Reactome | DUSP9 [cytosol]

DUSP9 [cytosol]

Stable Identifier

R-HSA-5675351

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q99956 DUSP9

Gene Names

DUSP9, MKP4

Chain

chain:1-384

Reference Genes

BioGPS Gene:1852 DUSP9

COSMIC (genes):DUSP9 DUSP9

CTD Gene:1852 DUSP9

dbSNP Gene:1852 DUSP9

ENSEMBL:ENSG00000130829 DUSP9

HGNC:3076 DUSP9

KEGG Gene (Homo sapiens):1852 DUSP9

Monarch:1852 DUSP9

NCBI Gene:1852 DUSP9

OMIM:300134 DUSP9

UCSC:Q99956 DUSP9

Reference Transcript

Other Identifiers

0002690519

11731750_s_at

11755621_x_at

1443_at

17108056

1852

205777_at

3995773

3995777

3995779

3995780

3995781

3995782

3995783

3995784

3995785

3995786

3995787

3995788

3995789

40186_at

8170695

A_14_P109655

A_24_P417189

GE60251

GO:0000165

GO:0000187

GO:0000188

GO:0003674

GO:0004721

GO:0004722

GO:0004725

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005737

GO:0005829

GO:0006464

GO:0006470

GO:0006950

GO:0007165

GO:0007254

GO:0008138

GO:0008150

GO:0008219

GO:0008330

GO:0016311

GO:0016787

GO:0016791

GO:0017017

GO:0019899

GO:0035335

GO:0035970

GO:0040007

GO:0043065

GO:0043226

GO:0048856

GO:0051019

GO:0060420

GO:0070373

GO:0106306

GO:0106307

HMNXSV003043390

ILMN_1712314

ILMN_1724034

PH_hs_0008587

TC0X000753.hg

TC0X001927.hg

Y08302_at

g4503420_3p_at

Participates

as a member of

cytosolic MAPK DUSPs [cytosol] (Homo sapiens)

Inferred To

Homologues of DUSP9 [cytosol] (Caenorhabditis elegans)

Homologues of DUSP9 [cytosol] (Saccharomyces cerevisiae)

Dusp9 [cytosol] (Mus musculus)

Dusp9 [cytosol] (Rattus norvegicus)

DUSP9 [cytosol] (Caenorhabditis elegans)

DUSP9 [cytosol] (Canis familiaris)

DUSP9 [cytosol] (Sus scrofa)

MSG5 [cytosol] (Saccharomyces cerevisiae)

Mkp3 [cytosol] (Drosophila melanogaster)

SDP1 [cytosol] (Saccharomyces cerevisiae)

lip-1 [cytosol] (Caenorhabditis elegans)

dusp9 [cytosol] (Xenopus tropicalis)

pmp1 [cytosol] (Schizosaccharomyces pombe)

Cross References

RefSeq

NP_001305432.1, XP_011529426.1, NP_001386.1

OpenTargets

ENSG00000130829

IntEnz

3.1.3.16

GeneCards

Q99956

HPA

ENSG00000130829-DUSP9

Ensembl

ENSG00000130829, ENST00000370167, ENST00000342782, ENSP00000359186, ENSP00000345853

PRO

Q99956

Pharos - Targets

Q99956

PDB

3LJ8, 2HXP

HMDB Protein

HMDBP08916

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q16539 MAPK14	7	MAPK14 [secretory granule lumen] (R-HSA-6803300) MAPK14 [extracellular region] (R-HSA-6806453) MAPK14 [ficolin-1-rich granule lumen] (R-HSA-6803280) MAPK14 [nucleoplasm] (R-HSA-446223) MAPK14 [cytosol] (R-HSA-428933) p-T180,Y182-MAPK14 [cytosol] (R-HSA-428935) p-T180,Y182-MAPK14 [nucleoplasm] (R-HSA-446227)	0.716	4
UniProt:P28482 MAPK1	18	MAPK1 [endoplasmic reticulum lumen] (R-HSA-9636293) MAPK1 [ficolin-1-rich granule lumen] (R-HSA-6800964) MAPK1 [extracellular region] (R-HSA-6806250) MAPK1 [azurophil granule lumen] (R-HSA-6799225) p-T185,Y187 MAPK1 E322V [cytosol] (R-HSA-9652797) p-T185,Y187 MAPK1 E322K [cytosol] (R-HSA-9652175) p-T185,Y187 MAPK1 E81K [cytosol] (R-HSA-9652799) p-T185,Y187 MAPK1 S142L [cytosol] (R-HSA-9652808) p-T185,Y187 MAPK1 P58L [cytosol] (R-HSA-9652806) p-T185,Y187 MAPK1 D321V [cytosol] (R-HSA-9652791) p-T185,Y187 MAPK1 D321N [cytosol] (R-HSA-9652785) p-T185,Y187 MAPK1 E322A [cytosol] (R-HSA-9652794) p-T185,Y187 MAPK1 P58G [cytosol] (R-HSA-9652802) p-T185-MAPK1 [cytosol] (R-HSA-9635773) MAPK1 [nucleoplasm] (R-HSA-199960) MAPK1 [cytosol] (R-HSA-59282) p-T185,Y187-MAPK1 [cytosol] (R-HSA-109853) p-T185,Y187-MAPK1 [nucleoplasm] (R-HSA-112354)	0.659	4
UniProt:P27361 MAPK3	6	MAPK3 [endoplasmic reticulum lumen] (R-HSA-9636295) p-T202-MAPK3 [cytosol] (R-HSA-9635775) MAPK3 [nucleoplasm] (R-HSA-73724) MAPK3 [cytosol] (R-HSA-59284) p-T202,Y204-MAPK3 [nucleoplasm] (R-HSA-112359) p-T202,Y204-MAPK3 [cytosol] (R-HSA-109842)	0.615	3
UniProt:P47811 Mapk14	7	Mapk14 [secretory granule lumen] (R-MMU-6803300) Mapk14 [extracellular region] (R-MMU-6806453) Mapk14 [ficolin-1-rich granule lumen] (R-MMU-6803280) Mapk14 [nucleoplasm] (R-MMU-446223) MAP kinase p38 alpha [cytosol] (R-MMU-448843) phospho-MAP kinase p38 alpha [cytosol] (R-MMU-448842) p-T180,Y182-Mapk14 [nucleoplasm] (R-MMU-1605486)	0.527	2

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