Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
RBX1 [nucleoplasm]
Stable Identifier
R-HSA-1234142
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
RNF75, ROC1, ZYP, E3 ubiquitin-protein ligase RBX1
Icon
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
S Phase (Homo sapiens)
Synthesis of DNA (Homo sapiens)
Switching of origins to a post-replicative state (Homo sapiens)
Orc1 removal from chromatin (Homo sapiens)
Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Homo sapiens)
SCF (SKP2) complex [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to chemical stress (Homo sapiens)
KEAP1-NFE2L2 pathway (Homo sapiens)
Nuclear events mediated by NFE2L2 (Homo sapiens)
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Homo sapiens)
BTRC binds p-S344, 347 NFE2L2 (Homo sapiens)
BTRC:SKP1:CUL1:RBX1:p-S344, S347 NFE2L2 [nucleoplasm] (Homo sapiens)
BTRC:SKP1:RBX1:CUL1 [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
BTRC:SKP1:RBX1:CUL1 [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
NFE2L2 is ubiquitinated by BTRC:SKP1:CUL1:RBX1 (Homo sapiens)
BTRC:SKP1:CUL1:RBX1:p-S344, S347 NFE2L2 [nucleoplasm] (Homo sapiens)
BTRC:SKP1:RBX1:CUL1 [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
BTRC:SKP1:CUL1:RBX1:ub,p-S335, S338 NFE2L2 [nucleoplasm] (Homo sapiens)
BTRC:SKP1:RBX1:CUL1 [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
Ub,pS335,S338,T NFE2L2 is degraded (Homo sapiens)
BTRC:SKP1:CUL1:RBX1:ub,p-S335, S338 NFE2L2 [nucleoplasm] (Homo sapiens)
BTRC:SKP1:RBX1:CUL1 [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
BTRC:SKP1:RBX1:CUL1 [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
Regulation of BACH1 activity (Homo sapiens)
BACH1:FBXL17 binds SCF(SKP2) complex (Homo sapiens)
BACH1:FBXL17:SCF (SKP2) [nucleoplasm] (Homo sapiens)
SCF (SKP2) complex [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
SCF (SKP2) complex [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
FBXL17 ubiquitinates BACH1 (in BACH1:FBXL17:SCF (SKP2)) (Homo sapiens)
BACH1:FBXL17:SCF (SKP2) [nucleoplasm] (Homo sapiens)
SCF (SKP2) complex [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
SCF (SKP2) complex [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
Cellular response to hypoxia (Homo sapiens)
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Homo sapiens)
Nuclear VBC complex ubiquitinylates HIF-alpha (Homo sapiens)
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 [nucleoplasm] (Homo sapiens)
VHL:EloB,C:CUL2:RBX1 [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
ub-HIF-alpha:VHL:EloB,C:CUL2:RBX1 [nucleoplasm] (Homo sapiens)
VHL:EloB,C:CUL2:RBX1 [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
Nuclear VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Homo sapiens)
VHL:EloB,C:CUL2:RBX1 [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 [nucleoplasm] (Homo sapiens)
VHL:EloB,C:CUL2:RBX1 [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol (Homo sapiens)
ub-HIF-alpha:VHL:EloB,C:CUL2:RBX1 [nucleoplasm] (Homo sapiens)
VHL:EloB,C:CUL2:RBX1 [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
DNA Repair (Homo sapiens)
DNA Damage Bypass (Homo sapiens)
Recognition of DNA damage by PCNA-containing replication complex (Homo sapiens)
RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (Homo sapiens)
RAD18:UBE2B,RBX1:CUL4:DDB1:DTL [nucleoplasm] (Homo sapiens)
