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p-T359,S363,S380.T573,S732-RPS6KA1 [cytosol]
Stable Identifier
R-HSA-9619993
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Phospho (T359,S363,S380,T573,S732)-Ribosomal protein S6 kinase alpha 1, p-T359,S363,S380.T573,S732-RSK1
Locations in the PathwayBrowser
Expand all
Neuronal System (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
Activation of NMDA receptors and postsynaptic events (Homo sapiens)
Post NMDA receptor activation events (Homo sapiens)
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling (Homo sapiens)
RSK activation (Homo sapiens)
PDPK1 phosphorylates RSKs (Homo sapiens)
p-T359,S363,S380,T573,T732-RSK [cytosol] (Homo sapiens)
p-T359,S363,S380.T573,S732-RPS6KA1 [cytosol] (Homo sapiens)
RSKs autophosphorylate (Homo sapiens)
p-T359,S363,S380,T573,T732-RSK [cytosol] (Homo sapiens)
p-T359,S363,S380.T573,S732-RPS6KA1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q15418 RPS6KA1
Gene Names
RPS6KA1, MAPKAPK1A, RSK1
Chain
chain:1-735
Reference Genes
BioGPS Gene:6195 RPS6KA1
COSMIC (genes):RPS6KA1 RPS6KA1
CTD Gene:6195 RPS6KA1
dbSNP Gene:6195 RPS6KA1
ENSEMBL:ENSG00000117676 RPS6KA1
ENSEMBL:ENSG00000117676.14 RPS6KA1
ENSEMBL:ENSG00000281877.3 RPS6KA1
HGNC:10430 RPS6KA1
KEGG Gene (Homo sapiens):6195 RPS6KA1
Monarch:6195 RPS6KA1
NCBI Gene:6195 RPS6KA1
OMIM:601684 RPS6KA1
UCSC:Q15418 RPS6KA1
Reference Transcript
RefSeq:NM_001006665.1 RPS6KA1
RefSeq:NM_002953.3 RPS6KA1
RefSeq:NM_001330441.1 RPS6KA1
Other Identifiers
1127_at
11741035_a_at
11741036_a_at
11744156_a_at
11749492_a_at
16661206
203379_PM_at
203379_at
2326562
2326563
2326565
2326572
2326575
2326576
2326577
2326578
2326579
2326580
2326582
2326584
2326585
2326587
2326589
2326590
2326591
2326592
2326593
2326595
2326596
2326598
2326600
2326601
2326602
2326604
2326605
2326606
2326608
2326609
2326610
2326611
2326612
2326613
6195
7899192
A_14_P138281
A_24_P396650
A_33_P3352307
GE57581
GO:0000166
GO:0000287
GO:0003824
GO:0004672
GO:0004674
GO:0004711
GO:0004712
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006351
GO:0006355
GO:0006468
GO:0006915
GO:0007049
GO:0007165
GO:0007268
GO:0012501
GO:0016301
GO:0016310
GO:0016740
GO:0023052
GO:0030154
GO:0030307
GO:0032007
GO:0035556
GO:0036211
GO:0043027
GO:0043066
GO:0043154
GO:0043226
GO:0043555
GO:0043620
GO:0045202
GO:0045597
GO:0045893
GO:0045944
GO:0046872
GO:0048856
GO:0072574
GO:0098772
GO:0106310
GO:0140096
GO:2000491
HMNXSV003053586
ILMN_1715173
L07597_at
PH_hs_0009027
TC01000347.hg
g4506732_3p_at
Participates
as a member of
p-T359,S363,S380,T573,T732-RSK [cytosol] (Homo sapiens)
Other forms of this molecule
RPS6KA1 [nucleoplasm]
p-4S,T359,T573-RPS6KA1 [nucleoplasm]
RPS6KA1 [cytosol]
p-T359,S363,T573-RPS6KA1 [cytosol]
p-S221,T459,S363,S380,T573,S732-RPS6KA1 [cytosol]
p-S221,T359,S363,S380,T573,S732-RPS6KA1 [nucleoplasm]
Modified Residues
Name
O-phospho-L-threonine at 359
Coordinate
359
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-serine at 363
Coordinate
363
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 380
Coordinate
380
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-threonine at 573
Coordinate
573
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-serine at 732
Coordinate
732
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_001317370.1
,
NP_001006666.1
,
NP_002944.2
ZINC - World Drugs
KS6A1_HUMAN
Guide to Pharmacology - Targets
