Reactome | DHPS [cytosol]

DHPS [cytosol]

Stable Identifier

R-HSA-204630

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Deoxyhypusine synthase monomer

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P49366 DHPS

Gene Names

DHPS, DS

Chain

chain:1-369

Reference Genes

BioGPS Gene:1725 DHPS

COSMIC (genes):DHPS DHPS

CTD Gene:1725 DHPS

dbSNP Gene:1725 DHPS

ENSEMBL:ENSG00000095059 DHPS

ENSEMBL_homo_sapiens_GENE:ENSG00000095059.17 DHPS

HGNC:2869 DHPS

KEGG Gene (Homo sapiens):1725 DHPS

Monarch:1725 DHPS

NCBI Gene:1725 DHPS

OMIM:600944 DHPS

UCSC:P49366 DHPS

Reference Transcript

Other Identifiers

11717445_a_at

11717446_x_at

11737565_a_at

11753957_a_at

11761643_x_at

16869228

1725

202802_PM_at

202802_at

207831_PM_x_at

207831_x_at

211558_PM_s_at

211558_s_at

37721_at

37722_s_at

3851604

3851605

3851607

3851608

3851609

3851612

3851614

3851615

3851617

3851618

3851621

3851622

3851623

3851625

3851626

8034454

A_23_P501887

GE58271

GO:0002376

GO:0003824

GO:0005515

GO:0005737

GO:0005829

GO:0006412

GO:0007155

GO:0008216

GO:0008284

GO:0008612

GO:0016740

GO:0034038

GO:0036211

GO:0042102

GO:0042593

GO:0042802

GO:0046203

GO:0051604

HMNXSV003039414

ILMN_1687279

ILMN_2326997

TC19001204.hg

TC19002343.hg

U26266_s_at

U79262_at

g1373016_3p_s_at

g7108339_3p_s_at

Participates

as a component of

DHPS tetramer [cytosol] (Homo sapiens)

Inferred To

DHPS [cytosol] (Bos taurus)

DHPS [cytosol] (Caenorhabditis elegans)

DHPS [cytosol] (Canis familiaris)

DHPS [cytosol] (Dictyostelium discoideum)

DHPS [cytosol] (Drosophila melanogaster)

DHPS [cytosol] (Mus musculus)

DHPS [cytosol] (Plasmodium falciparum)

DHPS [cytosol] (Rattus norvegicus)

DHPS [cytosol] (Saccharomyces cerevisiae)

DHPS [cytosol] (Schizosaccharomyces pombe)

DHPS [cytosol] (Sus scrofa)

dhps [cytosol] (Xenopus tropicalis)

wu:fb52g04 [cytosol] (Danio rerio)

Cross References

RefSeq

XP_011526072.1, NP_001921.1, NP_001193903.1, NP_037538.1

OpenTargets

ENSG00000095059

IntEnz

2.5.1.46

GeneCards

P49366

HPA

ENSG00000095059-DHPS

Ensembl

ENSP00000471886, ENST00000594424, ENST00000210060, ENST00000351660, ENSP00000221303, ENSP00000210060, ENSG00000095059

PRO

P49366

Pharos - Targets

P49366

HMDB Protein

HMDBP00219

PDB

6XXK, 6PGR, 6XXH, 1DHS, 6XXL, 7A6S, 1ROZ, 6P4V, 6XXI, 8A0E, 6XXM, 1RLZ, 7A6T, 6WKZ, 6XXJ, 6WL6, 8A0F, 8A0G, 1RQD

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P27361 MAPK3	6	MAPK3 [endoplasmic reticulum lumen] (R-HSA-9636295) p-T202-MAPK3 [cytosol] (R-HSA-9635775) MAPK3 [nucleoplasm] (R-HSA-73724) MAPK3 [cytosol] (R-HSA-59284) p-T202,Y204-MAPK3 [cytosol] (R-HSA-109842) p-T202,Y204-MAPK3 [nucleoplasm] (R-HSA-112359)	0.919	10
UniProt:P09455 RBP1	1	RBP1 [cytosol] (R-HSA-74841)	0.556	3
UniProt:P26367 PAX6	1	PAX6 [nucleoplasm] (R-HSA-3009044)	0.556	3
UniProt:P28482 MAPK1	18	MAPK1 [endoplasmic reticulum lumen] (R-HSA-9636293) MAPK1 [azurophil granule lumen] (R-HSA-6799225) MAPK1 [extracellular region] (R-HSA-6806250) MAPK1 [ficolin-1-rich granule lumen] (R-HSA-6800964) p-T185,Y187 MAPK1 E322V [cytosol] (R-HSA-9652797) p-T185,Y187 MAPK1 E322K [cytosol] (R-HSA-9652175) p-T185,Y187 MAPK1 E81K [cytosol] (R-HSA-9652799) p-T185,Y187 MAPK1 S142L [cytosol] (R-HSA-9652808) p-T185,Y187 MAPK1 P58L [cytosol] (R-HSA-9652806) p-T185,Y187 MAPK1 D321V [cytosol] (R-HSA-9652791) p-T185,Y187 MAPK1 D321N [cytosol] (R-HSA-9652785) p-T185,Y187 MAPK1 E322A [cytosol] (R-HSA-9652794) p-T185,Y187 MAPK1 P58G [cytosol] (R-HSA-9652802) p-T185-MAPK1 [cytosol] (R-HSA-9635773) MAPK1 [nucleoplasm] (R-HSA-199960) MAPK1 [cytosol] (R-HSA-59282) p-T185,Y187-MAPK1 [cytosol] (R-HSA-109853) p-T185,Y187-MAPK1 [nucleoplasm] (R-HSA-112354)	0.527	8

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