the MCC complex (Homo sapiens)
Activated MAD2L1 [cytosol] (Homo sapiens)
hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Homo sapiens)
Activated MAD2L1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13257 MAD2L1
Gene Names
MAD2L1, MAD2
Chain
initiator methionine:, chain:2-205
Reference Genes
BioGPS Gene:4085 MAD2L1
COSMIC (genes):MAD2L1 MAD2L1
CTD Gene:4085 MAD2L1
dbSNP Gene:4085 MAD2L1
ENSEMBL:ENSG00000164109 MAD2L1
HGNC:6763 MAD2L1
KEGG:hsa:4085 MAD2L1
Monarch:4085 MAD2L1
NCBI Gene:4085 MAD2L1
OMIM:601467 MAD2L1
UCSC:Q13257 MAD2L1
Reference Transcript
RefSeq:NM_002358.4 MAD2L1
Participates
as a component of
MAD2*CDC20 complex [cytosol] (Homo sapiens)
hBUBR1:hBUB3:MAD2* complex [cytosol] (Homo sapiens)
hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Homo sapiens)
Kinetochore:Mad1:MAD2* Complex [cytosol] (Homo sapiens)
as an input of
Inactivation of APC/C via CDC20 sequestration (Homo sapiens)
Formation of the MCC complex (Homo sapiens)
as an output of
Release of activated MAD2 from kinetochores (Homo sapiens)
Other forms of this molecule
MAD2L1 [cytosol]
Inferred To
Mad2l1 [cytosol]
(Mus musculus)
Mad2l1 [cytosol]
(Rattus norvegicus)
MAD2L1 [cytosol]
(Bos taurus)
MAD2L1 [cytosol]
(Canis familiaris)
MAD2L1 [cytosol]
(Gallus gallus)
MAD2L1 [cytosol]
(Sus scrofa)
mdf-2 [cytosol]
(Caenorhabditis elegans)
MAD2 [cytosol]
(Saccharomyces cerevisiae)
mad2 [cytosol]
(Drosophila melanogaster)
mad2 [cytosol]
(Schizosaccharomyces pombe)
mad2l1 [cytosol]
(Danio rerio)
mad2l1 [cytosol]
(Xenopus tropicalis)
mad2l1-1; mad2l1-2 [cytosol]
(Dictyostelium discoideum)
Cross References
RefSeq
NP_002349.1
OpenTargets
ENSG00000164109
ENSEMBL
ENST00000333047
,
ENST00000296509
,
ENSG00000164109
,
ENSP00000332295
,
ENSP00000296509
GeneCards
MAD2L1
HPA
ENSG00000164109-MAD2L1
PRO
Q13257
Pharos - Targets
Q13257
PDB
1GO4
,
5KHU
,
2V64
,
2VFX
,
6TLJ
,
3GMH
,
6F0X
,
1DUJ
,
1S2H
,
2QYF
,
5LCW
,
1KLQ
Interactors (54)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q12834 CDC20
3
CDC20 [cytosol]
(R-HSA-141412)
CDC20 [nucleoplasm]
(R-HSA-174112)
PolyUb-CDC20 [nucleoplasm]
(R-HSA-6783069)
0.982
39
UniProt:Q9Y6D9 MAD1L1
1
MAD1L1 [cytosol]
(R-HSA-141433)
0.982
51
UniProt:Q15013 MD2BP
0.963
21
UniProt:P30260 CDC27
2
CDC27 [cytosol]
(R-HSA-174073)
CDC27 [nucleoplasm]
(R-HSA-174175)
0.922
11
UniProt:O60566 BUB1B
1
BUB1B [cytosol]
(R-HSA-141436)
0.914
15
UniProt:Q13257 MAD2L1
2
MAD2L1 [cytosol]
(R-HSA-141400)
