Reactome | DUSP9 [cytosol]

DUSP9 [cytosol]

Stable Identifier

R-HSA-5675351

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

Expand all

Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - FLT3 Signaling (Homo sapiens)
    - RAF/MAP kinase cascade (Homo sapiens)
      - Negative regulation of MAPK pathway (Homo sapiens)
        
        Cytosolic DUSPs dephosphorylate MAPKs (Homo sapiens)
        
        cytosolic MAPK DUSPs [cytosol] (Homo sapiens)
        
        DUSP9 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q99956 DUSP9

Gene Names

DUSP9, MKP4

Chain

chain:1-384

Reference Genes

BioGPS Gene:1852 DUSP9

COSMIC (genes):DUSP9 DUSP9

CTD Gene:1852 DUSP9

dbSNP Gene:1852 DUSP9

ENSEMBL:ENSG00000130829 DUSP9

HGNC:3076 DUSP9

KEGG Gene (Homo sapiens):1852 DUSP9

Monarch:1852 DUSP9

NCBI Gene:1852 DUSP9

OMIM:300134 DUSP9

UCSC:Q99956 DUSP9

Reference Transcript

Other Identifiers

0002690519

04658+3.1.3.16

04660+3.1.3.16

05235+3.1.3.16

11731750_s_at

11755621_x_at

1443_at

17108056

1852

205777_at

2HXP

3336

3995773

3995777

3995779

3995780

3995781

3995782

3995783

3995784

3995785

3995786

3995787

3995788

3995789

3LJ8

40186_at

8170695

A_14_P109655

A_24_P417189

CAA69610

CCDS14724

CH471172

DUSP9

DUSP9-201

DUSP9-202

EAW72847

EAW72848

EAW72849

ENSG00000130829

ENSP00000345853

ENSP00000359186

ENST00000342782

ENST00000342782.3

ENST00000370167

ENST00000370167.8

EntrezGene:1852

EntrezGene:DUSP9

g4503420_3p_at

GE60251

GO:0000165

GO:0000187

GO:0000188

GO:0003674

GO:0004721

GO:0004725

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005737

GO:0005829

GO:0006464

GO:0006470

GO:0006950

GO:0007165

GO:0007254

GO:0008138

GO:0008150

GO:0016311

GO:0016787

GO:0016791

GO:0017017

GO:0035335

GO:0043226

HGNC:3076

HPA003336

ILMN_1712314

ILMN_1724034

IPR000340

IPR000387

IPR001763

IPR008343

IPR020422

IPR029021

IPR036873

MIM:300134

NM_001318503

NM_001395

NP_001305432

NP_001386

PF00581

PF00782

PH_hs_0008587

PR01764

SM00195

SM00450

TC0X000753.hg

TC0X001927.hg

U52111

UPI0000049C1B

XM_011531123

XM_011531124

XP_011529425

XP_011529426

Y08302

Y08302_at

Participant Of

hasMember

cytosolic MAPK DUSPs [cytosol]

Inferred To

Dusp9 [cytosol] (Mus musculus)

Dusp9 [cytosol] (Rattus norvegicus)

DUSP9 [cytosol] (Bos taurus)

DUSP9 [cytosol] (Canis familiaris)

DUSP9 [cytosol] (Dictyostelium discoideum)

DUSP9 [cytosol] (Plasmodium falciparum)

DUSP9 [cytosol] (Sus scrofa)

Mkp3 [cytosol] (Drosophila melanogaster)

dusp7 [cytosol] (Danio rerio)

lip-1 [cytosol] (Caenorhabditis elegans)

dusp9 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_001305432.1, NP_001386.1, XP_011529426.1

OpenTargets

ENSG00000130829

HPA

ENSG00000130829-DUSP9

GeneCards

Q99956

Ensembl

ENST00000342782, ENST00000370167, ENSG00000130829, ENSP00000345853, ENSP00000359186

PRO

Q99956

HMDB Protein

HMDBP08916

PDB

2HXP, 3LJ8

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P28482 MAPK1	8	MAPK1 [azurophil granule lumen] (R-HSA-6799225) MAPK1 [endoplasmic reticulum lumen] (R-HSA-9636293) MAPK1 [extracellular region] (R-HSA-6806250) MAPK1 [ficolin-1-rich granule lumen] (R-HSA-6800964) MAPK1 [cytosol] (R-HSA-59282) p-T185,Y187-MAPK1 [cytosol] (R-HSA-109853) MAPK1 [nucleoplasm] (R-HSA-199960) p-T185,Y187-MAPK1 [nucleoplasm] (R-HSA-112354)	0.547	3
UniProt:P47811 Mapk14	7	Mapk14 [extracellular region] (R-MMU-6806453) Mapk14 [secretory granule lumen] (R-MMU-6803300) Mapk14 [ficolin-1-rich granule lumen] (R-MMU-6803280) MAP kinase p38 alpha [cytosol] (R-MMU-448843) phospho-MAP kinase p38 alpha [cytosol] (R-MMU-448842) Mapk14 [nucleoplasm] (R-MMU-446223) p-T180,Y182-Mapk14 [nucleoplasm] (R-MMU-1605486)	0.527	2
UniProt:Q16539 MAPK14	7	MAPK14 [extracellular region] (R-HSA-6806453) MAPK14 [secretory granule lumen] (R-HSA-6803300) MAPK14 [ficolin-1-rich granule lumen] (R-HSA-6803280) MAPK14 [cytosol] (R-HSA-428933) p-T180,Y182-MAPK14 [cytosol] (R-HSA-428935) MAPK14 [nucleoplasm] (R-HSA-446223) p-T180,Y182-MAPK14 [nucleoplasm] (R-HSA-446227)	0.508	2