Reactome | p-T359,S363,S380.T573,S732-RPS6KA1 [cytosol]

p-T359,S363,S380.T573,S732-RPS6KA1 [cytosol]

Stable Identifier

R-HSA-9619993

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Phospho (T359,S363,S380,T573,S732)-Ribosomal protein S6 kinase alpha 1, p-T359,S363,S380.T573,S732-RSK1

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q15418 RPS6KA1

Gene Names

RPS6KA1, MAPKAPK1A, RSK1

Chain

chain:1-735

Reference Genes

BioGPS Gene:6195 RPS6KA1

COSMIC (genes):RPS6KA1 RPS6KA1

CTD Gene:6195 RPS6KA1

dbSNP Gene:6195 RPS6KA1

ENSEMBL:ENSG00000117676 RPS6KA1

HGNC:10430 RPS6KA1

KEGG:hsa:6195 RPS6KA1

Monarch:6195 RPS6KA1

NCBI Gene:6195 RPS6KA1

OMIM:601684 RPS6KA1

UCSC:Q15418 RPS6KA1

Reference Transcript

Other Identifiers

1127_at

11741035_a_at

11741036_a_at

11744156_a_at

11749492_a_at

16661206

16661253

203379_PM_at

203379_at

2326562

2326563

2326564

2326565

2326572

2326575

2326576

2326577

2326578

2326579

2326580

2326581

2326582

2326583

2326584

2326585

2326586

2326587

2326588

2326589

2326590

2326591

2326592

2326593

2326594

2326595

2326596

2326598

2326600

2326601

2326602

2326604

2326605

2326606

2326607

2326608

2326609

2326610

2326611

2326612

2326613

6195

7899192

A_14_P138281

A_24_P396650

A_33_P3352307

GE57581

GO:0000287

GO:0003824

GO:0004672

GO:0004674

GO:0004711

GO:0004712

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006355

GO:0006468

GO:0007165

GO:0007268

GO:0016740

GO:0023052

GO:0030307

GO:0032007

GO:0035556

GO:0043027

GO:0043066

GO:0043226

GO:0043555

GO:0045202

GO:0045597

GO:0045893

GO:0045944

GO:0046872

GO:0072574

GO:0098772

GO:0106310

GO:0140096

GO:2000491

HMNXSV003008905

HMNXSV003053586

ILMN_1715173

ILMN_2251452

L07597_at

PH_hs_0009027

TC01000347.hg

TC01000348.hg

g4506732_3p_at

Participates

as a member of

p-T359,S363,S380,T573,T732-RSK [cytosol] (Homo sapiens)

Other forms of this molecule

p-S221,T359,S363,S380,T573,S732-RPS6KA1 [nucleoplasm]

p-S221,T459,S363,S380,T573,S732-RPS6KA1 [cytosol]

p-T359,S363,T573-RPS6KA1 [cytosol]

RPS6KA1 [cytosol]

p-4S,T359,T573-RPS6KA1 [nucleoplasm]

RPS6KA1 [nucleoplasm]

Modified Residues

Name

O-phospho-L-threonine at 359

Coordinate

359

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Name

O-phospho-L-serine at 363

Coordinate

363

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 380

Coordinate

380

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-threonine at 573

Coordinate

573

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Name

O-phospho-L-serine at 732

Coordinate

732

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

NP_002944.2, NP_001006666.1, NP_001317370.1

Guide to Pharmacology - Targets

1527

OpenTargets

ENSG00000117676

ENSEMBL

ENST00000629832, ENSG00000281877, ENSP00000435412, ENSP00000487349, ENSP00000432281, ENSP00000487166, ENSP00000486881, ENST00000374168, ENST00000628256, ENSP00000487553, ENSP00000431651, ENST00000531382, ENST00000631108, ENST00000530003, ENST00000628081, ENSP00000363283, ENSG00000117676, ENST00000526792

ZINC - FDA approved

KS6A1_HUMAN

ZINC - Substances

KS6A1_HUMAN

ZINC - Biogenic

KS6A1_HUMAN

ZINC target

Q15418

PRO

Q15418

GlyGen

Q15418

PDB

7PC8, 7P74, 8WF4, 8XOV, 4H3P, 3TEI, 2Z7Q, 3RNY, 5CSN, 2Z7R, 2WNT, 5CSI, 5CSJ, 5N7F, 2Z7S, 5N7D, 5N7G, 5V62, 4NIF, 7QQL, 5CSF, 6TWY, 5V61