Activated MAD2L1 [cytosol]
(R-HSA-141447)
0.889
9
UniProt:Q14145 KEAP1
3
KEAP1 [cytosol]
(R-HSA-976038)
ub-KEAP1 [cytosol]
(R-HSA-9766647)
Ub-KEAP1 [cytosol]
(R-HSA-6782766)
0.831
8
UniProt:Q9Y3Q8 T22D4
0.801
8
UniProt:Q7L775 EPMIP
0.742
5
UniProt:Q562F6 SGO2
1
SGOL2 [cytosol]
(R-HSA-376242)
0.731
11
UniProt:Q9UJX5 ANAPC4
2
ANAPC4 [cytosol]
(R-HSA-174168)
ANAPC4 [nucleoplasm]
(R-HSA-174115)
0.725
7
UniProt:P06213 INSR
6
INSR(28-758) [plasma membrane]
(R-HSA-74668)
p-6Y-INSR(763-1382) [plasma membrane]
(R-HSA-74670)
INSR(763-1382) [plasma membrane]
(R-HSA-74669)
INSR(28-758) [endosome membrane]
(R-HSA-141718)
INSR(763-1382) [endosome membrane]
(R-HSA-141722)
p-6Y-INSR(763-1382) [endosome membrane]
(R-HSA-141719)
0.701
4
IntAct:EBI-1563533 MAD2 PEPTIDE
0.667
3
UniProt:O95235 KIF20A
3
KIF20A [cytosol]
(R-HSA-1015868)
p-S528-KIF20A [nucleoplasm]
(R-HSA-156685)
KIF20A [nucleoplasm]
(R-HSA-156721)
0.643
3
UniProt:Q9UJX2 CDC23
2
CDC23 [cytosol]
(R-HSA-174137)
CDC23 [nucleoplasm]
(R-HSA-174228)
0.643
3
UniProt:Q9Y2K7 KDM2A
1
KDM2A [nucleoplasm]
(R-HSA-3214392)
0.643
4
UniProt:P78536 ADAM17
6
ADAM17 [plasma membrane]
(R-HSA-179878)
ADAM17(215-827) [plasma membrane]
(R-HSA-9663048)
ADAM17 [Golgi membrane]
(R-HSA-9662835)
ADAM17(1-214) [Golgi membrane]
(R-HSA-9662784)
ADAM17(215-827) [Golgi membrane]
(R-HSA-9662839)
ADAM17 [endoplasmic reticulum lumen]
(R-HSA-9662763)
0.581
3
UniProt:Q9JJ66
3
Cdc20 [nucleoplasm]
(R-MMU-6783069)
Cdc20 [nucleoplasm]
(R-MMU-174112)
Cdc20 [cytosol]
(R-MMU-141412)
0.564
2
UniProt:Q9DCX1 MD2BP
0.564
2
UniProt:Q8BGZ4
2
Cdc23 [nucleoplasm]
(R-MMU-174228)
Cdc23 [cytosol]
(R-MMU-174137)
0.564
2
UniProt:Q8R349
2
Cdc16 [nucleoplasm]
(R-MMU-174049)
Cdc16 [cytosol]
(R-MMU-174156)
0.564
2
UniProt:O00560 SDCBP
3
SDCBP [cytosol]
(R-HSA-373639)
SDCBP [azurophil granule lumen]
(R-HSA-6799372)
SDCBP [extracellular region]
(R-HSA-6806206)
0.556
3
IntAct:EBI-25890541 CCSB
0.556
3
UniProt:O75140-2 DEPDC5
0.556
3
UniProt:P06213-2 INSR
0.556
3
UniProt:Q9H2P0 ADNP
0.527
2
UniProt:O76064 RNF8
1
RNF8 [nucleoplasm]
(R-HSA-5682539)
0.527
2
UniProt:Q3V6T2 CCDC88A
1
CCDC88A [cytosol]
(R-HSA-9715191)
0.527
2
UniProt:Q8TEQ6 GEMIN5
2
GEMIN5 [cytosol]
(R-HSA-191833)
GEMIN5 [nucleoplasm]
(R-HSA-191765)
0.527
3
UniProt:P49643 PRIM2
1
PRIM2 [nucleoplasm]
(R-HSA-68495)
0.527
2
UniProt:Q9H1A4 ANAPC1
2
ANAPC1 [cytosol]
(R-HSA-174189)
ANAPC1 [nucleoplasm]
(R-HSA-174217)
0.527
2
UniProt:Q8N6N3 CA052
0.527
3
