Reactome | TNIP1 [cytosol]

TNIP1 [cytosol]

Stable Identifier

R-HSA-5690853

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

TNFAIP3-interacting protein 1, TNIP1_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q15025 TNIP1

Gene Names

TNIP1, KIAA0113, NAF1

Chain

chain:1-636

Reference Genes

BioGPS Gene:10318 TNIP1

COSMIC (genes):NAF1 TNIP1

COSMIC (genes):TNIP1 TNIP1

CTD Gene:10318 TNIP1

dbSNP Gene:10318 TNIP1

ENSEMBL:ENSG00000145901 TNIP1

HGNC:16903 TNIP1

Monarch:10318 TNIP1

NCBI Gene:10318 TNIP1

OMIM:607714 TNIP1

UCSC:Q15025 TNIP1

Reference Transcript

Other Identifiers

10318

11715898_a_at

11744745_a_at

11744746_x_at

11745731_x_at

11750133_x_at

11750443_x_at

11750986_a_at

11750987_x_at

17001763

207196_PM_s_at

207196_s_at

243423_PM_at

243423_at

2881671

2881673

2881674

2881675

2881676

2881677

2881678

2881679

2881680

2881681

2881682

2881683

2881684

2881685

2881686

2881687

2881688

2881689

2881692

2881693

2881694

2881695

2881696

2881697

2881698

2881700

2881702

2881704

2881706

2881707

2881709

2881710

2881713

2881715

2881716

2881717

2881718

2881722

2881723

2881730

3725450

38970_s_at

38971_r_at

69657_at

8115210

82059_i_at

82061_r_at

89794_at

A_23_P19036

A_23_P30435

D30755_at

GE81591

GO:0002376

GO:0002755

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006355

GO:0006357

GO:0006412

GO:0006952

GO:0006954

GO:0007155

GO:0007159

GO:0009101

GO:0042802

GO:0043122

GO:0043124

GO:0043226

GO:0045071

GO:0045944

GO:0050729

GO:0051019

GO:0070373

GO:0071222

GO:1901135

GO:1903003

HMNXSV003037255

ILMN_1703650

PH_hs_0012005

PH_hs_0023969

TC05001946.hg

TC05003310.hg

g5174608_3p_a_at

Participates

as a member of

TNIPs [cytosol] (Homo sapiens)

Inferred To

HDA2 [cytosol] (Saccharomyces cerevisiae)

tnip1 [cytosol] (Danio rerio)

tnip1 [cytosol] (Xenopus tropicalis)

Tnip1 [cytosol] (Mus musculus)

Tnip1 [cytosol] (Rattus norvegicus)

TNIP1 [cytosol] (Bos taurus)

TNIP1 [cytosol] (Canis familiaris)

TNIP1 [cytosol] (Gallus gallus)

TNIP1 [cytosol] (Sus scrofa)

Cross References

OpenTargets

ENSG00000145901

ENSEMBL

ENSP00000429891, ENST00000610535, ENST00000522226, ENST00000523200, ENST00000521591, ENST00000524280, ENST00000523338, ENST00000520931, ENST00000315050, ENSP00000429912, ENST00000518977, ENSP00000483944, ENSP00000428243, ENSP00000431105, ENSP00000430760, ENSP00000428187, ENSP00000430971, ENSP00000317891