RBX1:CUL4:DDB1:DTL [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
RAD18:UBE2B,RBX1:CUL4:DDB1:DTL:PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Homo sapiens)
RAD18:UBE2B,RBX1:CUL4:DDB1:DTL [nucleoplasm] (Homo sapiens)
RBX1:CUL4:DDB1:DTL [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Homo sapiens)
RAD18:UBE2B,RBX1:CUL4:DDB1:DTL [nucleoplasm] (Homo sapiens)
RBX1:CUL4:DDB1:DTL [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
RAD18:UBE2B,RBX1:CUL4:DDB1:DTL:PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Homo sapiens)
RAD18:UBE2B,RBX1:CUL4:DDB1:DTL [nucleoplasm] (Homo sapiens)
RBX1:CUL4:DDB1:DTL [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
Nucleotide Excision Repair (Homo sapiens)
Global Genome Nucleotide Excision Repair (GG-NER) (Homo sapiens)
DNA Damage Recognition in GG-NER (Homo sapiens)
PARP1 or PARP2 PARylates DDB2 and autoPARylates (Homo sapiens)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Homo sapiens)
PAR-UV-DDB [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB:PARP1,PARP2 [nucleoplasm] (Homo sapiens)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB [nucleoplasm] (Homo sapiens)
UV-DDB [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
PARP1 or PARP2 binds DDB2 at GG-NER site (Homo sapiens)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB [nucleoplasm] (Homo sapiens)
UV-DDB [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB:PARP1,PARP2 [nucleoplasm] (Homo sapiens)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB [nucleoplasm] (Homo sapiens)
UV-DDB [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
UV-DDB ubiquitinates XPC (Homo sapiens)
UV-DDB [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB [nucleoplasm] (Homo sapiens)
UV-DDB [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB [nucleoplasm] (Homo sapiens)
UV-DDB [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site (Homo sapiens)
UV-DDB:COP9 Signalosome [nucleoplasm] (Homo sapiens)
UV-DDB [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB [nucleoplasm] (Homo sapiens)
UV-DDB [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
Dual Incision in GG-NER (Homo sapiens)
3'-incision of DNA by ERCC5 (XPG) in GG-NER (Homo sapiens)
GG-NER incision complex:5'-incised damaged DNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
PAR-UV-DDB [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
PAR-UV-DDB [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Homo sapiens)
GG-NER incision complex:5'-incised damaged DNA [nucleoplasm] (Homo sapiens)
PAR-UV-DDB [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
GG-NER incision complex:Open bubble dsDNA [nucleoplasm] (Homo sapiens)
GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] (Homo sapiens)
Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Homo sapiens)
PAR-UV-DDB [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
DNA polymerases delta, epsilon or kappa bind the GG-NER site (Homo sapiens)
GG-NER incision complex:5'-incised damaged DNA [nucleoplasm] (Homo sapiens)
PAR-UV-DDB [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
GG-NER incision complex:5'-incised damaged DNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
PAR-UV-DDB [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
Formation of Incision Complex in GG-NER (Homo sapiens)
Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER (Homo sapiens)