UniProt:P41212 ETV6
14
ETV6(1-384)-p-6Y-FLT3(573-993) fusion [cytosol]
(R-HSA-9703308)
ETV6(1-154)insGSFILG-p-6Y-FLT3(573-993) fusion [cytosol]
(R-HSA-9703302)
ETV6(1-336)insGCS-p-6Y-FLT3(573-993) fusion [cytosol]
(R-HSA-9703305)
ETV6(1-301)-p-6Y-FLT3(574-993) fusion [cytosol]
(R-HSA-9703318)
ETV6(1-384)-p-3Y-FLT3(659-1620) fusion [cytosol]
(R-HSA-9703313)
ETV6(1-154)insGSFILG-FLT3(573-993) fusion [cytosol]
(R-HSA-9703312)
ETV6(1-336)insGCS-FLT3(573-993) fusion [cytosol]
(R-HSA-9703320)
ETV6(1-384)-FLT3(573-993) fusion [cytosol]
(R-HSA-9703307)
ETV6(1-301)-FLT3(574-993) fusion [cytosol]
(R-HSA-9703315)
ETV6(1-384)-FLT3(569-993) fusion [cytosol]
(R-HSA-9697944)
ETV6(1-384)-PDGFRA(552-1089) fusion [plasma membrane]
(R-HSA-9673898)
ETV6(1-154)-PDGFRB(527-1106) fusion [plasma membrane]
(R-HSA-9673893)
p-11Y-ETV6(1-384)-PDGFRA(552-1089) fusion [plasma membrane]
(R-HSA-9673905)
p-12Y-ETV6(1-154)-PDGFRB(527-1106) fusion [plasma membrane]
(R-HSA-9673912)
0.527
2
UniProt:Q9UBZ4 APEX2
0.527
2
UniProt:Q13042 CDC16
2
CDC16 [cytosol]
(R-HSA-174156)
CDC16 [nucleoplasm]
(R-HSA-174049)
0.527
3
UniProt:Q9UPN9 TRIM33
1
TRIM33 [nucleoplasm]
(R-HSA-870522)
0.527
2
UniProt:O75380 NDUFS6
1
NDUFS6 [mitochondrial inner membrane]
(R-HSA-163922)
0.527
2
UniProt:Q14839 CHD4
1
CHD4 [nucleoplasm]
(R-HSA-3702078)
0.527
2
UniProt:Q13309 SKP2
3
SKP2 [nucleoplasm]
(R-HSA-975554)
PolyUb-SKP2 [nucleoplasm]
(R-HSA-9687073)
SKP2 [cytosol]
(R-HSA-975495)
0.527
2
UniProt:O43511 SLC26A4
6
SLC26A4 T416P [plasma membrane]
(R-HSA-5627850)
SLC26A4 H723R [plasma membrane]
(R-HSA-5627865)
SLC26A4 L236P [plasma membrane]
(R-HSA-5627857)
SLC26A4 F667C [plasma membrane]
(R-HSA-5627873)
SLC26A4 E384G [plasma membrane]
(R-HSA-5627860)
SLC26A4 [plasma membrane]
(R-HSA-425403)
0.527
2
UniProt:P09884 POLA1
1
POLA1 [nucleoplasm]
(R-HSA-68487)
0.527
3
UniProt:Q9H8H0 NOL11
1
NOL11 [nucleoplasm]
(R-HSA-6790684)
0.527
3
UniProt:Q9Y232 CDYL
0.527
3
UniProt:Q15545 TAF7
1
TAF7 [nucleoplasm]
(R-HSA-212347)
0.527
2
UniProt:Q6ZRI6 CO039
0.527
3
UniProt:Q8WWK9 CKAP2
0.527
2
UniProt:O95873 CF047
0.527
2
UniProt:Q5JTV8 TOR1AIP1
1
TOR1AIP1 [cytosol]
(R-HSA-9715083)
0.527
2
UniProt:Q14181 POLA2
1
POLA2 [nucleoplasm]
(R-HSA-68493)
0.527
2
UniProt:Q96RK0 CIC
0.527
2
UniProt:Q9UHF7 TRPS1
0.527
2
UniProt:O43314 PPIP5K2
1
PPIP5K2 [cytosol]
(R-HSA-1604631)
0.527
2
UniProt:Q9ULJ3 ZBT21
0.527
2
UniProt:Q6ZRS2 SRCAP
0.527
2
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