Reactome | DHPS [cytosol]

DHPS [cytosol]

Stable Identifier

R-HSA-204630

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Deoxyhypusine synthase monomer

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P49366 DHPS

Gene Names

DHPS, DS

Chain

chain:1-369

Reference Genes

BioGPS Gene:1725 DHPS

COSMIC (genes):DHPS DHPS

CTD Gene:1725 DHPS

dbSNP Gene:1725 DHPS

ENSEMBL:ENSG00000095059 DHPS

HGNC:2869 DHPS

Monarch:1725 DHPS

NCBI Gene:1725 DHPS

OMIM:600944 DHPS

UCSC:P49366 DHPS

Reference Transcript

Other Identifiers

11717445_a_at

11717446_x_at

11737565_a_at

11753957_a_at

11761643_x_at

16869228

1725

202802_PM_at

202802_at

207831_PM_x_at

207831_x_at

211558_PM_s_at

211558_s_at

37721_at

37722_s_at

3851604

3851605

3851606

3851607

3851608

3851609

3851610

3851611

3851612

3851613

3851614

3851615

3851616

3851617

3851618

3851619

3851620

3851621

3851622

3851623

3851624

3851625

3851626

8034454

A_23_P501887

GE58271

GO:0003824

GO:0005515

GO:0005737

GO:0005829

GO:0006412

GO:0008216

GO:0008284

GO:0008612

GO:0016740

GO:0034038

GO:0042102

GO:0042593

GO:0042802

GO:0046203

GO:0051604

HMNXSV003039414

ILMN_1687279

ILMN_1752967

ILMN_2326997

TC19001204.hg

TC19002343.hg

U26266_s_at

U79262_at

g1373016_3p_s_at

g7108339_3p_s_at

Participates

as a component of

DHPS tetramer [cytosol] (Homo sapiens)

Inferred To

DHPS [cytosol] (Bos taurus)

DHPS [cytosol] (Caenorhabditis elegans)

DHPS [cytosol] (Canis familiaris)

DHPS [cytosol] (Dictyostelium discoideum)

DHPS [cytosol] (Drosophila melanogaster)

DHPS [cytosol] (Mus musculus)

DHPS [cytosol] (Plasmodium falciparum)

DHPS [cytosol] (Rattus norvegicus)

DHPS [cytosol] (Saccharomyces cerevisiae)

DHPS [cytosol] (Schizosaccharomyces pombe)

DHPS [cytosol] (Sus scrofa)

dhps [cytosol] (Danio rerio)

dhps [cytosol] (Xenopus tropicalis)

Cross References

OpenTargets

ENSG00000095059

ENSEMBL

ENST00000594424, ENSP00000210060, ENSP00000221303, ENST00000210060, ENSP00000471886, ENST00000351660

IntEnz

2.5.1.46

HPA

ENSG00000095059-DHPS

PRO

P49366

Pharos - Targets

P49366

PDB

8A0G, 6WKZ, 1RQD, 6PGR, 7A6T, 6XXI, 6XXH, 7A6S, 6WL6, 6XXK, 6P4V, 1ROZ, 6XXJ, 1RLZ, 8A0F, 6XXM, 6XXL, 8A0E, 1DHS

HMDB Protein

HMDBP00219

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P27361 MAPK3	6	p-T202,Y204-MAPK3 [nucleoplasm] (R-HSA-112359) p-T202,Y204-MAPK3 [cytosol] (R-HSA-109842) MAPK3 [cytosol] (R-HSA-59284) MAPK3 [nucleoplasm] (R-HSA-73724) p-T202-MAPK3 [cytosol] (R-HSA-9635775) MAPK3 [endoplasmic reticulum lumen] (R-HSA-9636295)	0.919	10
UniProt:P28482 MAPK1	18	p-T185,Y187-MAPK1 [nucleoplasm] (R-HSA-112354) p-T185,Y187-MAPK1 [cytosol] (R-HSA-109853) MAPK1 [cytosol] (R-HSA-59282) MAPK1 [nucleoplasm] (R-HSA-199960) p-T185-MAPK1 [cytosol] (R-HSA-9635773) p-T185,Y187 MAPK1 P58G [cytosol] (R-HSA-9652802) p-T185,Y187 MAPK1 E322A [cytosol] (R-HSA-9652794) p-T185,Y187 MAPK1 D321N [cytosol] (R-HSA-9652785) p-T185,Y187 MAPK1 D321V [cytosol] (R-HSA-9652791) p-T185,Y187 MAPK1 P58L [cytosol] (R-HSA-9652806) p-T185,Y187 MAPK1 S142L [cytosol] (R-HSA-9652808) p-T185,Y187 MAPK1 E81K [cytosol] (R-HSA-9652799) p-T185,Y187 MAPK1 E322K [cytosol] (R-HSA-9652175) p-T185,Y187 MAPK1 E322V [cytosol] (R-HSA-9652797) MAPK1 [azurophil granule lumen] (R-HSA-6799225) MAPK1 [extracellular region] (R-HSA-6806250) MAPK1 [ficolin-1-rich granule lumen] (R-HSA-6800964) MAPK1 [endoplasmic reticulum lumen] (R-HSA-9636293)	0.643	10
UniProt:P09455 RBP1	1	RBP1 [cytosol] (R-HSA-74841)	0.556	3
UniProt:P26367 PAX6	1	PAX6 [nucleoplasm] (R-HSA-3009044)	0.556	3
UniProt:Q13895 BYSL	2	BYSL [nucleoplasm] (R-HSA-6791526) BYSL [cytosol] (R-HSA-6791518)	0.527	3
UniProt:P23246 SFPQ	3	SFPQ [nucleoplasm] (R-HSA-3900138) p-Y-SFPQ [nucleoplasm] (R-HSA-8849461) SFPQ [cytosol] (R-HSA-9635505)	0.527	2

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