GG-NER incision complex:Open bubble dsDNA [nucleoplasm] (Homo sapiens)
GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] (Homo sapiens)
Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Homo sapiens)
PAR-UV-DDB [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] (Homo sapiens)
Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Homo sapiens)
PAR-UV-DDB [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
CHD1L is recruited to GG-NER site (Homo sapiens)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Homo sapiens)
PAR-UV-DDB [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Homo sapiens)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Homo sapiens)
PAR-UV-DDB [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Homo sapiens)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Homo sapiens)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Homo sapiens)
PAR-UV-DDB [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Homo sapiens)
Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB [nucleoplasm] (Homo sapiens)
PAR-UV-DDB [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
Formation of the pre-incision complex in GG-NER (Homo sapiens)
GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] (Homo sapiens)
Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Homo sapiens)
PAR-UV-DDB [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Homo sapiens)
PAR-UV-DDB [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
RNF111 ubiquitinates SUMOylated XPC (Homo sapiens)
Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Homo sapiens)
PAR-UV-DDB [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
Ub,SUMO:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Homo sapiens)
PAR-UV-DDB [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
Recruitment of XPA and release of CAK (Homo sapiens)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Homo sapiens)
PAR-UV-DDB [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Homo sapiens)
PAR-UV-DDB [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
SUMOylation of XPC (Homo sapiens)
Ub,SUMO:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Homo sapiens)
PAR-UV-DDB [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Homo sapiens)
Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB [nucleoplasm] (Homo sapiens)
PAR-UV-DDB [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
TFIIH binds GG-NER site to form a verification complex (Homo sapiens)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Homo sapiens)
PAR-UV-DDB [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Homo sapiens)
PAR-UV-DDB [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Homo sapiens)
Dual incision in TC-NER (Homo sapiens)
3' incision by ERCC5 (XPG) in TC-NER (Homo sapiens)
TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Homo sapiens)
TC-NER incision complex [nucleoplasm] (Homo sapiens)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Homo sapiens)
TC-NER incision complex [nucleoplasm] (Homo sapiens)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
DNA polymerases delta, epsilon or kappa bind the TC-NER site (Homo sapiens)
TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
ERCC2-facilitated RNA Pol II backtracking in TC-NER (Homo sapiens)
TC-NER pre-incision complex [nucleoplasm] (Homo sapiens)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
