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Activated MAD2L1
Stable Identifier
R-HSA-141447
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle Checkpoints (Homo sapiens)
Mitotic Spindle Checkpoint (Homo sapiens)
Amplification of signal from the kinetochores (Homo sapiens)
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (Homo sapiens)
MAD2 converted to an inhibitory state via interaction with Mad1 (Homo sapiens)
Kinetochore:Mad1:MAD2* Complex [cytosol] (Homo sapiens)
Activated MAD2L1 [cytosol] (Homo sapiens)
Release of activated MAD2 from kinetochores (Homo sapiens)
Activated MAD2L1 [cytosol] (Homo sapiens)
Kinetochore:Mad1:MAD2* Complex [cytosol] (Homo sapiens)
Activated MAD2L1 [cytosol] (Homo sapiens)
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components (Homo sapiens)
Inactivation of APC/C via CDC20 sequestration (Homo sapiens)
Activated MAD2L1 [cytosol] (Homo sapiens)
MAD2*CDC20 complex [cytosol] (Homo sapiens)
Activated MAD2L1 [cytosol] (Homo sapiens)
Inactivation of APC/C via direct inhibition of the APC/C complex (Homo sapiens)
Binding of the MCC complex to the APC/C complex (Homo sapiens)
MCC:APC/C complex [cytosol] (Homo sapiens)
hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Homo sapiens)
Activated MAD2L1 [cytosol] (Homo sapiens)
hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Homo sapiens)
Activated MAD2L1 [cytosol] (Homo sapiens)
Formation of the MCC complex (Homo sapiens)
Activated MAD2L1 [cytosol] (Homo sapiens)
hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Homo sapiens)
Activated MAD2L1 [cytosol] (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Regulation of mitotic cell cycle (Homo sapiens)
APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (Homo sapiens)
APC/C:Cdc20 mediated degradation of mitotic proteins (Homo sapiens)
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint (Homo sapiens)
APC-Cdc20 mediated degradation of Nek2A (Homo sapiens)
Association of Nek2A with MCC:APC/C (Homo sapiens)
MCC:APC/C complex [cytosol] (Homo sapiens)
hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Homo sapiens)
Activated MAD2L1 [cytosol] (Homo sapiens)
Nek2A:MCC:APC/C complex [cytosol] (Homo sapiens)
MCC:APC/C complex [cytosol] (Homo sapiens)
hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Homo sapiens)
Activated MAD2L1 [cytosol] (Homo sapiens)
Degradation of multiubiquitinated Nek2A (Homo sapiens)
MCC:APC/C complex [cytosol] (Homo sapiens)
hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Homo sapiens)
Activated MAD2L1 [cytosol] (Homo sapiens)
Multiubiquitinated Nek2A [cytosol] (Homo sapiens)
Nek2A:MCC:APC/C complex [cytosol] (Homo sapiens)
MCC:APC/C complex [cytosol] (Homo sapiens)
hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Homo sapiens)
Activated MAD2L1 [cytosol] (Homo sapiens)
Multiubiquitination of Nek2A (Homo sapiens)
Multiubiquitinated Nek2A [cytosol] (Homo sapiens)
Nek2A:MCC:APC/C complex [cytosol] (Homo sapiens)
