Reactome | FBXL17 [nucleoplasm]

FBXL17 [nucleoplasm]

Stable Identifier

R-HSA-9708570

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q9UF56 FBXL17

Gene Names

FBXL17, FBL17, FBX13, FBXO13

Chain

chain:1-701

Reference Genes

BioGPS Gene:64839 FBXL17

COSMIC (genes):FBXL17 FBXL17

CTD Gene:64839 FBXL17

dbSNP Gene:64839 FBXL17

ENSEMBL:ENSG00000145743 FBXL17

ENSEMBL_homo_sapiens_GENE:ENSG00000145743.18 FBXL17

HGNC:13615 FBXL17

KEGG Gene (Homo sapiens):64839 FBXL17

Monarch:64839 FBXL17

NCBI Gene:64839 FBXL17

OMIM:609083 FBXL17

UCSC:Q9UF56 FBXL17

Reference Transcript

RefSeq:NM_001163315.2 FBXL17

Other Identifiers

11734075_a_at

11759124_at

11759125_at

16998700

227203_PM_at

227203_at

242034_PM_at

242034_at

2870115

2870116

2870125

2870163

2870178

2870193

2870210

2870216

2870217

2870218

2870221

2870222

2870223

2870224

2870225

2870226

2870227

2870228

2870229

2870230

2870231

2870232

2870233

2870234

2870235

2870236

2870237

44481_at

59404_at

64839

8113445

A_32_P137632

A_32_P20288

A_33_P3314436

A_33_P3314441

GE578509

GO:0000209

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006515

GO:0007399

GO:0008589

GO:0014033

GO:0016567

GO:0019005

GO:0023052

GO:0030154

GO:0030163

GO:0031146

GO:0036211

GO:0043153

GO:0043161

GO:0043226

GO:0048856

HMNXSV003054937

HMNXSV003055457

Hs.118531.0.A1_3p_at

Hs.179112.0.A1_3p_at

ILMN_1715901

TC05001660.hg

Participates

as an output of

FBXL17 ubiquitinates BACH1 (in BACH1:FBXL17:SCF (SKP2)) (Homo sapiens)

as a component of

BACH1:FBXL17 [nucleoplasm] (Homo sapiens)

as an input of

FBXL17 binds BACH1:MAFK (Homo sapiens)

Inferred To

Skp2 [nucleoplasm] (Drosophila melanogaster)

Fbxl17 [nucleoplasm] (Mus musculus)

Ghost homologue of FBXL17 [nucleoplasm] (Rattus norvegicus)

skpt-1 [nucleoplasm] (Caenorhabditis elegans)

F1NKQ0 [nucleoplasm] (Gallus gallus)

FBXL17 [nucleoplasm] (Bos taurus)

FBXL17 [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

NP_001156787.2

OpenTargets

ENSG00000145743

GeneCards

Q9UF56

HPA

ENSG00000145743-FBXL17

Ensembl

ENSG00000145743, ENSP00000437464, ENST00000542267

PRO

Q9UF56

Pharos - Targets

Q9UF56

PDB

6WCQ, 6W66

Interactors (22)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63208 SKP1	2	SKP1 [nucleoplasm] (R-HSA-187538) SKP1 [cytosol] (R-HSA-174150)	0.737	16
UniProt:O14867 BACH1	5	BACH1 [nucleoplasm] (R-HSA-9707688) BACH1 [cytosol] (R-HSA-9708429) PolyUb-BACH1 [nucleoplasm] (R-HSA-9708486) p-Y483 BACH1 [nucleoplasm] (R-HSA-9762202) p-Y483 BACH1 [cytosol] (R-HSA-9762206)	0.643	5
UniProt:Q9Y2M5 KLHL20	1	KLHL20 [cytosol] (R-HSA-976032)	0.643	6
UniProt:Q8WVZ9 KBTBD7	1	KBTBD7 [cytosol] (R-HSA-5658415)	0.643	7
UniProt:Q9UBP0-1 SPAST			0.602	4
UniProt:Q9P2J3 KLHL9	1	KLHL9 [cytosol] (R-HSA-976056)	0.597	8
UniProt:Q9UBP0 SPAST	1	SPAST [cytosol] (R-HSA-9668426)	0.591	3
UniProt:Q53G59 KLHL12	1	KLHL12 [cytosol] (R-HSA-1504203)	0.558	11
UniProt:Q9Y2Z0 SUGT1	1	SUGT1 [cytosol] (R-HSA-874107)	0.527	5
UniProt:Q86UZ6 ZBT46			0.527	2
UniProt:Q13618 CUL3	3	G76-NEDD8-K712-CUL3 [cytosol] (R-HSA-8952516) CUL3 [nucleoplasm] (R-HSA-5635033) CUL3 [cytosol] (R-HSA-975979)	0.527	4
UniProt:B2RXF5 ZBT42			0.527	3
UniProt:Q13616 CUL1	3	G76-NEDD8-K720-CUL1 [cytosol] (R-HSA-8952519) CUL1 [nucleoplasm] (R-HSA-187551) CUL1 [cytosol] (R-HSA-174230)	0.527	8
UniProt:Q99592 ZBT18			0.527	3
UniProt:Q9P2N7 KLHL13	1	KLHL13 [cytosol] (R-HSA-976041)	0.527	6
UniProt:Q9NXS3 KLH28			0.527	3
UniProt:Q6TDP4 KLH17			0.527	4
UniProt:O95198 KLHL2	1	KLHL2 [cytosol] (R-HSA-8863217)	0.527	7
UniProt:Q6JEL2 KLH10			0.527	3
UniProt:Q9P2G3 KLH14			0.527	3
UniProt:Q8NFY9 KBTBD8	1	KBTBD8 [cytosol] (R-HSA-8863192)	0.499	3
UniProt:Q14145 KEAP1	3	Ub-KEAP1 [cytosol] (R-HSA-6782766) ub-KEAP1 [cytosol] (R-HSA-9766647) KEAP1 [cytosol] (R-HSA-976038)	0.462	7

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