Reactome | PRKAG1 [nucleoplasm]

PRKAG1 [nucleoplasm]

Stable Identifier

R-HSA-2151202

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

AMPK gamma1, 5'-AMP-activated protein kinase subunit gamma-1, AAKG1_HUMAN

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Activity through Phosphorylation (Homo sapiens)
        
        AMPK phosphorylates TP53 (Homo sapiens)
        
        Activated AMPK heterotrimer [nucleoplasm] (Homo sapiens)
        
        AMPK gamma [nucleoplasm] (Homo sapiens)
        
        PRKAG1 [nucleoplasm] (Homo sapiens)

Organelle biogenesis and maintenance (Homo sapiens)

- Mitochondrial biogenesis (Homo sapiens)
  - Activation of PPARGC1A (PGC-1alpha) by phosphorylation (Homo sapiens)
    - AMPK phosphorylates PPARGC1A (Homo sapiens)
      - p-AMPK heterotrimer:AMP [nucleoplasm] (Homo sapiens)
        
        p-AMPK heterotrimer [nucleoplasm] (Homo sapiens)
        
        AMPK gamma [nucleoplasm] (Homo sapiens)
        
        PRKAG1 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P54619 PRKAG1

Gene Names

PRKAG1

Chain

chain:1-331

Reference Genes

BioGPS Gene:5571 PRKAG1

COSMIC (genes):PRKAG1 PRKAG1

CTD Gene:5571 PRKAG1

dbSNP Gene:5571 PRKAG1

ENSEMBL:ENSG00000181929.13 PRKAG1

HGNC:9385 PRKAG1

KEGG Gene (Homo sapiens):5571 PRKAG1

Monarch:5571 PRKAG1

NCBI Gene:5571 PRKAG1

OMIM:602742 PRKAG1

UCSC:P54619 PRKAG1

Reference Transcript

Other Identifiers

11730242_a_at

11741462_a_at

16764131

201805_PM_at

201805_at

34346_at

3453557

3453558

3453559

3453561

3453562

3453563

3453564

3453565

3453566

3453567

3453568

3453570

3453573

3453583

3453588

3453589

3453590

3453591

5571

7962935

A_23_P36513

A_33_P3340254

GE59156

GO:0000166

GO:0003824

GO:0004672

GO:0004691

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005975

GO:0006091

GO:0006110

GO:0006468

GO:0006629

GO:0006631

GO:0006633

GO:0006913

GO:0007165

GO:0007283

GO:0008603

GO:0010628

GO:0016020

GO:0016208

GO:0016301

GO:0016310

GO:0016740

GO:0019887

GO:0019901

GO:0022414

GO:0023052

GO:0031588

GO:0031669

GO:0032559

GO:0036211

GO:0042149

GO:0043226

GO:0043531

GO:0045860

GO:0050790

GO:0051170

GO:0055086

GO:0071900

GO:0098772

GO:0140096

GO:1901135

HMNXSV003016868

HMNXSV003050202

ILMN_1751984

ILMN_2412101

PH_hs_0000393

TC12003276.hg

U42412_at

g4506060_3p_at

Participates

as a member of

AMPK gamma [nucleoplasm] (Homo sapiens)

Other forms of this molecule

PRKAG1 [cytosol]

Inferred To

wu:fa94d09 [nucleoplasm] (Danio rerio)

Homologues of PRKAG1 [nucleoplasm] (Sus scrofa)

SNF4Agamma [nucleoplasm] (Drosophila melanogaster)

PRKAG1 [nucleoplasm] (Bos taurus)

PRKAG1 [nucleoplasm] (Canis familiaris)

PRKAG1 [nucleoplasm] (Mus musculus)

PRKAG1 [nucleoplasm] (Rattus norvegicus)

PRKAG1 [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

XP_011536864.1, XP_006719562.1, NP_001193638.1, NP_001193639.1, NP_002724.1

Guide to Pharmacology - Targets

1545

OpenTargets

ENSG00000181929

GeneCards

P54619

HPA

ENSG00000181929-PRKAG1

ZINC target

P54619

Ensembl

ENST00000552212, ENST00000316299, ENSG00000181929, ENSP00000447433, ENSP00000448972, ENSP00000323867, ENST00000548065

PRO

P54619

Pharos - Targets

P54619

Orphanet

28979

PDB

2UV7, 7JHG, 6C9H, 4REW, 5ISO, 6B1U, 6C9G, 4CFF, 4RER, 7M74, 2UV6, 2UV4, 6B2E, 2UV5, 7MYJ, 4ZHX, 6C9F, 7JIJ, 4CFE, 6C9J, 7JHH, 5EZV

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P54646 PRKAA2	4	PRKAA2 [cytosol] (R-HSA-200405) p-T172-PRKAA2 [cytosol] (R-HSA-200417) p-T172-PRKAA2 [nucleoplasm] (R-HSA-164171) PRKAA2 [nucleoplasm] (R-HSA-163682)	0.905	13
UniProt:O75385 ULK1	7	ULK1 [recycling endosome] (R-HSA-8854761) p-S758-ULK1 [cytosol] (R-HSA-5672131) p-S317,467,556,638,T575-ULK1 [cytosol] (R-HSA-5673747) ULK1 [cytosol] (R-HSA-1632847) ULK1 [mitochondrial outer membrane] (R-HSA-8948145) p-T180,S317,S467,S556,S638,T575-ULK1 [endoplasmic reticulum membrane] (R-HSA-8948047) p-T180,S317,S467,S556,S638,T575-ULK1 [cytosol] (R-HSA-5675858)	0.669	3
UniProt:P55212 CASP6	5	CASP6(194-293) [nucleoplasm] (R-HSA-352246) CASP6(24-179) [nucleoplasm] (R-HSA-352247) CASP6(24-179) [cytosol] (R-HSA-350313) CASP6(194-293) [cytosol] (R-HSA-266128) CASP6 (1-293) [cytosol] (R-HSA-6798132)	0.556	3
UniProt:P26367 PAX6	1	PAX6 [nucleoplasm] (R-HSA-3009044)	0.556	3