MCC:APC/C complex [cytosol] (Homo sapiens)
hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Homo sapiens)
Activated MAD2L1 [cytosol] (Homo sapiens)
Nek2A:MCC:APC/C complex [cytosol] (Homo sapiens)
MCC:APC/C complex [cytosol] (Homo sapiens)
hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Homo sapiens)
Activated MAD2L1 [cytosol] (Homo sapiens)
Cdc20:Phospho-APC/C mediated degradation of Cyclin A (Homo sapiens)
Association of Cyclin A with the APC/C (Homo sapiens)
Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Homo sapiens)
MCC:APC/C complex [cytosol] (Homo sapiens)
hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Homo sapiens)
Activated MAD2L1 [cytosol] (Homo sapiens)
MCC:APC/C complex [cytosol] (Homo sapiens)
hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Homo sapiens)
Activated MAD2L1 [cytosol] (Homo sapiens)
Degradation multiubiquitinated Cyclin A (Homo sapiens)
MCC:APC/C complex [cytosol] (Homo sapiens)
hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Homo sapiens)
Activated MAD2L1 [cytosol] (Homo sapiens)
multiubiquitinated Cyclin A associated with MCC:APC/C complex [cytosol] (Homo sapiens)
Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Homo sapiens)
MCC:APC/C complex [cytosol] (Homo sapiens)
hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Homo sapiens)
Activated MAD2L1 [cytosol] (Homo sapiens)
Ubiquitination of Cyclin A by APC/C:Cdc20 complex (Homo sapiens)
Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Homo sapiens)
MCC:APC/C complex [cytosol] (Homo sapiens)
hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Homo sapiens)
Activated MAD2L1 [cytosol] (Homo sapiens)
MCC:APC/C complex [cytosol] (Homo sapiens)
hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Homo sapiens)
Activated MAD2L1 [cytosol] (Homo sapiens)
multiubiquitinated Cyclin A associated with MCC:APC/C complex [cytosol] (Homo sapiens)
Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Homo sapiens)
MCC:APC/C complex [cytosol] (Homo sapiens)
hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Homo sapiens)
Activated MAD2L1 [cytosol] (Homo sapiens)
Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 (Homo sapiens)
MCC:APC/C complex [cytosol] (Homo sapiens)
hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Homo sapiens)
Activated MAD2L1 [cytosol] (Homo sapiens)
hBUBR1:hBUB3:MAD2* complex [cytosol] (Homo sapiens)
Activated MAD2L1 [cytosol] (Homo sapiens)
Regulation of APC/C activators between G1/S and early anaphase (Homo sapiens)
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components (Homo sapiens)
Inactivation of APC/C via CDC20 sequestration (Homo sapiens)
Activated MAD2L1 [cytosol] (Homo sapiens)
MAD2*CDC20 complex [cytosol] (Homo sapiens)
Activated MAD2L1 [cytosol] (Homo sapiens)
Inactivation of APC/C via direct inhibition of the APC/C complex (Homo sapiens)
Binding of the MCC complex to the APC/C complex (Homo sapiens)
