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Cul3 [cytosol]
Stable Identifier
R-DME-975979
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
cytosol
Synonyms
CUL3, Q8IP45
Locations in the PathwayBrowser
Expand all
Immune System (Drosophila melanogaster)
Adaptive Immune System (Drosophila melanogaster)
Class I MHC mediated antigen processing & presentation (Drosophila melanogaster)
Antigen processing: Ubiquitination & Proteasome degradation (Drosophila melanogaster)
Interaction of E3 with substrate and E2-Ub complex (Drosophila melanogaster)
Ag-substrate:E3:E2:Ub [cytosol] (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
RBX1:CUL3:BTB [cytosol] (Drosophila melanogaster)
Cul3 [cytosol] (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
RBX1:CUL3:BTB [cytosol] (Drosophila melanogaster)
Cul3 [cytosol] (Drosophila melanogaster)
Polyubiquitination of substrate (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
RBX1:CUL3:BTB [cytosol] (Drosophila melanogaster)
Cul3 [cytosol] (Drosophila melanogaster)
E3:K48-polyubiquitinated substrate [cytosol] (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
RBX1:CUL3:BTB [cytosol] (Drosophila melanogaster)
Cul3 [cytosol] (Drosophila melanogaster)
E3:Ub:substrate [cytosol] (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
RBX1:CUL3:BTB [cytosol] (Drosophila melanogaster)
Cul3 [cytosol] (Drosophila melanogaster)
Release of E3 from polyubiquitinated substrate (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
RBX1:CUL3:BTB [cytosol] (Drosophila melanogaster)
Cul3 [cytosol] (Drosophila melanogaster)
E3:K48-polyubiquitinated substrate [cytosol] (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
RBX1:CUL3:BTB [cytosol] (Drosophila melanogaster)
Cul3 [cytosol] (Drosophila melanogaster)
Transfer of Ub from E2 to substrate and release of E2 (Drosophila melanogaster)
Ag-substrate:E3:E2:Ub [cytosol] (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
RBX1:CUL3:BTB [cytosol] (Drosophila melanogaster)
Cul3 [cytosol] (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
RBX1:CUL3:BTB [cytosol] (Drosophila melanogaster)
Cul3 [cytosol] (Drosophila melanogaster)
E3:Ub:substrate [cytosol] (Drosophila melanogaster)
E3 ligases in proteasomal degradation [cytosol] (Drosophila melanogaster)
RBX1:CUL3:BTB [cytosol] (Drosophila melanogaster)
Cul3 [cytosol] (Drosophila melanogaster)
Metabolism of proteins (Drosophila melanogaster)
Post-translational protein modification (Drosophila melanogaster)
Neddylation (Drosophila melanogaster)
AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Drosophila melanogaster)
NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5 [cytosol] (Drosophila melanogaster)
CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Drosophila melanogaster)
RBX1:CUL3:BTB [cytosol] (Drosophila melanogaster)
Cul3 [cytosol] (Drosophila melanogaster)
CAND1 binds cytosolic CRL E3 ubiquitin ligases (Drosophila melanogaster)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Drosophila melanogaster)
CRL E3 ubiquitin ligases [cytosol] (Drosophila melanogaster)
RBX1:CUL3:BTB [cytosol] (Drosophila melanogaster)
Cul3 [cytosol] (Drosophila melanogaster)
CRL E3 ubiquitin ligases [cytosol] (Drosophila melanogaster)
RBX1:CUL3:BTB [cytosol] (Drosophila melanogaster)
Cul3 [cytosol] (Drosophila melanogaster)
COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Drosophila melanogaster)
CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Drosophila melanogaster)
CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Drosophila melanogaster)
RBX1:CUL3:BTB [cytosol] (Drosophila melanogaster)
Cul3 [cytosol] (Drosophila melanogaster)
NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex (Drosophila melanogaster)
CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Drosophila melanogaster)
RBX1:CUL3:BTB [cytosol] (Drosophila melanogaster)
Cul3 [cytosol] (Drosophila melanogaster)
NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5 [cytosol] (Drosophila melanogaster)
CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Drosophila melanogaster)
RBX1:CUL3:BTB [cytosol] (Drosophila melanogaster)
Cul3 [cytosol] (Drosophila melanogaster)
Signal Transduction (Drosophila melanogaster)
MAPK family signaling cascades (Drosophila melanogaster)
MAPK1/MAPK3 signaling (Drosophila melanogaster)
RAF/MAP kinase cascade (Drosophila melanogaster)
Regulation of RAS by GAPs (Drosophila melanogaster)
KBTBD7:CUL3:RBX1 ubiquitinates NF1 (Drosophila melanogaster)
KBTBD7:CUL3:RBX1 [cytosol] (Drosophila melanogaster)
Cul3 [cytosol] (Drosophila melanogaster)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Drosophila melanogaster)
RHOBTB3 ATPase cycle (Drosophila melanogaster)
RHOBTB3 binds interacting proteins at trans-Golgi network (Drosophila melanogaster)
RHOBTB3 interacting proteins [cytosol] (Drosophila melanogaster)
Cul3 [cytosol] (Drosophila melanogaster)
RHOBTB3:ATP:RHOBTB3 interacting proteins [trans-Golgi network membrane] (Drosophila melanogaster)
RHOBTB3 interacting proteins [cytosol] (Drosophila melanogaster)
Cul3 [cytosol] (Drosophila melanogaster)
Signaling by Rho GTPases (Drosophila melanogaster)
RHO GTPase cycle (Drosophila melanogaster)
RHOBTB GTPase Cycle (Drosophila melanogaster)
RHOBTB1 GTPase cycle (Drosophila melanogaster)
RHOBTB1 binds interacting proteins at the endosome membrane (Drosophila melanogaster)
RHOBTB1 interacting proteins [cytosol] (Drosophila melanogaster)
Cul3 [cytosol] (Drosophila melanogaster)
RHOBTB1:GTP:RHOBTB1 interacting proteins [endosome membrane] (Drosophila melanogaster)
RHOBTB1 interacting proteins [cytosol] (Drosophila melanogaster)
Cul3 [cytosol] (Drosophila melanogaster)
RHOBTB2 GTPase cycle (Drosophila melanogaster)
RHOBTB2 binds interacting proteins at the endosome membrane (Drosophila melanogaster)
RHOBTB2 interacting proteins [cytosol] (Drosophila melanogaster)
Cul3 [cytosol] (Drosophila melanogaster)
RHOBTB2:GTP:RHOBTB2 interacting proteins [endosome membrane] (Drosophila melanogaster)
RHOBTB2 interacting proteins [cytosol] (Drosophila melanogaster)
Cul3 [cytosol] (Drosophila melanogaster)
Signaling by WNT (Drosophila melanogaster)
TCF dependent signaling in response to WNT (Drosophila melanogaster)
Degradation of DVL (Drosophila melanogaster)
DVL is ubiquitinated by CUL3:KLHL12:RBX1 (Drosophila melanogaster)
DVL:CUL3:KLHL12:RBX1 [cytosol] (Drosophila melanogaster)
CUL3:KLHL12:RBX1 [cytosol] (Drosophila melanogaster)
Cul3 [cytosol] (Drosophila melanogaster)
ub-DVL:CUL3:KLHL12:RBX1 [cytosol] (Drosophila melanogaster)
CUL3:KLHL12:RBX1 [cytosol] (Drosophila melanogaster)
Cul3 [cytosol] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:Q8IP45
Gene Names
Cul3
Reference Genes
BioGPS Gene:34896 Cul3
ENSEMBL:FBgn0261268
Flybase:FBgn0261268
Monarch:34896 Cul3
NCBI Gene:34896 Cul3
UCSC:Q8IP45 Cul3
Reference Transcript
RefSeq:NM_165112.2 Cul3
Other Identifiers
153701_at
1624970_s_at
1632211_at
34896
GO:0000209
GO:0005829
GO:0006511
GO:0006919
GO:0007278
GO:0007283
GO:0007291
GO:0007409
GO:0007423
GO:0007476
GO:0016567
GO:0022414
GO:0023052
GO:0030154
GO:0030163
GO:0030431
GO:0031461
GO:0031463
GO:0031625
GO:0035324
GO:0036211
GO:0043161
GO:0045187
GO:0045475
GO:0045879
GO:0048813
GO:0048856
GO:0060090
GO:0070936
GO:0098917
GO:0099524
GO:0120177
GO:1901044
GO:2000495
Participates
as a member of
RHOBTB1 interacting proteins [cytosol] (Drosophila melanogaster)
RHOBTB2 interacting proteins [cytosol] (Drosophila melanogaster)
RHOBTB3 interacting proteins [cytosol] (Drosophila melanogaster)
as a component of
CUL3:KLHL12:RBX1 [cytosol] (Drosophila melanogaster)
KBTBD7:CUL3:RBX1 [cytosol] (Drosophila melanogaster)
RBX1:CUL3:BTB [cytosol] (Drosophila melanogaster)
Other forms of this molecule
Cul3 [cytosol]
Cul3 [nucleoplasm]
Inferred From
CUL3 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_723909.2
Flybase
FBgn0261268
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