Ubiquitinated,hyperphosphorylated RNA Pol II:Partially open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
ERCC3-facilitated RNA Pol II backtracking in TC-NER (Homo sapiens)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
Ubiquitinated,hyperphosphorylated RNA Pol II:Partially open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
ERCC5 and RPA bind TC-NER site (Homo sapiens)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
Formation of TC-NER Pre-Incision Complex (Homo sapiens)
Assembly of the pre-incision complex in TC-NER (Homo sapiens)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Homo sapiens)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
ERCC8 (CSA) binds stalled RNA Pol II (Homo sapiens)
ERCC8:DDB1:CUL4:RBX1:COP9 Signalosome [nucleoplasm] (Homo sapiens)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II (Homo sapiens)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
UVSSA:USP7 deubiquitinates ERCC6 (Homo sapiens)
TC-NER pre-incision complex [nucleoplasm] (Homo sapiens)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Homo sapiens)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
Gap-filling DNA repair synthesis and ligation in TC-NER (Homo sapiens)
Ligation of newly synthesized repair patch to incised DNA in TC-NER (Homo sapiens)
TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
TC-NER post-incision complex:dsDNA with transcription bubble [nucleoplasm] (Homo sapiens)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Homo sapiens)
TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
Recovery of RNA synthesis after TC-NER (Homo sapiens)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
TC-NER post-incision complex:dsDNA with transcription bubble [nucleoplasm] (Homo sapiens)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
DNA Replication (Homo sapiens)
Synthesis of DNA (Homo sapiens)
Switching of origins to a post-replicative state (Homo sapiens)
Orc1 removal from chromatin (Homo sapiens)
Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Homo sapiens)
SCF (SKP2) complex [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by ALK in cancer (Homo sapiens)
Signaling by ALK fusions and activated point mutants (Homo sapiens)
Nuclear events stimulated by ALK signaling in cancer (Homo sapiens)
MAPK1 phsophorylates ZC3HCF1 in a NPM-ALK-dependent manner (Homo sapiens)
NPM1-p-7Y ALK fusion dimer:CUL1:RBX1:SKP1:ZC3HC1 [nucleoplasm] (Homo sapiens)
CUL1:RBX1:SKP1:ZC3HC1 [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
NPM1p-7Y ALK fusion dimer:CUL1:RBX1:SKP1:p-S354 ZC3HC1 [nucleoplasm] (Homo sapiens)
CUL1:RBX1:SKP1:p-S354 ZC3HC1 [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
NPM1-ALK fusion dimer binds SKP1:CUL1:RBX1:ZC3HC1 (Homo sapiens)
CUL1:RBX1:SKP1:ZC3HC1 [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
NPM1-p-7Y ALK fusion dimer:CUL1:RBX1:SKP1:ZC3HC1 [nucleoplasm] (Homo sapiens)
CUL1:RBX1:SKP1:ZC3HC1 [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
Signaling by NOTCH1 in Cancer (Homo sapiens)
FBXW7 Mutants and NOTCH1 in Cancer (Homo sapiens)
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling (Homo sapiens)
FBXW7 WD mutants do not bind NICD1 (Homo sapiens)
FBXW7 WD mutants:SKP1:CUL1:RBX1 [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer (Homo sapiens)
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants (Homo sapiens)