MCC:APC/C complex [cytosol] (Homo sapiens)
hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Homo sapiens)
Activated MAD2L1 [cytosol] (Homo sapiens)
hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Homo sapiens)
Activated MAD2L1 [cytosol] (Homo sapiens)
Formation of the MCC complex (Homo sapiens)
Activated MAD2L1 [cytosol] (Homo sapiens)
hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Homo sapiens)
Activated MAD2L1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13257 MAD2L1
Gene Names
MAD2L1, MAD2
Chain
initiator methionine:1, chain:2-205
Reference Genes
BioGPS Gene:4085 MAD2L1
COSMIC (genes):MAD2L1 MAD2L1
CTD Gene:4085 MAD2L1
dbSNP Gene:4085 MAD2L1
ENSEMBL:ENSG00000164109 MAD2L1
ENSEMBL:ENSG00000164109 MAD2L1
HGNC:6763 MAD2L1
KEGG Gene (Homo sapiens):hsa:4085 MAD2L1
Monarch:4085 MAD2L1
NCBI Gene:4085 MAD2L1
OMIM:601467 MAD2L1
UCSC:Q13257 MAD2L1
Reference Transcript
RefSeq:NM_002358.3 MAD2L1
Other Identifiers
0003850519
11720185_a_at
11720186_s_at
11748136_a_at
1554768_a_at
16979389
1721_g_at
1DUJ
1KLQ
1S2H
203362_s_at
236312_at
2783728
2783729
2783730
2783731
2783732
2783733
2783734
2783735
2783736
2783737
2783739
2783742
2783743
2783744
2783745
2QYF
2V64
2VFX
3348
3538716
3538718
3538720
3538721
3538722
37282_at
3GMH
4085
46436_at
55824_at
5KHU
5LCW
8102560
A_23_P92441
AAC50781
AAC52060
AAH00356
AAH05945
AAH70283
AAK38174
AAN74648
AAY40945
AB056160
AC097173
AF202269
AF202270
AF202271
AF202272
AF202273
AF394735
AJ000186
AK223433
AK298228
AK313827
BAB63410
BAD97153
BAG36562
BAG60497
BC000356
BC005945
BC070283
CAA03943
CCDS3715
CH471056
EAX05271
EAX05273
ENSG00000164109
ENSP00000296509
ENSP00000332295
ENST00000296509
ENST00000333047
EntrezGene:4085
g6466452_3p_s_at
GE59318
GO:0000070
GO:0000278
GO:0000775
GO:0000776
GO:0000777
GO:0000922
GO:0003674
GO:0005515
GO:0005575
GO:0005622
GO:0005623
GO:0005634
GO:0005635
GO:0005643
GO:0005654
GO:0005694
GO:0005737
GO:0005829
GO:0005856
GO:0006464
GO:0007049
GO:0007059
GO:0007062
GO:0007093
GO:0007094
GO:0008150
GO:0008219
GO:0009056
GO:0031145
GO:0042177
GO:0042802
GO:0042803
GO:0043066
GO:0043161
GO:0043226
GO:0043234
GO:0045930
GO:0048471
GO:0051276
GO:0051301
GO:0051436
GO:0051437
GO:0072686
GO:0090267
GO:0140014
GO:1904667
HGNC:6763
HPA003348
Hs.44380.0.A1_3p_at
Hs2.79078.2.S1_3p_s_at
ILMN_1777564
ILMN_2112460
IPR003511
IPR027097
IPR036570
MAD2L1
MAD2L1-201
MAD2L1-202
MIM:601467
NM_002358
NP_002349
PF02301
TC04001507.hg
U31278
U65410
U65410_at
uc003idl.3
uc003idm.3
UPI0000000A29
UPI000007408B
Participant Of
input
Formation of the MCC complex
Inactivation of APC/C via CDC20 sequestration
output
Release of activated MAD2 from kinetochores
hasComponent
hBUBR1:hBUB3:MAD2* complex [cytosol]
hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol]
Kinetochore:Mad1:MAD2* Complex [cytosol]
MAD2*CDC20 complex [cytosol]
Other forms of this molecule
MAD2L1 [cytosol]
Inferred To
Activated MAD2L1 [cytosol] (Arabidopsis thaliana)