HPA

ENSG00000145901-TNIP1

PRO

Q15025

Pharos - Targets

Q15025

Orphanet

TNIP1

PDB

7EAO, 7EB9, 7EAL

Interactors (18)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96CV9 OPTN	6	p-S177,S473,S513-OPTN [cytosol] (R-HSA-9687840) OPTN [cytosol] (R-HSA-9687907) p-S177-OPTN [cytosol] (R-HSA-2562525) p-S177-OPTN [nucleoplasm] (R-HSA-2562595) OPTN [Golgi membrane] (R-HSA-2161111) OPTN [recycling endosome membrane] (R-HSA-8854141)	0.966	22
UniProt:P21580 TNFAIP3	1	TNFAIP3 [cytosol] (R-HSA-688989)	0.906	12
UniProt:P51959 CCNG1	1	CCNG1 [nucleoplasm] (R-HSA-6792489)	0.834	8
UniProt:Q9H267 VPS33B	3	VPS33B [cytosol] (R-HSA-9636417) p-Y133-VPS33B [cytosol] (R-HSA-9636380) VPS33B [endosome membrane] (R-HSA-2197801)	0.805	9
UniProt:Q00403 GTF2B	1	GTF2B [nucleoplasm] (R-HSA-65888)	0.781	7
UniProt:Q13526 PIN1	2	PIN1 [nucleoplasm] (R-HSA-936016) PIN1 [cytosol] (R-HSA-9626823)	0.781	7
UniProt:P19838 NFKB1	8	3xUb-p-S927,S932-NFKB1(1-968) [cytosol] (R-HSA-451619) p-S927,S932-NFKB1(1-968) [cytosol] (R-HSA-451611) NFKB1(1-968) [cytosol] (R-HSA-451607) NFKB1(1-433) [nucleoplasm] (R-HSA-177655) NFKB1(1-433) [cytosol] (R-HSA-168168) NFKB1(1-968) [specific granule lumen] (R-HSA-6799557) NFKB1(1-968) [extracellular region] (R-HSA-6806304) NFKB1(1-968) [secretory granule lumen] (R-HSA-6801004)	0.725	6
UniProt:Q13895 BYSL	2	BYSL [nucleoplasm] (R-HSA-6791526) BYSL [cytosol] (R-HSA-6791518)	0.718	8
UniProt:P40222 TXLNA	1	TXLNA [cytosol] (R-HSA-449124)	0.718	6
UniProt:Q96T60 PNKP	1	PNKP [nucleoplasm] (R-HSA-5649651)	0.718	6
UniProt:Q9Y6K9 IKBKG	12	IKBKG [cytosol] (R-HSA-168108) Ub-285-IKBKG [cytosol] (R-HSA-741397) K63polyUb-IKBKG [cytosol] (R-HSA-202530) IKBKG [nucleoplasm] (R-HSA-4755413) monoSUMO1-K277,K309-IKBKG [nucleoplasm] (R-HSA-4755449) IKBKG 420Wext447 [cytosol] (R-HSA-5262978) IKBKG R175P [cytosol] (R-HSA-5262916) IKBKG R173G [cytosol] (R-HSA-5262966) IKBKG C417R [cytosol] (R-HSA-5262858) IKBKG E391* [cytosol] (R-HSA-5262924) IKBKG L153R [cytosol] (R-HSA-5262879) IKBKG D406V [cytosol] (R-HSA-5262943)	0.709	6
UniProt:Q08426 EHHADH	2	EHHADH [peroxisomal matrix] (R-HSA-400155) EHHADH [cytosol] (R-HSA-9033147)	0.666	4
UniProt:Q9GZQ8 MAP1LC3B	3	MAP1LC3B [cytosol] (R-HSA-5205651) MAP1LC3B(2-121) [cytosol] (R-HSA-5682674) MAP1LC3B [autophagosome membrane] (R-HSA-5683641)	0.666	4
UniProt:Q96NC0 ZMAT2	1	ZMAT2 [nucleoplasm] (R-HSA-9770248)	0.556	3
UniProt:Q7L190 DPPA4	1	DPPA4 [nucleoplasm] (R-HSA-452999)	0.556	3
UniProt:Q96EZ8 MCRS1	1	MCRS1 [nucleoplasm] (R-HSA-3321849)	0.556	3
UniProt:Q9UM82 SPATA2	1	SPATA2 [cytosol] (R-HSA-9796351)	0.556	3
UniProt:P28482 MAPK1	18	p-T185,Y187-MAPK1 [nucleoplasm] (R-HSA-112354) p-T185,Y187-MAPK1 [cytosol] (R-HSA-109853) MAPK1 [cytosol] (R-HSA-59282) MAPK1 [nucleoplasm] (R-HSA-199960) p-T185-MAPK1 [cytosol] (R-HSA-9635773) p-T185,Y187 MAPK1 P58G [cytosol] (R-HSA-9652802) p-T185,Y187 MAPK1 E322A [cytosol] (R-HSA-9652794) p-T185,Y187 MAPK1 D321N [cytosol] (R-HSA-9652785) p-T185,Y187 MAPK1 D321V [cytosol] (R-HSA-9652791) p-T185,Y187 MAPK1 P58L [cytosol] (R-HSA-9652806) p-T185,Y187 MAPK1 S142L [cytosol] (R-HSA-9652808) p-T185,Y187 MAPK1 E81K [cytosol] (R-HSA-9652799) p-T185,Y187 MAPK1 E322K [cytosol] (R-HSA-9652175) p-T185,Y187 MAPK1 E322V [cytosol] (R-HSA-9652797) MAPK1 [azurophil granule lumen] (R-HSA-6799225) MAPK1 [extracellular region] (R-HSA-6806250) MAPK1 [ficolin-1-rich granule lumen] (R-HSA-6800964) MAPK1 [endoplasmic reticulum lumen] (R-HSA-9636293)	0.488	2

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