Reactome | Activated MAD2L1 [cytosol]

Activated MAD2L1 [cytosol]

Stable Identifier

R-HSA-141447

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Icon

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q13257 MAD2L1

Gene Names

MAD2L1, MAD2

Chain

initiator methionine:1, chain:2-205

Reference Genes

BioGPS Gene:4085 MAD2L1

COSMIC (genes):MAD2L1 MAD2L1

CTD Gene:4085 MAD2L1

dbSNP Gene:4085 MAD2L1

ENSEMBL:ENSG00000164109 MAD2L1

ENSEMBL_homo_sapiens_GENE:ENSG00000164109 MAD2L1

HGNC:6763 MAD2L1

KEGG Gene (Homo sapiens):4085 MAD2L1

Monarch:4085 MAD2L1

NCBI Gene:4085 MAD2L1

OMIM:601467 MAD2L1

UCSC:Q13257 MAD2L1

Reference Transcript

RefSeq:NM_002358.3 MAD2L1

Other Identifiers

0003850519

11720185_a_at

11720186_s_at

11748136_a_at

1554768_a_at

16979389

1721_g_at

1DUJ

1KLQ

1S2H

203362_s_at

236312_at

2783728

2783729

2783730

2783731

2783732

2783733

2783734

2783735

2783736

2783737

2783739

2783742

2783743

2783744

2783745

2QYF

2V64

2VFX

3348

3538716

3538718

3538720

3538721

3538722

37282_at

3GMH

4085

46436_at

55824_at

5KHU

5LCW

6F0X

8102560

A_23_P92441

AAC50781

AAC52060

AAH00356

AAH05945

AAH70283

AAK38174

AAN74648

AAY40945

AB056160

AC097173

AF202269

AF202270

AF202271

AF202272

AF202273

AF394735

AJ000186

AK223433

AK298228

AK313827

BAB63410

BAD97153

BAG36562

BAG60497

BC000356

BC005945

BC070283

CAA03943

CCDS3715

CH471056

D6RJE3

EAX05271

EAX05273

ENSG00000164109

ENSP00000296509

ENSP00000332295

ENST00000296509

ENST00000333047

EntrezGene:4085

g6466452_3p_s_at

GE59318

GO:0000070

GO:0000278

GO:0000775

GO:0000776

GO:0000777

GO:0000922

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005635

GO:0005654

GO:0005694

GO:0005737

GO:0005829

GO:0005856

GO:0006464

GO:0007049

GO:0007059

GO:0007093

GO:0007094

GO:0008022

GO:0008150

GO:0008219

GO:0009056

GO:0031145

GO:0032991

GO:0042177

GO:0042802

GO:0042803

GO:0043066

GO:0043226

GO:0044615

GO:0045930

GO:0048471

GO:0051276

GO:0051301

GO:0072686

GO:0090267

GO:0140014

GO:1901990

GO:1904667

HGNC:6763

HPA003348

Hs.44380.0.A1_3p_at

Hs2.79078.2.S1_3p_s_at

ILMN_1777564

ILMN_2112460

IPR003511

IPR027097

IPR036570

MAD2L1

MAD2L1-201

MAD2L1-202

MIM:601467

NM_002358

NP_002349

PF02301

TC04001507.hg

U31278

U65410

U65410_at

uc003idl.3

uc003idm.3

UPI0000000A29

UPI000007408B

Participant Of

hasComponent

input

output

Release of activated MAD2 from kinetochores

Other forms of this molecule

MAD2L1 [cytosol]

Inferred To

Activated MAD2L1 [cytosol] (Caenorhabditis elegans)

Activated MAD2L1 [cytosol] (Dictyostelium discoideum)

Activated MAD2L1 [cytosol] (Drosophila melanogaster)

Activated MAD2L1 [cytosol] (Saccharomyces cerevisiae)

Activated MAD2L1 [cytosol] (Schizosaccharomyces pombe)

MAD2L1 [cytosol] (Bos taurus)

MAD2L1 [cytosol] (Canis familiaris)