p-NICD1 PEST domain mutants do not bind FBXW7 (Homo sapiens)
FBXW7:SKP1:CUL1:RBX1 [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
Signaling by NOTCH1 PEST Domain Mutants in Cancer (Homo sapiens)
Constitutive Signaling by NOTCH1 PEST Domain Mutants (Homo sapiens)
p-NICD1 PEST domain mutants do not bind FBXW7 (Homo sapiens)
FBXW7:SKP1:CUL1:RBX1 [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX2 (Homo sapiens)
Regulation of RUNX2 expression and activity (Homo sapiens)
SCF(SKP2) complex binds RUNX2 (Homo sapiens)
RUNX2:SCF(SKP2) [nucleoplasm] (Homo sapiens)
SCF (SKP2) complex [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
SCF (SKP2) complex [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
SCF(SKP2) polyubiquitinates RUNX2 (Homo sapiens)
RUNX2:SCF(SKP2) [nucleoplasm] (Homo sapiens)
SCF (SKP2) complex [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
SCF (SKP2) complex [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Neddylation (Homo sapiens)
AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex (Homo sapiens)
NEDD8-AcM-UBE2M:CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUND1,2,4,5 [nucleoplasm] (Homo sapiens)
CRL4 E3 ubiquitin ligase:COMMDs:CCDC22 [nucleoplasm] (Homo sapiens)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
NEDD8-CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [nucleoplasm] (Homo sapiens)
NEDD8-CRL4 E3 ligase complex [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus (Homo sapiens)
CRL4 E3 ubiquitin ligase:CAND1 [nucleoplasm] (Homo sapiens)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex (Homo sapiens)
CRL4 E3 ubiquitin ligase:CAND1 [nucleoplasm] (Homo sapiens)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
CRL4 E3 ubiquitin ligase:COMMDs:CCDC22 [nucleoplasm] (Homo sapiens)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex (Homo sapiens)
CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [nucleoplasm] (Homo sapiens)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
NEDD8-CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [nucleoplasm] (Homo sapiens)
NEDD8-CRL4 E3 ligase complex [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex (Homo sapiens)
CRL4 E3 ubiquitin ligase:COMMDs:CCDC22 [nucleoplasm] (Homo sapiens)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
NEDD8-AcM-UBE2M:CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUND1,2,4,5 [nucleoplasm] (Homo sapiens)
CRL4 E3 ubiquitin ligase:COMMDs:CCDC22 [nucleoplasm] (Homo sapiens)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Hedgehog (Homo sapiens)
Hedgehog 'on' state (Homo sapiens)
GLI2,3 are degraded by the proteasome (Homo sapiens)
SPOP:CUL3:RBX1 [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
ub-2p-GLI2,3:SPOP:CUL3:RBX1 [nucleoplasm] (Homo sapiens)
SPOP:CUL3:RBX1 [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
SPOP:CUL3:RBX1 ubiquitinates GLI2,3 (Homo sapiens)
2p-GLI:SPOP:CUL3:RBX1 [nucleoplasm] (Homo sapiens)
SPOP:CUL3:RBX1 [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
ub-2p-GLI2,3:SPOP:CUL3:RBX1 [nucleoplasm] (Homo sapiens)
SPOP:CUL3:RBX1 [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
phosphorylated GLI proteins bind SPOP:CUL3:RBX1 (Homo sapiens)
2p-GLI:SPOP:CUL3:RBX1 [nucleoplasm] (Homo sapiens)
SPOP:CUL3:RBX1 [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
