Reactome | DUSP5 [nucleoplasm]

DUSP5 [nucleoplasm]

Stable Identifier

R-HSA-5675342

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

Expand all

Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - FLT3 Signaling (Homo sapiens)
    - RAF/MAP kinase cascade (Homo sapiens)
      - Negative regulation of MAPK pathway (Homo sapiens)
        
        Nuclear DUSPs dephosphorylate MAPKs (Homo sapiens)
        
        nuclear MAPK DUSPs [nucleoplasm] (Homo sapiens)
        
        DUSP5 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q16690 DUSP5

Gene Names

DUSP5, VH3

Chain

chain:1-384

Reference Genes

BioGPS Gene:1847 DUSP5

COSMIC (genes):DUSP5 DUSP5

CTD Gene:1847 DUSP5

dbSNP Gene:1847 DUSP5

ENSEMBL:ENSG00000138166 DUSP5

HGNC:3071 DUSP5

KEGG Gene (Homo sapiens):1847 DUSP5

Monarch:1847 DUSP5

NCBI Gene:1847 DUSP5

OMIM:603069 DUSP5

UCSC:Q16690 DUSP5

Reference Transcript

RefSeq:NM_004419.3 DUSP5

Other Identifiers

0002340309

11717863_a_at

16709128

1847

209457_at

3263755

3263756

3263757

3263758

3263759

3263760

3263764

3263768

3263772

3263773

3263774

529_at

7930413

A_23_P150018

GE58962

GO:0000165

GO:0000187

GO:0000188

GO:0001706

GO:0003674

GO:0004721

GO:0004725

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0006464

GO:0006470

GO:0007165

GO:0008138

GO:0008150

GO:0008330

GO:0009790

GO:0016311

GO:0016787

GO:0016791

GO:0017017

GO:0019899

GO:0035335

GO:0035970

GO:0043226

GO:0048646

GO:0048856

GO:0051019

ILMN_1656501

PH_hs_0030877

TC10000801.hg

U15932_at

g642012_3p_at

Participant Of

hasMember

nuclear MAPK DUSPs [nucleoplasm]

Inferred To

mpl2 [nucleoplasm] (Dictyostelium discoideum)

mpl1 [nucleoplasm] (Dictyostelium discoideum)

DUSP5 [nucleoplasm] (Canis familiaris)

DUSP5 [nucleoplasm] (Dictyostelium discoideum)

DUSP5 [nucleoplasm] (Gallus gallus)

DUSP5 [nucleoplasm] (Plasmodium falciparum)

DUSP5 [nucleoplasm] (Sus scrofa)

DUSP5 [nucleoplasm] (Xenopus tropicalis)

dusp5 [nucleoplasm] (Danio rerio)

Dusp5 [nucleoplasm] (Mus musculus)

Dusp5 [nucleoplasm] (Rattus norvegicus)

Homologues of DUSP5 [nucleoplasm] (Dictyostelium discoideum)

mpl3 [nucleoplasm] (Dictyostelium discoideum)

Cross References

RefSeq

NP_004410.3

OpenTargets

ENSG00000138166

IntEnz

3.1.3.48

GeneCards

Q16690

HPA

ENSG00000138166-DUSP5

Ensembl

ENSG00000138166, ENSP00000358596, ENST00000369583

PRO

Q16690

HMDB Protein

HMDBP08912

PDB

2G6Z

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P28482 MAPK1	18	MAPK1 [azurophil granule lumen] (R-HSA-6799225) MAPK1 [endoplasmic reticulum lumen] (R-HSA-9636293) MAPK1 [extracellular region] (R-HSA-6806250) MAPK1 [ficolin-1-rich granule lumen] (R-HSA-6800964) p-T185,Y187 MAPK1 E322V [cytosol] (R-HSA-9652797) p-T185,Y187 MAPK1 E322K [cytosol] (R-HSA-9652175) p-T185,Y187 MAPK1 E81K [cytosol] (R-HSA-9652799) p-T185,Y187 MAPK1 S142L [cytosol] (R-HSA-9652808) p-T185,Y187 MAPK1 P58L [cytosol] (R-HSA-9652806) p-T185,Y187 MAPK1 D321V [cytosol] (R-HSA-9652791) p-T185,Y187 MAPK1 D321N [cytosol] (R-HSA-9652785) p-T185,Y187 MAPK1 E322A [cytosol] (R-HSA-9652794) p-T185,Y187 MAPK1 P58G [cytosol] (R-HSA-9652802) p-T185-MAPK1 [cytosol] (R-HSA-9635773) MAPK1 [nucleoplasm] (R-HSA-199960) p-T185,Y187-MAPK1 [cytosol] (R-HSA-109853) MAPK1 [cytosol] (R-HSA-59282) p-T185,Y187-MAPK1 [nucleoplasm] (R-HSA-112354)	0.543	3

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