Activated MAD2L1 [cytosol] (Caenorhabditis elegans)
Activated MAD2L1 [cytosol] (Dictyostelium discoideum)
Activated MAD2L1 [cytosol] (Drosophila melanogaster)
Activated MAD2L1 [cytosol] (Oryza sativa)
Activated MAD2L1 [cytosol] (Saccharomyces cerevisiae)
Activated MAD2L1 [cytosol] (Schizosaccharomyces pombe)
MAD2L1 [cytosol] (Bos taurus)
MAD2L1 [cytosol] (Canis familiaris)
MAD2L1 [cytosol] (Danio rerio)
MAD2L1 [cytosol] (Gallus gallus)
MAD2L1 [cytosol] (Mus musculus)
MAD2L1 [cytosol] (Rattus norvegicus)
MAD2L1 [cytosol] (Sus scrofa)
MAD2L1 [cytosol] (Taeniopygia guttata)
MAD2L1 [cytosol] (Xenopus tropicalis)
Homologues of Activated MAD2L1 [cytosol] (Caenorhabditis elegans)
Homologues of Activated MAD2L1 [cytosol] (Oryza sativa)
Homologues of MAD2L1 [cytosol] (Bos taurus)
Homologues of MAD2L1 [cytosol] (Canis familiaris)
Homologues of MAD2L1 [cytosol] (Gallus gallus)
Cross References
RefSeq
NP_002349.1
GeneCards
Q13257
DOCK Blaster
3GMH
,
2QYF
,
2V64
,
2VFX
,
1GO4
PRO
Q13257
PDB
1KLQ
,
5LCW
,
5KHU
,
1DUJ
,
2QYF
,
1S2H
,
2VFX
,
1GO4
,
2V64
,
3GMH
Interactors (22)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q12834 CDC20
3
CDC20 [nucleoplasm]
(R-HSA-174112)
CDC20 [cytosol]
(R-HSA-141412)
PolyUb-CDC20 [nucleoplasm]
(R-HSA-6783069)
0.979
33
UniProt:Q9Y6D9 MAD1L1
1
MAD1L1 [cytosol]
(R-HSA-141433)
0.968
23
UniProt:Q15013 MD2BP
0.926
13
UniProt:Q13257 MAD2L1
2
Activated MAD2L1 [cytosol]
(R-HSA-141447)
MAD2L1 [cytosol]
(R-HSA-141400)
0.889
9
UniProt:O60566 BUB1B
1
BUB1B [cytosol]
(R-HSA-141436)
0.883
14
UniProt:P30260 CDC27
2
CDC27 [nucleoplasm]
(R-HSA-174175)
CDC27 [cytosol]
(R-HSA-174073)
0.871
8
UniProt:Q14145 KEAP1
2
KEAP1 [cytosol]
(R-HSA-976038)
Ub-KEAP1 [cytosol]
(R-HSA-6782766)
0.77
6
IntAct:EBI-1563533 MAD2 PEPTIDE
0.667
3
UniProt:Q9Y3Q8 T22D4
0.666
4
UniProt:Q562F6 SGO2
1
SGOL2 [cytosol]
(R-HSA-376242)
0.649
10
UniProt:P78536 ADAM17
1
ADAM17 [plasma membrane]
(R-HSA-179878)
0.581
3
UniProt:Q8BGZ4 CDC23
0.564
2
UniProt:Q9DCX1 MD2BP
0.564
2
UniProt:Q8R349
2
CDC16 [cytosol]
(R-MMU-174156)
CDC16 [nucleoplasm]
(R-MMU-174049)
0.564
2
UniProt:Q9JJ66
3
CDC20 [nucleoplasm]
(R-MMU-174112)
PolyUb-CDC20 [nucleoplasm]
(R-MMU-6783069)
CDC20 [cytosol]
(R-MMU-141412)
0.564
2
UniProt:O00560 SDCBP
3
SDCBP [extracellular region]
(R-HSA-6806206)
SDCBP [cytosol]
(R-HSA-373639)
SDCBP [azurophil granule lumen]
(R-HSA-6799372)
0.556
3
UniProt:Q9UJX5 ANAPC4
2
ANAPC4 [cytosol]
(R-HSA-174168)
ANAPC4 [nucleoplasm]
(R-HSA-174115)
0.527
5
UniProt:Q7L775 EPMIP
0.488
2
UniProt:Q96D03 DDT4L
0.488
2
UniProt:P06213-2 INSR
0.488
2
UniProt:O75140-2 DEPDC5
0.488
2
UniProt:P06213 INSR
6
INSR(763-1382) [endosome membrane]
(R-HSA-141722)
p-6Y-INSR(763-1382) [endosome membrane]
(R-HSA-141719)
INSR(28-758) [endosome membrane]
(R-HSA-141718)
INSR(763-1382) [plasma membrane]
(R-HSA-74669)
p-6Y-INSR(763-1382) [plasma membrane]
(R-HSA-74670)
INSR(28-758) [plasma membrane]
(R-HSA-74668)
0.463
2
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