SPOP:CUL3:RBX1 [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Signaling by NOTCH1 (Homo sapiens)
NOTCH1 Intracellular Domain Regulates Transcription (Homo sapiens)
Phosphorylated NICD1 binds FBXW7 (Homo sapiens)
FBXW7:SKP1:CUL1:RBX1 [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
p-NICD1:FBXW7:SKP1:CUL1:RBX1 [nucleoplasm] (Homo sapiens)
FBXW7:SKP1:CUL1:RBX1 [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
Ubiquitination of NICD1 by FBWX7 (Homo sapiens)
FBXW7:SKP1:CUL1:RBX1 [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
p-NICD1:FBXW7:SKP1:CUL1:RBX1 [nucleoplasm] (Homo sapiens)
FBXW7:SKP1:CUL1:RBX1 [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
Signaling by NOTCH4 (Homo sapiens)
Negative regulation of NOTCH4 signaling (Homo sapiens)
FBXW7 promotes ubiquitination of p-NICD4 (Homo sapiens)
FBXW7:SKP1:CUL1:RBX1 [nucleoplasm] (Homo sapiens)
RBX1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P62877 RBX1
Gene Names
RBX1, RNF75, ROC1
Chain
chain:1-108, initiator methionine:, chain:2-108
Reference Genes
BioGPS Gene:9978 RBX1
COSMIC (genes):RBX1 RBX1
CTD Gene:9978 RBX1
dbSNP Gene:9978 RBX1
ENSEMBL:ENSG00000100387 RBX1
ENSEMBL_homo_sapiens_GENE:ENSG00000100387.9 RBX1
HGNC:9928 RBX1
KEGG Gene (Homo sapiens):9978 RBX1
Monarch:9978 RBX1
NCBI Gene:9978 RBX1
OMIM:603814 RBX1
UCSC:P62877 RBX1
Reference Transcript
RefSeq:NM_014248.3 RBX1
Other Identifiers
11716334_a_at
11716335_x_at
16930518
218117_PM_at
218117_at
3946564
3946565
3946572
3946578
3946586
3946589
3946590
3946591
3946592
3946593
8073334
9978
A_33_P3246318
GE81903
GO:0000165
GO:0000209
GO:0002376
GO:0003824
GO:0004842
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006281
GO:0006511
GO:0006513
GO:0006974
GO:0007283
GO:0008270
GO:0016567
GO:0016740
GO:0019005
GO:0019788
GO:0022414
GO:0023052
GO:0030163
GO:0031146
GO:0031461
GO:0031462
GO:0031463
GO:0031464
GO:0031465
GO:0031466
GO:0031467
GO:0031625
GO:0032436
GO:0032480
GO:0034450
GO:0034644
GO:0036211
GO:0042110
GO:0043123
GO:0043161
GO:0043226
GO:0043687
GO:0045116
GO:0045732
GO:0046872
GO:0060090
GO:0061629
GO:0061630
GO:0061663
GO:0062197
GO:0070936
GO:0071230
GO:0090090
GO:0097602
GO:0140096
GO:0140627
GO:1902499
GO:1904263
HMNXSV003025083
PH_hs_0024230
g7657507_3p_at
Participates
as a component of
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Homo sapiens)
NEDD8-CRL4 E3 ligase complex [nucleoplasm] (Homo sapiens)
RBX1:CUL4:DDB1:DTL [nucleoplasm] (Homo sapiens)
CUL1:RBX1:SKP1:p-S354 ZC3HC1 [nucleoplasm] (Homo sapiens)
CUL1:RBX1:SKP1:ZC3HC1 [nucleoplasm] (Homo sapiens)
FBXW7 WD mutants:SKP1:CUL1:RBX1 [nucleoplasm] (Homo sapiens)
BTRC:SKP1:RBX1:CUL1 [nucleoplasm] (Homo sapiens)
SPOP:CUL3:RBX1 [nucleoplasm] (Homo sapiens)
FBXW7:SKP1:CUL1:RBX1 [nucleoplasm] (Homo sapiens)
UV-DDB [nucleoplasm] (Homo sapiens)
PAR-UV-DDB [nucleoplasm] (Homo sapiens)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
VHL:EloB,C:CUL2:RBX1 [nucleoplasm] (Homo sapiens)
SCF (SKP2) complex [nucleoplasm] (Homo sapiens)
Other forms of this molecule
RBX1 [cytosol]
Inferred To
RBX1 [nucleoplasm]
(Caenorhabditis elegans)
RBX1 [nucleoplasm]
(Canis familiaris)
RBX1 [nucleoplasm]
(Dictyostelium discoideum)
RBX1 [nucleoplasm]
(Drosophila melanogaster)
RBX1 [nucleoplasm]
(Gallus gallus)
RBX1 [nucleoplasm]
(Mus musculus)
RBX1 [nucleoplasm]
(Plasmodium falciparum)
RBX1 [nucleoplasm]
(Saccharomyces cerevisiae)
RBX1 [nucleoplasm]
(Schizosaccharomyces pombe)