ZINC - Investigational

KS6A1_HUMAN

GeneCards

RPS6KA1

HPA

ENSG00000117676-RPS6KA1

Pharos - Targets

Q15418

ZINC - Predictions - Purchasable

KS6A1_HUMAN

HMDB Protein

HMDBP01283

Interactors (15)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P28482 MAPK1	18	p-T185,Y187-MAPK1 [nucleoplasm] (R-HSA-112354) p-T185,Y187-MAPK1 [cytosol] (R-HSA-109853) MAPK1 [cytosol] (R-HSA-59282) MAPK1 [nucleoplasm] (R-HSA-199960) p-T185-MAPK1 [cytosol] (R-HSA-9635773) p-T185,Y187 MAPK1 P58G [cytosol] (R-HSA-9652802) p-T185,Y187 MAPK1 E322A [cytosol] (R-HSA-9652794) p-T185,Y187 MAPK1 D321N [cytosol] (R-HSA-9652785) p-T185,Y187 MAPK1 D321V [cytosol] (R-HSA-9652791) p-T185,Y187 MAPK1 P58L [cytosol] (R-HSA-9652806) p-T185,Y187 MAPK1 S142L [cytosol] (R-HSA-9652808) p-T185,Y187 MAPK1 E81K [cytosol] (R-HSA-9652799) p-T185,Y187 MAPK1 E322K [cytosol] (R-HSA-9652175) p-T185,Y187 MAPK1 E322V [cytosol] (R-HSA-9652797) MAPK1 [ficolin-1-rich granule lumen] (R-HSA-6800964) MAPK1 [extracellular region] (R-HSA-6806250) MAPK1 [azurophil granule lumen] (R-HSA-6799225) MAPK1 [endoplasmic reticulum lumen] (R-HSA-9636293)	0.896	12
UniProt:P51812 RPS6KA3	7	p-S227,T365,S369,S386,T577,T737-RPS6KA3 [nucleoplasm] (R-HSA-444286) p-T365,S369,S386,T577,T737-RPS6KA3 [cytosol] (R-HSA-9619989) p-S227,T365,S369,S386,T577,T737-RPS6KA3 [cytosol] (R-HSA-9619872) p-T365,S369,T577-RPS6KA3 [cytosol] (R-HSA-9619959) RPS6KA3 [cytosol] (R-HSA-444250) p-4S,T231,T365-RPS6KA3 [nucleoplasm] (R-HSA-199830) RPS6KA3 [nucleoplasm] (R-HSA-199869)	0.788	6
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.744	7
UniProt:P67870 CSNK2B	5	CSNK2B [cytosol] (R-HSA-201693) CSNK2B [nucleoplasm] (R-HSA-6805067) CSNK2B [ficolin-1-rich granule lumen] (R-HSA-6801290) CSNK2B [extracellular region] (R-HSA-6806508) CSNK2B [secretory granule lumen] (R-HSA-6801319)	0.725	5
UniProt:Q15349 RPS6KA2	7	p-S218,T356,S360,S377,T570,T730-RPS6KA2 [nucleoplasm] (R-HSA-444290) p-T356,S360,S377,T570,T730-RPS6KA2 [cytosol] (R-HSA-9619984) p-S218,T356,S360,S377,T570,T730-RPS6KA2 [cytosol] (R-HSA-9619869) p-T356,S360,T570-RPS6KA2 [cytosol] (R-HSA-9619955) RPS6KA2 [cytosol] (R-HSA-444252) p-4S,T356,T570-RPS6KA2 [nucleoplasm] (R-HSA-199871) RPS6KA2 [nucleoplasm] (R-HSA-199861)	0.725	5
UniProt:P08238 HSP90AB1	6	HSP90AB1 [lysosomal lumen] (R-HSA-9622846) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [secretory granule lumen] (R-HSA-6801477)	0.669	4
UniProt:Q14160 SCRIB	1	SCRIB [cytosol] (R-HSA-4608858)	0.611	3
UniProt:P04271 S100B	1	S100B [extracellular region] (R-HSA-879433)	0.544	2
UniProt:P46527 CDKN1B	8	p-Y88-CDKN1B [nucleoplasm] (R-HSA-8942808) CDKN1B [nucleoplasm] (R-HSA-182563) p-Y88-CDKN1B [cytosol] (R-HSA-8848438) CDKN1B [cytosol] (R-HSA-198622) p-T187-CDKN1B [nucleoplasm] (R-HSA-187525) p-T157-CDKN1B [cytosol] (R-HSA-198629) p-S10 CDKN1B [nucleoplasm] (R-HSA-9632832) p-S10 CDKN1B [cytosol] (R-HSA-9632829)	0.544	2
UniProt:P50552 VASP	1	VASP [cytosol] (R-HSA-446323)	0.544	4
UniProt:P07900 HSP90AA1	8	HSP90AA1 [lysosomal lumen] (R-HSA-9622850) HSP90AA1 [cytosol] (R-HSA-192864) HSP90AA1 [nucleoplasm] (R-HSA-5082401) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [secretory granule lumen] (R-HSA-6801515) HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912)	0.527	3
UniProt:P27361 MAPK3	6	p-T202,Y204-MAPK3 [nucleoplasm] (R-HSA-112359) p-T202,Y204-MAPK3 [cytosol] (R-HSA-109842) MAPK3 [cytosol] (R-HSA-59284) MAPK3 [nucleoplasm] (R-HSA-73724) p-T202-MAPK3 [cytosol] (R-HSA-9635775) MAPK3 [endoplasmic reticulum lumen] (R-HSA-9636295)	0.527	2
UniProt:Q13085 ACACA	2	Btn-ACACA [cytosol] (R-HSA-2976730) ACACA [cytosol] (R-HSA-1660609)	0.527	2
UniProt:A1JU68 A1JU68			0.499	3
UniProt:O43823 AKAP8			0.463	5

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