1527
OpenTargets
ENSG00000117676
ZINC - FDA approved
KS6A1_HUMAN
ZINC - Substances
KS6A1_HUMAN
ZINC target
Q15418
ZINC - Biogenic
KS6A1_HUMAN
PRO
Q15418
PDB
6TWY
,
5V61
,
5N7G
,
5N7D
,
5CSF
,
4NIF
,
7P74
,
5CSJ
,
2Z7R
,
7QQL
,
3RNY
,
5N7F
,
5V62
,
7PC8
,
4H3P
,
2WNT
,
5CSN
,
3TEI
,
2Z7S
,
5CSI
,
2Z7Q
ZINC - Investigational
KS6A1_HUMAN
HPA
ENSG00000117676-RPS6KA1
GeneCards
Q15418
Ensembl
ENST00000631108
,
ENST00000374168
,
ENST00000526792
,
ENSP00000431651
,
ENST00000628256
,
ENSP00000487349
,
ENSP00000487553
,
ENSP00000486881
,
ENSP00000363283
,
ENST00000531382
,
ENSG00000117676
,
ENSP00000487166
,
ENSP00000432281
,
ENSG00000281877
,
ENST00000628081
,
ENST00000530003
,
ENST00000629832
,
ENSP00000435412
Pharos - Targets
Q15418
ZINC - Predictions - Purchasable
KS6A1_HUMAN
HMDB Protein
HMDBP01283
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P28482 MAPK1
18
MAPK1 [endoplasmic reticulum lumen]
(R-HSA-9636293)
MAPK1 [azurophil granule lumen]
(R-HSA-6799225)
MAPK1 [extracellular region]
(R-HSA-6806250)
MAPK1 [ficolin-1-rich granule lumen]
(R-HSA-6800964)
p-T185,Y187 MAPK1 E322V [cytosol]
(R-HSA-9652797)
p-T185,Y187 MAPK1 E322K [cytosol]
(R-HSA-9652175)
p-T185,Y187 MAPK1 E81K [cytosol]
(R-HSA-9652799)
p-T185,Y187 MAPK1 S142L [cytosol]
(R-HSA-9652808)
p-T185,Y187 MAPK1 P58L [cytosol]
(R-HSA-9652806)
p-T185,Y187 MAPK1 D321V [cytosol]
(R-HSA-9652791)
p-T185,Y187 MAPK1 D321N [cytosol]
(R-HSA-9652785)
p-T185,Y187 MAPK1 E322A [cytosol]
(R-HSA-9652794)
p-T185,Y187 MAPK1 P58G [cytosol]
(R-HSA-9652802)
p-T185-MAPK1 [cytosol]
(R-HSA-9635773)
MAPK1 [nucleoplasm]
(R-HSA-199960)
MAPK1 [cytosol]
(R-HSA-59282)
p-T185,Y187-MAPK1 [cytosol]
(R-HSA-109853)
p-T185,Y187-MAPK1 [nucleoplasm]
(R-HSA-112354)
0.816
7
UniProt:P08238 HSP90AB1
6
HSP90AB1 [secretory granule lumen]
(R-HSA-6801477)
HSP90AB1 [extracellular region]
(R-HSA-6806463)
HSP90AB1 [ficolin-1-rich granule lumen]
(R-HSA-6801491)
HSP90AB1 [cytosol]
(R-HSA-419617)
HSP90AB1 [nucleoplasm]
(R-HSA-5082399)
HSP90AB1 [lysosomal lumen]
(R-HSA-9622846)
0.669
4
UniProt:Q14160 SCRIB
1
SCRIB [cytosol]
(R-HSA-4608858)
0.611
3
UniProt:P04271 S100B
1
S100B [extracellular region]
(R-HSA-879433)
0.544
2
UniProt:P46527 CDKN1B
8
p-S10 CDKN1B [cytosol]
(R-HSA-9632829)
p-S10 CDKN1B [nucleoplasm]
(R-HSA-9632832)
p-T157-CDKN1B [cytosol]
(R-HSA-198629)
CDKN1B [cytosol]
(R-HSA-198622)
p-T187-CDKN1B [nucleoplasm]
(R-HSA-187525)
CDKN1B [nucleoplasm]
(R-HSA-182563)
p-Y88-CDKN1B [nucleoplasm]
(R-HSA-8942808)
p-Y88-CDKN1B [cytosol]
(R-HSA-8848438)
0.544
2
UniProt:P50552 VASP
1
VASP [cytosol]
(R-HSA-446323)
0.544
4
UniProt:P27361 MAPK3
6
MAPK3 [endoplasmic reticulum lumen]
(R-HSA-9636295)
p-T202-MAPK3 [cytosol]
(R-HSA-9635775)
MAPK3 [nucleoplasm]
(R-HSA-73724)
MAPK3 [cytosol]
(R-HSA-59284)
p-T202,Y204-MAPK3 [cytosol]
(R-HSA-109842)
p-T202,Y204-MAPK3 [nucleoplasm]
(R-HSA-112359)
0.527
2
UniProt:P07900 HSP90AA1
8
HSP90AA1 [endocytic vesicle lumen]
(R-HSA-3221912)
HSP90AA1 [secretory granule lumen]
(R-HSA-6801515)
HSP90AA1 [extracellular region]
(R-HSA-3221946)
HSP90AA1 [ficolin-1-rich granule lumen]
(R-HSA-6801470)
HSP90AA1 [plasma membrane]
(R-HSA-534996)
HSP90AA1 [nucleoplasm]
(R-HSA-5082401)
HSP90AA1 [cytosol]
(R-HSA-192864)
HSP90AA1 [lysosomal lumen]
(R-HSA-9622850)
0.527
3
UniProt:Q13085 ACACA
2
Btn-ACACA [cytosol]
(R-HSA-2976730)
ACACA [cytosol]
(R-HSA-1660609)
0.527
2
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