RBX1 [nucleoplasm]
(Sus scrofa)
LOC780968 [nucleoplasm]
(Bos taurus)
Rbx1 [nucleoplasm]
(Rattus norvegicus)
rbx1 [nucleoplasm]
(Danio rerio)
rbx1 [nucleoplasm]
(Xenopus tropicalis)
Cross References
RefSeq
NP_055063.1
OpenTargets
ENSG00000100387
IntEnz
2.3.2.32
HPA
ENSG00000100387-RBX1
GeneCards
P62877
Ensembl
ENST00000216225
,
ENSG00000100387
,
ENSP00000216225
PRO
P62877
Pharos - Targets
P62877
PDB
8JAV
,
7PLO
,
8OR0
,
1LDK
,
8JAS
,
8Q7R
,
3DQV
,
7Z8V
,
8H35
,
8JAQ
,
8H34
,
7ZBW
,
2HYE
,
8H33
,
8KHP
,
3RTR
,
8B3I
,
7B5S
,
4F52
,
1U6G
,
7B5N
,
2LGV
,
8OR4
,
7B5M
,
8OR3
,
7B5L
,
3DPL
,
8QU8
,
8OR2
,
8GQ6
,
4P5O
,
8H37
,
8R5H
,
8H3R
,
8H36
,
8CDK
,
8CDJ
,
6TTU
,
7ZBZ
,
8H3Q
,
7Z8T
,
1LDJ
,
6R6H
,
7Z8R
,
6R7N
,
8H3F
,
6R7I
,
8H3A
,
7OKQ
,
6R7H
,
6R7F
,
7Z8B
,
8PQL
,
5N4W
,
8H38
Interactors (24)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13616 CUL1
3
G76-NEDD8-K720-CUL1 [cytosol]
(R-HSA-8952519)
CUL1 [nucleoplasm]
(R-HSA-187551)
CUL1 [cytosol]
(R-HSA-174230)
0.978
31
UniProt:Q13617 CUL2
3
G76-NEDD8-K689-CUL2 [cytosol]
(R-HSA-8952511)
CUL2 [nucleoplasm]
(R-HSA-1234126)
CUL2 [cytosol]
(R-HSA-416982)
0.85
9
UniProt:Q13620 CUL4B
2
CUL4B [nucleoplasm]
(R-HSA-975973)
G76-NEDD8-K859-CUL4B [nucleoplasm]
(R-HSA-8952522)
0.823
8
UniProt:P61081 UBE2M
5
AcM-UBE2M [nucleoplasm]
(R-HSA-8952502)
G76-NEDD8-C111-AcM-UBE2M [nucleoplasm]
(R-HSA-8952508)
UBE2M [cytosol]
(R-HSA-947619)
AcM-UBE2M [cytosol]
(R-HSA-8951627)
G76-NEDD8-C111-AcM-UBE2M [cytosol]
(R-HSA-4419894)
0.754
7
UniProt:Q13618 CUL3
3
G76-NEDD8-K712-CUL3 [cytosol]
(R-HSA-8952516)
CUL3 [nucleoplasm]
(R-HSA-5635033)
CUL3 [cytosol]
(R-HSA-975979)
0.743
5
UniProt:Q86VP6 CAND1
5
CAND1 [cytosol]
(R-HSA-5691146)
CAND1 [ficolin-1-rich granule lumen]
(R-HSA-6801399)
CAND1 [extracellular region]
(R-HSA-6806498)
CAND1 [secretory granule lumen]
(R-HSA-6801390)
CAND1 [nucleoplasm]
(R-HSA-8955089)
0.708
10
UniProt:Q92990 GLMN
1
GLMN [cytosol]
(R-HSA-8951779)
0.666
7
UniProt:Q92466 DDB2
3
PolyUb-DDB2 [nucleoplasm]
(R-HSA-6783035)
PAR-DDB2 [nucleoplasm]
(R-HSA-5696654)
DDB2 [nucleoplasm]
(R-HSA-53491)
0.643
3
UniProt:Q86XK2 FBXO11
1
FBXO11 [cytosol]
(R-HSA-8955092)
0.643
3
UniProt:Q13619 CUL4A
2
CUL4A [nucleoplasm]
(R-HSA-976006)
G76-NEDD8-K705-CUL4A [nucleoplasm]
(R-HSA-8952514)
0.643
4
UniProt:P63208 SKP1
2
SKP1 [nucleoplasm]
(R-HSA-187538)
SKP1 [cytosol]
(R-HSA-174150)
0.643
3
UniProt:P58004 SESN2
1
SESN2 [cytosol]
(R-HSA-5629143)
0.641
3
UniProt:P40337 VHL
3
monoSUMO1-K159,171,196-VHL [nucleoplasm]
(R-HSA-4551697)
VHL [nucleoplasm]
(R-HSA-1234127)
VHL [cytosol]
(R-HSA-391423)
0.623
4
UniProt:Q13309 SKP2
3
SKP2 [cytosol]
(R-HSA-975495)
PolyUb-SKP2 [nucleoplasm]
(R-HSA-9687073)
SKP2 [nucleoplasm]
(R-HSA-975554)
0.623
4
UniProt:Q93034 CUL5
2
CUL5 [cytosol]
(R-HSA-180528)
G76-NEDD8-K724-CUL5 [cytosol]
(R-HSA-8952014)
0.611
3
UniProt:P59991 KRTAP12-2
1
KRTAP12-2 [cytosol]
(R-HSA-6810271)
0.556
3
UniProt:Q9BYU1 PBX4
0.556
3
UniProt:Q96SW2 CRBN
1
CRBN [cytosol]
(R-HSA-8863300)
0.528
2
UniProt:Q9UK73 FEM1B
1
FEM1B [cytosol]
(R-HSA-201572)
0.527
3
UniProt:O94952 FBXO21
1
FBXO21 [cytosol]
(R-HSA-8862592)
0.527
2
UniProt:Q9H469 FBXL15
1
FBXL15 [cytosol]
(R-HSA-8862625)
0.527
2
UniProt:A0A663DJA2 ORF10
0.527
2
UniProt:Q16531 DDB1
1
DDB1 [nucleoplasm]
(R-HSA-53489)
0.527
3
UniProt:Q15910 EZH2
1
EZH2 [nucleoplasm]
(R-HSA-212298)
0.527
4
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text