MAD2L1 [cytosol] (Danio rerio)

MAD2L1 [cytosol] (Gallus gallus)

MAD2L1 [cytosol] (Mus musculus)

MAD2L1 [cytosol] (Rattus norvegicus)

MAD2L1 [cytosol] (Sus scrofa)

MAD2L1 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_002349.1

OpenTargets

ENSG00000164109

GeneCards

Q13257

DOCK Blaster

2V64, 2QYF, 1GO4, 2VFX, 3GMH

PRO

Q13257

PDB

5LCW, 2V64, 2VFX, 1DUJ, 1S2H, 3GMH, 2QYF, 6F0X, 1GO4, 1KLQ, 5KHU

Interactors (22)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q12834 CDC20	3	CDC20 [nucleoplasm] (R-HSA-174112) CDC20 [cytosol] (R-HSA-141412) PolyUb-CDC20 [nucleoplasm] (R-HSA-6783069)	0.979	33
UniProt:Q9Y6D9 MAD1L1	1	MAD1L1 [cytosol] (R-HSA-141433)	0.972	27
UniProt:Q15013 MD2BP			0.926	13
UniProt:Q13257 MAD2L1	2	Activated MAD2L1 [cytosol] (R-HSA-141447) MAD2L1 [cytosol] (R-HSA-141400)	0.889	9
UniProt:O60566 BUB1B	1	BUB1B [cytosol] (R-HSA-141436)	0.883	14
UniProt:P30260 CDC27	2	CDC27 [nucleoplasm] (R-HSA-174175) CDC27 [cytosol] (R-HSA-174073)	0.871	8
UniProt:Q14145 KEAP1	2	KEAP1 [cytosol] (R-HSA-976038) Ub-KEAP1 [cytosol] (R-HSA-6782766)	0.77	6
IntAct:EBI-1563533 MAD2 PEPTIDE			0.667	3
UniProt:Q9Y3Q8 T22D4			0.666	4
UniProt:Q562F6 SGO2	1	SGOL2 [cytosol] (R-HSA-376242)	0.649	10
UniProt:P78536 ADAM17	1	ADAM17 [plasma membrane] (R-HSA-179878)	0.581	3
UniProt:Q8BGZ4	2	CDC23 [cytosol] (R-MMU-174137) CDC23 [nucleoplasm] (R-MMU-174228)	0.564	2
UniProt:Q9DCX1 MD2BP			0.564	2
UniProt:Q8R349	2	CDC16 [cytosol] (R-MMU-174156) CDC16 [nucleoplasm] (R-MMU-174049)	0.564	2
UniProt:Q9JJ66	3	CDC20 [nucleoplasm] (R-MMU-174112) PolyUb-CDC20 [nucleoplasm] (R-MMU-6783069) CDC20 [cytosol] (R-MMU-141412)	0.564	2
UniProt:O00560 SDCBP	3	SDCBP [extracellular region] (R-HSA-6806206) SDCBP [cytosol] (R-HSA-373639) SDCBP [azurophil granule lumen] (R-HSA-6799372)	0.556	3
UniProt:Q9UJX5 ANAPC4	2	ANAPC4 [cytosol] (R-HSA-174168) ANAPC4 [nucleoplasm] (R-HSA-174115)	0.527	5
UniProt:Q7L775 EPMIP			0.488	2
UniProt:Q96D03 DDT4L			0.488	2
UniProt:P06213-2 INSR			0.488	2
UniProt:O75140-2 DEPDC5			0.488	2
UniProt:P06213 INSR	6	INSR(763-1382) [endosome membrane] (R-HSA-141722) p-6Y-INSR(763-1382) [endosome membrane] (R-HSA-141719) INSR(28-758) [endosome membrane] (R-HSA-141718) INSR(763-1382) [plasma membrane] (R-HSA-74669) p-6Y-INSR(763-1382) [plasma membrane] (R-HSA-74670) INSR(28-758) [plasma membrane] (R-HSA-74668)	0.463	2